Potential effects of carbamylation on the prothrombin time, activated partial thromboplastin time, and fibrinogen.

The article discusses a study which examined the effects of carbamylation induced by potassium cyanates (KOCN), a well-established carbamylating agent used in vitro models, and urea on prothrombin time (PT), activated partial thromboplastin time (aPTT), and fibrinogen measured in pooled normal human plasma. Topics include how a normal plasma pool (NPP) used in the study was prepared, PT, aPTT, and fibrinogen values after the KOCN, and factor that may affect the results of coagulation tests.