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Objective: In this study, we investigated the clinical characteristics and survival outcomes of patients diagnosed with special types of breast cancer who presented to our clinic. Methods: The demographic, clinicopathological, and survival characteristics of all rare, histologically special subtype breast cancer patients who applied to Sivas Cumhuriyet University Oncology Center between 2010 and 2020 were retrospectively reviewed. Results: The records of 1198 patients with invasive breast cancer were examined, and 104 of them (8%) were identified as having other histological special subtypes. Of these, 19 (8%) had apocrine cancer, 19 (8%) had mucinous type, 17 (7%) had invasive cribriform, 15 (6%) had invasive papillary, 11 (4%) had metaplastic type, 9 (4%) had invasive micropapillary, 6 (2%) had neuroendocrine, 3 (1%) had tubular type, 3 (1%) had microinvasive type, and 2 (1%) had undifferentiated carcinoma. The majority of these patients, 102 (98%), were female, with a median age of 52 years (range 26-82). Of the women, 60 (59%) were postmenopausal, and 42 (41%) were premenopausal. The ECOG Performance Score (PS) was 0 in 79 (76%) patients, 1 in 17 (16%) patients, and 2 in 8 (8%) patients. Upon evaluation, 50 patients (48%) had comorbid conditions, and 26 patients (25%) had a family history of breast cancer. At diagnosis, 25 patients (24%) were stage I, 50 (48%) were stage II, 26 (25%) were stage III, and 3 (3%) were stage IV. Histopathologically, 75 patients (72%) were estrogen receptor (ER)-positive, 69 (66%) were progesterone receptor (PR)-positive, and 26 (25%) were HER2-positive. An intraductal component was detected in 54 (60%) patients, and multicentricity was observed in 15 (16%) patients. A modified radical mastectomy was performed on 56 (54%) patients, while breast-conserving surgery was performed on 45 (43%) patients. Adjuvant chemotherapy was administered to 76 (73%) patients, hormonal therapy to 73 (70%), and radiotherapy to 72 (68%). The median follow-up period was 54 months (range 1-201). During follow-up, metastasis was detected in 13 patients (13%), and recurrence was detected in 7 patients (7%). The 5-year and 10-year overall survival rates were 86% and 77%, respectively, while the 5-year and 10-year event-free survival rates were 79% and 70%, respectively. Conclusion: In our study, the majority of patients with special type breast carcinoma were non-metastatic, and histopathologically, they were hormone receptor-positive with low grade. There was no statistically significant difference in 5-year and 10-year overall survival or event-free survival among the pecial types. [ABSTRACT FROM AUTHOR]

Copyright of Advances in Women's Studies is the property of Ataturk University Coordinatorship of Scientific Journals and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

One of the main purposes is to examine the relationship between cancer response style, metacognition, and anxiety of newly diagnosed and remission breast cancer patients based on the metacognitive model. Second is to evaluate difference between newly diagnosed and remission breast patients in manner of cancer response style, metacognition, and anxiety levels. A total of 110 early-stage breast cancer patients (56 newly diagnosed, 54 in remission) from one of the government hospital in Türkiye, Muğla were enrolled from November 2022 to August 2023. The participants completed sociodemographic and medical information, the Metacognition Scale (SBS-30), Cancer Response Style Scale, and Generalized Anxiety Scale-Revised (GADS-R). The average scores of the participants on the Generalized Anxiety Scale were determined as 1591,12 ± 282,62, in those who were in newly diagnosed and was determined 1284.44 ± 445.34 in remission. Anxiety has a positive correlation with metacognitive activity and emotion-oriented strategies (P

