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Postprandial Hyperglycemia Stimulates Neuroglial Plasticity in Hypothalamic POMC Neurons after a Balanced Meal.
- Source :
-
Cell reports [Cell Rep] 2020 Mar 03; Vol. 30 (9), pp. 3067-3078.e5. - Publication Year :
- 2020
-
Abstract
- Mechanistic studies in rodents evidenced synaptic remodeling in neuronal circuits that control food intake. However, the physiological relevance of this process is not well defined. Here, we show that the firing activity of anorexigenic POMC neurons located in the hypothalamus is increased after a standard meal. Postprandial hyperactivity of POMC neurons relies on synaptic plasticity that engages pre-synaptic mechanisms, which does not involve structural remodeling of synapses but retraction of glial coverage. These functional and morphological neuroglial changes are triggered by postprandial hyperglycemia. Chemogenetically induced glial retraction on POMC neurons is sufficient to increase POMC activity and modify meal patterns. These findings indicate that synaptic plasticity within the melanocortin system happens at the timescale of meals and likely contributes to short-term control of food intake. Interestingly, these effects are lost with a high-fat meal, suggesting that neuroglial plasticity of POMC neurons is involved in the satietogenic properties of foods.<br />Competing Interests: Declaration of Interests The authors declare no competing interests.<br /> (Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Blood Glucose metabolism
Electrophysiological Phenomena
Feeding Behavior
Hyperglycemia blood
Mice, Inbred C57BL
Mice, Transgenic
Postprandial Period
Synapses metabolism
Hyperglycemia physiopathology
Hypothalamus metabolism
Meals
Neuroglia pathology
Neuronal Plasticity
Neurons metabolism
Pro-Opiomelanocortin metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2211-1247
- Volume :
- 30
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Cell reports
- Publication Type :
- Academic Journal
- Accession number :
- 32130907
- Full Text :
- https://doi.org/10.1016/j.celrep.2020.02.029