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Aim: Rectus abdominal diastasis (RAD) can cause mainly incontinence and lower-back pain. Despite its high incidence, there is no consensus regarding surgical indication. We aimed at comparing RAD repair (minimally invasive technique with mesh implant) with no treatment (standard of care – SOC) through cost-effectiveness and budget impact analyses from both National Healthcare Service (NHS) and societal perspectives in Italy. Methods: A model was developed including social costs and productivity losses derived by the online administration of a socio-economic questionnaire, including the EuroQol for the assessment of quality of life. Costs for the NHS were based on reimbursement tariffs. Results: Over a lifetime horizon, estimated costs were 64,115€ for SOC and 46,541€ for RAD repair in the societal perspective; QALYs were 19.55 and 25.75 for the two groups, respectively. Considering the NHS perspective, RAD repair showed an additional cost per patient of 5,104€ compared to SOC, leading to an ICUR of 824€. RAD repair may be either cost-saving or cost-effective compared to SOC depending on the perspective considered. Considering a current scenario of 100% SOC, an increased diffusion of RAD repair from 2 to 10% in the next 5 years would lead to an incremental cost of 184,147,624€ for the whole society (87% borne by the NHS) and to incremental 16,155 QALYs. Conclusion: In light of the lack of economic evaluations for minimally invasive RAD repair, the present study provides relevant clinical and economic evidence to help improving the decision-making process and allocating scarce resources between competing ends. [ABSTRACT FROM AUTHOR]

Effective website management is crucial for organizations seeking to engage users and communicate effectively with stakeholders. This research explores the role of specialized expertise in typography, audio and visual design, copywriting, and the implementation of Rapid Application Development (RAD) frameworks in optimizing website management practices. By leveraging the skills of typography, design, and copywriting specialists, organizations create visually appealing and engaging online experiences that effectively convey messages and drive user interaction. Additionally, adopting RAD methodologies enables agile and iterative website development processes, allowing for quick prototyping, feedback integration, and rapid deployment of updates. Through synthesizing expert knowledge and RAD principles, organizations enhance their online presence, meet the evolving needs of users and stakeholders, and achieve their strategic objectives in today's dynamic digital landscape.

E-commerce is a buying and selling process carried out via a digital platform, utilizing the internet as a transaction medium. The existence of e-commerce makes it easier to buy and sell online, which is the key to business development and potential profits in the future. Online business competition is increasingly intense, even reaching price competition. Bratajaya Farm Animal Shop chose to use the e-commerce platform as a way to sell their products. With this e-commerce, it is hoped that it will make it easier for customers to look for sacrificial animals without having to come directly to the shop which takes time. E-commerce technology design for the sale of sacrificial animals at the Bratajaya Farm Shop using the PHP programming language and MySQL database and testing using Blackbox testing. The method used for the E-Commerce system uses Content Based Filtering, with the Content Based Filtering method it can make it easier for customers to search for the animal category to choose. [ABSTRACT FROM AUTHOR]

Introduction: This report aimed to compare ventral extended vision extraperitoneal (ETEP) and preaponeurotic repair (REPA) techniques in terms of surgical procedure, outcomes, and patient evolution. Methods: This was a retrospective study performed at a tertiary care academic center between 2017 and 2022. All consecutive patients operated on for midline hernias and rectus diastasis using REPA and ETEP were included. Follow-up visits were at 15 days, 30 days, and 6 months postoperative. Age, sex, BMI, American Surgical Anesthesiologic Classification (ASA), surgical time, need for conversion to open surgery, time of stay, seroma, hematoma, surgical site infection (SSI), recurrence, and re-interventions were assessed. Results: For the present study, 148 patients were included. From them, 62 patients received the REPA procedure and 86 were operated on using the ETEP technique. REPA average time was 105 minutes (interquartile range [IR] 80–130), and ETEP average time was 120 minutes (RIC 95–285) (p = 0.03). Ambulatory procedures were 32.3% (n = 20) REPA and 20.9% (n = 18) ETEP (p = 0.23). In REPA, the mean time for drain extraction was 11.92 days and 8 days in ETEP (p < 0.001). Seroma incidence was identified in 40.3% (n = 25) of the REPA cases and 5.8% (n = 5) of the ETEP procedures (p = 0.001). In a multivariate analysis for seroma incidence REPA technique was associated with a significant risk of its incidence [odds ratio (OR) 16, 67 95% confidence interval ((CI95) 4.67–59.52), p < 0.001]. Conclusion: REPA and ETEP are safe and reproducible. Both approaches reported short hospitalization times and almost no major complications. We found a longer surgical time in ETEP and a higher incidence of seroma in REPA. [ABSTRACT FROM AUTHOR]

Fruit skin color is an important trait of the hawthorn tree, which has an important influence on fruit quality. Crataegus pinnatifida Bge. var. Major N.E.Br. Is one of the most widely cultivated varieties in China and has a long history of medicinal use. In recent years, it has attracted the attention of the world due to its nutritional and medicinal values. Skin color is the focus of breeders and food processors. At present, skin color-related genes have still not been mapped. In this study, "Shandong Da Mianqiu" (\, red skin color), "Da Huang Mianzha" (_, yellow skin color) and 131 F1 hybrids were used to construct genetic map of hawthorn by RAD-seq, and QTL mapping was performed by combining these features with the hue angle and the observed color. In this study, 13,260 SNP was assigned to 17 linkage groups, with an integrated map covering 2,297.75 cM was constructed. A total of 5 QTLs related to hawthorn skin color were detected on LG1, LG3 and LG15. Whether hue angle or pericarp color acts as phenotype for QTL mapping, the candidate genes include bHLH086, WD repeat regions and Myb-like. bHLH, WDand Myb play an important role in the color regulation of Hawthorn skin color. These results lay a solid foundation for QTL mapping and molecular markerassisted breeding of hawthorn. [ABSTRACT FROM AUTHOR]

