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23 results on '"van der Pal, H.J.H."'

2. Chronic fatigue in childhood cancer survivors is associated with lifestyle and psychosocial factors; a DCCSS LATER study

Author

Penson, A., Walraven, I., Bronkhorst, E., Grootenhuis, M.A., Maurice-Stam, H., de Beijer, I., van der Heiden-van der Loo, M., Tissing, W.J.E., van der Pal, H.J.H., de Vries, A.C.H., Bresters, D., Ronckers, C.M., van den Heuvel-Eibrink, M.M., Neggers, S., Versluys, B.A.B., Louwerens, M., Pluijm, S.M.F., Blijlevens, N., van Dulmen-den Broeder, E., Kremer, L.C.M., Knoop, H., and Loonen, J.

Published
2023
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3. Female reproductive function after treatment of childhood acute lymphoblastic leukemia

Author

van Dulmen-den Broeder E, van den Berg M, van Dijk M, W.J.E. (Wim) Tissing, Dorine Bresters, van den Heuvel-Eibrink M, Catharina C. M. Beerendonk, Cécile M. Ronckers, L. C. M. Kremer, van der Pal, H.J.H., Gertjan J.L. Kaspers, A. Overbeek, van der Heiden-van der Loo M, Roshandel R, Jacqueline J. Loonen, van Leeuwen F, Birgitta Versluys, C.B. Lambalk, Obstetrics and gynaecology, Pediatric surgery, CCA - Cancer Treatment and quality of life, Amsterdam Reproduction & Development (AR&D), and Guided Treatment in Optimal Selected Cancer Patients (GUTS)

Subjects
Adult, Anti-Mullerian Hormone, Pediatrics, medicine.medical_specialty, childhood cancer survivors, pregnancy outcomes, acute lymphoblastic leukemia, Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18], 03 medical and health sciences, Ovarian function, 0302 clinical medicine, Cancer Survivors, Pregnancy, Medicine, Humans, reproductive function, Child, Childhood Acute Lymphoblastic Leukemia, Retrospective Studies, Menarche, fertility, business.industry, Obstetrics, Hematology, Odds ratio, Total body irradiation, Precursor Cell Lymphoblastic Leukemia-Lymphoma, medicine.disease, Antral follicle, Pediatric cancer, Women's cancers Radboud Institute for Health Sciences [Radboudumc 17], pediatric cancer, Reproductive Health, Oncology, 030220 oncology & carcinogenesis, Pediatrics, Perinatology and Child Health, Cohort, Female, Follicle Stimulating Hormone, business, After treatment, 030215 immunology
Abstract

Contains fulltext : 244604.pdf (Publisher’s version ) (Closed access) BACKGROUND: The aim was to evaluate self-reported reproductive characteristics and markers of ovarian function in a nationwide cohort of female survivors of childhood acute lymphoblastic leukemia (ALL), because prior investigations have produced conflicting data. PROCEDURE: Self-reported reproductive characteristics were assessed by questionnaire among 357 adult 5-year survivors, treated between 1964 and 2002, and 836 controls. Ovarian function was assessed by serum levels of anti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH), and inhibin B and by antral follicle count (AFC). Differences between controls and (subgroups of) survivors (total group, chemotherapy [CT]-only group, CT and radiotherapy [RT] group) were analyzed. RESULTS: Survivors treated with CT only do not differ from controls regarding timing of menarche, virginity status, desire for children, or pregnancy rates. Compared to controls, the CT+RT group was at significantly increased risk of a younger age at menarche (P

Published
2021

4. Health-related quality of life in Dutch adult survivors of childhood cancer: A nation-wide cohort study

Author

van Erp, L.M.E., primary, Maurice-Stam, H., additional, Kremer, L.C.M., additional, Tissing, W.J.E., additional, van der Pal, H.J.H., additional, de Vries, A.C.H., additional, van den Heuvel-Eibrink, M.M., additional, Versluys, B.A.B., additional, Loonen, J.J., additional, Bresters, D., additional, Louwerens, M., additional, van der Heiden-van der Loo, M., additional, van den Berg, M.H., additional, Ronckers, C.M., additional, van der Kooi, A.L.L.F., additional, van Gorp, M., additional, van Dulmen-den Broeder, E., additional, and Grootenhuis, M.A., additional

Published
2021
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5. Diagnostic tools for early detection of cardiac dysfunction in childhood cancer survivors: Methodological aspects of the Dutch late effects after childhood cancer (LATER) cardiology study

