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Researchers from Jiaxing University in the People's Republic of China have discovered a new mechanism of depression-related neuroinflammation involving the protein kinase HIPK2. Through their study using a mouse model of depression, they found that HIPK2 mediates the M1 polarization of microglial cells via STAT3, exacerbating neuroinflammation and abnormal behaviors. This research suggests that HIPK2 could be a promising therapeutic target for depression. The study was supported by the Natural Science Foundation of Zhejiang Province and the Science and Technology Planning Project of Jiaxing. [Extracted from the article]

A study conducted at the Affiliated Hospital of Jiaxing University in China focused on the predictive value of immune-related parameters in severe Mycoplasma pneumoniae pneumonia (MPP) in children. The research analyzed data from 245 MPP patients, with 79 diagnosed with severe MPP. Parameters such as white blood cell counts, lymphocyte subsets, and monocyte counts were found to be associated with the severity of MPP. The study concluded that a predictive model based on age, CD3CD19%, and monocyte counts could aid in the early diagnosis of severe MPP in children, particularly those aged 5 years. [Extracted from the article]

A study conducted in Jiaxing, People's Republic of China, examined the impact of dietary titanium dioxide nanoparticles (TiO NPs) on intestinal health and stem cells in mice with enteritis. The research found that exposure to TiO NPs worsened enteritis by impairing intestinal epithelial regeneration and disrupting stem cell function through a mechanism involving Wnt signaling. These findings suggest potential adverse effects of TiO NPs on intestinal stem cells and emphasize the importance of particle size optimization for TiO food additives. The study was published in Food and Chemical Toxicology and peer-reviewed. [Extracted from the article]

A recent study conducted by researchers at Jiaxing University in China explores the use of remote surgery and the importance of cross-regional information transmission and processing in this field. The study focuses on the implementation of service function chain scheduling technology to efficiently allocate computing resources in data centers. The researchers propose a novel multi-cloud collaborative medical information network framework and develop a multiple-state-action deep reinforcement learning algorithm to solve the scheduling problem. Simulation results demonstrate the effectiveness of this approach in minimizing end-to-end delay. The study has been peer-reviewed and published in IEEE Transactions on Network and Service Management. [Extracted from the article]

Researchers from Jiaxing University in China have conducted a study to establish a rat model for karoshi, or death from overwork. The model involved subjecting rats to weight-bearing swimming and sleep deprivation for seven days. The researchers analyzed the physiological and behavioral changes in the rats, as well as the cardiac functions, using omics approaches. The study identified various metabolic adaptations and reprogramming in response to overwork, providing insights into the mechanisms involved in overwork-related pathologies. The findings contribute to our understanding of karoshi and lay a foundation for further research in this field. [Extracted from the article]

A study conducted at the Second Hospital of Jiaxing in China explored the association between TIMP metallopeptidase inhibitor 3 (TIMP-3) levels and the risk of venous thromboembolism (VTE). The researchers used a two-sample Mendelian randomization analysis and found that genetically predicted high levels of TIMP-3 were positively associated with an increased risk of VTE, pulmonary embolism (PE), and deep vein thrombosis (DVT). The study suggests that strategies targeting TIMP-3 may be useful for the prevention and treatment of VTE. Further investigation is needed to understand the underlying mechanism. [Extracted from the article]

A recent study conducted at Jiaxing University in China has explored the use of immune amplifying hydrogel microspheres with STING activation for tumor retention in photoimmunotherapy. The researchers aimed to address the challenges of poor tumor retention and cytokine storm associated with systemic administration of STING agonists. The study demonstrated that the hydrogel microspheres improved tumor retention and enhanced the infiltration of T cells in tumors, presenting a potential therapeutic strategy for innate immunotherapy in osteosarcoma and other immunosuppressive tumors. This research has been peer-reviewed and provides valuable insights into the field of immunotherapy. [Extracted from the article]

Researchers from Zhejiang Chinese Medicine University in Jiaxing, China have presented new data on atrial fibrillation (AF), a common cardiac arrhythmia. The study focuses on the role of a protein called DACT2 in the signaling pathways involved in cardiac fibrosis, which promotes the onset and progression of AF. The researchers suggest that understanding the effects of DACT2 on these pathways could be helpful in the treatment of AF. The study was supported by the Natural Science Foundation of Zhejiang Province. [Extracted from the article]

A new study conducted at Jiaxing University in China explores the role of brain oxygen dynamics in stroke pathophysiology. The researchers used a bioluminescence-based oxygen sensing technique called Green enhanced Nano-lantern (GeNL) to monitor oxygen fluctuations in awake mice. The study reveals the complexity of oxygen dynamics in the brain and suggests that hypoxic pockets within the cerebral cortex may impact ischemic injury and recovery. The findings highlight the importance of understanding pre-existing oxygen dynamics for addressing brain ischemia and offer potential strategies for more effective stroke treatments and rehabilitation. [Extracted from the article]

The article focuses on new research from Zhejiang University investigating algal odorous risks in pilot-scale drinking water distribution systems (DWDS). Topics include the factors influencing algal occurrence and odorant release, the differential responses of two algae species (Microcystis aeruginosa and Pseudanabaena sp.) to water treatments and flow velocities, and the need for tailored management strategies to address various algal-related odor problems in DWDS.

