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40 results on '"van der Velden, Lilly-Ann"'

1. Neoadjuvant immunotherapy with nivolumab and ipilimumab induces major pathological responses in patients with head and neck squamous cell carcinoma

Author

Vos, Joris L., Elbers, Joris B. W., Krijgsman, Oscar, Traets, Joleen J. H., Qiao, Xiaohang, van der Leun, Anne M., Lubeck, Yoni, Seignette, Iris M., Smit, Laura A., Willems, Stefan M., van den Brekel, Michiel W. M., Dirven, Richard, Baris Karakullukcu, M., Karssemakers, Luc, Klop, W. Martin C., Lohuis, Peter J. F. M., Schreuder, Willem H., Smeele, Ludi E., van der Velden, Lilly-Ann, Bing Tan, I., Onderwater, Suzanne, Jasperse, Bas, Vogel, Wouter V., Al-Mamgani, Abrahim, Keijser, Astrid, van der Noort, Vincent, Broeks, Annegien, Hooijberg, Erik, Peeper, Daniel S., Schumacher, Ton N., Blank, Christian U., de Boer, Jan Paul, Haanen, John B. A. G., and Zuur, Charlotte L.

Published
2021
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3. Table S1 to S3 from The Anatomical Location Shapes the Immune Infiltrate in Tumors of Same Etiology and Affects Survival

Author

Santegoets, Saskia J., primary, van Ham, Vanessa J., primary, Ehsan, Ilina, primary, Charoentong, Pornpimol, primary, Duurland, Chantal L., primary, van Unen, Vincent, primary, Höllt, Thomas, primary, van der Velden, Lilly-Ann, primary, van Egmond, Sylvia L., primary, Kortekaas, Kim E., primary, de Vos van Steenwijk, Peggy J., primary, van Poelgeest, Mariëtte I.E., primary, Welters, Marij J.P., primary, and van der Burg, Sjoerd H., primary

Published
2023
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4. Supplementary Methods from Intratumoral HPV16-Specific T Cells Constitute a Type I–Oriented Tumor Microenvironment to Improve Survival in HPV16-Driven Oropharyngeal Cancer

Author

Welters, Marij J.P., primary, Ma, Wenbo, primary, Santegoets, Saskia J.A.M., primary, Goedemans, Renske, primary, Ehsan, Ilina, primary, Jordanova, Ekaterina S., primary, van Ham, Vanessa J., primary, van Unen, Vincent, primary, Koning, Frits, primary, van Egmond, Sylvia I., primary, Charoentong, Pornpimol, primary, Trajanoski, Zlatko, primary, van der Velden, Lilly-Ann, primary, and van der Burg, Sjoerd H., primary

Published
2023
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5. Supplementary Figures from Intratumoral HPV16-Specific T Cells Constitute a Type I–Oriented Tumor Microenvironment to Improve Survival in HPV16-Driven Oropharyngeal Cancer

Author

Welters, Marij J.P., primary, Ma, Wenbo, primary, Santegoets, Saskia J.A.M., primary, Goedemans, Renske, primary, Ehsan, Ilina, primary, Jordanova, Ekaterina S., primary, van Ham, Vanessa J., primary, van Unen, Vincent, primary, Koning, Frits, primary, van Egmond, Sylvia I., primary, Charoentong, Pornpimol, primary, Trajanoski, Zlatko, primary, van der Velden, Lilly-Ann, primary, and van der Burg, Sjoerd H., primary

Published
2023
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6. Figure S1 to S5 from The Anatomical Location Shapes the Immune Infiltrate in Tumors of Same Etiology and Affects Survival

Author

Santegoets, Saskia J., primary, van Ham, Vanessa J., primary, Ehsan, Ilina, primary, Charoentong, Pornpimol, primary, Duurland, Chantal L., primary, van Unen, Vincent, primary, Höllt, Thomas, primary, van der Velden, Lilly-Ann, primary, van Egmond, Sylvia L., primary, Kortekaas, Kim E., primary, de Vos van Steenwijk, Peggy J., primary, van Poelgeest, Mariëtte I.E., primary, Welters, Marij J.P., primary, and van der Burg, Sjoerd H., primary

Published
2023
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11. Quality of life and quality of care as experienced by patients with advanced cancer and their relatives: A multicentre observational cohort study (eQuiPe)