Objective: This study aimed to evaluate the anticancer effect of NCB-0846, a TNIK inhibitor, in MCF-7 cells and to assess its impact on the expression levels of NF-κB and TNFA at the gene level. Materials and Methods: The MCF-7 cell line was cultured at 37°C in a 5% CO2 atmosphere using Dulbecco’s Modified Eagle Medium (DMEM) supplemented with 10% fetal bovine serum (FBS) and antibiotics (50 IU/mL penicillin and 50 mg/mL streptomycin). Cell viability was analyzed using the CCK-8 assay to determine the cytotoxic effect of NCB- 0846. Acridine Orange/Propidium Iodide (AO/PI) staining was performed to evaluate the effect of NCB-0846 on cellular morphology in the MCF-7 cell line. Total RNA was isolated from cells treated with NCB-0846. Data analysis was performed using the SPSS 22.0 statistical program. Results: The data indicated that NCB-0846 significantly decreased the viability rates of MCF-7 cells in a dose-dependent manner (1-3 μM, p

Objective: This study aims to examine the relationship of women's breast cancer fatalism perceptions with health beliefs and early diagnosis behaviors. Method: This descriptive and relational design study was conducted with 400 women. Data were collected using the Personal Information Form', the 'Breast Cancer Health Belief Model Scale', and the 'Breast Cancer Fatalism Scale'. Results: Women who had high Breast Cancer Fatalism Scale mean scores were found to have low levels of breast self-exam (BSE) and clinical breast exam (p< .05). While a negative relationship was detected between health motivation, BSE benefits, BSE self-efficacy, and mammography benefits sub-scale scores of the Breast Cancer Health Belief Model Scale, a positive relationship was detected between susceptibility, seriousness, BSE barriers, and mammography barriers sub-scales and Breast Cancer Fatalism Scale scores. Conclusion: As a result, a negative relationship was found between women's breast cancer fatalism, health beliefs and early diagnosis behaviors. It is recommended that health professionals evaluate individuals' health beliefs and breast cancer fatalism perception level and take these factors into account in their education planning in order to increase women's screening behavior.

Objective: To investigate the relationship between self-efficacy, marital status, and quality of life among Banda Aceh Hospital chemotherapy patients in Indonesia.Methods: The descriptive design was correlational with a cross-sectional approach. Sampling type of the research method used purposive sampling. The sample size of 100 breast cancer patients undergoing chemotherapy met the inclusion criteria. Instruments for this research used the Questionnaire Quality of Life-Breast Cancer (QOL-BC) and the Symptom Management Breast Cancer Self-Efficacy Scale (SMSES-BC). Multiple linear regression and spearman rank correlation were used in this analysis.Results: Self-efficacy (P

Metastasis is the most common intraocular malignancy. These lesions are the smallest metastases in the human body that can be directly detected with a biomicroscope. Choroidal metastasis most commonly originates from primary cancer of the breast and lungs. Breast cancer is the most common type of cancer in women. In this case, a 42-year-old female with choroidal metastasis secondary to breast cancer is presented using multimodal imaging. [ABSTRACT FROM AUTHOR]

Objective: Autophagy plays a significant role in breast cancer tumorigenesis, including triple-negative breast cancer. Research indicates that hydroxychloroquine and thymoquinone modulate autophagy, potentially suppressing its activity. However, their combined effects on autophagy in triple-negative breast cancer remain unexplored. In this study, we investigated the potential anti-cancer and autophagy-modulating effects of hydroxychloroquine-thymoquinone combination on triple-negative breast cancer cells in vitro. Material and Method: The viability of MDA-MB-231 cells was evaluated after treatment with hydroxychloroquine (10-210 µM) and thymoquinone (5-45 µM) for 24 and 48 hours using the WST-1 assay. Combination effects were analyzed using the Chou-Talalay method with CompuSyn (v.10). Autophagic vesicles were visualized using an Autophagy Detection Kit and fluorescence microscopy to investigate their role in the decrease in cell viability. Statistical analysis was performed with GraphPad Prism (v.8.3.0). Results: At both 24- and 48-hour intervals post-treatment, a significant decrease in viability was observed for both hydroxychloroquine and thymoquinone treatments individually (p<0.0001). The combination of these drugs revealed pronounced synergistic effects at 24 hours, whereas antagonistic effects were noted at 48 hours (combination index>1). At 24 hours, favorable dose reduction effects were evident (dose reduction index >1), while the 48-hour results showed an unfavorable reduction (dose reduction index<1). Consequently, the 24-hour synergistic effects resulted in a reduction in autophagic vesicles (p<0.0001). Conclusion: This study revealed, for the first time, a time-dependent decrease in triple-negative breast cancer cell viability via the autophagy mechanism induced by hydroxychloroquine and thymoquinone, highlighting their novel implications for triple-negative breast cancer treatment and autophagy modulation. [ABSTRACT FROM AUTHOR]