A study conducted at Jiaxing University in the People's Republic of China investigated the efficacy and safety of combining pulsed radiofrequency of the dorsal root ganglion with ozone injection for treating acute herpes zoster neuralgia in middle-aged and elderly adults. The study involved 164 patients who were randomly assigned to two groups: one receiving the combined treatment and the other receiving only pulsed radiofrequency. The results showed that the combined treatment was more effective in reducing pain and the need for medication, as well as decreasing the incidence of postherpetic neuralgia. No adverse reactions were reported. The study suggests that this combined therapy may provide longer-lasting pain relief and improved quality of life compared to pulsed radiofrequency treatment alone. [Extracted from the article]

A recent study conducted at Jiaxing University in China has found that glial growth factor 2 (GGF2) treatment can alleviate damage to the blood-brain barrier (BBB) caused by ischemia and reperfusion. The BBB is crucial for maintaining the integrity of the central nervous system, and its impairment can lead to complications following stroke treatment. The researchers discovered that GGF2 treatment reduced BBB damage, decreased transcellular and paracellular permeability, and inhibited the activation of inflammatory factors. These findings suggest that GGF2 could be a potential therapeutic option for reducing BBB damage in acute ischemic stroke. [Extracted from the article]

A recent study conducted at the Jiaxing Center for Disease Control and Prevention in China has focused on Salmonella, a bacteria that causes the disease salmonellosis. The study aimed to develop a multiplex fluorescence PCR method for detecting ten major virulence genes in Salmonella. The researchers successfully designed primer pairs specific to the target genes and analyzed sixty Salmonella strains, finding that all strains contained seven or more of the tested virulence genes. The newly developed method was found to be straightforward, cost-effective, and high-throughput, with the potential to become a routine method for analyzing Salmonella virulence genes. [Extracted from the article]

A study conducted by researchers at Jiaxing University in China aimed to investigate the relationship between gut microbiota (GM) and aneurysm development. The study utilized mendelian randomization (MR) techniques to establish a causal link between specific components of GM and various types of aneurysms. The findings revealed varying associations between microbial taxa and different types of aneurysms, providing valuable knowledge that may contribute to the development of microbiome-based interventions and the identification of biomarkers for targeted prevention strategies. The research has been peer-reviewed and published in Cerebrovascular Diseases. [Extracted from the article]

A study conducted by researchers at Jiaxing University in China has found that 1-ethoxycarbonyl-beta-carboline (EBC) inhibits the M2 polarization of tumor-associated macrophages, which plays a role in tumor growth. The study used network pharmacology, molecular docking, and molecular dynamics analyses to explore the mechanism of EBC's action. The researchers discovered that EBC was associated with 51 proteins, with HDAC2 being the main target. In vitro experiments showed that EBC hindered the M2 polarization of macrophages, and in a mouse model, it inhibited tumor growth and the levels of M2 macrophages. The study concludes that EBC has anti-tumor effects by inhibiting HDAC2-mediated M2 polarization. [Extracted from the article]

A recent study conducted by researchers at Jiaxing University in China explores the use of ultrasound-guided nerve blocks for managing pain in patients with extremity trauma. The study highlights the benefits of these techniques, including reduced reliance on opioids, decreased healthcare costs, and improved patient outcomes. However, challenges may arise due to the need for patient cooperation during the procedures. The researchers emphasize the importance of further research and integration of these techniques to enhance pain management protocols in trauma centers. [Extracted from the article]

Researchers at Jiaxing University in China have developed a new metamaterial based on vanadium dioxide-silicon arrays that can achieve an ultra-high Q-factor of up to 165,198. The metamaterial's resonance response is mainly affected by strong magnetic resonance, which is realized through coupling localized plasmon resonance with lattice resonance. The proposed metamaterial also features amplitude tunability with a modulation depth of 98.8% and has potential applications in terahertz devices such as sensors, filters, and optical switches. The research was supported by the Ministry of Education of the People's Republic of China. [Extracted from the article]