Author

van Roij, Janneke, primary, Raijmakers, Natasja, additional, Ham, Laurien, additional, van den Beuken-van Everdingen, Marieke, additional, van den Borne, Ben, additional, Creemers, Geert-Jan, additional, Cornelis Hunting, Jarmo, additional, Kuip, Evelien, additional, van Leeuwen, Lobke, additional, van Laarhoven, Hanneke, additional, Mandigers, Caroline, additional, Nieboer, Peter, additional, van der Velden, Lilly-Ann, additional, Zuylen, Lia van, additional, Gelissen, John, additional, Zijlstra, Myrte, additional, Brom, Linda, additional, Fransen, Heidi P., additional, and van de Poll-Franse, Lonneke, additional

Published
2022
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15. Prospective cohort study of patients with advanced cancer and their relatives on the experienced quality of care and life (eQuiPe study): A study protocol

Author

van Roij, Janneke, Zijlstra, Myrte, Ham, Laurien, Brom, Linda, Fransen, Heidi, Vreugdenhil, Art, Raijmakers, Natasja, van de Poll-Franse, Lonneke, Youssef-Elsoud, Maggy, Creemers, Geert-Jan, van den Borne, Ben, de Jong, Wouter, Baars, Arnold, van den Beuken - van Everdingen, Marieke, Kuip, Evelien, Bunnik, René, Hendriks, Mathijs, Mandigers, Caroline, van Basten, Jean-Paul, van Kampen - van den Boogaart, Vivian, Werner, Philo, van Zuylen, Lia, de Graeff, Alexander, van Lindert, Anne, Soesan, Marcel, Hunting, Jarmo, Smals, Arno, van de Winkel, Linda, Stege, Gerben, Verhaert, Liese, Peters, Natascha, Pepels, Manon, Smilde, Tineke, Nieboer, Peter, de Hosson, Sander, den Boer, Marien, Pitz, Cordula, Heyne, Rick, Tjin-A-Ton, Manuel, van der Padt - Pruijsten, Annemieke, van den Berg, Paul, Krouwels, Frans, van Leeuwen-Snoeks, Lobke, van der Meer, Femke, Vos, Allert, Veldhuis, Gerrit Jan, Poppema, Boelo, Thijs-Visser, Martine, Heller-Baan, Roxane, van Laren, Marjolein, van den Brink, Karen Maassen, Douma, Gea, Kloover, Jeroen, Sommeijer, Dirkje, Pronk, Lemke, Janssens - van Vliet, Ellen, van der Velden, Lilly-Ann, Hafkamp, Emma, Codrington, Henk, Tarasevych, Svitlana, van Bochove, Aart, de Boer, Jaap, Vink, Geraldine, Oncology, Medical and Clinical Psychology, Internal medicine, CCA - Cancer Treatment and quality of life, and VU University medical center

Subjects
Adult, Quality of life, medicine.medical_specialty, Palliative care, Population, lcsh:Special situations and conditions, Disease, Cohort Studies, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], 03 medical and health sciences, 0302 clinical medicine, Clinical Protocols, Neoplasms, Surveys and Questionnaires, Advanced cancer, Study protocol, Humans, Medicine, Family, Longitudinal Studies, Prospective Studies, 030212 general & internal medicine, Prospective study, education, Prospective cohort study, Netherlands, Quality of Health Care, Terminal Care, education.field_of_study, business.industry, lcsh:RC952-1245, Quality of care, General Medicine, Relatives, Cancer registry, Longitudinal cohort study, 030220 oncology & carcinogenesis, Family medicine, Population study, business, Cohort study
Abstract

Background Palliative care is becoming increasingly important because the number of patients with an incurable disease is growing and their survival is improving. Previous research tells us that early palliative care has the potential to improve quality of life (QoL) in patients with advanced cancer and their relatives. According to limited research on palliative care in the Netherlands, patients with advanced cancer and their relatives find current palliative care suboptimal. The aim of the eQuiPe study is to understand the experienced quality of care (QoC) and QoL of patients with advanced cancer and their relatives to further improve palliative care. Methods A prospective longitudinal observational cohort study is conducted among patients with advanced cancer and their relatives. Patients and relatives receive a questionnaire every 3 months regarding experienced QoC and QoL during the palliative trajectory. Bereaved relatives receive a final questionnaire 3 to 6 months after the patients’ death. Data from questionnaires are linked with detailed clinical data from the Netherlands Cancer Registry (NCR). By means of descriptive statistics we will examine the experienced QoC and QoL in our study population. Differences between subgroups and changes over time will be assessed while adjusting for confounding factors. Discussion This study will be the first to prospectively and longitudinally explore experienced QoC and QoL in patients with advanced cancer and their relatives simultaneously. This study will provide us with population-based information in patients with advanced cancer and their relatives including changes over time. Results from the study will inform us on how to further improve palliative care. Trial registration Trial NL6408 (NTR6584). Registered in Netherlands Trial Register on June 30, 2017.

