37 results on '"de Metz, Jesse"'
Search Results
2. Health-related quality of life one year after refractory cardiac arrest treated with conventional or extracorporeal CPR; a secondary analysis of the INCEPTION-trial
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van de Koolwijk, Anina F., Delnoij, Thijs S.R., Suverein, Martje M., Essers, Brigitte A.B., Hermanides, Renicus C., Otterspoor, Luuk C., Elzo Kraemer, Carlos V., Vlaar, Alexander P.J., van der Heijden, Joris J., Scholten, Erik, den Uil, Corstiaan A., Dos Reis Miranda, Dinis, Akin, Sakir, de Metz, Jesse, van der Horst, Iwan C.C., Winkens, Bjorn, Maessen, Jos G., Lorusso, Roberto, and van de Poll, Marcel C.G.
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- 2024
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3. Favorable resuscitation characteristics in patients undergoing extracorporeal cardiopulmonary resuscitation: A secondary analysis of the INCEPTION-trial
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Ubben, Johannes F.H., Heuts, Samuel, Delnoij, Thijs S.R., Suverein, Martje M., Hermanides, Renicus C., Otterspoor, Luuk C., Kraemer, Carlos V. Elzo, Vlaar, Alexander P.J., van der Heijden, Joris J., Scholten, Erik, den Uil, Corstiaan, Dos Reis Miranda, Dinis, Akin, Sakir, de Metz, Jesse, van der Horst, Iwan C.C., Winkens, Bjorn, Maessen, Jos G., Lorusso, Roberto, and van de Poll, Marcel C.G.
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- 2024
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4. The interaction of thrombocytopenia, hemorrhage, and platelet transfusion in venoarterial extracorporeal membrane oxygenation: a multicenter observational study
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Raasveld, Senta Jorinde, van den Oord, Claudia, Schenk, Jimmy, van den Bergh, Walter M., Oude Lansink - Hartgring, Annemieke, van der Velde, Franciska, Maas, Jacinta J., van de Berg, Pablo, Lorusso, Roberto, Delnoij, Thijs S. R., Dos Reis Miranda, Dinis, Scholten, Erik, Taccone, Fabio Silvio, Dauwe, Dieter F., De Troy, Erwin, Hermans, Greet, Pappalardo, Federico, Fominskiy, Evgeny, Ivancan, Višnja, Bojčić, Robert, de Metz, Jesse, van den Bogaard, Bas, Donker, Dirk W., Meuwese, Christiaan L., De Bakker, Martin, Reddi, Benjamin, Henriques, José P. S., Broman, Lars Mikael, Dongelmans, Dave A., and Vlaar, Alexander P. J.
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- 2023
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5. International Survey on Mechanical Ventilation During Extracorporeal Membrane Oxygenation
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van Minnen, Olivier, Jolink, Floris E.J., van den Bergh, Walter M., Droogh, Joep M., Oude Lansink-Hartgring, Annemieke, Vlaar, Alexander P. J., Raasveld, S. Jorinde, Donker, Dirk W., Hermens, Jeannine A. J., Cornet, Alexander D., Vermeijden, J. Wytze, Oude Velthuis, Bob, van den Brule, Judith M. D., Kraemer, C. V. Elzo, Maas, Jacinta J., Janson, Jeroen, Lopez Matta, Jorge, Delnoij, Thijs S. R., van de Poll, Marcel, Akin, Sakir, de Metz, Jesse, van den Bogaard, Bas, Otterspoor, Luuk, Scholten, Erik, van de Pol, Ineke, Kuijpers, Marijn, van Koppenhagen, Laurien, Dos Reis Miranda, Dinis, Meuwese, Christiaan, and Bunge, Jeroen
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- 2024
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6. Plasma Transfusion and Procoagulant Product Administration in Extracorporeal Membrane Oxygenation: A Secondary Analysis of an International Observational Study on Current Practices
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van Haeren, Maite M.T., Raasveld, Senta Jorinde, Karami, Mina, Miranda, Dinis Dos Reis, Mandigers, Loes, Dauwe, Dieter F., De Troy, Erwin, Pappalardo, Federico, Fominskiy, Evgeny, van den Bergh, Walter M., Oude Lansink-Hartgring, Annemieke, van der Velde, Franciska, Maas, Jacinta J., van de Berg, Pablo, de Haan, Maarten, Donker, Dirk W., Meuwese, Christiaan L., Taccone, Fabio Silvio, Peluso, Lorenzo, Lorusso, Roberto, Delnoij, Thijs S.R., Scholten, Erik, Overmars, Martijn, Ivancan, Višnja, Bojčić, Robert, de Metz, Jesse, van den Bogaard, Bas, de Bakker, Martin, Reddi, Benjamin, Hermans, Greet, Broman, Lars Mikael, Henriques, José P.S., Schenk, Jimmy, Vlaar, Alexander P.J., and Müller, Marcella C.A.
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- 2023
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7. Reduced anticoagulation targets in extracorporeal life support (RATE): study protocol for a randomized controlled trial
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van Minnen, Olivier, Oude Lansink-Hartgring, Annemieke, van den Boogaard, Bas, van den Brule, Judith, Bulpa, Pierre, Bunge, Jeroen J. H., Delnoij, Thijs S. R., Elzo Kraemer, Carlos V., Kuijpers, Marijn, Lambermont, Bernard, Maas, Jacinta J., de Metz, Jesse, Michaux, Isabelle, van de Pol, Ineke, van de Poll, Marcel, Raasveld, S. Jorinde, Raes, Matthias, dos Reis Miranda, Dinis, Scholten, Erik, Simonet, Olivier, Taccone, Fabio S., Vallot, Frederic, Vlaar, Alexander P. J., and van den Bergh, Walter M.
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- 2022
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8. Cost-effectiveness of extracorporeal cardiopulmonary resuscitation vs. conventional cardiopulmonary resuscitation in out-of-hospital cardiac arrest: a pre-planned, trial-based economic evaluation.