Copyright of SHILAP Revista de Lepidopterologia is the property of Sociedad Hispano-Luso-Americana de Lepidopterologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Several factors contribute to the importance of designing a coral monitoring system. Firstly, coral reefs are ecologically crucial ecosystems, providing habitat for numerous marine species and supporting biodiversity. Therefore, monitoring coral reefs is essential for understanding population dynamics and ecosystem health. Secondly, coral reefs are vulnerable to climate change, pollution, overfishing, and human activities. With a monitoring system, we can identify factors damaging coral reefs and take necessary prevention or restoration actions. Thirdly, coral reef monitoring aids in informing policies and sustainable resource management. By comprehensively understanding coral reef conditions, we can develop more effective management strategies to protect and preserve these ecosystems for future generations. This research aims to design a coral monitoring system to identify factors contributing to coral reef degradation. The method employed is Rapid Application Development (RAD), with stages including requirement planning, user design, construction, and cutover. The findings of this study indicate that the application can meet user needs. The findings of this research emphasize the urgent need for the development and implementation of coral monitoring applications as a strategic step toward reducing environmental degradation for ecological sustainability. The research underscores the critical role of monitoring tools in assessing and mitigating the impacts of human activities and environmental stressors on coral reef ecosystems through comprehensive data analysis and evaluation. This highlights the importance of proactive measures to address the increasing threats facing coral reefs and emphasizes the significance of technological innovations in facilitating practical conservation efforts.

As institutions cope with the difficult task of managing scarce resources to support student learning, college writing centers, like other student services, need to be able to articulate and, at times, quantify the benefits they offer the populations they serve. This study examined outcomes associated with visiting the writing center at one American community college in a southern town. Using binary logistic regression, the researchers compared the effects of writing center visitation on the probability of passing and/or earning an A for students enrolled in introductory English and psychology courses, while accounting for other student- level covariates including prior GPA, SES, and minority status. Results indicated that writing center visitors were significantly more likely to pass their English courses and were more likely to earn As in both subjects. Further, the level of visitation was a significant predictor of student outcomes, particularly in English courses, with students who visited the most frequently experiencing a significantly increased likelihood of both passing and earning As. Overall, these results suggested that writing center visitation was meaningfully associated with students' success in these courses at this institution, after accounting for additional individual- level variables commonly identified as predictors of educational outcomes. [ABSTRACT FROM AUTHOR]

This study focuses on developing an automated feeding tool for fish farming in Pesawaran, a region known for its aquaculture potential. Aquaculture, crucial for global food needs, requires efficient and sustainable management, especially in feeding, a critical factor in fish growth and health. Traditional manual feeding methods are time-consuming and prone to errors, affecting fish productivity and growth. The research aimed to enhance feed management efficiency, minimize feeding errors, and improve the sustainability and productivity of fish farming in Pesawaran. The initial phase involved analyzing the needs of fish farmers, environmental factors, and fish species. The design of the automation tool emphasized ergonomics, reliability, and ease of use. The Rapid Application Development (RAD) method was employed, focusing on quick and iterative development. This method was applied at the Pokdakan Pemuda Tani RPL in Negeri Sakti Village, Gedong Tataan District, Pesawaran Regency, from July to November 2023. The application of RAD in designing the Pokdakan Pesawaran fish-feeding automation tool yielded positive outcomes. The fast, responsive development process, which actively involved users, led to a practical solution well-received by the fish farming community. This research demonstrates the value of RAD principles in providing practical, locally relevant solutions and guiding the development of adaptive, user-oriented aquaculture technology.

Housing is a key social determinant of health and health care utilization. Although stigmatized due to poor quality, public housing may provide stability and affordability needed for individuals to engage in health care utilization behaviors. For low-income women of reproductive age (15-44 y), this has implications for long-term reproductive health trajectories. In a sample of 5,075 women, we used electronic health records (EHR) data from 2006 to 2011 to assess outpatient and emergency department (ED) visits across six public housing sites in San Francisco, CA. Non-publicly housed counterparts were selected from census tracts surrounding public housing sites. Multivariable regression models adjusted for age and insurance status estimated incidence rate ratios (IRR) for outpatient visits (count) and odds ratios (OR) for ED visit (any/none). We obtained race/ethnicity-specific associations overall and by public housing site. Analyses were completed in December 2020. Public housing was consistently associated with health care utilization among the combined Asian, Alaskan Native/Native American, Native Hawaiian/Pacific Islander, and Other (AANHPI/Other) group. Public housing residents had fewer outpatient visits (IRR: 0.86; 95% Confidence Interval [CI]: 0.81, 0.93) and higher odds of an ED visit (OR: 1.81; 95% CI: 1.32, 2.48). Black women had higher odds of an ED visits (OR: 1.32; 95% CI: 1.07, 1.63), but this was driven by one public housing site (site-specific OR: 2.34; 95% CI: 1.12, 4.88). Variations by race/ethnicity and public housing site are integral to understanding patterns of health care utilization among women of reproductive age to potentially improve women's long-term health trajectories.

