Upregulation of endogenous thrombopoietin receptor (MPL) with in vivo passage of calreticulin (CALR) mutant Ba/F3 cells, highlighting MPL as the requisite cytokine receptor for CALR mediated transformation.

Authors :: Brooks SA
Kim DM
Morse SJ
Nguyen QH
Craver BM
Lai HY
Fleischman AG
Source :: Leukemia research [Leuk Res] 2019 Jul; Vol. 82, pp. 11-14. Date of Electronic Publication: 2019 May 09.
Publication Year :: 2019

Subjects :: Animals
Calreticulin metabolism
Carcinogenesis metabolism
Carcinogenesis pathology
Cell Line, Tumor
Cell Proliferation
Disease Models, Animal
Genetic Vectors chemistry
Genetic Vectors metabolism
Hematologic Neoplasms metabolism
Hematologic Neoplasms mortality
Hematologic Neoplasms pathology
Humans
Mice
Mice, Inbred BALB C
Myeloproliferative Disorders metabolism
Myeloproliferative Disorders mortality
Myeloproliferative Disorders pathology
Precursor Cells, B-Lymphoid metabolism
Precursor Cells, B-Lymphoid pathology
Precursor Cells, B-Lymphoid transplantation
Receptors, Thrombopoietin metabolism
Retroviridae genetics
Retroviridae metabolism
Survival Analysis
Transduction, Genetic
Transgenes
Transplantation, Heterologous
Calreticulin genetics
Carcinogenesis genetics
Gene Expression Regulation, Neoplastic
Hematologic Neoplasms genetics
Myeloproliferative Disorders genetics
Receptors, Thrombopoietin genetics

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