1. CMA restricted to mammals and birds: myth or reality?
- Author
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Julien Bobe, Brigitte Mourot, Amaury Herpin, Iban Seiliez, Vincent Veron, Laury Lescat, Yann Guiguen, Nutrition, Métabolisme, Aquaculture (NuMéA), Institut National de la Recherche Agronomique (INRA)-Université de Pau et des Pays de l'Adour (UPPA), Laboratoire de Physiologie et Génomique des Poissons (LPGP), Institut National de la Recherche Agronomique (INRA)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), ANR-17-CE20-0033 ‘Fish-and-Chap’, Animal Physiology and Livestock Systems, and ANR-17-CE20-0033,Fish-and-Chap,REGARD SUR L'AUTOPHAGIE MÉDIÉE PAR LES CHAPERONES CHEZ LES POISSONS(2017)
- Subjects
0301 basic medicine ,[SDV]Life Sciences [q-bio] ,poisson zèbre ,LAMP2A ,0302 clinical medicine ,Chaperone-mediated autophagy ,modèle génétique ,poisson ,cyprinidae ,Clade ,chaperone-mediated autophagy ,Zebrafish ,ComputingMilieux_MISCELLANEOUS ,health care economics and organizations ,mammifère ,humanities ,oryzias latipes ,danio rerio ,danio devario ,expression des gènes ,autophagy ,séquence d'expression ,autophagie ,Biology ,Tetrapod ,Birds ,reproduction ,03 medical and health sciences ,genetic models ,Genetic model ,evolution ,oiseau ,Animals ,mammals ,Amino Acid Sequence ,RNA, Messenger ,adrianichthyidae ,Molecular Biology ,fish ,medaka ,Lysosomal proteolysis ,Cell Biology ,biology.organism_classification ,030104 developmental biology ,Sequence homology ,Gene Expression Regulation ,Evolutionary biology ,séquence d'arn ,Commentary ,RNA-seq ,030217 neurology & neurosurgery ,Function (biology) ,Molecular Chaperones - Abstract
International audience; Chaperone-mediated autophagy (CMA) is a major pathway of lysosomal proteolysis essential for the control of intermediary metabolism. So far, the absence of any identifiable LAMP2A—a necessary and limiting protein for CMA—outside of the tetrapod clade, led to the paradigm that this cellular function was (presumably) restricted to mammals and birds. However, after we identified expressed sequences displaying high sequence homology with the mammalian LAMP2A in several fish species, our findings challenge that view and suggest that CMA likely appeared much earlier during evolution than initially thought. Hence, our results do not only shed an entirely new light on the evolution of CMA, but also bring new perspectives on the possible use of complementary genetic models, such as zebrafish or medaka for studying CMA function from a comparative angle/view.
- Published
- 2018