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Chronic treatment with myo-inositol reduces white adipose tissue accretion and improves insulin sensitivity in female mice
- Source :
- Journal of Nutritional Biochemistry, Journal of Nutritional Biochemistry, Elsevier, 2013, 24 (2), pp.457-66. ⟨10.1016/j.jnutbio.2012.01.008⟩
- Publication Year :
- 2013
- Publisher :
- HAL CCSD, 2013.
-
Abstract
- International audience; Type 2 diabetes is a complex disease characterized by a state of insulin resistance in peripheral tissues such as skeletal muscle, adipose tissue or liver. Some inositol isomers have been reported to possess insulin-mimetic activity and to be efficient in lowering blood glucose level. The aim of the present study was to assess in mice the metabolic effects of a chronic treatment with myo-inositol, the most common stereoisomer of inositol. Mice given myo-inositol treatment (0.9 or 1.2 mg g(-1) day(-1), 15 days, orally or intraperitoneally) exhibited an improved glucose tolerance due to a greater insulin sensitivity. Mice treated with myo-inositol exhibited a decreased white adipose tissue accretion (-33%, P
Details
- Language :
- English
- ISSN :
- 09552863
- Database :
- OpenAIRE
- Journal :
- Journal of Nutritional Biochemistry, Journal of Nutritional Biochemistry, Elsevier, 2013, 24 (2), pp.457-66. ⟨10.1016/j.jnutbio.2012.01.008⟩
- Accession number :
- edsair.dedup.wf.001..37ffdd46b0b0a07f91e77ee53136b662
- Full Text :
- https://doi.org/10.1016/j.jnutbio.2012.01.008⟩