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Measuring the micromechanical properties of oesophageal mucosa with atomic force microscopy
- Source :
- Biosurface and Biotribology (2020)
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- The micromechanical properties of soft tissue can be used as markers for the physiological state and function of the tissue. Deep understanding of the micromechanics of soft tissue, such as the oesophagus, is of great significance to the design of artificial oesophagi, endoscope materials and coatings for medical devices. Here, the micromechanical properties of oesophageal mucosa were studied under different loading rates, deflections, and dwell time by using atomic force microscopy. The micromechanical properties of soft tissue included elastic modulus, plasticity and adhesion force. Results showed that the micromechanical properties changed with increasing loading rate, deflection and dwell time. The micromechanical properties of oesophageal mucosa were related to time-dependent behaviours, such as contact stress, energy transformation, and strain gradient plasticity. Furthermore, the heterogeneity of oesophageal mucosa affected the micromechanical properties. The force mapping mode was a reliable and effective means to study the micromechanical properties of soft tissue. The results can provide a basis and technical support for the diagnosis of oesophageal diseases from a microscale as well as a material design perspective.
- Subjects :
- atomic force microscopy
micromechanics
biomechanics
adhesion
biological tissues
diseases
elastic moduli
patient diagnosis
plasticity
soft tissue
endoscope materials
elastic modulus
adhesion force
loading rates
deflections
dwell time
contact stress
energy transformation
strain gradient plasticity
oesophageal mucosa heterogeneity
oesophageal disease diagnosis
Biotechnology
TP248.13-248.65
Biochemistry
QD415-436
Subjects
Details
- Language :
- English
- ISSN :
- 24054518
- Database :
- Directory of Open Access Journals
- Journal :
- Biosurface and Biotribology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.35a9823ac514bcd9245a1cc4e5c87f6
- Document Type :
- article
- Full Text :
- https://doi.org/10.1049/bsbt.2020.0015