Author

Leerink, J.M. (Jan M.), Feijen, E.L.A.M. (E. Lieke A.M.), van der Pal, H.J.H. (Helena J.H.), Kok, W.E.M. (Wouter), Mavinkurve-Groothuis, A.M.C. (Annelies M.C.), Kapusta, L. (Livia), Pinto, Y.M. (Yigal), Maas, A.H.E.M. (Angela H.E.M.), Bellersen, L. (Louise), Teske, A.J. (Arco J.), Ronckers, C.M. (Cécile), Louwerens, M. (Marlous), Dalen, E.C. (Elvira) van, Dulmen-den Broeder, E. (Eline) van, Batenburg, L. (Lilian), Heiden-Van der Loo, M. (Margriet) van der, Heuvel-Eibrink, M.M. (Marry) van den, van Leeuwen, F.E. (Flora E.), Vries, A.C.H. (Andrica) de, Weijers, G. (Gert), Korte, C.L. (Chris) de, Loonen, J.J. (Jacqueline), Neggers, S.J.C.M.M. (Sebastian J.C.M.M.), Versluys, A.B.B. (A.B. Birgitta), Tissing, W.J.E. (Wim), Kremer, L.C.M. (Leontien C.M.), Leerink, J.M. (Jan M.), Feijen, E.L.A.M. (E. Lieke A.M.), van der Pal, H.J.H. (Helena J.H.), Kok, W.E.M. (Wouter), Mavinkurve-Groothuis, A.M.C. (Annelies M.C.), Kapusta, L. (Livia), Pinto, Y.M. (Yigal), Maas, A.H.E.M. (Angela H.E.M.), Bellersen, L. (Louise), Teske, A.J. (Arco J.), Ronckers, C.M. (Cécile), Louwerens, M. (Marlous), Dalen, E.C. (Elvira) van, Dulmen-den Broeder, E. (Eline) van, Batenburg, L. (Lilian), Heiden-Van der Loo, M. (Margriet) van der, Heuvel-Eibrink, M.M. (Marry) van den, van Leeuwen, F.E. (Flora E.), Vries, A.C.H. (Andrica) de, Weijers, G. (Gert), Korte, C.L. (Chris) de, Loonen, J.J. (Jacqueline), Neggers, S.J.C.M.M. (Sebastian J.C.M.M.), Versluys, A.B.B. (A.B. Birgitta), Tissing, W.J.E. (Wim), and Kremer, L.C.M. (Leontien C.M.)

Abstract

Background: Cancer therapy-related cardiac dysfunction and heart failure are major problems in long-term childhood cancer survivors (CCS). We hypothesize that assessment of more sensitive echo- and electrocardiographic measurements, and/or biomarkers will allow for improved recognition of patients with cardiac dysfunction before heart failure develops, and may also identify patients at lower risk for heart failure. Objective: To describe the methodology of the Dutch LATER cardiology study (LATER CARD). Methods: The LATER CARD study is a cross-sectional study in long-term CCS treated with (potentially) cardiotoxic cancer therapies and sibling controls. We will evaluate 1) the prevalence and associated (treatment related) risk factors of subclinical cardiac dysfunction in CCS compared to sibling controls and 2) the diagnostic value of echocardiography including myocardial strain and diastolic function parameters, blood biomarkers for cardiomyocyte apoptosis, oxidative stress, cardiac remodeling and inflammation and ECG or combinations of them in the surveillance for cancer therapy-related cardiac dysfunction. From 2017 to 2020 we expect to include 1900 CCS and 500 siblings. Conclusions: The LATER CARD study will provide knowledge on different surveillance modalities for detection of cardiac dysfunction in long-term CCS at risk for heart f

Published
2020
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6. Biomarkers for detection of anthracycline-induced cardiomyopathy in childhood cancer survivors: a case-control study in the Dutch LATER cohort study

Author

Leerink, J.M, primary, Feijen, E.A.M, additional, Mavinkurve-Groothuis, A.M.C, additional, Tissing, W.J.E, additional, Louwerens, M, additional, Van Den Heuvel-Eibrink, M.M, additional, Versluys, A.B, additional, Van Dulmen-Den Broeder, E, additional, De Vries, A.C.H, additional, Van Der Pal, H.J.H, additional, Kapusta, L, additional, Loonen, J, additional, Pinto, Y.M, additional, Kremer, L.C.M, additional, and Kok, W.E.M, additional