Copyright of Gümüshane Üniversitesi Saglik Bilimleri Dergisi is the property of Gumushane University, Faculty of Health Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Gümüshane Üniversitesi Saglik Bilimleri Dergisi is the property of Gumushane University, Faculty of Health Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Gümüshane Üniversitesi Saglik Bilimleri Dergisi is the property of Gumushane University, Faculty of Health Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Journal of Nursology is the property of Ataturk University Coordinatorship of Scientific Journals and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Ege Journal of Medicine is the property of Ege University, Faculty of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Ege Journal of Medicine is the property of Ege University, Faculty of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: MicroRNAs(miRNAs) have been demonstrated to contribute to cancer development by playing essential roles in processes including proliferation, migration, invasion, and metastasis. One of the most serious issues in breast cancer (BC) is drug resistance. Recent research suggests that miRNAs may play a role in drug resistance. Using diverse datasets and in silico approaches, we focused on the BC/drug resistance/miRNA link in our study. Material and Methods: GSE73736 and GSE71142 geo datasets (for miRNAs) and GSE162187 geo dataset (for genes) were obtained from the GEO database to detect differently expressed miRNAs and genes using the R software “LIMMA” package. Potential target genes of screened differentially expressed miRNAs (DE-miRNAs) were predicted using miRMap, miRTarbase, and miRNet tools. Differently expressed genes (DE-genes) were filtered and common DE-genes were identified via TCGA data and miRNet. Afterward, Enrichr, and Funrich tools were used to perform GO annotation and KEGG pathway enrichment analysis. KMplot and GEPIA2 web tools were utilized to investigate further hub miRNAs and genes’ expression and prognostic effects. Results: 3 miRNAs that were considerably downregulated and had prognostic significance in BC were identified using the criteria defined in the investigated geo datasets. MiR-586, which is expected to be more closely linked to BC, has been found to have the ability to target 5 genes involved in BC resistance to therapy. GO, KEGG, and survival analysis showed that the probable target genes of miR-586 could be closely connected to BC. Conclusion: In this study, a comprehensive BC-drug resistance-miRNA-gene network was established and new targets for the treatment and prognosis of BC were revealed using bioinformatics data. [ABSTRACT FROM AUTHOR]

Aim: The PREDICT tool is used to estimate survival in breast cancer patients according to the types of treatment given. This study aimed to assess the accuracy of the PREDICT tool and identify the prognostic factors for survival in patients with breast cancer. Material and Methods: A retrospective study was performed based on data collected from the Hospital Sultanah Nur Zahirah, Terengganu, Malaysia. All female patients diagnosed with stage I to IV breast cancer were identified from the year 2011 to 2017. Results: Based on data from 355 eligible patients, the predicted and observed 5-year overall survival rates were 75.8% and 75.2%, respectively. The model performed fairly well, with the area under the curve (AUC) of 0.747 (95% confidence interval (CI): 0.69-0.81) in the predicted 5-year overall survival. Among the 585 patients diagnosed with stage I to IV breast cancer, stage at the presentation (stage III hazard ratio (HR): 5.80, 95% CI: 1.69-19.94, p=0.005, stage IV HR: 10.61, 95% CI: 3.09-36.49, p<0.001), without surgical treatment (HR: 2.29, 95% CI: 1.73-3.00, p<0.001), without radiotherapy (HR: 1.92, 95% CI: 1.41-2.62, p<0.001), and without neoadjuvant chemotherapy (HR: 0.63, 95% CI: 0.47-0.86, p=0.003) were associated with death in breast cancer patients. Conclusion: The PREDICT tool accurately estimated the 5-year overall survival in the study center. It might serve as a useful prognostication tool during consultation. Late stages of the disease, patients without surgical treatment, and patients without radiotherapy were associated with a higher risk of death in breast cancer. [ABSTRACT FROM AUTHOR]