Copyright of Stanovništvo is the property of Demographic Research Center of Institute of Social Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Rapid Application Development (RAD) is a software development method that speeds up software production by reducing complex and time-consuming processes. RAD can be used as a reference for developing superior information systems in speed, accuracy and lower cost. In this study, the application of the RAD method will be carried out to design a business website selling Mamigaya breastfeeding clothes by testing using EUCS and blackbox testing. The first phase of RAD is understanding fast design system analysis & requirements. Requires a high level or knowledgeable end user to define what the system function should be. The second stage is a repetition of the prototype cycles development stage, namely development, demonstration, refine. This includes creating physical designs for databases and mainly focuses on translating designs into programming code. Based on the results obtained from a survey using EUCS, the satisfaction level of respondents reached 88.58% and the results of blackbox testing showed that the features on the website could function. Thus, it can be concluded that the application of RAD can produce a good website. [ABSTRACT FROM AUTHOR]

Efficiency and effectiveness are crucial in the food & beverage industry. Conventional methods employed by companies often lead to discrepancies between actual stock and the stock available for sale, resulting in significant losses. To address this issue, a point-of-sales-based system has been implemented, enabling companies to monitor transaction activities seamlessly. The research utilized the RAD (Rapid Application Development) method to develop a concise and fast software application. Furthermore, hashing and encryption methods have been incorporated to enhance database security, utilizing the SHA-512 algorithm for hashing and data encryption. This research has yielded a point-of-sales website-based application that supports various business processes. The website has been tailored to meet the specific requirements outlined by the company owner. The UAT test results have demonstrated that the application encompasses

Antropološko istraživanje – sprovedeno u periodu od 2020. do 2022. godine – dizajnirano je s ciljem da uputi u najvažnija pitanja koja se odnose na strukturalne preduslove za rad u starosti, ali i na motive trinaest sagovornika za preduzimanje poslovnih aktivnosti nakon penzionisanja. Na ovaj način bilo je moguće odgovoriti i na neka ključna pitanja koja se tiču kvaliteta života u starosti, i to na osnovu procena ljudi koji ga žive, što je u skladu sa antropološkom orijentacijom preduzetog kvalitativnog istraživanja. Rad u starosti bio je tako shvatan ili kao preimućstvo ili kao egzistencijalna nužnost, što je dalje imalo implikacija i na pojedine strategije delovanja pojedinaca. Među njima, kao najznačajnije, izdvajaju se one koje podrazumevaju nastavak rada u okviru ranijih obrazovnih i radnih usmerenja ili pak potpunu promenu delatnosti od one u kojoj su ostvarili pravo na penziju. Na osnovu dobijenih etnografskih podataka bilo je moguće konstatovati i specifičan vid preduzetništva poput srebrnog preduzetništva, pored rada u okviru neformalne ekonomije i/ili prema propisanim zakonskim rešenjima.

Abstract Effective management of protected species requires information on appropriate evolutionary and geographic population boundaries and knowledge of how the physical environment and life‐history traits combine to shape the population structure and connectivity. Saltwater crocodiles (Crocodylus porosus) are the largest and most widely distributed of living crocodilians, extending from Sri Lanka to Southeast Asia and down to northern Australia. Given the long‐distance movement capabilities reported for C. porosus, management units are hypothesised to be highly connected by migration. However, the magnitude, scale, and consistency of connection across managed populations are not fully understood. Here we used an efficient genotyping method that combines DArTseq and sequence capture to survey ≈3000 high‐quality genome‐wide single nucleotide polymorphisms from 1176 C. porosus sampled across nearly the entire range of the species in Queensland, Australia. We investigated historical and present‐day connectivity patterns using fixation and diversity indices coupled with clustering methods and the spatial distribution of kin pairs. We inferred kinship using forward simulation coupled with a kinship estimation method that is robust to unspecified population structure. The results demonstrated that the C. porosus population has substantial genetic structure with six broad populations correlated with geographical location. The rate of gene flow was highly correlated with spatial distance, with greater differentiation along the east coast compared to the west. Kinship analyses revealed evidence of reproductive philopatry and limited dispersal, with approximately 90% of reported first and second‐degree relatives showing a pairwise distance of

Traditional conservation practices have primarily relied on maintaining biodiversity by preserving species and habitats in place. Many regions are experiencing unprecedented environmental conditions, shifts in species distribution and habitats, and high turnover in species composition, resulting in ecological transformation. Natural resource managers have lacked tools for identifying and selecting strategies to manage ecosystem transformation. A recently formalized decision support framework provides a way for managers to resist, accept, or direct (RAD) the trajectory of change. We begin by identifying how historical conservation practices are built into the RAD framework. Next, we describe how RAD can be used to implement climate change adaptation actions, using examples from the Mojave Desert to provide ecological context. Third, we discuss how the RAD framework can assist with the creation of conservation portfolios, facilitating the maintenance of overall biodiversity across a landscape. Preserving species assemblages in their current state, or restoring them to historical conditions, will not always be possible, and RAD allows for explicit deliberation about when and where to prioritize scarce resources. We conclude with a set of guidelines for conservation practitioners or managers moving forward. Although operating under an increasingly uncertain future is daunting, managers can utilize RAD to conserve biodiversity and effectively handle ecosystem transformation. [ABSTRACT FROM AUTHOR]

Copyright of Prilozi za Istrazivanje Hrvatske Filozofske Bastine is the property of Institut za Filosofiju and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