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Delnoij, Thijs S R, Suverein, Martje M, Essers, Brigitte A B, Hermanides, Renicus C, Otterspoor, Luuk, Elzo Kraemer, Carlos V, Vlaar, Alexander P J, van der Heijden, Joris J, Scholten, Erik, den Uil, Corstiaan, Akin, Sakir, de Metz, Jesse, van der Horst, Iwan C C, Maessen, Jos G, Lorusso, Roberto, van de Poll, Marcel C G, Bruinsma, George J Brandon Bravo, Kraemer, Carlos V Elzo, Jansen, Tim, and van den Bogaard, Bas
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- 2024
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9. Cost-Effectiveness of ECPR Versus CCPR in OHCA; a Trial-Based Economic Evaluation
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Delnoij, Thijs, primary, Suverein, Martje M., additional, Essers, Brigitte A.B., additional, Hermanides, Renicus C., additional, Otterspoor, Luuk, additional, Elzo Kraemer, Carlos V., additional, Vlaar, Alexander P. J., additional, van der Heijden, Joris J., additional, Scholten, Erik, additional, den Uil, Corstiaan, additional, Akin, Sakir, additional, de Metz, Jesse, additional, van der Horst, Iwan C.C., additional, Maessen, Jos G., additional, Lorusso, Roberto, additional, van de Poll, Marcel C.G., additional, and Investigators, INCEPTION, additional
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- 2024
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10. Behavioural artificial intelligence technology for COVID-19 intensivist triage decisions: making the implicit explicit
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de Metz, Jesse, Thoral, Patrick J., Chorus, Caspar G., Elbers, Paul W. G., and van den Bogaard, Bas
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- 2021
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11. Transfusion of red blood cells in venoarterial extracorporeal membrane oxygenation: A multicenter retrospective observational cohort study
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Raasveld, Senta Jorinde, primary, Karami, Mina, additional, Schenk, Jimmy, additional, Dos Reis Miranda, Dinis, additional, Mandigers, Loes, additional, Dauwe, Dieter F., additional, De Troy, Erwin, additional, Pappalardo, Federico, additional, Fominskiy, Evgeny, additional, van den Bergh, Walter M., additional, Oude Lansink‐Hartgring, Annemieke, additional, van der Velde, Franciska, additional, Maas, Jacinta J., additional, van de Berg, Pablo, additional, de Haan, Maarten, additional, Donker, Dirk W., additional, Meuwese, Christiaan L., additional, Taccone, Fabio Silvio, additional, Peluso, Lorenzo, additional, Lorusso, Roberto, additional, Delnoij, Thijs S. R., additional, Scholten, Erik, additional, Overmars, Martijn, additional, Ivančan, Višnja, additional, Bojčić, Robert, additional, de Metz, Jesse, additional, van den Bogaard, Bas, additional, de Bakker, Martin, additional, Reddi, Benjamin, additional, Hermans, Greet, additional, Broman, Lars Mikael, additional, Henriques, José P. S., additional, and Vlaar, Alexander P. J., additional
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- 2023
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12. Transfusion of red blood cells in venoarterial extracorporeal membrane oxygenation:A multicenter retrospective observational cohort study
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Raasveld, Senta Jorinde, Karami, Mina, Schenk, Jimmy, Dos Reis Miranda, Dinis, Mandigers, Loes, Dauwe, Dieter F., De Troy, Erwin, Pappalardo, Federico, Fominskiy, Evgeny, van den Bergh, Walter M., Oude Lansink-Hartgring, Annemieke, van der Velde, Franciska, Maas, Jacinta J., van de Berg, Pablo, de Haan, Maarten, Donker, Dirk W., Meuwese, Christiaan L., Taccone, Fabio Silvio, Peluso, Lorenzo, Lorusso, Roberto, Delnoij, Thijs S.R., Scholten, Erik, Overmars, Martijn, Ivančan, Višnja, Bojčić, Robert, de Metz, Jesse, van den Bogaard, Bas, de Bakker, Martin, Reddi, Benjamin, Hermans, Greet, Broman, Lars Mikael, Henriques, José P.S., Vlaar, Alexander P.J., Raasveld, Senta Jorinde, Karami, Mina, Schenk, Jimmy, Dos Reis Miranda, Dinis, Mandigers, Loes, Dauwe, Dieter F., De Troy, Erwin, Pappalardo, Federico, Fominskiy, Evgeny, van den Bergh, Walter M., Oude Lansink-Hartgring, Annemieke, van der Velde, Franciska, Maas, Jacinta J., van de Berg, Pablo, de Haan, Maarten, Donker, Dirk W., Meuwese, Christiaan L., Taccone, Fabio Silvio, Peluso, Lorenzo, Lorusso, Roberto, Delnoij, Thijs S.R., Scholten, Erik, Overmars, Martijn, Ivančan, Višnja, Bojčić, Robert, de Metz, Jesse, van den Bogaard, Bas, de Bakker, Martin, Reddi, Benjamin, Hermans, Greet, Broman, Lars Mikael, Henriques, José P.S., and Vlaar, Alexander P.J.
- Abstract
Background: Evidence-based recommendations for transfusion in patients with venoarterial extracorporeal membrane oxygenation (VA ECMO) are scarce. The current literature is limited to single-center studies with small sample sizes, therefore complicating generalizability. This study aims to create an overview of red blood cell (RBC) transfusion in VA ECMO patients. Methods: This international mixed-method study combined a survey with a retrospective observational study in 16 centers. The survey inventoried local transfusion guidelines. Additionally, retrospective data of all adult patients with a VA ECMO run >24 h (January 2018 until July 2019) was collected of patient, ECMO, outcome, and daily transfusion parameters. All patients that received VA ECMO for primary cardiac support were included, including surgical (i.e., post-cardiotomy) and non-surgical (i.e., myocardial infarction) indications. The primary outcome was the number of RBC transfusions per day and in total. Univariable logistic regressions and a generalized linear mixed model (GLMM) were performed to assess factors associated with RBC transfusion. Results: Out of 419 patients, 374 (89%) received one or more RBC transfusions. During a median ECMO run of 5 days (1st–3rd quartile 3–8), patients received a median total of eight RBC units (1st–3rd quartile 3–17). A lower hemoglobin (Hb) prior to ECMO, longer ECMO-run duration, and hemorrhage were associated with RBC transfusion. After correcting for duration and hemorrhage using a GLMM, a different transfusion trend was found among the regimens. No unadjusted differences were found in overall survival between either transfusion status or the different regimens, which remained after adjustment for potential confounders. Conclusion: RBC transfusion in patients on VA ECMO is very common. The sum of RBC transfusions increases rapidly after ECMO initiation, and is dependent on the
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- 2023
13. Plasma Transfusion and Procoagulant Product Administration in Extracorporeal Membrane Oxygenation:A Secondary Analysis of an International Observational Study on Current Practices
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Van Haeren, Maite M.T., Raasveld, Senta Jorinde, Karami, Mina, Miranda, Dinis Dos Reis, Mandigers, Loes, Dauwe, Dieter F., De Troy, Erwin, Pappalardo, Federico, Fominskiy, Evgeny, Van Den Bergh, Walter M., Oude Lansink-Hartgring, Annemieke, Van Der Velde, Franciska, Maas, Jacinta J., Van De Berg, Pablo, De Haan, Maarten, Donker, Dirk W., Meuwese, Christiaan L., Taccone, Fabio Silvio, Peluso, Lorenzo, Lorusso, Roberto, Delnoij, Thijs S.R., Scholten, Erik, Overmars, Martijn, Ivancan, Višnja, Bojčić, Robert, De Metz, Jesse, Van Den Bogaard, Bas, De Bakker, Martin, Reddi, Benjamin, Hermans, Greet, Broman, Lars Mikael, Henriques, José P.S., Schenk, Jimmy, Vlaar, Alexander P.J., Müller, Marcella C.A., Van Haeren, Maite M.T., Raasveld, Senta Jorinde, Karami, Mina, Miranda, Dinis Dos Reis, Mandigers, Loes, Dauwe, Dieter F., De Troy, Erwin, Pappalardo, Federico, Fominskiy, Evgeny, Van Den Bergh, Walter M., Oude Lansink-Hartgring, Annemieke, Van Der Velde, Franciska, Maas, Jacinta J., Van De Berg, Pablo, De Haan, Maarten, Donker, Dirk W., Meuwese, Christiaan L., Taccone, Fabio Silvio, Peluso, Lorenzo, Lorusso, Roberto, Delnoij, Thijs S.R., Scholten, Erik, Overmars, Martijn, Ivancan, Višnja, Bojčić, Robert, De Metz, Jesse, Van Den Bogaard, Bas, De Bakker, Martin, Reddi, Benjamin, Hermans, Greet, Broman, Lars Mikael, Henriques, José P.S., Schenk, Jimmy, Vlaar, Alexander P.J., and Müller, Marcella C.A.
