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Dietary (n-3) polyunsaturated fatty acids improve adipocyte insulin action and glucose metabolism in insulin-resistant rats: relation to membrane fatty acids.
- Source :
-
The Journal of nutrition [J Nutr] 1996 Aug; Vol. 126 (8), pp. 1951-8. - Publication Year :
- 1996
-
Abstract
- To study the effects of dietary fish oil on insulin-stimulated glucose metabolism in adipocytes of insulin-resistant rats (rats fed 50% sucrose and 30% fat), eighteen 5-wk-old Sprague-Dawley rats were fed, for 6 wk, a diet containing 30% fat as either fish oil (FO) or a mixture of vegetable and animal oils [control oils (CO)]. A third reference group was fed a standard diet (62% corn starch and 13% fat). At the end of the 6-wk period, the two experimental groups had comparable plasma glucose concentrations that were higher than that found in the reference group. FO feeding corrected the hyperinsulinemia of the experimental rats (P < 0.05) to reach values in the reference group. Plasma triacylglycerol (P < 0.01) and cholesterol (P < 0.001) concentrations were also lower in rats fed FO than in those fed CO. The body weights of FO-fed rats were similar to that of CO-fed rats, but epididymal adipose tissue weight was lower (P < 0.01). Adipocytes of FO-fed rats, compared with those of CO-fed rats, had high insulin-stimulated glucose transport (P < 0.05), oxidation (P < 0.001) and incorporation into total lipids (P < 0.05). The incorporation of (n-3) polyunsaturated fatty acids in adipocyte membrane phospholipids was higher in FO-fed rats than in those fed CO (P < 0.0001). Insulin action was positively correlated with the fatty acid unsaturation index in membrane phospholipids. Thus dietary fish oil has beneficial effects on insulinemia, plasma lipids and insulin-stimulated glucose metabolism in insulin-resistant slightly diabetic rats.
- Subjects :
- Adipocytes drug effects
Adipocytes ultrastructure
Animals
Blood Glucose metabolism
Body Weight physiology
Cell Membrane chemistry
Cell Membrane metabolism
Cell Membrane physiology
Cholesterol blood
Diet veterinary
Dietary Carbohydrates pharmacology
Dietary Fats pharmacology
Eating physiology
Fatty Acids metabolism
Fatty Acids, Omega-3 metabolism
Insulin blood
Lipid Metabolism
Lipids analysis
Lipids blood
Male
Membrane Lipids analysis
Random Allocation
Rats
Rats, Sprague-Dawley
Triglycerides blood
Adipocytes metabolism
Fatty Acids analysis
Fatty Acids, Omega-3 pharmacology
Glucose metabolism
Insulin pharmacology
Insulin Resistance physiology
Membrane Lipids metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0022-3166
- Volume :
- 126
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- The Journal of nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 8759367
- Full Text :
- https://doi.org/10.1093/jn/126.8.1951