Copyright of Balikesir Health Sciences Journal / Balıkesir Sağlık Bilimleri Dergisi is the property of Balikesir Health Sciences Journal (BAUN Health Sci J) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Istanbul Gelisim University Journal of Health Sciences / İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi is the property of Istanbul Gelisim Universitesi Saglik Bilimleri Yuksekokulu and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Istanbul Gelisim University Journal of Health Sciences / İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi is the property of Istanbul Gelisim Universitesi Saglik Bilimleri Yuksekokulu and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Artuklu Health is the property of Mardin Artuklu University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Anatolian Journal of General Medical Research is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of University of Health Sciences Journal of Nursing is the property of Saglik Bilimleri Universitesi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Academic Research in Nursing (JAREN) is the property of Hemsirelikte Egitim ve Arastirma Dergisi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Health Sciences / Sağlık Bilimleri Dergisi is the property of Erciyes Universitesi Saglik Bilimleri Dergisi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: Curcumin is considered an epigenetic regulator with anticancer effects. The micro-RNA (miRNA) miR-145-5p is a tumor suppressor that shows low expression levels in various cancers, including breast cancer (BC). This study aims to investigate whether curcumin inhibits MCF-7 human BC cell line proliferation and migration by regulating miR-145-5p and its possible target genes. Material and Method: MCF-7 cells were treated with curcumin and its solvent control. Additionally, cells were transfected with an miR-145-5p mimic and a non-targeting miRNA mimic. Cell viability was then evaluated, and the scratch wound assay was used to assess cell migration. The study predicts the miR-145- 5p putative target genes by searching for overlapping genes in the miRNet and miRTarBase v8 databases via the overexpressed genes in the BC tissue samples in the Cancer Genome Atlas (TCGA) datasets. Expression levels of miR-145-5p and the selected genes were detected using the quantitative real-time polymerase chain reaction (qRT-PCR). The 2-ΔΔCt method was used for the quantification analysis, with p<0.05 being considered statistically significant. Result: Curcumin treatment and overexpression of miR-145- 5p via the transfection of an miR-145-5p mimic significantly decreased the proliferation and migration of MCF-7 cells. Moreover, curcumin treatment significantly increased the expression of miR-145-5p. The possible target genes of miR-145- 5p (i.e., MCM2, MMP1, MMP9, EEF1A2) were downregulated in curcumin-treated MCF-7 cells. Additionally, miR-145-5p mimictransfected cells showed low expression levels of the MCM2, MMP1, and MMP9 genes. Conclusion: Curcumin inhibits the proliferation and migration of MCF-7 cells by acting on miR-145-5p and its possible target genes. [ABSTRACT FROM AUTHOR]

Objective: Breast cancer is a type of cancer that originates in breast tissue cells. It is the most common cancer type in the world after lung cancer. The prognosis of the disease mostly depends on the type and stage of cancer. One of the worst prognoses is seen in a specific type called Triple-negative breast cancer (TNBC), which represents not having any of the three most recognized receptors, namely estrogen, progesterone, and c-erb2 receptors. Our objective was to determine the difference in overall and disease-free survival for breast cancer types categorized by receptor status. Methods: This is a retrospective matched case-control study with breast cancer patients of two types. A total of 102 patients were divided equally into having TNBC of 51 patients in one arm and triple-positive breast cancer (TPBC) of 51 patients in the other arm. Analyses were run for disease prognostic values and patients' demographic values. Results: Disease free survival were 63±10.6 months and 93.2±4.9 months in the fifth year for the TNBC and TPBC groups, respectively. (p=0.004) Overall survival was significantly different as 73.9±7.3 months for TNBC and 97.7±2.3 months for TPBC (p=0.002). Conclusion: TNBC prognosis is worse than that of other breast cancer types. The most important reason is being unable to use hormonal treatment because of the receptor status, and a disease-specific targeted treatment could not have been developed so far. Therefore, it is necessary to identify new molecular targets and develop treatments for them. [ABSTRACT FROM AUTHOR]

