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A clinicopathological study and prognostic factor analysis of 177 salivary duct carcinoma patients from The Netherlands
- Source :
- International Journal of Cancer, 143(4), 758-766. Wiley, International Journal of Cancer, International journal of cancer, 143(4), 758-766. Wiley-Liss Inc., International Journal of Cancer, 143(4), 758-766. Wiley-Liss Inc.
- Publication Year :
- 2018
-
Abstract
- Salivary duct carcinoma (SDC) is a subtype of salivary gland cancer with a dismal prognosis and a need for better prognostication and novel treatments. The aim of this national cohort study was to investigate clinical outcome, prognostic factors, androgen receptor (AR) and human epidermal growth factor receptor 2 (HER2) expression. SDC patients diagnosed between 1990 and 2014 were identified by the Nationwide Network and Registry of Histo‐ and Cytopathology in the Netherlands (PALGA). Subsequently, medical records were evaluated and pathological diagnoses reviewed. Data were analyzed for overall survival (OS), disease‐free survival (DFS), distant metastasis‐free survival (DMFS) and prognostic factors. AR was evaluated by immunohistochemistry (IHC), HER2 by IHC and fluorescent in‐situ hybridization. A total of 177 patients were included. The median age was 65 years, 75% were male. At diagnosis, 68% presented with lymph node metastases and 6% with distant metastases. Median OS, DFS and DMFS were 51, 23 and 26 months, respectively. In patients presenting without distant metastases, the absolute number of positive lymph nodes was associated with poor OS and DMFS in a multivariable analysis. AR and HER2 were positive in 161/168 (96%) and 44/153 (29%) tumors, respectively, and were not prognostic factors. SDC has a dismal prognosis with primary lymph node involvement in the majority of patients. The absolute number of lymph node metastases was found to be the only prognostic factor for DMFS and OS. AR expression and—to a lesser extent—HER2 expression hold promise for systemic treatment in the metastatic and eventually adjuvant setting.<br />What's new? Salivary duct carcinoma (SDC) is a rare and often fatal malignancy. Little is known about associations between its pathological features and clinical outcome. In this study, clinicopathological factors were analyzed for 177 patients diagnosed with SDC in The Netherlands between 1990 and 2014. The data show that median overall survival (OS) and distant metastasis‐free survival (DMFS) were 51 and 26 months, respectively. At diagnosis, 68% of patients presented with lymph node metastases. Lymph node positivity was associated with poor OS and poor DMFS. The absolute number of metastatic lymph nodes was the only significant prognostic factor for survival in a multivariate analysis. Androgen receptor and human epidermal growth factor 2 (HER2) were positive in 96% and 29%, respectively and were not a prognostic factor.
- Subjects :
- Adult
Male
DATABASE
Receptor, ErbB-2
receptor
Receptor, ErbB-2/metabolism
Receptors, Androgen/metabolism
THERAPY
survival
Disease-Free Survival
ErbB-2
Recurrence
ErbB‐2
Journal Article
FAILURE
Humans
Salivary Ducts
Neoplasm Metastasis
Carcinoma/pathology
salivary duct carcinoma
Aged
Netherlands
Aged, 80 and over
OUTCOMES
Carcinoma
Palliative Care
ANDROGEN RECEPTOR
Salivary Ducts/pathology
Chemoradiotherapy, Adjuvant
Middle Aged
Prognosis
Salivary Gland Neoplasms
Survival Rate
androgen receptors
Receptors, Androgen
Lymphatic Metastasis
immunohistochemistry
Female
in situ hybridization
fluorescence
Factor Analysis, Statistical
Salivary Gland Neoplasms/pathology
Cancer Epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 00207136
- Database :
- OpenAIRE
- Journal :
- International Journal of Cancer, 143(4), 758-766. Wiley, International Journal of Cancer, International journal of cancer, 143(4), 758-766. Wiley-Liss Inc., International Journal of Cancer, 143(4), 758-766. Wiley-Liss Inc.
- Accession number :
- edsair.pmid.dedup....33cf42d85871cffcae6b4eaf9d604f8d