1. Endothelial Glycocalyx Degradation Patterns in Sepsis-Associated Pediatric Acute Respiratory Distress Syndrome: A Single Center Retrospective Observational Study.
- Author
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Hippensteel, Joseph, Miller, Kristen, Oshima, Kaori, Pham, Andrew, Richter, Robert, Belperio, John, Sierra, Yamila, Mourani, Peter, Schmidt, Eric, Sapru, Anil, Maddux, Aline, Schwingshackl, Andreas, and Sallee, Colin
- Subjects
acute respiratory distress syndrome ,glycocalyx ,glycosaminoglycan ,mechanical ventilation ,pediatric intensive care ,pediatrics ,proteoglycan ,sepsis ,Humans ,Child ,Retrospective Studies ,Syndecan-1 ,Chondroitin Sulfates ,Prospective Studies ,Glycocalyx ,Respiratory Distress Syndrome ,Sepsis ,Heparitin Sulfate ,Biomarkers ,Proteoglycans ,Disaccharides - Abstract
BACKGROUND: Sepsis-associated destruction of the pulmonary microvascular endothelial glycocalyx (EGCX) creates a vulnerable endothelial surface, contributing to the development of acute respiratory distress syndrome (ARDS). Constituents of the EGCX shed into circulation, glycosaminoglycans and proteoglycans, may serve as biomarkers of endothelial dysfunction. We sought to define the patterns of plasma EGCX degradation products in children with sepsis-associated pediatric ARDS (PARDS), and test their association with clinical outcomes. METHODS: We retrospectively analyzed a prospective cohort (2018-2020) of children (≥1 month to 60% of the severe PARDS patients (test for trend, p = 0.04). Higher total heparan sulfate and N-sulfated disaccharide levels were independently associated with fewer 28-day ventilator-free days in children with sepsis-associated PARDS (all p
- Published
- 2024