1. Glycemic disorders in patients with pheochromocytomas and sympathetic paragangliomas.
- Author
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Araujo-Castro, Marta, Mínguez Ojeda, César, García Centeno, Rogelio, López-García, María-Carmen, Lamas, Cristina, Hanzu, Felicia Alexandra, Mora, Mireia, del Castillo Tous, María, Rodríguez de Vera Gómez, Pablo, Parra Ramírez, Paola, Alvarez-Escola, Cristina, Blanco Carrera, Concepción, Barahona San Millán, Rebeca, Recasens, Mónica, Valdés, Nuria, Gracia Gimeno, Paola, de Miguel Novoa, Paz, Vicente, Almudena, Manjón, Laura, and García Sanz, Iñigo
- Subjects
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HYPERTENSION risk factors , *BLOOD sugar , *BODY mass index , *DIABETES , *GLYCOSYLATED hemoglobin - Abstract
The objective of our study was to determine the prevalence of g lycemic disorders (diabetes mellitus and prediabetes) in patients with pheochromocytomas and sympathetic paragangliomas (PPGLs) and identify risk factors for their development and the likelihood of their resolution after surgery. A multicentric retrospective study of patients with PPGLs submitted to surgery between 2000 and 2021 in 17 Spanish hospitals was performed. Diabetes-specific data were collected at diagnosis, in the immediate- and long-term postsurgical follow-up. A total of 229 patients with PPGLs were included (218 with pheochromocytomas and 11 with sympathetic paragangliomas). Before surgery, glycemic disorders were diagnosed in 35.4% of the patients (n = 81): 54 with diabetes and 27 with prediabetes. The variables independently associated with a higher risk of glycemic disorders were sporadic PPGL (odds ratio (OR) = 3.26 (1.14-9.36)) and hypertension (OR = 3.14 (1.09-9.01)). A significant decrease in fasting plasma glucose and HbA1c levels was observed after surgery, in the short-term and long-term follow-up (P < 0.001). After a median follow-up of 48.5 months (range 3.3-168.9), after surgery, 52% of diabetic and 68% of prediabetic patients experienced a complete resolution. Lower body mass index (BMI) (P = 0.001), lower glucose levels (P = 0.047) and shorter duration of diabetes prior to surgery (P = 0.021) were associated with a higher probability of diabetes resolution. In conclusion, glycemic disorders in patients with PPGLs are present in more than a third of them at diagnosis. Sporadic PPGLs and hypertension are risk factors for their development. More than 50% of cases experience a complete resolution of the glycemic disorder after resection of the PPGLs. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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