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2 results on '"lectin induced aggregation"'

1. Influence of wortmannin of aggregation ability of neutrophylic granulocytes under type 1 diabetes mellitus

Author

M. Zdioruk, M. Barska, I. Brodyak, O. Vovk, A. Urbanovich, and N. Sybirna

Subjects
neutrohylic granulocytes, sialic containing glycoprotein, lectin induced aggregation, type 1 diabetes mellitus, Biology (General), QH301-705.5
Abstract

The determination wortmanin influence on aggregation ability of neutro­phylic granulocytes induced by specific lectins such as WGA, SNA and MAA was conducted. Distinct functional changes of the leucocytes under type 1 diabetes mellitus contingently by quantitative increasing of plasmatic membrane sialic containing glycoprotein receptors which contain in their structure NeuNAc(α2→6)DGal/DgalNAc carbohydrate, but not NeuNAc(α2→3)DGal/DgalNAc carbohydrate were revealed. Enhanced ability of neutrophylic granulocytes aggregation under influence of specific lectins at type 1 diabetes mellitus and weak answer of wortmanin inhibition may used as test system for determination of dearrangements in functional changes of the leukocytes under type 1 diabetes mellitus.

Published
2009
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2. Influence of wortmannin of aggregation ability of neutrophylic granulocytes under type 1 diabetes mellitus

Author

O. Vovk, I. V. Brodyak, U. Urbanovich, Mykola Zdioruk, Natalia Sybirna, and M. L. Barska

Subjects
medicine.medical_specialty, Type 1 diabetes, QH301-705.5, business.industry, medicine.disease, Wortmannin, chemistry.chemical_compound, Endocrinology, chemistry, Internal medicine, sialic containing glycoprotein, medicine, lectin induced aggregation, neutrohylic granulocytes, Biology (General), business, type 1 diabetes mellitus
Abstract

The determination wortmanin influence on aggregation ability of neutro­phylic granulocytes induced by specific lectins such as WGA, SNA and MAA was conducted. Distinct functional changes of the leucocytes under type 1 diabetes mellitus contingently by quantitative increasing of plasmatic membrane sialic containing glycoprotein receptors which contain in their structure NeuNAc(α2→6)DGal/DgalNAc carbohydrate, but not NeuNAc(α2→3)DGal/DgalNAc carbohydrate were revealed. Enhanced ability of neutrophylic granulocytes aggregation under influence of specific lectins at type 1 diabetes mellitus and weak answer of wortmanin inhibition may used as test system for determination of dearrangements in functional changes of the leukocytes under type 1 diabetes mellitus.

Published
2009

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