Copyright of Pamukkale Medical Journal is the property of Pamukkale Journal of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Medical Clinics / Tıp Fakültesi Klinikleri Dergisi is the property of Journal of Medical Clinics / Tip Fakültesi Klinikleri Dergisi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Acibadem Saglik Bilimleri Dergisi is the property of Acibadem University Medical School and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: In this study, it was aimed for third-year medical school students to improve their knowledge, examination skills and attitudes about breast cancer, and to experience the skills of taking a disease history, communicating effectively and giving bad news. Methods: The present study was carried out with 406 3rd-year medical faculty students from Akdeniz University and a semi-experimental method was employed. The content of implementation consists of improving the students' skills in receiving disease history from the patient and "clinical breast examination" on breast model, as well as informing the patient about the examination findings. Before the application, all students were given theoretical information about the subject and practiced with a learning guide on clinical breast examination. The pretest-posttest results of surveys received from the participating students and the standardized patient practice feedback form were analyzed. Results: Examining the surveys conducted before and after the implementation with 406 students, it was found that the students learned what the risk factors related with breast cancer are and they could question them while receiving the patient history (p<0.05). Their ability to perform breast examination was improved and they could detect the lump in breast (p<0.05). They gained experience about informing the patients and referring them to the departments related with preliminary diagnosis of breast cancer, as well as giving bad news (p<0.05). Conclusions: With a suitable scenario and planned educations, "Standardized Patient Practice" can be successfully used in preclinical educations. [ABSTRACT FROM AUTHOR]

Objective: This study sought to discern the differential impacts of communicating individualized breast cancer risk versus disseminating generic breast cancer information on women's proclivity towards breast cancer screenings. Method: A structured experimental design was used, including 300 female volunteers aged between 40-69, who had not previously been diagnosed with breast cancer, in Erzincan. Data collection entailed a face-to-face administration of a 22-item questionnaire complemented by the ASSISTS scale. Participants were randomized into two conditions: one receiving a standardized briefing on breast cancer screening modalities, and the other being apprised of their lifetime risk of breast cancer development based on the modified Gail model. Results: Post-intervention, 55.8% (n=72) of the risk-informed cohort and 40.5% (n=41) of the generic information cohort expressed a willingness to undergo screening (p=0.022). Notably, the group informed of their personalized risk exhibited a more pronounced uptick in requests for breast self-examination, clinical breast examination, and mammography screening compared to their counterparts. Conclusions: The communication of personalized breast cancer risk proves to be a more efficacious and time-efficient strategy than generic information dissemination in bolstering screening participation rates. [ABSTRACT FROM AUTHOR]

Objective: Breast cancer (BC) is the most frequent cancer among women. Many BC patients suffer from sleep problems, which have a negative impact on their quality of life (QoL). Our study aims to investigate sleep problems in BC patients treated with active chemotherapy or in remission in comparison with a healthy control group (HCG), given the importance of sleep disorders and QoL. Materials and Methods: A multicenter, cross-sectional study was conducted. Four different surveys including sociodemographic characteristics questionnaire, Pittsburgh sleep quality index (PSQI), hospital anxiety and depression scale and The European Organisation for Research and Treatment of Cancer core quality of life questionnaire (QLQ-C30) were used to collect study parameters. Results: Of 164 participants, the mean age was 42.0±11.7 years. Overall PSQI median score for all participants was 6 points (range, 3-9 points). PSQI median value was higher in cancer patients compared to the control group, which were 6 points (range, 4-9 points), and 4 points (range, 3-7 points), respectively (p=0.004). The mean depression score was 5 points (range, 3-8 points) in BC patients, and 4 points (range, 2-6 points) in HCGs, respectively (p=0.025). Having BC diagnosis was an independent factor increasing the risk of bad sleep quality in compared to healthy controls (odds ratio: 2.568, 95% confidence interval: 1.169-5.645; p=0.019). Conclusion: There was a close association between poor sleep quality, depression and QoL scores in patients with BC. In patients with breast cancer, appropriate management of associated comorbidities will aid a better quality of life in these patients. [ABSTRACT FROM AUTHOR]

