Back to Search
Start Over
CMA restricted to mammals and birds: myth or reality?
- Source :
- Autophagy, Autophagy, Taylor & Francis, 2018, 14 (7), pp.1267-1270. ⟨10.1080/15548627.2018.1460021⟩
- Publication Year :
- 2018
- Publisher :
- HAL CCSD, 2018.
-
Abstract
- International audience; Chaperone-mediated autophagy (CMA) is a major pathway of lysosomal proteolysis essential for the control of intermediary metabolism. So far, the absence of any identifiable LAMP2A—a necessary and limiting protein for CMA—outside of the tetrapod clade, led to the paradigm that this cellular function was (presumably) restricted to mammals and birds. However, after we identified expressed sequences displaying high sequence homology with the mammalian LAMP2A in several fish species, our findings challenge that view and suggest that CMA likely appeared much earlier during evolution than initially thought. Hence, our results do not only shed an entirely new light on the evolution of CMA, but also bring new perspectives on the possible use of complementary genetic models, such as zebrafish or medaka for studying CMA function from a comparative angle/view.
- Subjects :
- 0301 basic medicine
[SDV]Life Sciences [q-bio]
poisson zèbre
LAMP2A
0302 clinical medicine
Chaperone-mediated autophagy
modèle génétique
poisson
cyprinidae
Clade
chaperone-mediated autophagy
Zebrafish
ComputingMilieux_MISCELLANEOUS
health care economics and organizations
mammifère
humanities
oryzias latipes
danio rerio
danio devario
expression des gènes
autophagy
séquence d'expression
autophagie
Biology
Tetrapod
Birds
reproduction
03 medical and health sciences
genetic models
Genetic model
evolution
oiseau
Animals
mammals
Amino Acid Sequence
RNA, Messenger
adrianichthyidae
Molecular Biology
fish
medaka
Lysosomal proteolysis
Cell Biology
biology.organism_classification
030104 developmental biology
Sequence homology
Gene Expression Regulation
Evolutionary biology
séquence d'arn
Commentary
RNA-seq
030217 neurology & neurosurgery
Function (biology)
Molecular Chaperones
Subjects
Details
- Language :
- English
- ISSN :
- 15548627 and 15548635
- Database :
- OpenAIRE
- Journal :
- Autophagy, Autophagy, Taylor & Francis, 2018, 14 (7), pp.1267-1270. ⟨10.1080/15548627.2018.1460021⟩
- Accession number :
- edsair.doi.dedup.....f7a3b20b1f4b5efd9216cb9a572caefc