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Polyphenolic Composition and in Vitro Antihypertensive and Anti-Inflammatory Effects of Cuphea lindmaniana and Cuphea urbaniana.
- Source :
-
Chemistry & biodiversity [Chem Biodivers] 2021 Jul; Vol. 18 (7), pp. e2100041. Date of Electronic Publication: 2021 Jun 08. - Publication Year :
- 2021
-
Abstract
- The present study investigates the chemical composition, anti-inflammatory, and antihypertensive activities, in vitro, from extracts of Cuphea lindmaniana and Cuphea urbaniana leaves. The extraction was performed ultrasound-assisted, and UHPLC/MS analysis was in positive mode ionization. The anti-inflammatory activity of the extracts and miquelianin were assayed at concentrations 0.001-10 μg/mL by chemotaxis on rat polymorphonuclear neutrophils. The antihypertensive activity was performed by angiotensin-converting enzyme (ACE) inhibition. From the nineteen proposed compounds, six of them are described for the first time in this genus. The extracts displayed antichemotactic effect with a reduction of 100 % of the neutrophil migration, in vitro, in most concentrations. The ACE-inhibition presented results ranging from 19.58 to 22.82 %. In conclusion, C. lindmaniana and C. urbaniana extracts contain a rich diversity of flavonoids and display in vitro anti-inflammatory and antihypertensive potential. Thus, this study could serve as a scientific baseline for further investigation, on developmental novel products with therapeutic actions.<br /> (© 2021 Wiley-VHCA AG, Zurich, Switzerland.)
- Subjects :
- Angiotensin-Converting Enzyme Inhibitors chemistry
Angiotensin-Converting Enzyme Inhibitors isolation & purification
Angiotensins antagonists & inhibitors
Angiotensins metabolism
Animals
Anti-Inflammatory Agents chemistry
Anti-Inflammatory Agents isolation & purification
Antihypertensive Agents chemistry
Antihypertensive Agents isolation & purification
Lipopolysaccharides antagonists & inhibitors
Lipopolysaccharides pharmacology
Plant Extracts chemistry
Plant Extracts isolation & purification
Polyphenols chemistry
Polyphenols isolation & purification
Rats
Angiotensin-Converting Enzyme Inhibitors pharmacology
Anti-Inflammatory Agents pharmacology
Antihypertensive Agents pharmacology
Cuphea chemistry
Neutrophils drug effects
Plant Extracts pharmacology
Polyphenols pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1612-1880
- Volume :
- 18
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Chemistry & biodiversity
- Publication Type :
- Academic Journal
- Accession number :
- 34000101
- Full Text :
- https://doi.org/10.1002/cbdv.202100041