Published
2020

19. A clinicopathological study and prognostic factor analysis of 177 salivary duct carcinoma patients from The Netherlands

Author

Boon, Eline, Bel, Miranda, van Boxtel, Wim, van der Graaf, Winette T. A., van Es, Robert J. J., Eerenstein, Simone E. J., Baatenburg de Jong, Robert J., van den Brekel, Michiel W. M., van der Velden, Lilly‐Ann, Witjes, Max J. H., Hoeben, Ann, Willems, Stefan M., Bloemena, Elisabeth, Smit, Laura A., Oosting, Sjoukje F., Jonker, Marianne A., Flucke, Uta E., van Herpen, Carla M. L., Guided Treatment in Optimal Selected Cancer Patients (GUTS), ​Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), Damage and Repair in Cancer Development and Cancer Treatment (DARE), RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Interne Geneeskunde, MUMC+: MA Medische Oncologie (9), MKA AMC (OII, ACTA), MKA Vumc (OII, ACTA), and Otorhinolaryngology and Head and Neck Surgery

Subjects
Adult, Male, DATABASE, Receptor, ErbB-2, receptor, Receptor, ErbB-2/metabolism, Receptors, Androgen/metabolism, THERAPY, survival, Disease-Free Survival, ErbB-2, Recurrence, ErbB‐2, Journal Article, FAILURE, Humans, Salivary Ducts, Neoplasm Metastasis, Carcinoma/pathology, salivary duct carcinoma, Aged, Netherlands, Aged, 80 and over, OUTCOMES, Carcinoma, Palliative Care, ANDROGEN RECEPTOR, Salivary Ducts/pathology, Chemoradiotherapy, Adjuvant, Middle Aged, Prognosis, Salivary Gland Neoplasms, Survival Rate, androgen receptors, Receptors, Androgen, Lymphatic Metastasis, immunohistochemistry, Female, in situ hybridization, fluorescence, Factor Analysis, Statistical, Salivary Gland Neoplasms/pathology, Cancer Epidemiology
Abstract

Salivary duct carcinoma (SDC) is a subtype of salivary gland cancer with a dismal prognosis and a need for better prognostication and novel treatments. The aim of this national cohort study was to investigate clinical outcome, prognostic factors, androgen receptor (AR) and human epidermal growth factor receptor 2 (HER2) expression. SDC patients diagnosed between 1990 and 2014 were identified by the Nationwide Network and Registry of Histo‐ and Cytopathology in the Netherlands (PALGA). Subsequently, medical records were evaluated and pathological diagnoses reviewed. Data were analyzed for overall survival (OS), disease‐free survival (DFS), distant metastasis‐free survival (DMFS) and prognostic factors. AR was evaluated by immunohistochemistry (IHC), HER2 by IHC and fluorescent in‐situ hybridization. A total of 177 patients were included. The median age was 65 years, 75% were male. At diagnosis, 68% presented with lymph node metastases and 6% with distant metastases. Median OS, DFS and DMFS were 51, 23 and 26 months, respectively. In patients presenting without distant metastases, the absolute number of positive lymph nodes was associated with poor OS and DMFS in a multivariable analysis. AR and HER2 were positive in 161/168 (96%) and 44/153 (29%) tumors, respectively, and were not prognostic factors. SDC has a dismal prognosis with primary lymph node involvement in the majority of patients. The absolute number of lymph node metastases was found to be the only prognostic factor for DMFS and OS. AR expression and—to a lesser extent—HER2 expression hold promise for systemic treatment in the metastatic and eventually adjuvant setting., What's new? Salivary duct carcinoma (SDC) is a rare and often fatal malignancy. Little is known about associations between its pathological features and clinical outcome. In this study, clinicopathological factors were analyzed for 177 patients diagnosed with SDC in The Netherlands between 1990 and 2014. The data show that median overall survival (OS) and distant metastasis‐free survival (DMFS) were 51 and 26 months, respectively. At diagnosis, 68% of patients presented with lymph node metastases. Lymph node positivity was associated with poor OS and poor DMFS. The absolute number of metastatic lymph nodes was the only significant prognostic factor for survival in a multivariate analysis. Androgen receptor and human epidermal growth factor 2 (HER2) were positive in 96% and 29%, respectively and were not a prognostic factor.