A compelling interest in marine biology is to elucidate how species boundaries between sympatric free‐spawning marine invertebrates such as bivalve molluscs are maintained in the face of potential hybridization. Hybrid zones provide the natural resources for us to study the underlying genetic mechanisms of reproductive isolation between hybridizing species. Against this backdrop, we examined the occurrence of introgressive hybridization (introgression) between two bivalves distributed in the western Pacific margin, Atrina japonica and Atrina lischkeana, based on single‐nucleotide polymorphisms (SNPs) derived from restriction site‐associated DNA sequencing. Using 1066 ancestry‐informative SNP sites, we also investigated the extent of introgression within the genome to search for SNP sites with reduced interspecies gene flow. A series of our individual‐level clustering analyses including the principal component analysis, Bayesian model‐based clustering, and triangle plotting based on ancestry–heterozygosity relationships for an admixed population sample from the Seto Inland Sea (Japan) consistently suggested the presence of specimens with varying degrees of genomic admixture, thereby implying that the two species are not completely isolated. The Bayesian genomic cline analysis identified 10 SNP sites with reduced introgression, each of which was located within a genic region or an intergenic region physically close to a functional gene. No, or very few, heterozygotes were observed at these sites in the hybrid zone, suggesting that selection acts against heterozygotes. Accordingly, we raised the possibility that the SNP sites are within genomic regions that are incompatible between the two species. Our finding of restricted interspecies gene flow at certain genomic regions gives new insight into the maintenance of species boundaries in hybridizing broadcast‐spawning molluscs. [ABSTRACT FROM AUTHOR]

Sistem penjaminan mutu merupakan sistem yang mendukung proses kegiatan penjaminan mutu perguruan tinggi. Sistem penjaminan mutu konvensional menggunakan kertas membutuhkan biaya pengarsiban, ruang lebih luas dan proses dokumen tidak terpadu. Menjawab tantangan saat ini dibutuhkan sistem penjaminan mutu berbasis teknologi informasi yang memudahkan pekerjaan, realtime dan terpadu. Membangun sistem penjaminan mutu membutuhkan metode pengembangan perangkat lunak yang tepat diimplentasikan sesuai dengan kebutuhan saat ini. Penelitian ini bertujuan mengembangkan perangkat lunak penjaminan mutu berbasis teknologi informasi supaya memudahkan proses pelaksanaan kegiatan penjaminan mutu terarah dan efektif. Dalam penelitian ini, penulis menggunakan metode rapid Application Development (RAD) untuk pengembangan perangkat lunak penjaminan mutu. Metode RAD terdiri requirements planning phase, RAD design workshop dan implementation phase. Metode RAD sangat efektif dan tepat guna diimpelemtasikan pada sistem penjaminan mutu. Hasil kepuasan responden terhadap sistem penjaminan mutu sebesar 96% yang diukur menggunakan metode User Acceptance Test (UAT) menunjukkan bahwa metode RAD sangat cocok diimplemetasikan pada sistem penjaminan mutu.

Effective management of protected species requires information on appropriate evolutionary and geographic population boundaries and knowledge of how the physical environment and life‐history traits combine to shape the population structure and connectivity. Saltwater crocodiles (Crocodylus porosus) are the largest and most widely distributed of living crocodilians, extending from Sri Lanka to Southeast Asia and down to northern Australia. Given the long‐distance movement capabilities reported for C. porosus, management units are hypothesised to be highly connected by migration. However, the magnitude, scale, and consistency of connection across managed populations are not fully understood. Here we used an efficient genotyping method that combines DArTseq and sequence capture to survey ≈3000 high‐quality genome‐wide single nucleotide polymorphisms from 1176 C. porosus sampled across nearly the entire range of the species in Queensland, Australia. We investigated historical and present‐day connectivity patterns using fixation and diversity indices coupled with clustering methods and the spatial distribution of kin pairs. We inferred kinship using forward simulation coupled with a kinship estimation method that is robust to unspecified population structure. The results demonstrated that the C. porosus population has substantial genetic structure with six broad populations correlated with geographical location. The rate of gene flow was highly correlated with spatial distance, with greater differentiation along the east coast compared to the west. Kinship analyses revealed evidence of reproductive philopatry and limited dispersal, with approximately 90% of reported first and second‐degree relatives showing a pairwise distance of <50 km between sampling locations. Given the limited dispersal, lack of suitable habitat, low densities of crocodiles and the high proportion of immature animals in the population, future management and conservation interventions should be considered at regional and state‐wide scales. [ABSTRACT FROM AUTHOR]

Purpose: To evaluate the outcomes of REPA and establish if any differences in complications and evolution are present between males and females. Methods: A retrospective study including consecutive patients operated by REPA approach between November 2017 and April 2019 was conducted. Demographic data, operative times, postoperative complications, and hospital stay were analyzed. The EuraHS-QoL score was used to assess postoperative pain, daily activity constraints, and aesthetic discomfort. The results were compared between sexes. Statistical analysis was performed using SPSS 19. Results: Fifty-four patients were included and 53.7% were male. Patients had a mean age of 50.7 years and a mean BMI of 28.7. The average RAD (Rectus Abdominis Diastasis) size was 2.6 cm (range of 2–5 cm). Seroma was significantly more frequent in males, with an incidence of 55.2 and 24% for females (p = 0.02). Three cases required reintervention (5.5% of total cases), which corresponded to a cystic seroma, an abdominal wall hematoma, and a hernia recurrence. The three cases were males and a p value of 0.04 was obtained when comparing reintervention rates between males and females. No cases of surgical wound infection nor cutaneous necrosis were recorded. No conversions were needed. The mean postoperative pain was 2.25, the mean daily activity constraints score was 2.63, and the degree of aesthetic discomfort was 1.23 with no significant differences between groups. Conclusion: The correction of small midline defect associated with minor RAD using REPA seems feasible and reproducible. REPA had achieved good results in females, but in males, the outcomes were poorer. [ABSTRACT FROM AUTHOR]

