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Influence of wortmannin of aggregation ability of neutrophylic granulocytes under type 1 diabetes mellitus
- Source :
- Біологічні студії, Vol 3, Iss 2, Pp 133-140 (2009)
- Publication Year :
- 2009
- Publisher :
- Ivan Franko National University of Lviv, 2009.
-
Abstract
- The determination wortmanin influence on aggregation ability of neutro­phylic granulocytes induced by specific lectins such as WGA, SNA and MAA was conducted. Distinct functional changes of the leucocytes under type 1 diabetes mellitus contingently by quantitative increasing of plasmatic membrane sialic containing glycoprotein receptors which contain in their structure NeuNAc(α2→6)DGal/DgalNAc carbohydrate, but not NeuNAc(α2→3)DGal/DgalNAc carbohydrate were revealed. Enhanced ability of neutrophylic granulocytes aggregation under influence of specific lectins at type 1 diabetes mellitus and weak answer of wortmanin inhibition may used as test system for determination of dearrangements in functional changes of the leukocytes under type 1 diabetes mellitus.
- Subjects :
- medicine.medical_specialty
Type 1 diabetes
QH301-705.5
business.industry
medicine.disease
Wortmannin
chemistry.chemical_compound
Endocrinology
chemistry
Internal medicine
sialic containing glycoprotein
medicine
lectin induced aggregation
neutrohylic granulocytes
Biology (General)
business
type 1 diabetes mellitus
Subjects
Details
- ISSN :
- 23110783 and 19964536
- Volume :
- 3
- Database :
- OpenAIRE
- Journal :
- Studia Biologica
- Accession number :
- edsair.doi.dedup.....df13226f265549570d35e338fdbdad51