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2 results on '"oesophageal mucosa heterogeneity"'

1. Measuring the micromechanical properties of oesophageal mucosa with atomic force microscopy

Author

Chengxiong Lin, Jingyang Xie, and Wei Li

Subjects
atomic force microscopy, micromechanics, biomechanics, adhesion, biological tissues, diseases, elastic moduli, patient diagnosis, plasticity, soft tissue, endoscope materials, elastic modulus, adhesion force, loading rates, deflections, dwell time, contact stress, energy transformation, strain gradient plasticity, oesophageal mucosa heterogeneity, oesophageal disease diagnosis, Biotechnology, TP248.13-248.65, Biochemistry, QD415-436
Abstract

The micromechanical properties of soft tissue can be used as markers for the physiological state and function of the tissue. Deep understanding of the micromechanics of soft tissue, such as the oesophagus, is of great significance to the design of artificial oesophagi, endoscope materials and coatings for medical devices. Here, the micromechanical properties of oesophageal mucosa were studied under different loading rates, deflections, and dwell time by using atomic force microscopy. The micromechanical properties of soft tissue included elastic modulus, plasticity and adhesion force. Results showed that the micromechanical properties changed with increasing loading rate, deflection and dwell time. The micromechanical properties of oesophageal mucosa were related to time-dependent behaviours, such as contact stress, energy transformation, and strain gradient plasticity. Furthermore, the heterogeneity of oesophageal mucosa affected the micromechanical properties. The force mapping mode was a reliable and effective means to study the micromechanical properties of soft tissue. The results can provide a basis and technical support for the diagnosis of oesophageal diseases from a microscale as well as a material design perspective.

Published
2020
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2. Measuring the micromechanical properties of oesophageal mucosa with atomic force microscopy

Author

Wei Li, Chengxiong Lin, and Jingyang Xie

Subjects
elastic moduli, endoscope materials, Materials science, lcsh:Biotechnology, 0206 medical engineering, Biomedical Engineering, Biophysics, elastic modulus, 02 engineering and technology, Plasticity, biomechanics, diseases, lcsh:Biochemistry, Biomaterials, micromechanics, adhesion force, deflections, oesophageal mucosa heterogeneity, lcsh:TP248.13-248.65, lcsh:QD415-436, Elastic modulus, Microscale chemistry, loading rates, atomic force microscopy, Mechanical Engineering, Biomechanics, Micromechanics, Soft tissue, strain gradient plasticity, energy transformation, 021001 nanoscience & nanotechnology, 020601 biomedical engineering, Surfaces, Coatings and Films, adhesion, contact stress, Dwell time, Contact mechanics, dwell time, plasticity, biological tissues, patient diagnosis, oesophageal disease diagnosis, soft tissue, 0210 nano-technology, Biomedical engineering
Abstract

The micromechanical properties of soft tissue can be used as markers for the physiological state and function of the tissue. Deep understanding of the micromechanics of soft tissue, such as the oesophagus, is of great significance to the design of artificial oesophagi, endoscope materials and coatings for medical devices. Here, the micromechanical properties of oesophageal mucosa were studied under different loading rates, deflections, and dwell time by using atomic force microscopy. The micromechanical properties of soft tissue included elastic modulus, plasticity and adhesion force. Results showed that the micromechanical properties changed with increasing loading rate, deflection and dwell time. The micromechanical properties of oesophageal mucosa were related to time-dependent behaviours, such as contact stress, energy transformation, and strain gradient plasticity. Furthermore, the heterogeneity of oesophageal mucosa affected the micromechanical properties. The force mapping mode was a reliable and effective means to study the micromechanical properties of soft tissue. The results can provide a basis and technical support for the diagnosis of oesophageal diseases from a microscale as well as a material design perspective.

Published
2020

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