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Promoting endothelial recovery and reducing neointimal hyperplasia using sequential-like release of acetylsalicylic acid and paclitaxel-loaded biodegradable stents.
Promoting endothelial recovery and reducing neointimal hyperplasia using sequential-like release of acetylsalicylic acid and paclitaxel-loaded biodegradable stents.
- Source :
-
International journal of nanomedicine [Int J Nanomedicine] 2014 Aug 27; Vol. 9, pp. 4117-33. Date of Electronic Publication: 2014 Aug 27 (Print Publication: 2014). - Publication Year :
- 2014
-
Abstract
- Introduction: This work reports on the development of a biodegradable dual-drug-eluting stent with sequential-like and sustainable drug-release of anti-platelet acetylsalicylic acid and anti-smooth muscle cell (SMC) proliferative paclitaxel.<br />Methods: To fabricate the biodegradable stents, poly-L-lactide strips are first cut from a solvent-casted film. They are rolled onto the surface of a metal pin to form spiral stents. The stents are then consecutively covered by acetylsalicylic acid and paclitaxel-loaded polylactide-polyglycolide nanofibers via electrospinning.<br />Results: Biodegradable stents exhibit mechanical properties that are superior to those of metallic stents. Biodegradable stents sequentially release high concentrations of acetylsalicylic acid and paclitaxel for more than 30 and 60 days, respectively. In vitro, the eluted drugs promote endothelial cell numbers on days 3 and 7, and reduce the proliferation of SMCs in weeks 2, 4, and 8. The stents markedly inhibit the adhesion of platelets on days 3, 7, and 14 relative to a non-drug-eluting stent. In vivo, the implanted stent is intact, and no stent thrombosis is observed in the stent-implanted vessels without the administration of daily oral acetylsalicylic acid. Promotion of endothelial recovery and inhibition of neointimal hyperplasia are also observed on the stented vessels.<br />Conclusion: The work demonstrates the efficiency and safety of the biodegradable dual-drug-eluting stents with sequential and sustainable drug release to diseased arteries.
- Subjects :
- Animals
Aorta, Abdominal metabolism
Aorta, Abdominal surgery
Aspirin chemistry
Biocompatible Materials
Calcium-Binding Proteins metabolism
Electrochemical Techniques
Hyperplasia
Lactic Acid chemistry
Male
Microfilament Proteins metabolism
Nanotechnology
Paclitaxel chemistry
Platelet Adhesiveness drug effects
Polyesters chemistry
Polyglycolic Acid chemistry
Polylactic Acid-Polyglycolic Acid Copolymer
Rabbits
Calponins
Absorbable Implants
Aspirin pharmacokinetics
Aspirin pharmacology
Drug-Eluting Stents
Paclitaxel pharmacokinetics
Paclitaxel pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1178-2013
- Volume :
- 9
- Database :
- MEDLINE
- Journal :
- International journal of nanomedicine
- Publication Type :
- Academic Journal
- Accession number :
- 25206303
- Full Text :
- https://doi.org/10.2147/IJN.S67721