- Abstract
OBJECTIVES: To achieve optimal hemostatic balance in patients on extracorporeal membrane oxygenation (ECMO), a liberal transfusion practice is currently applied despite clear evidence. We aimed to give an overview of the current use of plasma, fibrinogen concentrate, tranexamic acid (TXA), and prothrombin complex concentrate (PCC) in patients on ECMO.DESIGN: A prespecified subanalysis of a multicenter retrospective study. Venovenous (VV)-ECMO and venoarterial (VA)-ECMO are analyzed as separate populations, comparing patients with and without bleeding and with and without thrombotic complications. SETTING: Sixteen international ICUs.PATIENTS: Adult patients on VA-ECMO or VV-ECMO.INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Of 420 VA-ECMO patients, 59% (n = 247) received plasma, 20% (n = 82) received fibrinogen concentrate, 17% (n = 70) received TXA, and 7% of patients (n = 28) received PCC. Fifty percent of patients (n = 208) suffered bleeding complications and 27% (n = 112) suffered thrombotic complications. More patients with bleeding complications than patients without bleeding complications received plasma (77% vs. 41%, p < 0.001), fibrinogen concentrate (28% vs 11%, p < 0.001), and TXA (23% vs 10%, p < 0.001). More patients with than without thrombotic complications received TXA (24% vs 14%, p = 0.02, odds ratio 1.75) in VA-ECMO, where no difference was seen in VV-ECMO. Of 205 VV-ECMO patients, 40% (n = 81) received plasma, 6% (n = 12) fibrinogen concentrate, 7% (n = 14) TXA, and 5% (n = 10) PCC. Thirty-nine percent (n = 80) of VV-ECMO patients suffered bleeding complications and 23% (n = 48) of patients suffered thrombotic complications. More patients with than without bleeding complications received plasma (58% vs 28%, p < 0.001), fibrinogen concentrate (13% vs 2%, p < 0.01), and TXA (11% vs 2%, p < 0.01).
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- 2023
14. The interaction of thrombocytopenia, hemorrhage, and platelet transfusion in venoarterial extracorporeal membrane oxygenation:a multicenter observational study
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Raasveld, Senta Jorinde, van den Oord, Claudia, Schenk, Jimmy, van den Bergh, Walter M., Oude Lansink - Hartgring, Annemieke, van der Velde, Franciska, Maas, Jacinta J., van de Berg, Pablo, Lorusso, Roberto, Delnoij, Thijs S.R., Dos Reis Miranda, Dinis, Scholten, Erik, Taccone, Fabio Silvio, Dauwe, Dieter F., De Troy, Erwin, Hermans, Greet, Pappalardo, Federico, Fominskiy, Evgeny, Ivancan, Višnja, Bojčić, Robert, de Metz, Jesse, van den Bogaard, Bas, Donker, Dirk W., Meuwese, Christiaan L., De Bakker, Martin, Reddi, Benjamin, Henriques, José P.S., Broman, Lars Mikael, Dongelmans, Dave A., Vlaar, Alexander P.J., Raasveld, Senta Jorinde, van den Oord, Claudia, Schenk, Jimmy, van den Bergh, Walter M., Oude Lansink - Hartgring, Annemieke, van der Velde, Franciska, Maas, Jacinta J., van de Berg, Pablo, Lorusso, Roberto, Delnoij, Thijs S.R., Dos Reis Miranda, Dinis, Scholten, Erik, Taccone, Fabio Silvio, Dauwe, Dieter F., De Troy, Erwin, Hermans, Greet, Pappalardo, Federico, Fominskiy, Evgeny, Ivancan, Višnja, Bojčić, Robert, de Metz, Jesse, van den Bogaard, Bas, Donker, Dirk W., Meuwese, Christiaan L., De Bakker, Martin, Reddi, Benjamin, Henriques, José P.S., Broman, Lars Mikael, Dongelmans, Dave A., and Vlaar, Alexander P.J.
- Abstract
Background: Thrombocytopenia, hemorrhage and platelet transfusion are common in patients supported with venoarterial extracorporeal membrane oxygenation (VA ECMO). However, current literature is limited to small single-center experiences with high degrees of heterogeneity. Therefore, we aimed to ascertain in a multicenter study the course and occurrence rate of thrombocytopenia, and to assess the association between thrombocytopenia, hemorrhage and platelet transfusion during VA ECMO. Methods: This was a sub-study of a multicenter (N = 16) study on transfusion practices in patients on VA ECMO, in which a retrospective cohort (Jan-2018–Jul-2019) focusing on platelets was selected. The primary outcome was thrombocytopenia during VA ECMO, defined as mild (100–150·109/L), moderate (50–100·109/L) and severe (< 50·109/L). Secondary outcomes included the occurrence rate of platelet transfusion, and the association between thrombocytopenia, hemorrhage and platelet transfusion, assessed through mixed-effect models.Results: Of the 419 patients included, median platelet count at admission was 179·109/L. During VA ECMO, almost all (N = 398, 95%) patients developed a thrombocytopenia, of which a significant part severe (N = 179, 45%). One or more platelet transfusions were administered in 226 patients (54%), whereas 207 patients (49%) suffered a hemorrhagic event during VA ECMO. In non-bleeding patients, still one in three patients received a platelet transfusion. The strongest association to receive a platelet transfusion was found in the presence of severe thrombocytopenia (adjusted OR 31.8, 95% CI 17.9–56.5). After including an interaction term of hemorrhage and thrombocytopenia, this even increased up to an OR of 110 (95% CI 34–360). Conclusions: Thrombocytopenia has a higher occurrence than is currently recognized. Severe thrombocytopenia is strongl
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- 2023
15. Plasma Transfusion and Procoagulant Product Administration in Extracorporeal Membrane Oxygenation: A Secondary Analysis of an International Observational Study on Current Practices
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Medische Staf Intensive Care, Other research (not in main researchprogram), Van Haeren, Maite M.T., Raasveld, Senta Jorinde, Karami, Mina, Miranda, Dinis Dos Reis, Mandigers, Loes, Dauwe, Dieter F., De Troy, Erwin, Pappalardo, Federico, Fominskiy, Evgeny, Van Den Bergh, Walter M., Oude Lansink-Hartgring, Annemieke, Van Der Velde, Franciska, Maas, Jacinta J., Van De Berg, Pablo, De Haan, Maarten, Donker, Dirk W., Meuwese, Christiaan L., Taccone, Fabio Silvio, Peluso, Lorenzo, Lorusso, Roberto, Delnoij, Thijs S.R., Scholten, Erik, Overmars, Martijn, Ivancan, Višnja, Bojčić, Robert, De Metz, Jesse, Van Den Bogaard, Bas, De Bakker, Martin, Reddi, Benjamin, Hermans, Greet, Broman, Lars Mikael, Henriques, José P.S., Schenk, Jimmy, Vlaar, Alexander P.J., Müller, Marcella C.A., Medische Staf Intensive Care, Other research (not in main researchprogram), Van Haeren, Maite M.T., Raasveld, Senta Jorinde, Karami, Mina, Miranda, Dinis Dos Reis, Mandigers, Loes, Dauwe, Dieter F., De Troy, Erwin, Pappalardo, Federico, Fominskiy, Evgeny, Van Den Bergh, Walter M., Oude Lansink-Hartgring, Annemieke, Van Der Velde, Franciska, Maas, Jacinta J., Van De Berg, Pablo, De Haan, Maarten, Donker, Dirk W., Meuwese, Christiaan L., Taccone, Fabio Silvio, Peluso, Lorenzo, Lorusso, Roberto, Delnoij, Thijs S.R., Scholten, Erik, Overmars, Martijn, Ivancan, Višnja, Bojčić, Robert, De Metz, Jesse, Van Den Bogaard, Bas, De Bakker, Martin, Reddi, Benjamin, Hermans, Greet, Broman, Lars Mikael, Henriques, José P.S., Schenk, Jimmy, Vlaar, Alexander P.J., and Müller, Marcella C.A.
