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4. Clonal Patterns Between Pouch Neoplasia and Prior Colorectal Neoplasia in Inflammatory Bowel Disease Patients:An Exploratory Cohort Study

Author

Te Groen, Maarten, Derikx, Lauranne A.A.P., van Lierop, Lisa, Ylstra, Bauke, Hoentjen, Frank, Nagtegaal, Iris D., Simmer, Femke, Te Groen, Maarten, Derikx, Lauranne A.A.P., van Lierop, Lisa, Ylstra, Bauke, Hoentjen, Frank, Nagtegaal, Iris D., and Simmer, Femke

Abstract

Prior colorectal neoplasia is the strongest predictor of pouch neoplasia in inflammatory bowel disease, but the underlying mechanism is unknown. We observed clonality between colorectal and pouch neoplasia in 30% of patients, indicating that most pouch neoplasia develops clonally independent from prior colorectal lesions.

Published
2023

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