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2. Potential effects of carbamylation on the prothrombin time, activated partial thromboplastin time, and fibrinogen.

Author

Mastella, Aline K., de Carvalho, José A. M., Pereira, Karla N., das Neves, Yasmin S., Stein, Carolina S., Bochi, Guilherme V., and Moresco, Rafael N.

Subjects
PROTEIN metabolism, PROTHROMBIN time, PARTIAL thromboplastin time, CHRONIC kidney failure, UREA, RISK assessment, FIBRINOGEN, INORGANIC compounds, PEPTIDES, DISEASE risk factors
Abstract

The article discusses a study which examined the effects of carbamylation induced by potassium cyanates (KOCN), a well-established carbamylating agent used in vitro models, and urea on prothrombin time (PT), activated partial thromboplastin time (aPTT), and fibrinogen measured in pooled normal human plasma. Topics include how a normal plasma pool (NPP) used in the study was prepared, PT, aPTT, and fibrinogen values after the KOCN, and factor that may affect the results of coagulation tests.

Published
2024
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