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- 2023
16. Transfusion of red blood cells in venoarterial extracorporeal membrane oxygenation: A multicenter retrospective observational cohort study
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Medische Staf Intensive Care, Other research (not in main researchprogram), Raasveld, Senta Jorinde, Karami, Mina, Schenk, Jimmy, Dos Reis Miranda, Dinis, Mandigers, Loes, Dauwe, Dieter F., De Troy, Erwin, Pappalardo, Federico, Fominskiy, Evgeny, van den Bergh, Walter M., Oude Lansink-Hartgring, Annemieke, van der Velde, Franciska, Maas, Jacinta J., van de Berg, Pablo, de Haan, Maarten, Donker, Dirk W., Meuwese, Christiaan L., Taccone, Fabio Silvio, Peluso, Lorenzo, Lorusso, Roberto, Delnoij, Thijs S.R., Scholten, Erik, Overmars, Martijn, Ivančan, Višnja, Bojčić, Robert, de Metz, Jesse, van den Bogaard, Bas, de Bakker, Martin, Reddi, Benjamin, Hermans, Greet, Broman, Lars Mikael, Henriques, José P.S., Vlaar, Alexander P.J., Medische Staf Intensive Care, Other research (not in main researchprogram), Raasveld, Senta Jorinde, Karami, Mina, Schenk, Jimmy, Dos Reis Miranda, Dinis, Mandigers, Loes, Dauwe, Dieter F., De Troy, Erwin, Pappalardo, Federico, Fominskiy, Evgeny, van den Bergh, Walter M., Oude Lansink-Hartgring, Annemieke, van der Velde, Franciska, Maas, Jacinta J., van de Berg, Pablo, de Haan, Maarten, Donker, Dirk W., Meuwese, Christiaan L., Taccone, Fabio Silvio, Peluso, Lorenzo, Lorusso, Roberto, Delnoij, Thijs S.R., Scholten, Erik, Overmars, Martijn, Ivančan, Višnja, Bojčić, Robert, de Metz, Jesse, van den Bogaard, Bas, de Bakker, Martin, Reddi, Benjamin, Hermans, Greet, Broman, Lars Mikael, Henriques, José P.S., and Vlaar, Alexander P.J.
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- 2023
17. The interaction of thrombocytopenia, hemorrhage, and platelet transfusion in venoarterial extracorporeal membrane oxygenation: a multicenter observational study
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Medische Staf Intensive Care, Other research (not in main researchprogram), Raasveld, Senta Jorinde, van den Oord, Claudia, Schenk, Jimmy, van den Bergh, Walter M., Oude Lansink - Hartgring, Annemieke, van der Velde, Franciska, Maas, Jacinta J., van de Berg, Pablo, Lorusso, Roberto, Delnoij, Thijs S.R., Dos Reis Miranda, Dinis, Scholten, Erik, Taccone, Fabio Silvio, Dauwe, Dieter F., De Troy, Erwin, Hermans, Greet, Pappalardo, Federico, Fominskiy, Evgeny, Ivancan, Višnja, Bojčić, Robert, de Metz, Jesse, van den Bogaard, Bas, Donker, Dirk W., Meuwese, Christiaan L., De Bakker, Martin, Reddi, Benjamin, Henriques, José P.S., Broman, Lars Mikael, Dongelmans, Dave A., Vlaar, Alexander P.J., Medische Staf Intensive Care, Other research (not in main researchprogram), Raasveld, Senta Jorinde, van den Oord, Claudia, Schenk, Jimmy, van den Bergh, Walter M., Oude Lansink - Hartgring, Annemieke, van der Velde, Franciska, Maas, Jacinta J., van de Berg, Pablo, Lorusso, Roberto, Delnoij, Thijs S.R., Dos Reis Miranda, Dinis, Scholten, Erik, Taccone, Fabio Silvio, Dauwe, Dieter F., De Troy, Erwin, Hermans, Greet, Pappalardo, Federico, Fominskiy, Evgeny, Ivancan, Višnja, Bojčić, Robert, de Metz, Jesse, van den Bogaard, Bas, Donker, Dirk W., Meuwese, Christiaan L., De Bakker, Martin, Reddi, Benjamin, Henriques, José P.S., Broman, Lars Mikael, Dongelmans, Dave A., and Vlaar, Alexander P.J.
