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The Role of Probiotics in Purine Metabolism, Hyperuricemia and Gout: Mechanisms and Interventions.

Authors :
James, Armachius
Ke, Hengming
Yao, Ting
Wang, Yousheng
Source :
Food Reviews International. 2023, Vol. 39 Issue 1, p261-277. 17p. 4 Diagrams, 1 Chart.
Publication Year :
2023

Abstract

Hyperuricemia and gout are metabolic diseases characterized with high serum urate and impact human health significantly. Although some drugs have been developed to treat gout, hyperuricemia represents a substantial health problem. Reducing purine absorption through intestinal microbiota, which can be managed through intake of probiotics, emerges as a promising way to reverse elevated serum urate. Probiotics have shown several benefits such as immune modulation and improvement of intestinal functions. Therefore, this review briefly summarizes purine metabolism and molecular mechanisms for hyperuricemia and gout with the focus on recent development on the use of probiotics to alleviate hyperuricemia and gout. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
87559129
Volume :
39
Issue :
1
Database :
Academic Search Index
Journal :
Food Reviews International
Publication Type :
Academic Journal
Accession number :
162900255
Full Text :
https://doi.org/10.1080/87559129.2021.1904412