1. Dengue seroprevalence among asymptomatic blood donors during an epidemic outbreak in Central-West Brazil.
- Author
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Slavov SN, Cilião-Alves DC, Gonzaga FAC, Moura DR, de Moura ACAM, de Noronha LAG, Cassemiro ÉM, Pimentel BMS, Costa FJQ, da Silva GA, Ramos DDAR, de Araújo WN, Kashima S, and Haddad R
- Subjects
- Adult, Antibodies, Viral immunology, Blood Transfusion, Brazil epidemiology, Cohort Studies, Dengue blood, Dengue epidemiology, Dengue virology, Dengue Virus genetics, Female, Humans, Immunoglobulin G immunology, Immunoglobulin M immunology, Male, Pilot Projects, RNA, Viral genetics, Seroepidemiologic Studies, Viremia blood, Viremia epidemiology, Viremia immunology, Viremia virology, Antibodies, Viral blood, Asymptomatic Infections epidemiology, Blood Donors statistics & numerical data, Dengue immunology, Dengue Virus immunology, Disease Outbreaks, Viral Nonstructural Proteins immunology
- Abstract
Dengue virus (DENV) transmission by blood transfusion is an important route of viral acquisition during outbreaks. The prevalence of DENV markers (viral RNA, NS1, anti-DENV IgM, and IgG) among blood donors in Central-West Brazil has never been evaluated. Our aim was to evaluate the full set of serological and molecular markers for DENV among blood donors of the Federal District of Brazil during an extensive outbreak in 2016. We found an anti-DENV IgM prevalence of 6.74% (n = 32/475). Of 475, 20 samples (4.21%) were also anti-DENV IgG positive. All samples were non-reactive for NS1 and DENV RNA. Our results imply that a significant proportion of the tested donors had experienced asymptomatic infection. More studies are necessary to evaluate the real prevalence of DENV viremia in blood donors from the Federal District of Brazil and if specific measures are needed to routinely test the blood donors for DENV RNA during outbreaks., Competing Interests: The authors have declared that no competing interests exist.
- Published
- 2019
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