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- 2023
18. Early Extracorporeal CPR for Refractory Out-of-Hospital Cardiac Arrest
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Medische Staf Intensive Care, Team Medisch, Other research (not in main researchprogram), Suverein, Martje M., Delnoij, Thijs S.R., Lorusso, Roberto, Brandon Bravo Bruinsma, George J., Otterspoor, Luuk, Elzo Kraemer, Carlos V., Vlaar, Alexander P.J., van der Heijden, Joris J., Scholten, Erik, den Uil, Corstiaan, Jansen, Tim, van den Bogaard, Bas, Kuijpers, Marijn, Lam, Ka Yan, Montero Cabezas, José M., Driessen, Antoine H.G., Rittersma, Saskia Z.H., Heijnen, Bram G., Dos Reis Miranda, Dinis, Bleeker, Gabe, de Metz, Jesse, Hermanides, Renicus S., Lopez Matta, Jorge, Eberl, Susanne, Donker, Dirk W., van Thiel, Robert J., Akin, Sakir, van Meer, Oene, Henriques, José, Bokhoven, Karen C., Mandigers, Loes, Bunge, Jeroen J.H., Bol, Martine E., Winkens, Bjorn, Essers, Brigitte, Weerwind, Patrick W., Maessen, Jos G., van de Poll, Marcel C.G., Medische Staf Intensive Care, Team Medisch, Other research (not in main researchprogram), Suverein, Martje M., Delnoij, Thijs S.R., Lorusso, Roberto, Brandon Bravo Bruinsma, George J., Otterspoor, Luuk, Elzo Kraemer, Carlos V., Vlaar, Alexander P.J., van der Heijden, Joris J., Scholten, Erik, den Uil, Corstiaan, Jansen, Tim, van den Bogaard, Bas, Kuijpers, Marijn, Lam, Ka Yan, Montero Cabezas, José M., Driessen, Antoine H.G., Rittersma, Saskia Z.H., Heijnen, Bram G., Dos Reis Miranda, Dinis, Bleeker, Gabe, de Metz, Jesse, Hermanides, Renicus S., Lopez Matta, Jorge, Eberl, Susanne, Donker, Dirk W., van Thiel, Robert J., Akin, Sakir, van Meer, Oene, Henriques, José, Bokhoven, Karen C., Mandigers, Loes, Bunge, Jeroen J.H., Bol, Martine E., Winkens, Bjorn, Essers, Brigitte, Weerwind, Patrick W., Maessen, Jos G., and van de Poll, Marcel C.G.
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- 2023
19. Early Extracorporeal CPR for Refractory Out-of-Hospital Cardiac Arrest
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Suverein, Martje M., primary, Delnoij, Thijs S.R., additional, Lorusso, Roberto, additional, Brandon Bravo Bruinsma, George J., additional, Otterspoor, Luuk, additional, Elzo Kraemer, Carlos V., additional, Vlaar, Alexander P.J., additional, van der Heijden, Joris J., additional, Scholten, Erik, additional, den Uil, Corstiaan, additional, Jansen, Tim, additional, van den Bogaard, Bas, additional, Kuijpers, Marijn, additional, Lam, Ka Yan, additional, Montero Cabezas, José M., additional, Driessen, Antoine H.G., additional, Rittersma, Saskia Z.H., additional, Heijnen, Bram G., additional, Dos Reis Miranda, Dinis, additional, Bleeker, Gabe, additional, de Metz, Jesse, additional, Hermanides, Renicus S., additional, Lopez Matta, Jorge, additional, Eberl, Susanne, additional, Donker, Dirk W., additional, van Thiel, Robert J., additional, Akin, Sakir, additional, van Meer, Oene, additional, Henriques, José, additional, Bokhoven, Karen C., additional, Mandigers, Loes, additional, Bunge, Jeroen J.H., additional, Bol, Martine E., additional, Winkens, Bjorn, additional, Essers, Brigitte, additional, Weerwind, Patrick W., additional, Maessen, Jos G., additional, and van de Poll, Marcel C.G., additional
- Published
- 2023
- Full Text
- View/download PDF
20. Reduced anticoagulation targets in extracorporeal life support (RATE): study protocol for a randomized controlled trial.
- Author
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UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - (MGD) Services des soins intensifs, van Minnen, Olivier, Oude Lansink-Hartgring, Annemieke, van den Boogaard, Bas, van den Brule, Judith, Bulpa, Pierre, Bunge, Jeroen J H, Delnoij, Thijs S R, Elzo Kraemer, Carlos V, Kuijpers, Marijn, Lambermont, Bernard, Maas, Jacinta J, de Metz, Jesse, Michaux, Isabelle, van de Pol, Ineke, van de Poll, Marcel, Raasveld, S Jorinde, Raes, Matthias, Dos Reis Miranda, Dinis, Scholten, Erik, Simonet, Olivier, Taccone, Fabio S, Vallot, Frederic, Vlaar, Alexander P J, van den Bergh, Walter M, UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - (MGD) Services des soins intensifs, van Minnen, Olivier, Oude Lansink-Hartgring, Annemieke, van den Boogaard, Bas, van den Brule, Judith, Bulpa, Pierre, Bunge, Jeroen J H, Delnoij, Thijs S R, Elzo Kraemer, Carlos V, Kuijpers, Marijn, Lambermont, Bernard, Maas, Jacinta J, de Metz, Jesse, Michaux, Isabelle, van de Pol, Ineke, van de Poll, Marcel, Raasveld, S Jorinde, Raes, Matthias, Dos Reis Miranda, Dinis, Scholten, Erik, Simonet, Olivier, Taccone, Fabio S, Vallot, Frederic, Vlaar, Alexander P J, and van den Bergh, Walter M
- Abstract
Although life-saving in selected patients, ECMO treatment still has high mortality which for a large part is due to treatment-related complications. A feared complication is ischemic stroke for which heparin is routinely administered for which the dosage is usually guided by activated partial thromboplastin time (aPTT). However, there is no relation between aPTT and the rare occurrence of ischemic stroke (1.2%), but there is a relation with the much more frequent occurrence of bleeding complications (55%) and blood transfusion. Both are strongly related to outcome. We will conduct a three-arm non-inferiority randomized controlled trial, in adult patients treated with ECMO. Participants will be randomized between heparin administration with a target of 2-2.5 times baseline aPTT, 1.5-2 times baseline aPTT, or low molecular weight heparin guided by weight and renal function. Apart from anticoagulation targets, treatment will be according to standard care. The primary outcome parameter is a combined endpoint consisting of major bleeding including hemorrhagic stroke, severe thromboembolic complications including ischemic stroke, and mortality at 6 months. We hypothesize that with lower anticoagulation targets or anticoagulation with LMWH during ECMO therapy, patients will have fewer hemorrhagic complications without an increase in thromboembolic complication or a negative effect on their outcome. If our hypothesis is confirmed, this study could lead to a change in anticoagulation protocols and a better outcome for patients treated with ECMO. ClinicalTrials.gov NCT04536272 . Registered on 2 September 2020. Netherlands Trial Register NL7969.
