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Randomized placebo-controlled intervention with n-3 LC-PUFA-supplemented yoghurt: effects on circulating eicosanoids and cardiovascular risk factors.
- Source :
-
Clinical nutrition (Edinburgh, Scotland) [Clin Nutr] 2013 Oct; Vol. 32 (5), pp. 686-96. Date of Electronic Publication: 2012 Dec 28. - Publication Year :
- 2013
-
Abstract
- Background & Aims: The study examined the value of n-3 LC-PUFA-enriched yogurt as means of improving cardiovascular health.<br />Design: Fifty three mildly hypertriacylglycerolemic subjects (TAG ≥ 1.7 mmol/L) participated in a randomized, placebo-controlled, double-blind, parallel designed study. The subjects consumed 1) control yoghurt; 2) yoghurt enriched with 0.8 g n-3 LC-PUFA/d; or 3) yoghurt enriched with 3 g n-3 LC-PUFA/d for a period of 10 wks. Blood samples were taken at the beginning and the end of the study period.<br />Results: Following daily intake of 3 g n-3 LC-PUFA for 10 weeks, n-3 LC-PUFA levels increased significantly in plasma and red blood cells (RBC) with concomitant increase in the EPA-derived mediators (PGE₃, 12-, 15-, 18-HEPE) in plasma whilst cardiovascular risk factors such as HDL, TAG, AA/EPA ratio, and n-3 index were improved (P < 0.05); the decrease of TAG and increase in HDL were associated with the CD36 genotype.<br />Conclusion: The observed increase of n-3 LC-PUFA in RBC and plasma lipids due to intake of n-3 LC-PUFA enriched yoghurt resulted in a reduction of cardiovascular risk factors and inflammatory mediators showing that daily consumption of n-3 PUFA enriched yoghurt can be an effective way of supplementing the daily diet and improving cardiovascular health.<br /> (Crown Copyright © 2013. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- Aged
CD36 Antigens genetics
Cardiovascular Diseases epidemiology
Cardiovascular Diseases etiology
Double-Blind Method
Eicosanoids metabolism
Erythrocytes metabolism
Fatty Acids, Omega-3 administration & dosage
Fatty Acids, Omega-3 blood
Female
Genetic Association Studies
Germany epidemiology
Humans
Hypertriglyceridemia genetics
Hypertriglyceridemia metabolism
Hypertriglyceridemia physiopathology
Hypolipidemic Agents administration & dosage
Hypolipidemic Agents blood
Lipoproteins, HDL blood
Male
Middle Aged
Polymorphism, Single Nucleotide
Risk Factors
Severity of Illness Index
Cardiovascular Diseases prevention & control
Eicosanoids blood
Fatty Acids, Omega-3 therapeutic use
Food, Fortified
Hypertriglyceridemia diet therapy
Hypolipidemic Agents therapeutic use
Yogurt
Subjects
Details
- Language :
- English
- ISSN :
- 1532-1983
- Volume :
- 32
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Clinical nutrition (Edinburgh, Scotland)
- Publication Type :
- Academic Journal
- Accession number :
- 23332800
- Full Text :
- https://doi.org/10.1016/j.clnu.2012.12.010