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Dengue seroprevalence among asymptomatic blood donors during an epidemic outbreak in Central-West Brazil.
- Source :
-
PloS one [PLoS One] 2019 Mar 25; Vol. 14 (3), pp. e0213793. Date of Electronic Publication: 2019 Mar 25 (Print Publication: 2019). - Publication Year :
- 2019
-
Abstract
- Dengue virus (DENV) transmission by blood transfusion is an important route of viral acquisition during outbreaks. The prevalence of DENV markers (viral RNA, NS1, anti-DENV IgM, and IgG) among blood donors in Central-West Brazil has never been evaluated. Our aim was to evaluate the full set of serological and molecular markers for DENV among blood donors of the Federal District of Brazil during an extensive outbreak in 2016. We found an anti-DENV IgM prevalence of 6.74% (n = 32/475). Of 475, 20 samples (4.21%) were also anti-DENV IgG positive. All samples were non-reactive for NS1 and DENV RNA. Our results imply that a significant proportion of the tested donors had experienced asymptomatic infection. More studies are necessary to evaluate the real prevalence of DENV viremia in blood donors from the Federal District of Brazil and if specific measures are needed to routinely test the blood donors for DENV RNA during outbreaks.<br />Competing Interests: The authors have declared that no competing interests exist.
- Subjects :
- Adult
Antibodies, Viral immunology
Blood Transfusion
Brazil epidemiology
Cohort Studies
Dengue blood
Dengue epidemiology
Dengue virology
Dengue Virus genetics
Female
Humans
Immunoglobulin G immunology
Immunoglobulin M immunology
Male
Pilot Projects
RNA, Viral genetics
Seroepidemiologic Studies
Viremia blood
Viremia epidemiology
Viremia immunology
Viremia virology
Antibodies, Viral blood
Asymptomatic Infections epidemiology
Blood Donors statistics & numerical data
Dengue immunology
Dengue Virus immunology
Disease Outbreaks
Viral Nonstructural Proteins immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 14
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 30908528
- Full Text :
- https://doi.org/10.1371/journal.pone.0213793