- Published
- 2022
21. Reduced anticoagulation targets in extracorporeal life support (RATE):study protocol for a randomized controlled trial
- Author
-
van Minnen, Olivier, Oude Lansink-Hartgring, Annemieke, van den Boogaard, Bas, van den Brule, Judith, Bulpa, Pierre, Bunge, Jeroen J.H., Delnoij, Thijs S.R., Elzo Kraemer, Carlos V., Kuijpers, Marijn, Lambermont, Bernard, Maas, Jacinta J., de Metz, Jesse, Michaux, Isabelle, van de Pol, Ineke, van de Poll, Marcel, Raasveld, S. Jorinde, Raes, Matthias, dos Reis Miranda, Dinis, Scholten, Erik, Simonet, Olivier, Taccone, Fabio S., Vallot, Frederic, Vlaar, Alexander P.J., van den Bergh, Walter M., van Minnen, Olivier, Oude Lansink-Hartgring, Annemieke, van den Boogaard, Bas, van den Brule, Judith, Bulpa, Pierre, Bunge, Jeroen J.H., Delnoij, Thijs S.R., Elzo Kraemer, Carlos V., Kuijpers, Marijn, Lambermont, Bernard, Maas, Jacinta J., de Metz, Jesse, Michaux, Isabelle, van de Pol, Ineke, van de Poll, Marcel, Raasveld, S. Jorinde, Raes, Matthias, dos Reis Miranda, Dinis, Scholten, Erik, Simonet, Olivier, Taccone, Fabio S., Vallot, Frederic, Vlaar, Alexander P.J., and van den Bergh, Walter M.
- Abstract
Background: Although life-saving in selected patients, ECMO treatment still has high mortality which for a large part is due to treatment-related complications. A feared complication is ischemic stroke for which heparin is routinely administered for which the dosage is usually guided by activated partial thromboplastin time (aPTT). However, there is no relation between aPTT and the rare occurrence of ischemic stroke (1.2%), but there is a relation with the much more frequent occurrence of bleeding complications (55%) and blood transfusion. Both are strongly related to outcome. Methods: We will conduct a three-arm non-inferiority randomized controlled trial, in adult patients treated with ECMO. Participants will be randomized between heparin administration with a target of 2–2.5 times baseline aPTT, 1.5–2 times baseline aPTT, or low molecular weight heparin guided by weight and renal function. Apart from anticoagulation targets, treatment will be according to standard care. The primary outcome parameter is a combined endpoint consisting of major bleeding including hemorrhagic stroke, severe thromboembolic complications including ischemic stroke, and mortality at 6 months. Discussion: We hypothesize that with lower anticoagulation targets or anticoagulation with LMWH during ECMO therapy, patients will have fewer hemorrhagic complications without an increase in thromboembolic complication or a negative effect on their outcome. If our hypothesis is confirmed, this study could lead to a change in anticoagulation protocols and a better outcome for patients treated with ECMO. Trial registration: ClinicalTrials.gov NCT04536272. Registered on 2 September 2020.
- Published
- 2022
22. RBC Transfusion in Venovenous Extracorporeal Membrane Oxygenation:A Multicenter Cohort Study
- Author
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Raasveld, Senta Jorinde, Karami, Mina, van den Bergh, Walter M., Lansink-Hartgring, Annemieke Oude, van der Velde, Franciska, Maas, Jacinta J., van de Berg, Pablo, de Haan, Maarten, Lorusso, Roberto, Delnoij, Thijs S.R., Dos Reis Miranda, Dinis, Mandigers, Loes, Scholten, Erik, Overmars, Martijn, Taccone, Fabio Silvio, Brasseur, Alexandre, Dauwe, Dieter F., de Troy, Erwin, Hermans, Greet, Meersseman, Philippe, Pappalardo, Federico, Fominskiy, Evgeny, Ivancan, Višnja, Bojčić, Robert, de Metz, Jesse, van den Bogaard, Bas, Donker, Dirk W., Meuwese, Christiaan L., de Bakker, Martin, Reddi, Benjamin, de Bruin, Sanne, Lagrand, Wim K., Henriques, José P.S., Broman, Lars M., Vlaar, Alexander P.J., Raasveld, Senta Jorinde, Karami, Mina, van den Bergh, Walter M., Lansink-Hartgring, Annemieke Oude, van der Velde, Franciska, Maas, Jacinta J., van de Berg, Pablo, de Haan, Maarten, Lorusso, Roberto, Delnoij, Thijs S.R., Dos Reis Miranda, Dinis, Mandigers, Loes, Scholten, Erik, Overmars, Martijn, Taccone, Fabio Silvio, Brasseur, Alexandre, Dauwe, Dieter F., de Troy, Erwin, Hermans, Greet, Meersseman, Philippe, Pappalardo, Federico, Fominskiy, Evgeny, Ivancan, Višnja, Bojčić, Robert, de Metz, Jesse, van den Bogaard, Bas, Donker, Dirk W., Meuwese, Christiaan L., de Bakker, Martin, Reddi, Benjamin, de Bruin, Sanne, Lagrand, Wim K., Henriques, José P.S., Broman, Lars M., and Vlaar, Alexander P.J.
- Abstract
OBJECTIVES: In the general critical care patient population, restrictive transfusion regimen of RBCs has been shown to be safe and is yet implemented worldwide. However, in patients on venovenous extracorporeal membrane oxygenation, guidelines suggest liberal thresholds, and a clear overview of RBC transfusion practice is lacking. This study aims to create an overview of RBC transfusion in venovenous extracorporeal membrane oxygenation. DESIGN: Mixed method approach combining multicenter retrospective study and survey. SETTING: Sixteen ICUs worldwide. PATIENTS: Patients receiving venovenous extracorporeal membrane oxygenation between January 2018 and July 2019. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: The primary outcome was the proportion receiving RBC, the amount of RBC units given daily and in total. Furthermore, the course of hemoglobin over time during extracorporeal membrane oxygenation was assessed. Demographics, extracorporeal membrane oxygenation characteristics, and patient outcome were collected. Two-hundred eight patients received venovenous extracorporeal membrane oxygenation, 63% male, with an age of 55 years (45–62 yr), mainly for acute respiratory distress syndrome. Extracorporeal membrane oxygenation duration was 9 days (5–14 d). Prior to extracorporeal membrane oxygenation, hemoglobin was 10.8g/dL (8.9–13.0g/dL), decreasing to 8.7g/dL (7.7–9.8g/dL) during extracorporeal membrane oxygenation. Nadir hemoglobin was lower on days when a transfusion was administered (8.1g/dL [7.4–9.3g/dL]). A vast majority of 88% patients received greater than or equal to 1 RBC transfusion, consisting of 1.6 U (1.3–2.3 U) on transfusion days. This high transfusion occurrence rate was also found in nonbleeding patients (81%). Patients with a liberal transfusion threshold (hemoglobin > 9g/dL) received more RBC in total per transfusion day and extracorporeal membrane oxygenation day. No differences in survival, hemorrhagic and thrombotic complication rates
- Published
- 2022
23. RBC Transfusion in Venovenous Extracorporeal Membrane Oxygenation: A Multicenter Cohort Study
- Author
-
Medische Staf Intensive Care, Other research (not in main researchprogram), Raasveld, Senta Jorinde, Karami, Mina, van den Bergh, Walter M., Oude Lansink-Hartgring, Annemieke, van der Velde, Franciska, Maas, Jacinta J., van de Berg, Pablo, de Haan, Maarten, Lorusso, Roberto, Delnoij, Thijs S.R., Dos Reis Miranda, Dinis, Mandigers, Loes, Scholten, Erik, Overmars, Martijn, Silvio Taccone, Fabio, Brasseur, Alexandre, Dauwe, Dieter F., De Troy, Erwin, Hermans, Greet, Meersseman, Philippe, Pappalardo, Federico, Fominskiy, Evgeny, Ivancan, Višnja, Bojčić, Robert, de Metz, Jesse, van den Bogaard, Bas, Donker, Dirk W., Meuwese, Christiaan L., de Bakker, Martin, Reddi, Benjamin, de Bruin, Sanne, Lagrand, Wim K., Henriques, José P.S., Broman, Lars M., Vlaar, Alexander P.J., Medische Staf Intensive Care, Other research (not in main researchprogram), Raasveld, Senta Jorinde, Karami, Mina, van den Bergh, Walter M., Oude Lansink-Hartgring, Annemieke, van der Velde, Franciska, Maas, Jacinta J., van de Berg, Pablo, de Haan, Maarten, Lorusso, Roberto, Delnoij, Thijs S.R., Dos Reis Miranda, Dinis, Mandigers, Loes, Scholten, Erik, Overmars, Martijn, Silvio Taccone, Fabio, Brasseur, Alexandre, Dauwe, Dieter F., De Troy, Erwin, Hermans, Greet, Meersseman, Philippe, Pappalardo, Federico, Fominskiy, Evgeny, Ivancan, Višnja, Bojčić, Robert, de Metz, Jesse, van den Bogaard, Bas, Donker, Dirk W., Meuwese, Christiaan L., de Bakker, Martin, Reddi, Benjamin, de Bruin, Sanne, Lagrand, Wim K., Henriques, José P.S., Broman, Lars M., and Vlaar, Alexander P.J.
