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Hydroxysafflor yellow A improves established monocrotaline-induced pulmonary arterial hypertension in rats
- Source :
- The Journal of International Medical Research
- Publication Year :
- 2016
- Publisher :
- SAGE Publications, 2016.
-
Abstract
- Objective To evaluate the beneficial effects of hydroxysafflor yellow A (HSYA) on monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH) in rats, and to investigate the main pathophysiological mechanism of HSYA in preventing development of MCT-induced PAH. Methods Four groups (control, control with HSYA treatment, MCT-exposed, and MCT-exposed with HSYA treatment) were evaluated at day 28 following MCT exposure. Haemodynamic measurements, right ventricular hypertrophy, morphometry, inflammatory cytokines and oxidant expression were assessed. Results HSYA significantly reduced haemodynamic changes, right ventricular hypertrophy and morphometric changes induced by exposure to MCT. HYSA also suppressed MCT-induced inflammation and oxidative stress in rat pulmonary tissue. Conclusions Experimental MCT-induced PAH may be reduced by HSYA treatment, and the mechanism may involve suppression of inflammation and oxidative stress.
- Subjects :
- Male
0301 basic medicine
Hemodynamics
030204 cardiovascular system & hematology
medicine.disease_cause
Biochemistry
chemistry.chemical_compound
Chalcone
0302 clinical medicine
Malondialdehyde
Medicine
oxidant
Monocrotaline
Quinones
General Medicine
Pathophysiology
8-Hydroxy-2'-Deoxyguanosine
safflower
medicine.symptom
pulmonary artery hypertension
medicine.medical_specialty
Hypertension, Pulmonary
hydroxysafflor
Inflammation
Vascular Remodeling
Proinflammatory cytokine
03 medical and health sciences
Right ventricular hypertrophy
Internal medicine
Animals
RNA, Messenger
Rats, Wistar
Hypertrophy, Right Ventricular
Chinese medicine
Superoxide Dismutase
business.industry
Biochemistry (medical)
Deoxyguanosine
Research Reports
Cell Biology
medicine.disease
Pulmonary hypertension
Oxidative Stress
030104 developmental biology
Endocrinology
Gene Expression Regulation
chemistry
business
Oxidative stress
Subjects
Details
- ISSN :
- 14732300 and 03000605
- Volume :
- 44
- Database :
- OpenAIRE
- Journal :
- Journal of International Medical Research
- Accession number :
- edsair.doi.dedup.....c4bb4e2270b3cc1c9bfcb2bc34b752ea