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Increase in omega-6 and decrease in omega-3 polyunsaturated fatty acid oxidation elevates the risk of exudative AMD development in adults with Chinese diet.
- Source :
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Free radical biology & medicine [Free Radic Biol Med] 2019 Dec; Vol. 145, pp. 349-356. Date of Electronic Publication: 2019 Oct 09. - Publication Year :
- 2019
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Abstract
- Appropriate diet is essential for the regulation of age-related macular degeneration (AMD). In particular the type of dietary polyunsaturated fatty acids (PUFA) and poor antioxidant status including carotenoid levels concomitantly contribute to AMD risk. Build-up of oxidative stress in AMD induces PUFA oxidation, and a mix of lipid oxidation products (LOPs) are generated. However, LOPs are not comprehensively evaluated in AMD. LOPs are considered biomarkers of oxidative stress but also contributes to inflammatory response. In this cross-sectional case-control study, plasma omega-6/omega-3 PUFA ratios and antioxidant status (glutathione, superoxide dismutase and catalase), and plasma and urinary LOPs (41 types) were determined to evaluate its odds-ratio in the risk of developing exudative AMD (n = 99) compared to age-gender-matched healthy controls (n = 198) in adults with Chinese diet. The odds ratio of developing exudative AMD increased with LOPs from omega-6 PUFA and decreased from those of omega-3 PUFA. These observations were associated with a high plasma omega-6/omega-3 PUFA ratio and low carotenoid levels. In short, poor PUFA and antioxidant status increased the production of omega-6 PUFA LOPs such as dihomo-isoprostane and dihomo-isofuran, and lowered omega-3 PUFA LOPs such as neuroprostanes due to the high omega-6/omega-3 PUFA ratios; they were also correlated to the risk of AMD development. These findings indicate the generation of specific LOPs is associated with the development of exudative AMD.<br /> (Copyright © 2019 Elsevier Inc. All rights reserved.)
- Subjects :
- 3-Hydroxyacyl CoA Dehydrogenases genetics
3-Hydroxyacyl CoA Dehydrogenases metabolism
Acetyl-CoA C-Acyltransferase genetics
Acetyl-CoA C-Acyltransferase metabolism
Aged
Aldehydes administration & dosage
Antioxidants administration & dosage
Biomarkers blood
Carbon-Carbon Double Bond Isomerases genetics
Carbon-Carbon Double Bond Isomerases metabolism
Carotenoids metabolism
Diet adverse effects
Enoyl-CoA Hydratase genetics
Enoyl-CoA Hydratase metabolism
Fatty Acids, Omega-3 metabolism
Fatty Acids, Omega-6 metabolism
Female
Humans
Isoprostanes administration & dosage
Lipid Peroxidation drug effects
Lipid Peroxidation genetics
Macular Degeneration etiology
Macular Degeneration genetics
Macular Degeneration pathology
Male
Middle Aged
Neuroprostanes administration & dosage
Oxidation-Reduction drug effects
Oxidative Stress genetics
Racemases and Epimerases genetics
Racemases and Epimerases metabolism
Risk Factors
Fatty Acids, Omega-3 administration & dosage
Fatty Acids, Omega-6 administration & dosage
Macular Degeneration metabolism
Oxidative Stress drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1873-4596
- Volume :
- 145
- Database :
- MEDLINE
- Journal :
- Free radical biology & medicine
- Publication Type :
- Academic Journal
- Accession number :
- 31605749
- Full Text :
- https://doi.org/10.1016/j.freeradbiomed.2019.10.007