- Published
- 2022
24. RBC Transfusion in Venovenous Extracorporeal Membrane Oxygenation: A Multicenter Cohort Study
- Author
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Raasveld, Senta Jorinde, primary, Karami, Mina, additional, van den Bergh, Walter M., additional, Oude Lansink-Hartgring, Annemieke, additional, van der Velde, Franciska, additional, Maas, Jacinta J., additional, van de Berg, Pablo, additional, de Haan, Maarten, additional, Lorusso, Roberto, additional, Delnoij, Thijs S. R., additional, Dos Reis Miranda, Dinis, additional, Mandigers, Loes, additional, Scholten, Erik, additional, Overmars, Martijn, additional, Silvio Taccone, Fabio, additional, Brasseur, Alexandre, additional, Dauwe, Dieter F., additional, De Troy, Erwin, additional, Hermans, Greet, additional, Meersseman, Philippe, additional, Pappalardo, Federico, additional, Fominskiy, Evgeny, additional, Ivancan, Višnja, additional, Bojčić, Robert, additional, de Metz, Jesse, additional, van den Bogaard, Bas, additional, Donker, Dirk W., additional, Meuwese, Christiaan L., additional, de Bakker, Martin, additional, Reddi, Benjamin, additional, de Bruin, Sanne, additional, Lagrand, Wim K., additional, Henriques, José P. S., additional, Broman, Lars M., additional, and Vlaar, Alexander P. J., additional
- Published
- 2022
- Full Text
- View/download PDF
25. Behavioural artificial intelligence technology for COVID-19 intensivist triage decisions: making the implicit explicit
- Author
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de Metz, Jesse (author), Thoral, Patrick J. (author), Chorus, C.G. (author), Elbers, Paul W.G. (author), van den Bogaard, Bas (author), de Metz, Jesse (author), Thoral, Patrick J. (author), Chorus, C.G. (author), Elbers, Paul W.G. (author), and van den Bogaard, Bas (author)
- Abstract
Transport and Logistics
- Published
- 2021
- Full Text
- View/download PDF
26. Very young children with uncomplicated falciparum malaria have higher risk of hypoglycaemia: a study from Suriname
- Author
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Zijlmans, Wilco C. W. R., van Kempen, Anne A. M. W., Ackermans, Mariëtte T., de Metz, Jesse, Kager, Piet A., and Sauerwein, Hans P.
- Published
- 2008
27. Dietary fat content alters insulin-mediated glucose metabolism in healthy men
- Author
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Bisschop, Peter H, de Metz, Jesse, Ackermans, Mariëtte T, Endert, Erik, Pijl, Hanno, Kuipers, Folkert, Meijer, Alfred J, Sauerwein, Hans P, and Romijn, Johannes A
- Published
- 2001
- Full Text
- View/download PDF
28. Telemedicine in a Dutch intensive care unit: A descriptive study of the first results
- Author
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van der Voort, Peter HJ, primary, de Metz, Jesse, additional, Wester, Jos PJ, additional, van Stijn, Ilse, additional, Feijen, Hilde Marieken, additional, Balzereit, Anja, additional, Rijkenberg, Saskia, additional, Obster, Renate, additional, and Bosman, Rob J, additional
- Published
- 2015
- Full Text
- View/download PDF
29. 'Het syndroom van Amice': als de patiënt een collega is en een collega de dokter
- Author
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de Metz, Jesse, Wijnandts, Paul, Levi, Marcel, Intensive Care Medicine, and Vascular Medicine
- Published
- 2009
30. Telemedicine in a Dutch intensive care unit: A descriptive study of the first results.
- Author
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van der Voort, Peter H. J., de Metz, Jesse, Wester, Jos P. J., van Stijn, Ilse, Feijen, Hilde Marieken, Balzereit, Anja, Rijkenberg, Saskia, Obster, Renate, and Bosman, Rob J.
