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Dietary polyphenols as a safe and novel intervention for modulating pain associated with intervertebral disc degeneration in an in-vivo rat model.
- Source :
-
PloS one [PLoS One] 2019 Oct 02; Vol. 14 (10), pp. e0223435. Date of Electronic Publication: 2019 Oct 02 (Print Publication: 2019). - Publication Year :
- 2019
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Abstract
- Developing effective therapies for back pain associated with intervertebral disc (IVD) degeneration is a research priority since it is a major socioeconomic burden and current conservative and surgical treatments have limited success. Polyphenols are naturally occurring compounds in plant-derived foods and beverages, and evidence suggests dietary supplementation with select polyphenol preparations can modulate diverse neurological and painful disorders. This study tested whether supplementation with a select standardized Bioactive-Dietary-Polyphenol-Preparation (BDPP) may alleviate pain symptoms associated with IVD degeneration. Painful IVD degeneration was surgically induced in skeletally-mature rats by intradiscal saline injection into three consecutive lumbar IVDs. Injured rats were given normal or BDPP-supplemented drinking water. In-vivo hindpaw mechanical allodynia and IVD height were assessed weekly for 6 weeks following injury. Spinal column, dorsal-root-ganglion (DRG) and serum were collected at 1 and 6 weeks post-operative (post-op) for analyses of IVD-related mechanical and biological pathogenic processes. Dietary BDPP significantly alleviated the typical behavioral sensitivity associated with surgical procedures and IVD degeneration, but did not modulate IVD degeneration nor changes of pro-inflammatory cytokine levels in IVD. Gene expression analyses suggested BDPP might have an immunomodulatory effect in attenuating the expression of pro-inflammatory cytokines in DRGs. This study supports the idea that dietary supplementation with BDPP has potential to alleviate IVD degeneration-related pain, and further investigations are warranted to identify the mechanisms of action of dietary BDPP.<br />Competing Interests: The authors have declared that no competing interests exist.
- Subjects :
- Animals
Back Pain diagnosis
Back Pain drug therapy
Back Pain physiopathology
Behavior, Animal
Biomarkers
Cytokines genetics
Cytokines metabolism
Disease Models, Animal
Ganglia, Spinal metabolism
Hyperalgesia etiology
Hyperalgesia metabolism
Hyperalgesia physiopathology
Inflammation Mediators metabolism
Low Back Pain diagnosis
Low Back Pain drug therapy
Low Back Pain etiology
Low Back Pain physiopathology
Male
Pain Measurement
Radiography
Rats
Back Pain etiology
Dietary Supplements
Intervertebral Disc Degeneration complications
Pain Management methods
Polyphenols administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 14
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 31577822
- Full Text :
- https://doi.org/10.1371/journal.pone.0223435