A recent report from the College of Mechanical and Electrical Engineering in Jiaxing, China discusses the development of flexible tactile sensors using carbon nanotubes. These sensors have potential applications in biomedicine, motion detection, and human-computer interaction. The researchers have created a composite material consisting of multiwalled carbon nanotubes, silver nanowires, and silicone rubber, which exhibits high sensitivity and flexibility. The sensors have shown good dynamic response, repeatability, and long life, making them suitable for use in smart robots, prosthetics, and wearable devices. The study provides valuable insights into the field of nanotechnology and carbon nanotubes. [Extracted from the article]

A recent report from Jiaxing, People's Republic of China, discusses the use of metal oxide nanozymes in optical biosensors for food safety detection. These nanozymes offer advantages over natural enzymes, such as stability, cost-effectiveness, and customizability. The review summarizes the catalytic mechanisms and research developments in optical biosensors based on metal oxide nanozymes, including colorimetric, fluorescent, chemiluminescent, and surface-enhanced Raman scattering biosensors. The application of these biosensors for detecting various food contaminants is highlighted, and the challenges and future prospects of metal oxide nanozymes for sensing applications are discussed. This research provides insights and inspiration for further investigations in this field. [Extracted from the article]

A recent study conducted by researchers at Jiaxing University in China explores the molecular mechanisms and potential therapeutic strategies of ferroptosis in ovarian cancer. Ovarian cancer is considered to be the most lethal cancer, with patients often being diagnosed at advanced stages due to the lack of sensitive diagnostic indicators. The study suggests that ferroptosis, a process that inhibits the proliferation of ovarian cancer cells and induces their demise, could be a promising target for treatment. However, further research is needed to develop safer and more efficient chemotherapy protocols for ovarian cancer and other malignancies. [Extracted from the article]

Researchers at Jiaxing University in China have developed a dual-targeted metal ion network hydrogel scaffold that promotes the integrated repair of tendon-bone interfaces. The scaffold is constructed using peptide-modified zeolitic imidazolate framework-8 (LZIF-8) and magnesium metal-organic framework (WMg-MOF), which release zinc ions to enhance collagen secretion and magnesium ions to induce cell differentiation, respectively. This scaffold has the potential to facilitate synchronized multitissue regeneration at the compromised tendon-bone interface, offering promising prospects for its application in the reconstruction of gradient structures. The research has been peer-reviewed and published in ACS Applied Materials & Interfaces. [Extracted from the article]

A recent study conducted by researchers from Jiaxing University in China has found a genetic link between hypothyroidism and alopecia areata, a condition that causes hair loss. The study utilized genome-wide association study data and Mendelian randomization analysis to determine that genetic variants associated with hypothyroidism significantly increase the risk of developing alopecia areata. The study also identified specific genes and pathways that may be involved in the development of the condition. These findings could potentially lead to the development of more effective treatment strategies for patients with alopecia areata. [Extracted from the article]

Researchers from Jiaxing University in the People's Republic of China have conducted a study on the use of Rgd-modified solid lipid nanoparticles to improve the oral absorption of the antitumor drug doxorubicin. The researchers found that the modified nanoparticles enhanced the oral bioavailability of doxorubicin in rats and improved its transport in a follicle-associated epithelium model. The study suggests that these nanoparticles could be a promising approach to improving the effectiveness of oral doxorubicin therapy. The research has been peer-reviewed and published in the Journal of Drug Delivery Science and Technology. [Extracted from the article]

A study conducted in Jiaxing, People's Republic of China, examined the diagnostic accuracy of CT-guided percutaneous lung biopsy for distinguishing benign and malignant solitary pulmonary nodules (SPNs). The researchers analyzed data from 112 patients with SPNs who underwent the biopsy procedure. They found that CT-guided percutaneous lung biopsy demonstrated excellent diagnostic efficacy and safety for distinguishing between benign and malignant SPNs. The study identified age, elevated tumor markers, and specific imaging signs as risk factors for malignant SPNs. [Extracted from the article]

A study conducted at First People's Hospital in Jiaxing, People's Republic of China, explored the use of circulating biomarkers as prediction tools for the diagnosis and prognosis of acute myocardial infarction (AMI). The study found that high levels of myoglobin (Mb) and troponin I (cTnI), as well as low levels of butyrylcholinesterase (BChE), were associated with an increased risk of AMI incidence and major adverse cardiovascular events (MACE). These biomarkers showed good diagnostic efficacy and could be used as sensitive factors in clinical AMI diagnosis and evaluation. The research provides a theoretical foundation for AMI diagnosis and MACE prevention in AMI patients. [Extracted from the article]