Published
2020
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7. Echocardiography for the 10-year prediction of cardiomyopathy in long-term survivors of childhood cancer

Author

Leerink, J.M, primary, Van Der Pal, H.J.H, additional, Feijen, E.A.M, additional, Meregalli, P.G, additional, Pourier, M.S, additional, Merkx, R, additional, Bellersen, L, additional, Van Dalen, E.C, additional, Loonen, J, additional, Pinto, Y.M, additional, Kapusta, L, additional, Kremer, L.C.M, additional, Mavinkurve-Groothuis, A.M.C, additional, and Kok, W.E.M, additional

Published
2020
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13. Pediatric Differentiated Thyroid Carcinoma in The Netherlands: A Nationwide Follow-Up Study:Journal of Clinical Endocrinology & Metabolism

Author

Hesselink, M. S. K., Nies, M., Bocca, G., Brouwers, A. H., Burgerhof, J.G.M., van Dam, Ewcm, Havekes, B., van den Heuvel-Eibrink, Marry M., Corssmit, E.P.M., Kremer, Leontien C. M., Netea-Maier, Romana T., van der Pal, H.J.H., Peeters, Robin P., Schmid, K. W., Smit, J. W. A., Williams, G. R., Plukker, John T. M., Ronckers, C.M., van Santen, Hanneke M., Tissing, Wim J. E., Links, T.P., Internal medicine, ICaR - Circulation and metabolism, and General practice

Abstract

Introduction: Treatment for differentiated thyroid carcinoma (DTC) in pediatric patients is based mainly on evidence from adult series due to lack of data from pediatric cohorts. Our objective was to evaluate presentation, treatment-related complications, and long-term outcome in patients with pediatric DTC in The Netherlands. Patients and Methods: In this nationwide study, presentation, complications, and outcome of patients with pediatric DTC (age at diagnosis

Published
2016

15. Intermediate and long-term adverse effects of radioiodine therapy for differentiated thyroid carcinoma – A systematic review

Author

Clement, S.C., primary, Peeters, R.P., additional, Ronckers, C.M., additional, Links, T.P., additional, van den Heuvel-Eibrink, M.M., additional, Nieveen van Dijkum, E.J.M., additional, van Rijn, R.R., additional, van der Pal, H.J.H., additional, Neggers, S.J., additional, Kremer, L.C.M., additional, van Eck-Smit, B.L.F., additional, and van Santen, H.M., additional

Published
2015
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16. Cardiovascular disease after treatment for childhood cancer

Author

van der Pal, H.J.H., Caron, H.N., van Leeuwen, F.E., Kremer, Leontien C.M., and Faculteit der Geneeskunde

Abstract

Een op de acht overlevenden van kinderkanker die bestraald zijn én behandeld werden met anthracyclines, heeft dertig jaar later een ernstige hartaandoening. Om kinderen met kanker te blijven volgen en controleren op late bijwerkingen, riep het Emma Kinderziekenhuis AMC in 1996 de Polikliniek Late Effecten Kindertumoren (PLEK) in het leven. Daarnaast beschikken onderzoekers over een database met gegevens over diagnose en behandeling van alle kinderen met kanker die in het EKZ/AMC opgenomen waren. Heleen van der Pal deed onderzoek in een cohort van 1362 patiënten die minstens vijf jaar na de behandeling nog in leven zijn. Ze vond 50 ernstige hartaandoeningen bij 42 patiënten. Meer dan de helft kampte met hartfalen, gevolgd door hartklepafwijkingen, ischemische hartziekten (zoals een infarct) en ritmestoornissen. Dertig jaar na de behandeling was de kans op een ernstige hartaandoening het grootst in de groep die zowel radiotherapie als anthracyclines kreeg. Een op de acht patiënten loopt dat risico. Uit echo’s van het hart bij jongvolwassenen die in hun kindertijd met middelen behandeld werden die potentieel schadelijk zijn voor het orgaan, bleek dat 27 procent van de 525 personen een verminderde hartfunctie had. Van der Pal denkt dat zij gaandeweg hartaandoeningen ontwikkelen die klachten kunnen geven. Sommige patiënten krijgen daarom preventief medicijnen. Ook wordt er bij een aantal van hen vaker een echo gemaakt.