Copyright of Filozofija i Drustvo is the property of University of Belgrade, Institute for Philosophy & Social Theory and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Reducing propagule pressure is critical for preventing the establishment and limiting the spread of invasive species. To reduce the risks associated with propagule pressure, the relative impacts of potential vectors contributing to invasions must be understood. In 2017, the red swamp crayfish (Procambarus clarkii) invasion expanded to include two new invasion fronts in Michigan, USA. To determine potential sources and make inferences about expansion dynamics among introduced populations, we developed genomic resources using restriction-site associated DNA (RAD) sequencing to genotype 175 red swamp crayfish at 1321 single nucleotide polymorphisms. Samples included potential wild and industry sources and collections within each Michigan invasion front. Results based on unsupervised clustering and multivariate analysis indicated that multiple, genetically distinct sources founded the Michigan invasions, which may include sources from the biological supply trade. Results support the recommendation that prevention strategies implement a multifaceted approach targeting diverse user groups associated with the live trades (e.g., biological supply, live food markets, and pet trade). In addition, regulatory frameworks that minimize the presence of a live invasive species should be adopted to reduce the risk of incidental introductions, geographic and demographic expansion, and establishment. [ABSTRACT FROM AUTHOR]

Reactive Attachment Disorder (RAD) is presumed to be a consequence of social neglect and deprivation of the kind particularly associated with institutional care. Despite its clinical relevance there is a lack of assessment tools for RAD based on the direct observation of child-caregiver interaction. Here we describe the development and validation of such a tool for use with preschool children, the Rating of Inhibited Attachment Disordered Behavior (RInAB). The RInAB is composed of 17 ratings grouped in three subscales assessing (1) Attachment, (2) Exploratory, and (3) Socioemotional behavior. Participants were 134 institutionalized preschool children (M = 54.84 months; SD = 10.83; 60% boys) and their caregivers. Adequate reliability was found for RInAB subscales and total score. Confirmatory factor analyses documented the three aforementioned RInAB subscales. Correlational analyses documented: (i) construct validity via positive and significant associations with caregiver sensitivity and quality of child-caregiver relationship; (ii) convergence validity via association evidence with some emotionally/withdrawn inhibited items of the Disturbed Attachment Interview (DAI), as well as, with Child Behavior Checklist (CBCL)'s somatic complaints and withdraw syndrome scales; and (iii) discriminant validity via nonsignificant or negative associations with DAI-indiscriminate subscale, Rating of Infant and Stranger Engagement (RISE) and CBCL-externalizing problems. Discussion highlights the contributions complementary roles of RInAB for a comprehensive assessment of child RAD-related functioning.

The development of Internet of Things (IoT) tools and components has often been used in agriculture, plantations, and smart homes. One of the microcontroller components can take advantage of the Raspberry Pi because it is similar to a small computer. Another thing that makes web-based application development can take advantage of Rapid Application Development (RAD) because it is considered very flexible and can iterate on the design and development section where that section requires special focus due to the possibility of the same error. There are several studies related to utilizing website development to help in hospitals. However, the real problem is that technology such as clinical information websites has not been widely used for small clinics. This development website is supported by the location of the clinics, which are far from the urban center. The Others is supported by research on website development in clinics, not too many. So this study has a goal, namely the development of a website application with the help of a Raspberry Pi as a computer replacement medium (having wifi and a processor) which is applied to clinical LED TV because there is no computer to display it, and making the administration of the website itself tested by testing and evaluation using Black Box and User Acceptance Test (UAT). In testing and evaluation, it was found that 5 trials of Black Box testing got good results with all categories achieved. 71.06% of UAT results are included in the "Satisfied" category on the UAT test, where the best result is "Very Satisfied". Furthermore, research has not focused on the actual application of IoT and needs to be studied more deeply in making IoT integrated with the website.

Genomic datasets continue to increase in number due to the ease of production for a wider selection of species including non-model organisms. For many of these species, especially those with large or polyploid genomes, highly contiguous and well-annotated genomes are still rare due to the complexity and cost involved in their assembly. As a result, a common starting point for genomic work in non-model species is the production of a linkage map. Dense linkage maps facilitate the analysis of genomic data in a variety of ways, from broad scale observations regarding genome structure e.g., chromosome number and type or sex-related structural differences, to fine scale patterns e.g., recombination rate variation and co-localization of differentiated regions. Here we present both sex-averaged and sex-specific linkage maps for Coregonus sp. Albock, a member of the European whitefish lineage (C. lavaretus spp. complex), containing 5395 single nucleotide polymorphism (SNP) loci across 40 linkage groups to facilitate future investigation into the genomic basis of whitefish adaptation and speciation. The map was produced using restriction-site associated digestion (RAD) sequencing data from two wild-caught parents and 156 F1 offspring. We discuss the differences between our sex-averaged and sex-specific maps and identify genome-wide synteny between C. sp. Albock and Atlantic Salmon (Salmo salar), which have diverged following the salmonid-specific whole genome duplication. Our analysis confirms that many patterns of synteny observed between Atlantic Salmon and Oncorhynchus and Salvelinus species are also shared by members of the Coregoninae subfamily. We also show that regions known for their species-specific rediploidization history can pose challenges for synteny identification since these regions have diverged independently in each salmonid species following the salmonid-specific whole genome duplication. The European whitefish map provided here will enable future studies to understand the distribution of loci of interest, e.g., FST outliers, along the whitefish genome as well as assisting with the de novo assembly of a whitefish reference genome.