A systematic review and meta-analysis conducted by investigators at First People's Hospital in Jiaxing, China, examined the impact of prior antiplatelet therapy (APT) on outcomes of acute ischemic stroke (AIS) patients undergoing endovascular treatment. The review included ten studies comparing outcomes between APT users and non-users, and found that there was no statistically significant difference in symptomatic intracranial hemorrhage (sICH) between the two groups. However, there was a tendency for higher mortality rates in prior APT users, and APT users had lower odds of functional independence compared to non-users. After adjusting for confounders, there was no difference in the odds of sICH, mortality, successful recanalization, and functional independence between APT users and non-users. [Extracted from the article]

A new report from Jiaxing, People's Republic of China, discusses the findings of a study on non-small cell lung cancer (NSCLC). NSCLC is the most common type of lung cancer and a major cause of cancer-related deaths worldwide. The study focused on a specific biomarker called circRANGAP1, which was found to be upregulated in NSCLC tissues and cells. The researchers discovered that circRANGAP1 plays a role in NSCLC development and metastasis by regulating the miR-512-5p/SOD2 axis. The findings suggest that targeting circRANGAP1 could be a potential strategy for inhibiting NSCLC progression. [Extracted from the article]

New research conducted at Jiaxing University in the People's Republic of China explores the potential of using poly(lactic-co-glycolic acid) (PLGA) to enhance the anti-inflammatory and anti-cancer activities of celecoxib (CXB) in a dichloromethane (DCM) environment. The study utilized various computational methods to analyze the binding effects and chemical reactivity parameters of CXB and PLGA. The findings suggest that the interaction between CXB and PLGA in state B, through hydrogen bonds, is stronger than in states A and C, leading to improved anti-inflammatory and anti-cancer activities. The research has been peer-reviewed and provides valuable insights into potential treatment options for cancer. [Extracted from the article]

A recent study conducted at the First Hospital of Jiaxing in China has investigated the risk factors for the recurrence of postherpetic trigeminal neuralgia after a specific treatment called extracranial nonsemilunar ganglion radiofrequency thermocoagulation. The study analyzed 76 patients with postherpetic trigeminal neuralgia who were treated with this therapy and followed up for 12 months. The researchers found that age and disease duration were independent factors influencing the recurrence of trigeminal neuralgia. They also developed a recurrence prediction model that can be used for clinical diagnosis and treatment. However, the study acknowledges the need for larger sample sizes and randomized controlled trials to further explore these findings. [Extracted from the article]

A report from the Department of Cardiovascular Medicine in Jiaxing, People's Republic of China discusses the diagnostic value of cTnl, NT-pro BNP, and combined tests in patients with acute myocardial infarction (AMI), or heart attack. The study used a retrospective observational design and included 221 AMI patients and 200 control group patients. The research found that the combined detection of cTnl and NT-pro BNP was effective in diagnosing AMI occurrence and assessing its severity. The study highlights the importance of prompt diagnosis for timely treatment and saving lives in AMI patients. [Extracted from the article]

A recent study conducted by researchers at Jiaxing University in China examined the incidence and prognosis of intrahepatic cholangiocarcinoma (ICC), the second most common primary liver cancer. The study analyzed a large sample of patient data from the Surveillance, Epidemiology, and End Results (SEER) database in the United States. The researchers found that the incidence of ICC has been increasing in recent years, and while treatment outcomes have improved, the prognosis for ICC patients remains worse than that of hepatocellular carcinoma (HCC) patients. The study emphasizes the need for a better understanding of ICC and the development of more effective treatment methods to improve patient outcomes. [Extracted from the article]

Keywords: Jiaxing; People's Republic of China; Asia; Cancer; Endometrial Cancer; Gynecology; Health and Medicine; Oncology; Women's Health EN Jiaxing People's Republic of China Asia Cancer Endometrial Cancer Gynecology Health and Medicine Oncology Women's Health 519 519 1 10/30/23 20231103 NES 231103 2023 OCT 31 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- Data detailed on Oncology - Endometrial Cancer have been presented. Microarray analysis observed altered expression of circFAT1 in endometrial cancer (EC) and its inverse correlation with miR-21.". [Extracted from the article]