Anti-nuclear antibodies (ANAs) are autoantibodies synthesized in response to the cell nucleus contents and use as biomarkers of systemic autoimmune diseases. Inflammation, apoptosis and necrosis of the cells are consequences that accompany breast cancer against which autoantibodies will be produced. In this study, we aimed to evaluate the presence of ANAs and anti-extractable nuclear antigens (anti-ENAs) in breast cancer. A total of 33 luminal A and luminal B breast cancer patients were assessed for presence of ANAs and anti-ENAs. All the patients had received hormone therapy at least for 6 months before the tests. Patients were screened to ANAs by indirect immunofluorescence on human epithelial type 2 (HEp-2) cells. AESKUBLOTS® ANA-17 comp kit was used to identify the concentrations of U1-snRNP, snRNP/Sm, SmD1, dsDNA, SS-A/Ro 60, SS-A/Ro 52, SS-B/La antibodies. Fifteen (45.5%) patients were luminal A and 18 (54.5%) patients were luminal B. The median of age was 57 and the median of tumor size was 25. 19 (57.6%) patients had grade I or II and 14 (42.4%) had grade III. 3 patients had ANAs test positive. All the patients who had positive ANA test were luminal A breast cancer and had grade I or II tumors and positive lymph node, whereas, pathological tumor stage were varied. No statistically significant association was found between ANAs positivity and molecular subtype, age, body mass index (BMI), grade, tumor stage or lymph node involvement. Moreover, there were negative correlations between the anti-U1-snRNP and anti-dsDNA with Ki-67 and a correlation between anti-snRNP/Sm and anti-SS-A/Ro 52 was found. Comparing with luminal A, anti-U1-snRNP and antisnRNP/Sm concentrations were statistically significantly lower in luminal B tumors (p= 0.015 and 0.016 respectively). Patients who had high grade tumors showed low concentrations of anti-snRNP/Sm (p=0.027), whereas patients who had lymph node metastasis showed high concentrations of anti-U1-snRNP (p=0.031). ANAs positivity was more common in luminal A breast cancer patients compared with luminal B. Anti-U1-snRNP and anti-snRNP/Sm concentrations were lower in luminal B. Moreover, patients who had high grade tumors showed low concentrations of anti-snRNP/Sm, whereas those who had lymph node metastasis showed high concentrations of anti-U1-snRNP. [ABSTRACT FROM AUTHOR]

Copyright of Androloji Bülteni (Andrology Bullettin) is the property of BAYT Ltd. Co and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background: Family health centers, which facilitate access to healthcare services in the community and are known for their reliability, play a critical role in the early diagnosis and screening of breast cancer. This study aims to assess the knowledge levels and awareness of breast cancer among family physicians and healthcare workers who play a vital role in increasing public awareness of breast cancer. Materials and Methods: This study was conducted with family physicians and healthcare workers serving in family health centers in Samsun province. An online survey using Google Forms was i mplemented to assess participants' knowledge and awareness about breast cancer. Results: A total of 263 people, 188 women (71.5%) and 75 men (21.5%), were included in the study. 44.5% of the participants were family physicians and 55.5% were family health workers. 96.8% of women reported having self-breast examination. Women who stated that they did not have a mammogram (38.8%) stated that the reason was that they did not have a ny complaints at a rate of 27.8%. Family physicians w ere more likely to respond to suggestions about breast cancer risks and symptoms than family health professionals (p<0.05); Women gave more correct answers than men (p<0.05). Conclusions: The study results indicate that women have good awareness of breast cancer screening, but participants have inadequate knowledge about national breast cancer standards and breast cancer risk factors. It is important to provide in-service training at regular intervals within the framework of the duties and responsibilities of health professionals in order to increase their knowledge about breast cancer early detection and screening programs and to develop positive health behavior changes. [ABSTRACT FROM AUTHOR]

