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1,321 results on '"p300-CBP Transcription Factors metabolism"'

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1. Pharmacological targeting of P300/CBP reveals EWS::FLI1-mediated senescence evasion in Ewing sarcoma.

2. AR coactivators, CBP/p300, are critical mediators of DNA repair in prostate cancer.

3. KAT tales: Functions of Gcn5 and PCAF lysine acetyltransferases in SAGA and ATAC.

4. PCAF-mediated acetylation of METTL3 impairs mRNA translation efficiency in response to oxidative stress.

5. Maintenance of thermogenic adipose tissues despite loss of the H3K27 acetyltransferases p300 or CBP.

6. LINC00887 promotes GCN5-dependent H3K27cr level and CRC metastasis via recruitment of YEATS2 and enhancing ETS1 expression.

7. Targeting CBP and p300: Emerging Anticancer Agents.

8. Rapid profiling of transcription factor-cofactor interaction networks reveals principles of epigenetic regulation.

9. Functional Investigations of p53 Acetylation Enabled by Heterobifunctional Molecules.

10. The Lysine Acetyltransferase PCAF Functionally Interacts with Estrogen Receptor Alpha in the Hippocampus of Gonadally Intact Male-But Not Female-Rats to Enhance Short-Term Memory.

11. Mechanism for controlled assembly of transcriptional condensates by Aire.

12. Molecular basis of the interactions between the disordered Neh4 and Neh5 domains of Nrf2 and CBP/p300 in oxidative stress response.

13. Cold atmospheric plasma enhances SLC7A11-mediated ferroptosis in non-small cell lung cancer by regulating PCAF mediated HOXB9 acetylation.

14. Inhibition of Renin Expression Is Regulated by an Epigenetic Switch From an Active to a Poised State.

15. PCAF promotes R-loop resolution via histone acetylation.

16. Design, Synthesis, and Evaluation of p53Y220C Acetylation Targeting Chimeras (AceTACs).

17. Charge Relaying within a Phospho-Motif Rescue Binding Competency of a Disordered Transcription Factor.

18. Oral Administration of a Specific p300/CBP Lysine Acetyltransferase Activator Induces Synaptic Plasticity and Repairs Spinal Cord Injury.

19. Organization of microtubule plus-end dynamics by phase separation in mitosis.

20. Aerobic training attenuates cardiac remodeling in mice post-myocardial infarction by inhibiting the p300/CBP-associated factor.

21. Apigenin suppresses epithelial-mesenchymal transition in high glucose-induced retinal pigment epithelial cell by inhibiting CBP/p300-mediated histone acetylation.

22. Design, synthesis and biological evaluation of new RNF126-based p300/CBP degraders.

23. PNSC928, a plant-derived compound, specifically disrupts CtBP2-p300 interaction and reduces inflammation in mice with acute respiratory distress syndrome.

24. Discovery of a Promising CBP/p300 Degrader XYD129 for the Treatment of Acute Myeloid Leukemia.

25. Acetylation of histones and non-histone proteins is not a mere consequence of ongoing transcription.

26. Targeting dependency on a paralog pair of CBP/p300 against de-repression of KREMEN2 in SMARCB1-deficient cancers.

27. Activation of AMPK inhibits cervical cancer growth by hyperacetylation of H3K9 through PCAF.

28. Andrographolide regulates H3 histone lactylation by interfering with p300 to alleviate aortic valve calcification.

29. GCN5 mediates DNA-PKcs crotonylation for DNA double-strand break repair and determining cancer radiosensitivity.

30. Discovery of Highly Potent and Efficient CBP/p300 Degraders with Strong In Vivo Antitumor Activity.

31. Characteristics of anticancer activity of CBP/p300 inhibitors - Features of their classes, intracellular targets and future perspectives of their application in cancer treatment.

32. The balance between nuclear import and export of NLRC5 regulates MHC class I transactivation.

33. The pRb/RBL2-E2F1/4-GCN5 axis regulates cancer stem cell formation and G0 phase entry/exit by paracrine mechanisms.

34. The histone lysine acetyltransferase KAT2B inhibits cholangiocarcinoma growth: evidence for interaction with SP1 to regulate NF2-YAP signaling.

35. Discovery of Novel PROTAC Degraders of p300/CBP as Potential Therapeutics for Hepatocellular Carcinoma.

36. P300/CBP Regulates HIF-1-Dependent Sympathetic Activation and Hypertension by Intermittent Hypoxia.

37. DOT1L decelerates the development of osteoporosis by inhibiting SRSF1 transcriptional activity via microRNA-181-mediated KAT2B inhibition.

38. Acetyltransferases CBP/p300 Control Transcriptional Switch of β-Catenin and Stat1 Promoting Osteoblast Differentiation.

39. The histone acetyl transferases CBP and p300 regulate stress response pathways in synovial fibroblasts at transcriptional and functional levels.

40. Inhibition of mitochondrial fatty acid β-oxidation activates mTORC1 pathway and protein synthesis via Gcn5-dependent acetylation of Raptor in zebrafish.

41. Acetyl-CoA biosynthesis drives resistance to histone acetyltransferase inhibition.

42. Discovery of berberine analogs as potent and highly selective p300/CBP HAT inhibitors.

43. Development of a multiplex assay to assess activated p300/CBP in circulating prostate tumor cells.

44. Epigenetic mechanisms to propagate histone acetylation by p300/CBP.

45. Unravelling the Role of P300 and TMPRSS2 in Prostate Cancer: A Literature Review.

46. Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis.

47. CBP and Gcn5 drive zygotic genome activation independently of their catalytic activity.

48. hMSCs-derived exosome circCDK13 inhibits liver fibrosis by regulating the expression of MFGE8 through miR-17-5p/KAT2B.

49. CRISPR-Cas9 genetic screen leads to the discovery of L-Moses, a KAT2B inhibitor that attenuates Tunicamycin-mediated neuronal cell death.

50. Identification and Characterization of p300-Mediated Lysine Residues in Cardiac SERCA2a.

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