1. Chronic treatment with myo-inositol reduces white adipose tissue accretion and improves insulin sensitivity in female mice
- Author
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Croze, Marine, Vella, Roxane, Pillon, Nicolas, Soula, Hédi, Hadji, Lilas, Guichardant, Michel, Soulage, Christophe, Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National de la Recherche Agronomique (INRA), This work was supported by INSERM and INSA-Lyon. M.L. CROZE, R.E. VELLA and L. HADJI were recipient for grants from the French 'Ministère de la Recherche et de la Technologie'., Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL)
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myo-inositol ,antioxidant ,skeletal muscle: white adipose tissue ,fat mas ,insulin-sensitizing ,[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition - Abstract
International audience; Type 2 diabetes is a complex disease characterized by a state of insulin resistance in peripheral tissues such as skeletal muscle, adipose tissue or liver. Some inositol isomers have been reported to possess insulin-mimetic activity and to be efficient in lowering blood glucose level. The aim of the present study was to assess in mice the metabolic effects of a chronic treatment with myo-inositol, the most common stereoisomer of inositol. Mice given myo-inositol treatment (0.9 or 1.2 mg g(-1) day(-1), 15 days, orally or intraperitoneally) exhibited an improved glucose tolerance due to a greater insulin sensitivity. Mice treated with myo-inositol exhibited a decreased white adipose tissue accretion (-33%, P
- Published
- 2013
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