Dengue seroprevalence among asymptomatic blood donors during an epidemic outbreak in Central-West Brazil.

Authors :: Slavov SN
Cilião-Alves DC
Gonzaga FAC
Moura DR
de Moura ACAM
de Noronha LAG
Cassemiro ÉM
Pimentel BMS
Costa FJQ
da Silva GA
Ramos DDAR
de Araújo WN
Kashima S
Haddad R
Source :: PloS one [PLoS One] 2019 Mar 25; Vol. 14 (3), pp. e0213793. Date of Electronic Publication: 2019 Mar 25 (Print Publication: 2019).
Publication Year :: 2019
Abstract: Dengue virus (DENV) transmission by blood transfusion is an important route of viral acquisition during outbreaks. The prevalence of DENV markers (viral RNA, NS1, anti-DENV IgM, and IgG) among blood donors in Central-West Brazil has never been evaluated. Our aim was to evaluate the full set of serological and molecular markers for DENV among blood donors of the Federal District of Brazil during an extensive outbreak in 2016. We found an anti-DENV IgM prevalence of 6.74% (n = 32/475). Of 475, 20 samples (4.21%) were also anti-DENV IgG positive. All samples were non-reactive for NS1 and DENV RNA. Our results imply that a significant proportion of the tested donors had experienced asymptomatic infection. More studies are necessary to evaluate the real prevalence of DENV viremia in blood donors from the Federal District of Brazil and if specific measures are needed to routinely test the blood donors for DENV RNA during outbreaks.<br />Competing Interests: The authors have declared that no competing interests exist.

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