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Your search keyword '"damage-specific scaffold"' showing total 2 results
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2 results on '"damage-specific scaffold"'

1. 3D Bioprinted Bacteriostatic Hyperelastic Bone Scaffold for Damage-Specific Bone Regeneration

Author

Ho Won Jang, Morteza Mahmoudi, Christopher N. LaRock, Janaina S. Martins, Nick J. Willett, Mohamed Yousef, Jarred Kaiser, Steven L. Goudy, Cong Cao, Mitchel B. Harris, Liqun Ning, Mohammadreza Shokouhimehr, Aron Lechtig, Ara Nazarian, Vahid Serpooshan, Martin L. Tomov, Andrea S. Theus, Archana Kamalakar, and Philip C. Hanna

Subjects
Polymers and Plastics, Superparamagnetic iron oxide nanoparticles, damage-specific scaffold, hyperelastic bone, 0206 medical engineering, 02 engineering and technology, Host tissue, Article, lcsh:QD241-441, Tissue engineering, lcsh:Organic chemistry, medicine, Bone regeneration, large bone fracture, Chemistry, Ossification, Regeneration (biology), superparamagnetic iron oxide nanoparticles, Bone scaffold, General Chemistry, 021001 nanoscience & nanotechnology, 020601 biomedical engineering, Embryonic stem cell, antibacterial, tissue engineering, bone 3D bioprinting, medicine.symptom, 0210 nano-technology, Biomedical engineering
Abstract

Current strategies for regeneration of large bone fractures yield limited clinical success mainly due to poor integration and healing. Multidisciplinary approaches in design and development of functional tissue engineered scaffolds are required to overcome these translational challenges. Here, a new generation of hyperelastic bone (HB) implants, loaded with superparamagnetic iron oxide nanoparticles (SPIONs), are 3D bioprinted and their regenerative effect on large non-healing bone fractures is studied. Scaffolds are bioprinted with the geometry that closely correspond to that of the bone defect, using an osteoconductive, highly elastic, surgically friendly bioink mainly composed of hydroxyapatite. Incorporation of SPIONs into HB bioink results in enhanced bacteriostatic properties of bone grafts while exhibiting no cytotoxicity. In vitro culture of mouse embryonic cells and human osteoblast-like cells remain viable and functional up to 14 days on printed HB scaffolds. Implantation of damage-specific bioprinted constructs into a rat model of femoral bone defect demonstrates significant regenerative effect over the 2-week time course. While no infection, immune rejection, or fibrotic encapsulation is observed, HB grafts show rapid integration with host tissue, ossification, and growth of new bone. These results suggest a great translational potential for 3D bioprinted HB scaffolds, laden with functional nanoparticles, for hard tissue engineering applications.

Published
2021

2. 3D Bioprinted Bacteriostatic Hyperelastic Bone Scaffold for Damage-Specific Bone Regeneration.

Author

Shokouhimehr, Mohammadreza, Theus, Andrea S., Kamalakar, Archana, Ning, Liqun, Cao, Cong, Tomov, Martin L., Kaiser, Jarred M., Goudy, Steven, Willett, Nick J., Jang, Ho Won, LaRock, Christopher N., Hanna, Philip, Lechtig, Aron, Yousef, Mohamed, Martins, Janaina Da Silva, Nazarian, Ara, Harris, Mitchel B., Mahmoudi, Morteza, and Serpooshan, Vahid

Subjects
*BONE regeneration, *IRON oxide nanoparticles, *BIOPRINTING, *TISSUE scaffolds, *TISSUE engineering, *BONE fractures
Abstract

Current strategies for regeneration of large bone fractures yield limited clinical success mainly due to poor integration and healing. Multidisciplinary approaches in design and development of functional tissue engineered scaffolds are required to overcome these translational challenges. Here, a new generation of hyperelastic bone (HB) implants, loaded with superparamagnetic iron oxide nanoparticles (SPIONs), are 3D bioprinted and their regenerative effect on large non-healing bone fractures is studied. Scaffolds are bioprinted with the geometry that closely correspond to that of the bone defect, using an osteoconductive, highly elastic, surgically friendly bioink mainly composed of hydroxyapatite. Incorporation of SPIONs into HB bioink results in enhanced bacteriostatic properties of bone grafts while exhibiting no cytotoxicity. In vitro culture of mouse embryonic cells and human osteoblast-like cells remain viable and functional up to 14 days on printed HB scaffolds. Implantation of damage-specific bioprinted constructs into a rat model of femoral bone defect demonstrates significant regenerative effect over the 2-week time course. While no infection, immune rejection, or fibrotic encapsulation is observed, HB grafts show rapid integration with host tissue, ossification, and growth of new bone. These results suggest a great translational potential for 3D bioprinted HB scaffolds, laden with functional nanoparticles, for hard tissue engineering applications. [ABSTRACT FROM AUTHOR]

Published
2021
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