Keywords: Jiaxing; People's Republic of China; Asia; Alcohol-Induced Diseases and Conditions; Alcoholic Hepatitis; Alcoholism; Digestive System Diseases and Conditions; Enzymes and Coenzymes; Gastroenterology; Genetics; Health and Medicine; Hepatitis; Infectious Diseases and Conditions; Kinase; Liver Diseases and Conditions EN Jiaxing People's Republic of China Asia Alcohol-Induced Diseases and Conditions Alcoholic Hepatitis Alcoholism Digestive System Diseases and Conditions Enzymes and Coenzymes Gastroenterology Genetics Health and Medicine Hepatitis Infectious Diseases and Conditions Kinase Liver Diseases and Conditions 623 623 1 10/16/23 20231016 NES 231016 2023 OCT 16 (NewsRx) -- By a News Reporter-Staff News Editor at Hepatitis Weekly -- Current study results on Alcohol-Induced Diseases and Conditions - Alcoholic Hepatitis have been published. Keywords for this news article include: Jiaxing, People's Republic of China, Asia, Alcohol-Induced Diseases and Conditions, Alcoholic Hepatitis, Alcoholism, Digestive System Diseases and Conditions, Enzymes and Coenzymes, Gastroenterology, Genetics, Health and Medicine, Hepatitis, Infectious Diseases and Conditions, Kinase, Liver Diseases and Conditions, Jiaxing University. [Extracted from the article]

Keywords: Jiaxing; People's Republic of China; Asia; Pharmacology; Drugs and Therapies EN Jiaxing People's Republic of China Asia Pharmacology Drugs and Therapies 691 691 1 09/25/23 20230929 NES 230929 2023 SEP 29 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- A new study on Drugs and Therapies - Pharmacology is now available. Keywords for this news article include: Jiaxing, People's Republic of China, Asia, Pharmacology, Drugs and Therapies, Jiaxing University. [Extracted from the article]

People's Republic of China, Asia, Emerging Technologies, Nanofibers, Nanotechnology, Risk and Prevention, Jiaxing Keywords: Jiaxing; People's Republic of China; Asia; Emerging Technologies; Nanofibers; Nanotechnology; Risk and Prevention EN Jiaxing People's Republic of China Asia Emerging Technologies Nanofibers Nanotechnology Risk and Prevention 2391 2391 1 09/11/23 20230915 NES 230915 2023 SEP 15 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators discuss new findings in Nanotechnology - Nanofibers. [Extracted from the article]

Keywords: Jiaxing; People's Republic of China; Asia; Allergic Rhinitis; Allergies; Allergy Research; Cytokines; Epithelial Cells; Health and Medicine; Immune System Diseases and Conditions; Inflammation; Intercellular Signaling Peptides and Proteins; Interleukin-13; Interleukins; Nose Diseases and Conditions; Otorhinolaryngologic Diseases and Conditions; Peptides; Proteins; Respiratory Tract Diseases and Conditions; Respiratory Tract Infections; Rhinitis EN Jiaxing People's Republic of China Asia Allergic Rhinitis Allergies Allergy Research Cytokines Epithelial Cells Health and Medicine Immune System Diseases and Conditions Inflammation Intercellular Signaling Peptides and Proteins Interleukin-13 Interleukins Nose Diseases and Conditions Otorhinolaryngologic Diseases and Conditions Peptides Proteins Respiratory Tract Diseases and Conditions Respiratory Tract Infections Rhinitis 953 953 1 09/04/23 20230908 NES 230908 2023 SEP 8 (NewsRx) -- By a News Reporter-Staff News Editor at Respiratory Therapeutics Week -- Current study results on Immune System Diseases and Conditions - Allergic Rhinitis have been published. Jiaxing, People's Republic of China, Asia, Allergic Rhinitis, Allergies, Allergy Research, Cytokines, Epithelial Cells, Health and Medicine, Immune System Diseases and Conditions, Inflammation, Intercellular Signaling Peptides and Proteins, Interleukin-13, Interleukins, Nose Diseases and Conditions, Otorhinolaryngologic Diseases and Conditions, Peptides, Proteins, Respiratory Tract Diseases and Conditions, Respiratory Tract Infections, Rhinitis. [Extracted from the article]

Furthermore, in vivo experiments indicated that BET decreased M2 macrophage polarization and infiltration in the microenvironment of liver cancer. Keywords: Jiaxing; People's Republic of China; Asia; Cancer; Connective Tissue Cells; Health and Medicine; Immunology; Liver Cancer; Macrophages; Mononuclear Phagocyte System; Myeloid Cells; Oncology; Phagocytes EN Jiaxing People's Republic of China Asia Cancer Connective Tissue Cells Health and Medicine Immunology Liver Cancer Macrophages Mononuclear Phagocyte System Myeloid Cells Oncology Phagocytes 282 282 1 09/04/23 20230905 NES 230905 2023 SEP 5 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Weekly -- Investigators discuss new findings in Oncology - Liver Cancer. [Extracted from the article]