Objective: Breast cancer is a challenging process that affects the diagnosed people and their social environment psychologically, physiologically, socially, and economically. The main purpose of this study is to investigate the effectiveness of the Online Cognitive Behavioral Stress Management (CBSM) for Cancer program, which is structured for people diagnosed with cancer to develop coping methods that will enable them to cope with the stress they experience healthily and actively. The research question is whether attending the CBSM program is effective for the psychological well-being of breast cancer patients or not. Material and Method: The study was completed with a total of 35 people, 17 in the experimental group and 18 in the control group. The pretest-posttest results of the experimental and control groups were analyzed. The independent sample t-test was used in the comparison of the two groups of experimental and control groups. Paired sample t-test was used to compare the pretest-posttest scores of each group. Results: There was a significant difference observed between the experimental and control groups in the post-test measurements in terms of psychosocial adjustment to illness, assessment of coping attitudes, depression, hope, state, and trait anxiety (p<0.001). There was no significant difference in the pre-test and post-test scores of the experimental and control groups in terms of mental adjustment to cancer. Conclusion: The CBSM program for breast cancer patients is effective in coping with daily and illness-related stress by increasing psychological well-being: increased psychosocial adjustment; adaptation and decreased depression, and anxiety [ABSTRACT FROM AUTHOR]

Copyright of Anatolian Clinic Journal of Medical Sciences is the property of Hayat Saglik ve Sosyal Hizmetler Vakfi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Faculty of Pharmacy of Ankara University / Ankara Üniversitesi Eczacilik Fakültesi Dergisi is the property of Ankara University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Fenerbahce University Journal of Health Sciences (FBU-JOSH) / Fenerbahçe Üniversitesi Sağlık Bilimleri Dergisi is the property of Fenerbahce University Journal of Health Sciences (FBU-JOSH) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Anatolian Environmental & Animal Science is the property of Bulent Verep and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This article summarizes a retrospective study that investigated the factors associated with achieving a pathological complete response (pCR) in breast cancer patients who received neoadjuvant chemotherapy (NAC). The study included 119 female patients diagnosed with invasive breast cancer. The primary outcome, pCR, was defined as the absence of residual invasive breast cancer in both the breast tissue and axillary lymph nodes. The study found that the molecular subtype was the only independent factor associated with pCR, with HER2-positive and triple-negative subtypes showing higher odds of achieving pCR compared to other subtypes. The study emphasizes the importance of considering molecular subtypes when determining treatment strategies for breast cancer patients undergoing NAC. [Extracted from the article]

Backgrounds: The aim of this study is to investigate the preferences of female patients regarding the choice of surgeon for breast examination and the factors impacting this preference. Methods: A questionnaire was administered by interviewing 746 patients who applied to the General Surgery outpatient clinic with complaints of breast disease, and the results were analyzed statistically. The questionnaire form included the patient's age, marital status, hormonal status, history of delivery, complaints, factors that may impact the choice of physician, educational status, physical examination findings, and imaging results. Results: The study group included 746 patients aged between 14 and 76 years. While 284 (38%) of our patients applied to the outpatient clinic within 7 days of their first symptoms, 462 (62%) applied more than 7 days later. Due to late admission, advanced-stage breast cancer was detected in 2.8% of the patients. The most common reason for the delay in admission was the feeling of embarrassment in females of all age groups. Conclusion: Women with breast disease apply to the physician in the late period due to feeling embarrassed, religious beliefs, spouse pressure, and having a reservation for being examined by a male doctor. Breast diseases could be detected and treated in an earlier period, by enabling patients to apply to a physician earlier, with training, especially for women. [ABSTRACT FROM AUTHOR]