- Subjects
- *
TELEMEDICINE , *INTENSIVE care units , *PATIENT satisfaction , *SEVERITY of illness index , *HEALTH information technology , *PUBLIC health , *FAMILIES & psychology , *APACHE (Disease classification system) , *CRITICAL care medicine , *LENGTH of stay in hospitals , *MEDICAL quality control , *RETROSPECTIVE studies , *HOSPITAL mortality - Abstract
Introduction: Tele-intensive care (teleIC) can be used to increase the level of care in the intensive care unit (ICU) with the tele-intensivist being at a remote site. In this study we describe the implementation and outcomes, including patient and family satisfaction, of the first Dutch teleIC.Methods: In a retrospective analysis the patient characteristics are described with a focus on patient outcomes and patient and family satisfaction. The teleIC started on 6 December 2010 in an ICU with three beds. Data for all admitted patients were collected from 1 January 2011 through 31 December 2013 from available systems. Severity of disease (APACHE IV) and standardized mortality ratios (SMR) were available over the complete calendar years 2012 and 2013. A prospective self-made survey of patient and family satisfaction was performed over a 14-month period after the implementation of teleIC.Results: In 2012 and 2013, 556 patients were admitted. The number of operating room recovery patients in the ICU declined over time. One hundred and seven patients were transferred to a higher-level ICU (19%). The SMR for non-transferred patients was 0.73 (95% CI (confidence interval) 0.54-0.98) and 0.66 (95% CI (confidence interval) 0.40-1.02) for transferred patients. These numbers are in line with national data. Thirty-six percent of family and 38% of the patients responded to the survey and showed a positive response concerning communication within the tele IC setting.Conclusion: Implementation of teleIC in a Dutch situation was successful and showed favourable results in patient outcomes and the satisfaction of patients and family members. [ABSTRACT FROM AUTHOR]- Published
- 2016
- Full Text
- View/download PDF
31. Glucose Kinetics during Fasting in Young Children with Severe and Non-severe Malaria in Suriname
- Author
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Zijlmans, Wilco, primary, Kager, Piet, additional, Sauerwein, Hans, additional, Ackermans, Mariëtte, additional, van Kempen, Anne, additional, and de Metz, Jesse, additional
- Published
- 2008
- Full Text
- View/download PDF
32. Global warming could affect outpatient attendance
- Author
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Linthorst, Gabor E, primary and de Metz, Jesse, additional
- Published
- 2008
- Full Text
- View/download PDF
33. Administration of lnterferon-γ in Healthy Subjects does not Modulate Thyroid Hormone Metabolism
- Author
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de Metz, Jesse, primary, Romijn, Johannes A., additional, Endert, Erik, additional, Corssmit, Eleonora P.M., additional, and Sauerwein, Hans P., additional
- Published
- 2000
- Full Text
- View/download PDF
34. Interferon-γ increase monocyte HLA-DR expression without effects on glucose and fat metabolism in postoperative patients.
- Author
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De Metz, Jesse, Romijn, Johannes A., Edert, Erik, Ackermans, Mariette T., Weverling, Gerri Jan, Busch, Olivier R., De Wit, Laurence Th., Gouma, Dirk J., Ten Berge, Ineke J. M., and Sauerwein, Hans P.
- Subjects
INTERFERONS ,IMMUNE system ,IMMUNITY endocrinology ,TISSUE wounds ,METABOLISM ,CELLULAR immunity - Abstract
Evaluates whether interferon-γ lacks potential harmful side effects on metabolic and endocrine pathways while maintaining its beneficial effects of the immune system. Decrease in cellular immunity; Association between tissue injury and decreased cellualr immunity and enhanced metabolism; Beneficial effects of interferon;&gamma on the immune system.
- Published
- 2004
- Full Text
- View/download PDF
35. [Thromboembolisms due to recreational use of nitrous oxide].
- Author
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Oomens T, Fokkema TMM, van den Bogaard B, de Metz J, van Nieuwenhuizen RC, Riezebos RK, and Kuipers RS
- Subjects
- Female, Humans, Male, Nervous System Diseases therapy, Peripheral Nervous System Diseases chemically induced, Risk Assessment, Substance-Related Disorders etiology, Thromboembolism therapy, Vitamin B 12 Deficiency etiology, Young Adult, Illicit Drugs adverse effects, Nervous System Diseases chemically induced, Nitrous Oxide adverse effects, Thromboembolism chemically induced, Vitamin B 12 Deficiency complications
- Abstract
Nitrous oxide (N2O) is increasingly used as a recreational drug, and is presumed relatively safe and innocent. The risks for neurological complications are often known, however the risks of serious thromboembolic events are not. We describe three cases of acute thromboembolic events resulting in serious cardiovascular complications after N2O abuse: one case of myocardial infarction that resulted in a reduced ejection fraction, one case of peripheral arterial occlusion that led to limb amputation and one case of pulmonary embolism that resulted in hemodynamic instability requiring extracorporeal membrane oxygenation (ECMO) and surgical removal. All patients were young adults with a low cardiovascular risk profile. N2O inactivates vitamin B12, leading to vitamin B12 deficiency and subsequent to hyperhomocysteinemia, which is associated with the formation of fibrinolysis-resistant blood thrombi. In conclusion, we contest the safety and innocence of recreational N2O (ab)use. Our three cases illustrate that, next to previously described neurological complications, the use of nitrous oxide is associated with thromboembolic cardiovascular complications, presumably mediated by hyperhomocysteinemia.
- Published
- 2021
36. ["The dear friend syndrome": if the patient is a colleague and the colleague is the doctor].
- Author
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de Metz J, Wijnandts P, and Levi M
- Subjects
- Adult, Humans, Male, Patient Rights, Physician's Role, Patients psychology, Physician-Patient Relations ethics, Physicians psychology
- Published
- 2009
37. Interferon-gamma increases monocyte HLA-DR expression without effects on glucose and fat metabolism in postoperative patients.
- Author
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de Metz J, Romijn JA, Endert E, Ackermans MT, Weverling GJ, Busch OR, de Wit LT, Gouma DJ, ten Berge IJ, and Sauerwein HP
- Subjects
- Aged, Blood Glucose drug effects, Energy Metabolism drug effects, Female, Glycerol metabolism, Hormones blood, Humans, Male, Middle Aged, Monocytes metabolism, Postoperative Period, Antineoplastic Agents administration & dosage, Blood Glucose metabolism, HLA-DR Antigens metabolism, Interferon-gamma administration & dosage, Lipid Metabolism, Monocytes drug effects
- Abstract
Tissue injury is associated with decreased cellular immunity and enhanced metabolism. Immunodepression is thought to be counteracted by interferon (IFN)-gamma, which increases human leukocyte antigen (HLA)-DR expression. Hypermetabolism could be enhanced by IFN-gamma because cytokines induce a hypermetabolic response to stress. In healthy humans, IFN-gamma enhanced HLA-DR expression without effects on glucose and fat metabolism. In the present study, we evaluated whether IFN-gamma lacks potential harmful side effects on metabolic and endocrine pathways while maintaining its beneficial effects on the immune system under conditions in which the inflammatory response system is activated. In 13 patients scheduled for major surgery, we studied HLA-DR expression on peripheral blood monocytes before surgery and postoperatively randomized the patients into an intervention and a placebo group. Subsequently, we evaluated the effects of a single dose of IFN-gamma vs. saline on short-term monocyte activation, glucose and lipid metabolism, and glucose and lipid regulatory hormones. HLA-DR expression on monocytes was restored from postoperative levels of 54% (42-60%; median and interquartiles) to 92% (91-96%) 24 h after IFN-gamma administration but stayed low in the placebo-treated patients. IFN-gamma did not affect glucose metabolism (plasma glucose, rate of appearance and disappearance of glucose) and lipid metabolism (plasma glycerol, plasma free fatty acids, and rates of appearance and disappearance of glycerol). IFN-gamma had no effect on plasma cortisol, adrenocorticotropic hormone, growth hormone, insulin, C-peptide, glucagon, epinephrine, and norepinephrine concentrations. We conclude that IFN-gamma exerts a favorable effect on cell-mediated immunity in patients after major surgery without effects on glucose and lipid metabolism.
- Published
- 2004
- Full Text
- View/download PDF
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