Background/Aim. Depression, as a common comorbidity in patients with rheumatoid arthritis (RA), has been found to affect the disease diagnosis and treatment response. Accordingly, the aim of the study was to investigate the occurrence of depressive symptoms among patients with RA and the association between RA and depression. Methods. The cross-sectional study included 69 patients with RA. The depressive symptoms in patients with RA were assessed using the Beck Depression Inventory (BDI), and RA activity was measured by Disease Activity Score-28 for RA with erythrocyte sedimentation rate (DAS28-ESR) and Clinical Disease Activity Index (CDAI). Results. It was found that 42% of respondents reported having depressive symptoms of different severity, among which the majority (23.2%) presented with mild symptoms. A mild positive correlation was found between the BDI and the DAS28-ESR (r = 0.39 p = 0.001), as well as between the BDI and the CDAI (r = 0.40 p = 0.001). Place of residence (t = -2.14 p = 0.03) and employment status (t = -2.81 p = 0.00) associated with depressive symptoms were also found to have statistically significant differences within the group of respondents. In addition, age had a positive correlation with the disease activity, as well as the place of residence and employment status. Conclusion. It has been observed that depressive symptoms in patients with RA were associated with disease activity, employment status, and place of residence. Therefore, there is an important need for integrating rheumatologic and mental health services for future research toward a better understanding of both depression and RA. [ABSTRACT FROM AUTHOR]

Genetic map is of vital importance to plant molecular genetic studies. It has been used for QTL mapping, gene cloning, and physical map construction. One common issue for construction of genetic maps is that one chromosome is divided into two or more groups based on low LOD values between each group. In this study, we constructed a genetic map from a F8 RIL population derived from two domesticated narrow-leafed lupin cultivars Uncrop and Tanjil. In the first round of analysis, 37 linkage subgroups were constructed for the 20 chromosomes. The number of subgroups was greater than the number of chromosomes. And then we merged the linkage subgroups belonging to the same chromosomes based on physical maps and other genetic maps constructed from different mapping populations. The DNA variations between the parents revealed that variation density was highly consistent with marker density in the genetic map, and that the large gaps (> 15 cM) in the same linkage groups resulted from the low DNA variations density in the large regions. Furthermore, the regions with less DNA variations between the two parents will facilitate the screening of the candidate genes located in the region. A single major QTL for grey leaf spot was identified on chromosome 19 from this mapping population. [ABSTRACT FROM AUTHOR]

Southwestern ponderosa pine forests are vulnerable to fire‐driven conversion in a warming and drying climate, yet little is known about what kinds of ecological communities may replace them. To characterize postfire vegetation trajectories and their environmental determinants, plant assemblages (361 sample plots including 229 vascular plant species, surveyed in 2017) were sampled within eight burns that occurred between 2000 and 2003. I used nonmetric multidimensional scaling, k‐means clustering, principal component analysis, and random forest models to assess relationships between vegetation pattern, topographic and landscape factors, and gridded climate data. I describe seven postfire community types, including regenerating forests of ponderosa pine, aspen, and mixed conifers, shrub‐dominated communities of Gambel oak and mixed species, and herb‐dominated communities of native bunchgrasses and mixtures of ruderal, native, and nonnative species. Forest recovery was generally associated with cooler, mesic sites in proximity to forested refugia; shifts toward scrub and grassland types were most common in warmer, dryer locations distant from forested refugia. Under future climate scenarios, models project decreases in postfire forest recovery and increases in nonforest vegetation. However, forest to nonforest conversion was partially offset under a scenario of reduced burn severity and increased retention of forested refugia, highlighting important management opportunities. Burning trends in the southwestern United States suggest that postfire vegetation will occupy a growing landscape fraction, compelling renewed management focus on these areas and paradigm shifts that accommodate ecological change. I illustrate how management decisions around resisting, accepting, or directing change could be informed by an understanding of processes and patterns of postfire community variation and likely future trajectories. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Language & Literary Studies / Folia Linguistica & Litteraria is the property of Journal of Language & Literary Studies / Folia Linguistica & Litteraria and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Abstract Background RADIALIS (RAD), belongs to the MYB gene family and regulates a variety of functions including floral dorsoventral asymmetry in Antirrhinum majus and development of fruit proteins in Solanum lycopersicum. RAD genes contain an SNF2_N superfamily domain. Here, we comprehensively identified 68 RAD genes from six different species including Arabidopsis and five species of cotton. Results Phylogenetic analysis classified RAD genes into five groups. Gene structure, protein motifs and conserved amino acid residues indicated that GhRAD genes were highly conserved during the evolutionary process. Chromosomal location information showed that GhRAD genes were distributed unevenly on different chromosomes. Collinearity and selection pressure analysis indicated RAD gene family expansion in G. hirsutum and G. barbadense with purifying selection pressure. Further, various growth and stress related promotor cis-acting elements were observed. Tissue specific expression level indicated that most GhRAD genes were highly expressed in roots and flowers (GhRAD2, GhRAD3, GhRAD4 and GhRAD11). Next, GhRAD genes were regulated by phytohormonal stresses (JA, BL and IAA). Moreover, Ghi-miRN1496, Ghi-miR1440, Ghi-miR2111b, Ghi-miR2950a, Ghi-miR390a, Ghi-miR390b and Ghi-miR7495 were the miRNAs targeting most of GhRAD genes. Conclusions Our study revealed that RAD genes are evolutionary conserved and might be involved in different developmental processes and hormonal stress response. Data presented in our study could be used as the basis for future studies of RAD genes in cotton.

During the Covid-19 pandemic, the lecture process was carried out online, so it impacted other academic activities such as the preparation of lecture schedules. The results of observations at the Faculty of Engineering and Science found that the practice of lecture schedules was carried out manually, such as the schedule coordination process was carried out face-to-face between study programs, faculties, and lecturers to overcome conflicts in the use of rooms and teaching time. Changes in the teaching schedule need to be re-checked on the use of the room and the lecturer's teaching time because it has not been documented with the information system. Hence, this study aims to build an information system for preparing lecture schedules using the Greedy Best First Search Method based on the willingness of lecturers to teach. The system was developed using the RAD (Rapid Application Development) and testing using BlackBox testing. The results of this study succeeded in building a lecture scheduling information system that was able to generate lecture schedules automatically and quickly without having to coordinate face-to-face to support online lectures during the Covid-19 pandemic.