Copyright of Firat Universitesi Sağlik Bilimleri Tip Dergisi is the property of Firat Universitesiu, Saglik Bilimleri Enstitusu and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The study aimed to explore the role of social support, coping strategies in fostering positive growth among Turkish women with breast cancer, utilizing a cross-sectional design. Involving 188 women from three hospital centers in Türkiye the research employed standardized measures such as The Ways of Coping Inventory and the Stress Related Growth Scale, alongside collecting socio-demographic and medical information. The results revealed significant positive correlations between social support, problem-solving, religious coping, and seeking social support coping strategies with positive growth (ps < 0.05). Conversely, helplessness coping strategies were inversely correlated with positive growth (ps < 0.05). Furthermore, multivariate analysis indicated that 61.2% of the positive growth score could be attributed to variables such as the stage of cancer, marital status, social support, problem-solving coping, and religious coping. The perceived availability of emotional support, particularly in the context of benefit finding, plays a crucial role in the patients' emotional adjustment. Conclusively, the findings suggest that enhancing social support, problem-solving, and religious coping could significantly improve the outcomes for Turkish women dealing with breast cancer. This research underscores the need for improvements in healthcare policies, support systems, and educational programs, proposing that such interventions should be integrated into healthcare services to effectively contribute to the positive growth of breast cancer patients.

Tc-99m methylene diphosphonate (MDP) is a bone imaging agent used for skeletal staging, but it can also be localized in extraosseous calcifying lesions. We report a case of an 84-year-old woman with breast carcinoma who underwent surgery followed by radiotherapy 10 years ago and now presented with a right axillary mass referred for Tc-99m MDP to exclude bone metastasis. Tc-99m MDP shows intense tracer uptake in the right thoracic region corresponding to the site of calcified soft tissue mass in the right lateral chest wall. Subsequent ultrasonography revealed an ill-defined lesion containing coarse calcifications. Biopsy showed radiation-induced sarcoma. Extra osseous Tc-99m MDP uptake may provide important diagnostic information that may alter patient management. [ABSTRACT FROM AUTHOR]

Breast cancer is one of the most prominent causes of mortality among women worldwide due to factors such as aggressive behavior of the cancer and resistance to chemotherapeutic agents. Resistance to chemotherapeutic drugs in cancer treatment is a common phenomenon, especially in progressive diseases with a high prevalence. Therefore the current study aimed to demonstrate the anti-cancer effects of GL on MDA-MB-231 and MCF-7 cell lines. We showed the effect of GL on cell proliferation using the MTS method, its effect on clone formation with a clonogenic test, and we also evaluated whether the apoptotic pathway was activated by western blot. GL significantly inhibited cell proliferation depending on the dose in MDA-MB-231 and MCF-7 cell lines and it significantly reduced the number of colonies compared to non-treated cells. In addition, GL induced the initiation of apoptosis in MDA-MB-231 and MCF-7 cells, as evidenced by an enhanced level of caspase-8 and caspase-9 and decreased expression of PARP. These results demonstrated the molecular mechanism underlying the anti-cancer effects of GL, suggesting that GL might be useful in anticancer therapy. Novel products, such as GL, undoubtedly have promise for the future.

Objective: Autoimmune diseases (ADs) are observed more frequently in patients with breast cancer (BC) compared to healthy population. However, the frequency of ADs in their relatives has not been studied. In the present study, we aimed to compare the frequency of ADs among the first-degree and other relatives of patients with BC with healthy controls. Methods: We included 100 women aged 18 years and older who were followed up with the diagnosis of BC in our oncology clinic, and randomly selected female employees aged 18 and over in our hospital as the control group. The frequencies of ADs among relatives of the two groups were investigated using a detailed questionnaire. Results: Frequency of having at least one relative with AD was 76% in the BC group and 36% in the control group (p<0.001). The frequency of ADs in the relatives of the BC group was 5.5 times higher than in the relatives of the control group. In detailed analyzes, when the degree of kinship was considered, it was found that the risk increased to 11.5 times in the first-degree relatives of BC patients; however, no increased risk was found among more distant relatives. Conclusion: In our study, we found more ADs among the first-degree relatives of patients with BC compared to the control group. This result suggests that common genetic factors may be playing roles in the pathogenesis of BC and ADs. [ABSTRACT FROM AUTHOR]

Copyright of Turkish Journal of Research & Development in Nursing / Hemşirelikte Araştırma Geliştirme Dergisi is the property of Association for Research & Development in Nursing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)