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Probing the anti-hyperlipidemic efficacy of the allspice (Pimenta officinalis Lindl.) in rats fed with high fat diet.
- Source :
-
Indian journal of physiology and pharmacology [Indian J Physiol Pharmacol] 2005 Jul-Sep; Vol. 49 (3), pp. 363-8. - Publication Year :
- 2005
-
Abstract
- In this study, the anti-hyperlipidemic effect of aqueous extract of Pimenta officinalis (APO) was investigated in experimental rats fed with high fat diet (HFD). Hyperlipidemia in experimental rats was evidenced by a significant enhancement in the level of glycerol, triglycerides and phopholipids in serum, and also in liver and kidney tissues. HFD caused oxidative stress in these animals as shown by marked increment in the levels of thiobarbituric acid reactive substances (TBARS) and diene conjugates (CD), and a distinct diminution in reduced glutathione (GSH) content in liver and kidneys. Antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) showed reduced activity in hyperlipidemic rats. All these biochemical parameters showed reliable signs of retrieving towards near-normalcy in APO-administered HFD fed rats. This study unveiled the anti-hyperlipidemic as well as antioxidant activity of APO.
- Subjects :
- Animals
Antioxidants administration & dosage
Antioxidants pharmacology
Catalase metabolism
Cholesterol blood
Glutathione Peroxidase metabolism
Hyperlipidemias blood
Hyperlipidemias enzymology
Hypolipidemic Agents administration & dosage
Kidney enzymology
Lipid Peroxidation drug effects
Liver enzymology
Male
Oxidative Stress drug effects
Phospholipids blood
Plant Extracts administration & dosage
Plant Leaves chemistry
Rats
Rats, Sprague-Dawley
Superoxide Dismutase metabolism
Thiobarbituric Acid Reactive Substances metabolism
Triglycerides blood
Dietary Fats administration & dosage
Hyperlipidemias prevention & control
Hypolipidemic Agents pharmacology
Pimenta
Plant Extracts pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0019-5499
- Volume :
- 49
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Indian journal of physiology and pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 16440858