Published
2018

21. The Anatomical Location Shapes the Immune Infiltrate in Tumors of Same Etiology and Affects Survival

Author

Santegoets, Saskia J., primary, van Ham, Vanessa J., additional, Ehsan, Ilina, additional, Charoentong, Pornpimol, additional, Duurland, Chantal L., additional, van Unen, Vincent, additional, Höllt, Thomas, additional, van der Velden, Lilly-Ann, additional, van Egmond, Sylvia L., additional, Kortekaas, Kim E., additional, de Vos van Steenwijk, Peggy J., additional, van Poelgeest, Mariëtte I.E., additional, Welters, Marij J.P., additional, and van der Burg, Sjoerd H., additional

Published
2019
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22. Intratumoral HPV16-Specific T Cells Constitute a Type I–Oriented Tumor Microenvironment to Improve Survival in HPV16-Driven Oropharyngeal Cancer

Author

Welters, Marij J.P., primary, Ma, Wenbo, additional, Santegoets, Saskia J.A.M., additional, Goedemans, Renske, additional, Ehsan, Ilina, additional, Jordanova, Ekaterina S., additional, van Ham, Vanessa J., additional, van Unen, Vincent, additional, Koning, Frits, additional, van Egmond, Sylvia I., additional, Charoentong, Pornpimol, additional, Trajanoski, Zlatko, additional, van der Velden, Lilly-Ann, additional, and van der Burg, Sjoerd H., additional

Published
2018
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26. A phase I study in patients with a human papillomavirus type 16 positive oropharyngeal tumor treated with second generation synthetic long peptide vaccine conjugated to a defined adjuvant.

Author

Slingerland, Marije, primary, Speetjens, Frank, additional, Welters, Marij, additional, Gelderblom, Hans, additional, Roozen, Inge, additional, van der Velden, Lilly-Ann, additional, Melief, Cornelis Joseph, additional, Zandvliet, Maarten, additional, van der Burg, Sjoerd, additional, and Ossendorp, Ferry, additional

Published
2016
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38. Geriatric assessment and 1-year mortality in older patients with cancer in the head and neck region: A cohort study.

Author

van Deudekom FJ, van der Velden LA, Zijl WH, Schimberg AS, Langeveld AP, Slingerland M, Blauw GJ, and Mooijaart SP

Subjects
Aged, Aged, 80 and over, Canes, Cohort Studies, Disabled Persons statistics & numerical data, Female, Humans, Male, Malnutrition epidemiology, Netherlands epidemiology, Retrospective Studies, Sex Factors, Walkers, Geriatric Assessment, Head and Neck Neoplasms mortality
Abstract

Background: The aim is to describe the association of functional capacity and cognitive functioning with 1-year mortality in older patients with cancer in the head and neck region., Methods: We performed a cohort study in which all patients aged 70 years and older received a geriatric screening before treatment. Main outcome was 1-year mortality., Results: A total of 102 patients were included. Median age was 78.7 years (interquartile range [IQR], 72.3-84.5), 25% were cognitive impaired, 40% were malnourished, and 28.4% used a walking device. Overall, 1-year mortality was 42.3%. Male sex (hazard ratio [HR], 4.30; 95% confidence interval [CI], 1.35-13.67), malnutrition (HR, 2.55; 95% CI, 1.19-5.16), and using a walking device (HR, 2.80; 95% CI 1.13-6.93) were associated with higher mortality risk, independent of stage and comorbidities., Conclusion: In older patients with head and neck cancer, the mortality rates are high. Nutritional status and mobility are determinants of 1-year mortality, independent of tumor stage, age, and comorbidity., (© 2019 The Authors. Head & Neck published by Wiley Periodicals, Inc.)