The L-type calcium currents conducted by the cardiac CaV1.2 calcium channel initiate excitation–contraction coupling and serve as a key regulator of heart rate, rhythm, and force of contraction. CaV1.2 is regulated by β-adrenergic/protein kinase A (PKA)- mediated protein phosphorylation, proteolytic processing, and autoinhibition by its carboxyl-terminal domain (CT). The small guanosine triphosphatase (GTPase) RAD (Ras associated with diabetes) has emerged as a potent inhibitor of CaV1.2, and accumulating evidence suggests a key role for RAD in mediating β-adrenergic/PKA upregulation of channel activity. However, the relative roles of direct phosphorylation of CaV1.2 channels and phosphorylation of RAD in channel regulation remain uncertain. Here, we investigated the hypothesis that these two mechanisms converge to regulate CaV1.2 channels. Both RAD and the proteolytically processed distal CT (dCT) strongly reduced CaV1.2 activity. PKA phosphorylation of RAD and phosphorylation of Ser- 1700 in the proximal CT (pCT) synergistically reversed this inhibition and increased CaV1.2 currents. Our findings reveal that the proteolytically processed form of CaV1.2 undergoes convergent regulation by direct phosphorylation of the CT and by phosphorylation of RAD. These parallel regulatory pathways provide a flexible mechanism for upregulation of the activity of CaV1.2 channels in the fight-or-flight response. [ABSTRACT FROM AUTHOR]

Copyright of Hudební Výchova is the property of Charles University Prague, Faculty of Education and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In making this Hajj and Umroh registration information system to develop a travel & tour business at PT Multazam Sriwijaya Barakah Palembang. PT Multazam Sriwijaya Barakah Palembang is a business in the field of travel services to tourism and providing available Hajj and Umroh services. In making this Information System, it is hoped that registration transactions will be carried out more efficiently and save time. The purpose of this creation is an effort to develop the registration business because PT Multazam Sriwijaya Barakah Palembang is a business that is already good in terms of business but still uses a manual system such as filling out forms, searching for data on prospective pilgrims makes it quite a long time because it has to collect from payment wintancy, therefore this Information System was created to improve the process of registration activities and make it easier for prospective pilgrims to be able to register data quickly the performance of system users to be able to manage data by importing, storing, and printing data according to the needs of prospective pilgrims. This website was created with the aim of, among others, providing solutions for prospective pilgrims to register for Hajj and Umroh and get information about hajj and umroh packages available. To achieve the expected research results, the research uses the RAD (Rapid Application Development) method. It is hoped that this website can be used for prospective pilgrims so that it makes it easier, faster to register. [ABSTRACT FROM AUTHOR]

The yellowfin seabream (Acanthopagrus latus Houttuyn 1782) is a commercially and ecologically important Sparidae species in the northern South China Sea. However, environmental pollution and overfishing result in serious decline of seabream natural population and germplasm degradation in recent years. In the present study, to promote the molecular-assisted selection (MAS), population selection, and enhancement and releasing of A. latus, the 112 novel single nucleotide polymorphism (SNP) markers were isolated by restriction-site associated DNA (RAD) sequencing, and then the polymorphism of these SNP markers were verified in 36 wild individuals. The results showed that the observed heterozygosity (Ho) and expected heterozygosity (HE) varied from 0.0278 to 0.6389 and 0.0540 to 0.4996, respectively. The PIC value and minor allele frequency (MAF) were between 0.0526 and 0.3748 and 0.0278–0.4861, respectively. Moreover, the FIS value ranged from − 0.2941 to 0.9449. Thirty-seven loci revealed noteworthy deviations from the Hardy–Weinberg equilibrium (HWE) after Bonferroni correction (p < 0.05), but no prominent linkage disequilibrium was detected. These novel developed SNPs will be useful for breeding, genetic diversity analysis, enhancement and releasing studies of seabream. [ABSTRACT FROM AUTHOR]

Adrenergic modulation of voltage gated Ca 2+ currents is a context specific process. In the heart Ca v 1.2 channels initiate excitation-contraction coupling. This requires PKA phosphorylation of the small GTPase Rad (Ras associated with diabetes) and involves direct phosphorylation of the Ca v 1.2 α 1 subunit at Ser1700. A contributing factor is the proximity of PKA to the channel through association with A-kinase anchoring proteins (AKAPs). Disruption of PKA anchoring by the disruptor peptide AKAP-IS prevents upregulation of Ca v 1.2 currents in tsA-201 cells. Biochemical analyses demonstrate that Rad does not function as an AKAP. Electrophysiological recording shows that channel mutants lacking phosphorylation sites (Ca v 1.2 STAA) lose responsivity to the second messenger cAMP. Measurements in cardiomyocytes isolated from Rad -/- mice show that adrenergic activation of Ca v 1.2 is attenuated but not completely abolished. Whole animal electrocardiography studies reveal that cardiac selective Rad KO mice exhibited higher baseline left ventricular ejection fraction, greater fractional shortening, and increased heart rate as compared to control animals. Yet, each parameter of cardiac function was slightly elevated when Rad -/- mice were treated with the adrenergic agonist isoproterenol. Thus, phosphorylation of Ca v 1.2 and dissociation of phospho-Rad from the channel are local cAMP responsive events that act in concert to enhance L-type calcium currents. This convergence of local PKA regulatory events at the cardiac L-type calcium channel may permit maximal β-adrenergic influence on the fight-or-flight response., Competing Interests: Conflict of interest The authors declare that they have no conflicts of interest with the contents of this article., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)

