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2 results on '"sequential-like and sustainable release"'

1. Promoting endothelial recovery and reducing neointimal hyperplasia using sequential-like release of acetylsalicylic acid and paclitaxel-loaded biodegradable stents

Author

Cheng-Hung Lee, Chia-Ying Yu, Shang-Hung Chang, Ming-Yi Hsu, Chao-Jan Wang, Ming-Shien Wen, Shih-Jung Liu, Wei-Jan Chen, Yu-Shien Ko, Kuo-Chun Hung, and I-Chang Hsieh

Subjects
Male, medicine.medical_treatment, Pharmaceutical Science, Biocompatible Materials, Pharmacology, mechanical properties, chemistry.chemical_compound, sequential-like and sustainable release, Polylactic Acid-Polyglycolic Acid Copolymer, International Journal of Nanomedicine, Drug Discovery, Absorbable Implants, Nanotechnology, Platelet, Aorta, Abdominal, Original Research, Neointimal hyperplasia, Aspirin, Microfilament Proteins, Drug-Eluting Stents, General Medicine, biodegradable drug-eluting stents, Hyperplasia, Endothelial stem cell, surgical procedures, operative, Paclitaxel, polylactide-polyglycolide, Rabbits, medicine.drug, medicine.medical_specialty, Materials science, Polyesters, Biophysics, Bioengineering, Biomaterials, Platelet Adhesiveness, In vivo, medicine, poly-L-lactide, Animals, cardiovascular diseases, Lactic Acid, Organic Chemistry, Calcium-Binding Proteins, Stent, Electrochemical Techniques, medicine.disease, equipment and supplies, Surgery, chemistry, Polyglycolic Acid
Abstract

Cheng-Hung Lee,1,2 Chia-Ying Yu,2 Shang-Hung Chang,1 Kuo-Chun Hung,1 Shih-Jung Liu,2 Chao-Jan Wang,3 Ming-Yi Hsu,3 I-Chang Hsieh,1 Wei-Jan Chen,1 Yu-Shien Ko,1 Ming-Shien Wen1 1Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital-Linkou, Tao-Yuan, Taiwan; 2Department of Mechanical Engineering, Chang Gung University, Tao-Yuan, Taiwan; 3Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital, Linkou, Tao-Yuan, Taiwan Introduction: This work reports on the development of a biodegradable dual-drug-eluting stent with sequential-like and sustainable drug-release of anti-platelet acetylsalicylic acid and anti-smooth muscle cell (SMC) proliferative paclitaxel.Methods: To fabricate the biodegradable stents, poly-L-lactide strips are first cut from a solvent-casted film. They are rolled onto the surface of a metal pin to form spiral stents. The stents are then consecutively covered by acetylsalicylic acid and paclitaxel-loaded polylactide-polyglycolide nanofibers via electrospinning.Results: Biodegradable stents exhibit mechanical properties that are superior to those of metallic stents. Biodegradable stents sequentially release high concentrations of acetylsalicylic acid and paclitaxel for more than 30 and 60 days, respectively. In vitro, the eluted drugs promote endothelial cell numbers on days 3 and 7, and reduce the proliferation of SMCs in weeks 2, 4, and 8. The stents markedly inhibit the adhesion of platelets on days 3, 7, and 14 relative to a non-drug-eluting stent. In vivo, the implanted stent is intact, and no stent thrombosis is observed in the stent-implanted vessels without the administration of daily oral acetylsalicylic acid. Promotion of endothelial recovery and inhibition of neointimal hyperplasia are also observed on the stented vessels.Conclusion: The work demonstrates the efficiency and safety of the biodegradable dual-drug-eluting stents with sequential and sustainable drug release to diseased arteries. Keywords: sequential-like and sustainable release, biodegradable drug-eluting stents, poly-L-lactide, polylactide-polyglycolide, mechanical properties&nbsp

Published
2014

2. Promoting endothelial recovery and reducing neointimal hyperplasia using sequential-like release of acetylsalicylic acid and paclitaxel-loaded biodegradable stents.

Author

Lee CH, Yu CY, Chang SH, Hung KC, Liu SJ, Wang CJ, Hsu MY, Hsieh IC, Chen WJ, Ko YS, and Wen MS

Subjects
Animals, Aorta, Abdominal metabolism, Aorta, Abdominal surgery, Aspirin chemistry, Biocompatible Materials, Calcium-Binding Proteins metabolism, Electrochemical Techniques, Hyperplasia, Lactic Acid chemistry, Male, Microfilament Proteins metabolism, Nanotechnology, Paclitaxel chemistry, Platelet Adhesiveness drug effects, Polyesters chemistry, Polyglycolic Acid chemistry, Polylactic Acid-Polyglycolic Acid Copolymer, Rabbits, Calponins, Absorbable Implants, Aspirin pharmacokinetics, Aspirin pharmacology, Drug-Eluting Stents, Paclitaxel pharmacokinetics, Paclitaxel pharmacology
Abstract

Introduction: This work reports on the development of a biodegradable dual-drug-eluting stent with sequential-like and sustainable drug-release of anti-platelet acetylsalicylic acid and anti-smooth muscle cell (SMC) proliferative paclitaxel., Methods: To fabricate the biodegradable stents, poly-L-lactide strips are first cut from a solvent-casted film. They are rolled onto the surface of a metal pin to form spiral stents. The stents are then consecutively covered by acetylsalicylic acid and paclitaxel-loaded polylactide-polyglycolide nanofibers via electrospinning., Results: Biodegradable stents exhibit mechanical properties that are superior to those of metallic stents. Biodegradable stents sequentially release high concentrations of acetylsalicylic acid and paclitaxel for more than 30 and 60 days, respectively. In vitro, the eluted drugs promote endothelial cell numbers on days 3 and 7, and reduce the proliferation of SMCs in weeks 2, 4, and 8. The stents markedly inhibit the adhesion of platelets on days 3, 7, and 14 relative to a non-drug-eluting stent. In vivo, the implanted stent is intact, and no stent thrombosis is observed in the stent-implanted vessels without the administration of daily oral acetylsalicylic acid. Promotion of endothelial recovery and inhibition of neointimal hyperplasia are also observed on the stented vessels., Conclusion: The work demonstrates the efficiency and safety of the biodegradable dual-drug-eluting stents with sequential and sustainable drug release to diseased arteries.

Published
2014
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