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2 results on '"hydroxysafflor"'

1. Hydroxysafflor yellow A improves established monocrotaline-induced pulmonary arterial hypertension in rats

Author

Xingwen Zhang, Yixiong Zhang, Zhou Zhou, Xiaotong Han, and Yanfei Long

Subjects
Male, 0301 basic medicine, Hemodynamics, 030204 cardiovascular system & hematology, medicine.disease_cause, Biochemistry, chemistry.chemical_compound, Chalcone, 0302 clinical medicine, Malondialdehyde, Medicine, oxidant, Monocrotaline, Quinones, General Medicine, Pathophysiology, 8-Hydroxy-2'-Deoxyguanosine, safflower, medicine.symptom, pulmonary artery hypertension, medicine.medical_specialty, Hypertension, Pulmonary, hydroxysafflor, Inflammation, Vascular Remodeling, Proinflammatory cytokine, 03 medical and health sciences, Right ventricular hypertrophy, Internal medicine, Animals, RNA, Messenger, Rats, Wistar, Hypertrophy, Right Ventricular, Chinese medicine, Superoxide Dismutase, business.industry, Biochemistry (medical), Deoxyguanosine, Research Reports, Cell Biology, medicine.disease, Pulmonary hypertension, Oxidative Stress, 030104 developmental biology, Endocrinology, Gene Expression Regulation, chemistry, business, Oxidative stress
Abstract

Objective To evaluate the beneficial effects of hydroxysafflor yellow A (HSYA) on monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH) in rats, and to investigate the main pathophysiological mechanism of HSYA in preventing development of MCT-induced PAH. Methods Four groups (control, control with HSYA treatment, MCT-exposed, and MCT-exposed with HSYA treatment) were evaluated at day 28 following MCT exposure. Haemodynamic measurements, right ventricular hypertrophy, morphometry, inflammatory cytokines and oxidant expression were assessed. Results HSYA significantly reduced haemodynamic changes, right ventricular hypertrophy and morphometric changes induced by exposure to MCT. HYSA also suppressed MCT-induced inflammation and oxidative stress in rat pulmonary tissue. Conclusions Experimental MCT-induced PAH may be reduced by HSYA treatment, and the mechanism may involve suppression of inflammation and oxidative stress.

Published
2016

2. Hydroxysafflor yellow A improves established monocrotaline-induced pulmonary arterial hypertension in rats.

Author

Han X, Zhang Y, Zhou Z, Zhang X, and Long Y

Subjects
8-Hydroxy-2'-Deoxyguanosine, Animals, Chalcone pharmacology, Chalcone therapeutic use, Deoxyguanosine analogs & derivatives, Deoxyguanosine metabolism, Gene Expression Regulation drug effects, Hemodynamics drug effects, Hypertension, Pulmonary complications, Hypertension, Pulmonary genetics, Hypertension, Pulmonary physiopathology, Hypertrophy, Right Ventricular complications, Hypertrophy, Right Ventricular drug therapy, Hypertrophy, Right Ventricular genetics, Hypertrophy, Right Ventricular physiopathology, Inflammation pathology, Male, Malondialdehyde metabolism, Monocrotaline, Oxidative Stress drug effects, Quinones pharmacology, RNA, Messenger genetics, RNA, Messenger metabolism, Rats, Wistar, Superoxide Dismutase metabolism, Vascular Remodeling drug effects, Chalcone analogs & derivatives, Hypertension, Pulmonary drug therapy, Quinones therapeutic use
Abstract

Objective: To evaluate the beneficial effects of hydroxysafflor yellow A (HSYA) on monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH) in rats, and to investigate the main pathophysiological mechanism of HSYA in preventing development of MCT-induced PAH., Methods: Four groups (control, control with HSYA treatment, MCT-exposed, and MCT-exposed with HSYA treatment) were evaluated at day 28 following MCT exposure. Haemodynamic measurements, right ventricular hypertrophy, morphometry, inflammatory cytokines and oxidant expression were assessed., Results: HSYA significantly reduced haemodynamic changes, right ventricular hypertrophy and morphometric changes induced by exposure to MCT. HYSA also suppressed MCT-induced inflammation and oxidative stress in rat pulmonary tissue., Conclusions: Experimental MCT-induced PAH may be reduced by HSYA treatment, and the mechanism may involve suppression of inflammation and oxidative stress., (© The Author(s) 2016.)

Published
2016
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