Sistem monitoring adalah sistem yang digunakan untuk melakukan pengawasan terhadap sarana dan prasarana fasilitas kegiatan belajar mengajar. Sistem monitoring yang berjalan sebelumnya adalah menggunakan microsoft excel sebagai media pembuatan form kemudian dicetak dan dicatat manual dikertas untuk setiap kegiatan monitoring fasilitas kelas kemudian diarsipkan kedalam ordner. Setiap kali diminta untuk rekapan laporan perbulan, petugas harus membuka kembali arsip dan merekap satu persatu laporan yang ada sehingga memakan banyak waktu mengingat teknologi sudah berkembang pesat. Permasalahan lainnya adalah terjadinya human error dimana petugas yang telah selesai melakukan monitoring terkadang lupa mengarsipkan form kedalam ordner sehingga pada saat diminta pelaporan oleh pimpinan, petugas harus mencari file yang hilang atau pelaporan menjadi tidak lengkap. Tujuan penelitian ini adalah untuk mempermudah proses pengawasan terhadap sarana dan prasarana fasilitas kegiatan belajar mengajar, karena sistem yang dibangun adalah sistem satu pintu dimana proses monitoring, proses perekapan dan hasil laporan ada didalam sistem. Metode yang digunakan adalah metode Rapid Application Development atau RAD yang terdiri dari tiga fase yaitu fase requirements planning, fase RAD design workshop dan fase implementasi serta untuk pengujian sistem menggunakan blackbox testing. Hasil yang didapat berupa sebuah sistem monitoring sarana dan prasarana dan penerapannya untuk kegiatan belajar mengajar pada perguruan tinggi swasta yang ada di Palembang yang merupakan pengembangan dari sistem sebelumnya.

Contemporary descriptions of ‘feral’ children generally preclude any insightful inference about the language deficits exhibited by these children, as well as the ultimate causes of their problems with language. However, they have been regularly used to support the view that language acquisition requires a proper social environment in order to occur. In this paper, we revisit the case for ‘feral’ children with the viewpoint that human evolution entailed a process of self-domestication that parallels what we find in domesticated animals. Because feralization commonly occurs in nature and because it entails a partial reversion of features of domestication, this self-domestication approach to the evolution of language reassesses the case for ‘feral’ children, particularly when compared with present-day conditions involving abnormal patterns of socialization, whether they are genetically-triggered as in autism spectrum disorder, or environmentally-triggered, as in reactive attachment disorder.

Traditional conservation practices have primarily relied on maintaining biodiversity by preserving species and habitats in place. Many regions are experiencing unprecedented environmental conditions, shifts in species distribution and habitats, and high turnover in species composition, resulting in ecological transformation. Natural resource managers have lacked tools for identifying and selecting strategies to manage ecosystem transformation. A recently formalized decision support framework provides a way for managers to resist, accept, or direct (RAD) the trajectory of change. We begin by identifying how historical conservation practices are built into the RAD framework. Next, we describe how RAD can be used to implement climate change adaptation actions, using examples from the Mojave Desert to provide ecological context. Third, we discuss how the RAD framework can assist with the creation of conservation portfolios, facilitating the maintenance of overall biodiversity across a landscape. Preserving species assemblages in their current state, or restoring them to historical conditions, will not always be possible, and RAD allows for explicit deliberation about when and where to prioritize scarce resources. We conclude with a set of guidelines for conservation practitioners or managers moving forward. Although operating under an increasingly uncertain future is daunting, managers can utilize RAD to conserve biodiversity and effectively handle ecosystem transformation.

Background/Aim. Risk factors concerning computer userelated migraine onsets are still unknown. The aim of this study was to determine the prevalence of headaches in computer users as well as the effects of computer use and behavior on the prediction of migraine presence. Methods. A cross-sectional study included 1,500 subjects from the general population who were given a questionnaire to assess the presence and type of headache and questions regarding computer-assisted behavior. All examinees were divided into two groups: the first group consisted of respondents who had a headache, and the second group consisted of subjects without a headache. Results. A total of 67.9% of the subjects had a headache, of which 23.9% had a migraine. Results of multinomial regression analysis showed that significant predictors of the migraine group, compared to the group without headache, were gender (female) and family anamnesis positive for migraine, as well as spending more time on the computer, making shorter and infrequent breaks in which physical activities were less included. Furthermore, members of the migraine group, compared with the group with other types of headaches, were younger and had family anamnesis, rarely made pauses during computer use, and their pauses were shorter. Conclusion. Improper and excessive computer use could be considered a risk factor for migraine occurrence, particularly in young people who have positive family anamnesis for migraine. [ABSTRACT FROM AUTHOR]

Copyright of Zagreb Law Review is the property of University of Zagreb Law School / Pravni fakultet Sveucilista u Zagrebu and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Graduation is an inauguration activity for students who have finished studying at a university. Graduation registration at the Cilacap State Polytechnic is still done conventionally, causing problems such as students who are not registered in the toga data collection, students who do not return the toga according to the specified time limit. In addition, the large number of students makes the data collection process take longer. In this case, the authors conducted research that aims to build a website-based graduation registration information system. Making this system requires a research methodology. Among them are data collection methods that include literature studies, observations, and interviews as well as the system development method used, namely Rapid Application Development (RAD). The results of the questionnaire with a total score of 182 show that the system is very good in assisting BAAK in graduation registration services and monitoring the number of graduates, as well as helping students register for graduation and their completeness, and the system can help submit and confirm trouble-free forms.