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A bioinformatic and mechanistic study elicits the antifibrotic effect of ursolic acid through the attenuation of oxidative stress with the involvement of ERK, PI3K/Akt, and p38 MAPK signaling pathways in human hepatic stellate cells and rat liver.

Authors :
Wenhua He
Feng Shi
Zhi-Wei Zhou
Bimin Li
Kunhe Zhang
Xinhua Zhang
Canhui Ouyang
Shu-Feng Zhou
Xuan Zhu
Source :
Drug Design, Development & Therapy; 2015, Vol. 9, p3989-4104, 116p
Publication Year :
2015

Details

Language :
English
ISSN :
11778881
Volume :
9
Database :
Complementary Index
Journal :
Drug Design, Development & Therapy
Publication Type :
Academic Journal
Accession number :
108817369
Full Text :
https://doi.org/10.2147/DDDT.S85426