KAT tales: Functions of Gcn5 and PCAF lysine acetyltransferases in SAGA and ATAC.

Authors :: Dent SYR
Source :: The Journal of biological chemistry [J Biol Chem] 2024 Oct; Vol. 300 (10), pp. 107744. Date of Electronic Publication: 2024 Sep 01.
Publication Year :: 2024
Abstract: The Allis group identified Gcn5 as the first transcription-related lysine acetyltransferase in 1996, providing a molecular "missing link" between chromatin organization and gene regulation. This review will focus on functions subsequently identified for Gcn5 and the closely related PCAF protein, in the context of two major complexes, SAGA and ATAC, and how the study of these enzymes informs long standing questions regarding the importance of lysine acetylation.<br />Competing Interests: Conflict of interest The author declares that they have no conflicts of interest with the contents of this article.<br /> (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)

Subjects :: Humans
Acetylation
Animals
Lysine Acetyltransferases metabolism
Lysine Acetyltransferases genetics
Trans-Activators metabolism
Trans-Activators genetics
Lysine metabolism
DNA-Binding Proteins metabolism
DNA-Binding Proteins genetics
Chromatin metabolism
Chromatin genetics
p300-CBP Transcription Factors metabolism
p300-CBP Transcription Factors genetics
Histone Acetyltransferases metabolism
Histone Acetyltransferases genetics

Full Text Access

Tools