Published
2019
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39. A clinicopathological study and prognostic factor analysis of 177 salivary duct carcinoma patients from The Netherlands.

Author

Boon E, Bel M, van Boxtel W, van der Graaf WTA, van Es RJJ, Eerenstein SEJ, Baatenburg de Jong RJ, van den Brekel MWM, van der Velden LA, Witjes MJH, Hoeben A, Willems SM, Bloemena E, Smit LA, Oosting SF, Jonker MA, Flucke UE, and van Herpen CML

Subjects
Adult, Aged, Aged, 80 and over, Carcinoma surgery, Carcinoma therapy, Chemoradiotherapy, Adjuvant, Disease-Free Survival, Factor Analysis, Statistical, Female, Humans, Lymphatic Metastasis, Male, Middle Aged, Neoplasm Metastasis, Netherlands, Palliative Care, Prognosis, Receptor, ErbB-2 metabolism, Receptors, Androgen metabolism, Recurrence, Salivary Ducts surgery, Salivary Gland Neoplasms radiotherapy, Salivary Gland Neoplasms surgery, Salivary Gland Neoplasms therapy, Survival Rate, Carcinoma pathology, Salivary Ducts pathology, Salivary Gland Neoplasms pathology
Abstract

Salivary duct carcinoma (SDC) is a subtype of salivary gland cancer with a dismal prognosis and a need for better prognostication and novel treatments. The aim of this national cohort study was to investigate clinical outcome, prognostic factors, androgen receptor (AR) and human epidermal growth factor receptor 2 (HER2) expression. SDC patients diagnosed between 1990 and 2014 were identified by the Nationwide Network and Registry of Histo- and Cytopathology in the Netherlands (PALGA). Subsequently, medical records were evaluated and pathological diagnoses reviewed. Data were analyzed for overall survival (OS), disease-free survival (DFS), distant metastasis-free survival (DMFS) and prognostic factors. AR was evaluated by immunohistochemistry (IHC), HER2 by IHC and fluorescent in-situ hybridization. A total of 177 patients were included. The median age was 65 years, 75% were male. At diagnosis, 68% presented with lymph node metastases and 6% with distant metastases. Median OS, DFS and DMFS were 51, 23 and 26 months, respectively. In patients presenting without distant metastases, the absolute number of positive lymph nodes was associated with poor OS and DMFS in a multivariable analysis. AR and HER2 were positive in 161/168 (96%) and 44/153 (29%) tumors, respectively, and were not prognostic factors. SDC has a dismal prognosis with primary lymph node involvement in the majority of patients. The absolute number of lymph node metastases was found to be the only prognostic factor for DMFS and OS. AR expression and-to a lesser extent-HER2 expression hold promise for systemic treatment in the metastatic and eventually adjuvant setting., (© 2018 The Authors International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.)

Published
2018
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40. [Cystic neck mass. Cervical cleft cyst or lymph node metastasis?].

Author

Schouten CS, Akrum RA, and van der Velden LA

Subjects
Biopsy, Fine-Needle, Diagnosis, Differential, Head and Neck Neoplasms diagnosis, Humans, Lymphatic Metastasis diagnosis, Lymphatic Metastasis pathology, Male, Middle Aged, Carcinoma, Squamous Cell diagnosis, Cysts diagnosis, Laryngeal Neoplasms diagnosis, Neoplasms, Unknown Primary diagnosis
Abstract

While most cystic neck masses are cervical cleft cysts, it is known that lymph node metastasis from a squamous cell carcinoma in Waldeyer's ring may undergo cystic degeneration and can mimic cervical cysts, leading to a mistaken diagnosis. A 54-year-old male presented with features of a cervical cleft cyst, which later proved to be a lymph node metastasis from a supraglottic laryngeal carcinoma. A 47-year-old male presented with an abscessing lymphadenitis; this turned out to be a metastasis of an unknown primary tumor. Investigations should include ultrasound-guided FNA (fine-needle aspiration) performed by an experienced radiologist. However, FNA outcomes are often inconclusive. In patients who are highly suspected of having a malignancy (those with a history of smoking and alcohol abuse), a panendoscopy with biopsies and tonsillectomy, preferably conducted by an otolaryngologist specialised in head and neck cancer, should be considered.

Published
2013

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