Published
2011

18. Is outcome of differentiated thyroid carcinoma influenced by tumor stage at diagnosis?

Author

Clement, S.C., primary, Kremer, L.C.M., additional, Links, T.P., additional, Mulder, R.L., additional, Ronckers, C.M., additional, van Eck-Smit, B.L.F., additional, van Rijn, R.R., additional, van der Pal, H.J.H., additional, Tissing, W.J.E., additional, Janssens, G.O., additional, van den Heuvel-Eibrink, M.M., additional, Neggers, S.J.C.M.M., additional, van Dijkum, E.J.M. Nieveen, additional, Peeters, R.P., additional, and van Santen, H.M., additional

Published
2015
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20. The usefulness of growth hormone treatment for psychological status in young adult survivors of childhood leukaemia; an open-label study

Author

Huisman, J., Aukema, E.J., Deijen, J.B., van den Coeverden, S.C.C.M., Kaspers, G.J.L., van der Pal, H.J.H., Delemarre-van de Waal, H.A., Huisman, J., Aukema, E.J., Deijen, J.B., van den Coeverden, S.C.C.M., Kaspers, G.J.L., van der Pal, H.J.H., and Delemarre-van de Waal, H.A.

Abstract

Background: To reduce the risk of brain damage children with acute lymphoblastic leukaemia (ALL) are nowadays mainly treated with intrathecal chemotherapy (ITC) instead of central nervous system (CNS) radiation therapy (CRT) to prevent CNS relapse. However, chemotherapy may also lead to cognitive deficits. As growth hormone deficiency (GHD) or impaired growth hormone secretion are frequently found in ALL patients treated with cranial radiation therapy and/or chemotherapy, we hypothesized that GH therapy may reduce cognitive deficits in these patients. Methods: Twenty young adult survivors of childhood ALL with reduced bone mineral density (<-1 SD) and/or low IGF-I SD-scores (<-1 SD) were included in the study. A final group of 13 patients (9 males and 4 females), mean age 23.7 ± 2.9 years (range 20 - 29.7) completed a 2-year treatment with GH. IQ and neuropsychological performance were assessed at pre-treatment (T1) and after one (T2) and two (T3) years. ANOVA was performed with assessment at T1, T2 and T3 as repeated measurements factor. Relations between test score changes and changes of IGF-I levels were determined by calculating the Pearson correlation coefficient. Results: Scores on the cognitive tests were in the normal range. Verbal short- and long-term memory performance decreased between T1 and T2, and increased between T2 and T3. Performance at T3 was not significantly different from that at T1. Performance for sustained attention improved from T1 to T2 and from T1 to T3. Visual-spatial memory was improved after one year of GH treatment. A significant positive correlation was found for Δ IGF-I (T2-T1) with difference scores of visual-spatial memory (T2-T1 and T3-T1), indicating that IGF-I increase after one year of GH treatment is associated with increase in cognitive-perceptual performance at month 12 and 24. Conclusion: Since the level of intellectual functioning of our patient cohort was in the normal range the present finding that GH treatment ha

Published
2008
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23. Meningioma and stroke among long-term childhood cancer survivors and recommendations for survivorship care

Author

Verbruggen, L.C., Kremer, Leontien C.M., Ronckers, Cecile M., van der Pal, H.J.H., and Faculteit der Geneeskunde

Abstract

Long term adverse side events among childhood cancer survivors (CCS) can negatively impact quality of life. A concern are late effects among CCS treated with radiotherapy directed to the upper body (i.e. brain, neck, and thorax, including spinal radiotherapy and total body irradiation). Damage to these areas might induce cerebrovascular events or subsequent central nervous system (CNS) tumors, including meningiomas. To improve quality of late effects care for survivors, clinical research studying long term adverse events is crucial. Evidence-based guidelines and recommendations are warranted to permit deliberate choices in clinical decision-making. The objectives of this thesis are: a) to increase knowledge on risk factors and clinical characteristics of late effects in CCS after treatment with upper body radiotherapy; b) to provide guidance on surveillance of Childhood Adolescent Young Adult cancer survivors (CAYA cancer survivors) with respect to subsequent CNS tumors and concerning COVID-19. In the first part of this thesis two retrospective clinical research studies are presented concerning cerebrovascular events (CVE) and meningioma as long-term adverse events after upper body radiotherapy. These studies are embedded within the Dutch Childhood Cancer Survivor Study (CCSS) LATER cohort. This cohort includes survivors who are diagnosed

Published
2022

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