88 results on '"ciprofloxacine"'
Search Results
2. Electrochemical Oxidation of Ciprofloxacin on COOH-Functionalized Multi-Walled Carbon Nanotube–Coated Vitreous Carbon Electrode.
- Author
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Chaabani, Amal, Ben Jabrallah, Taha, and Belhadj Tahar, Noureddine
- Abstract
This study deals with the use of a COOH-functionalized multi-walled carbon nanotube–coated glassy carbon electrode (f-MWCNT-coated GCE) to investigate the electrochemical oxidation of ciprofloxacin (CIP). The electrochemical behavior of CIP is investigated using cyclic voltammetry and square wave voltammetry in PBS buffer aqueous solutions. Cyclic voltammograms have shown that (1) CIP provided a well-defined irreversible oxidation peak at a potential of around 1 V and (2) modifying glassy carbon electrode surface by MWCNT leads to a significant improvement 3.6 and 1.5 folds of the electrochemical response as compared to that at bare GCE, and MWCNT-coated GCE, respectively. This improvement in the electrocatalytic activity of the electrode is attributed to the decrease of the charge transfer resistance. The influence of some controlled parameters (scan rate, pH, successive potential scans, and SMX concentration) on the electrochemical oxidation of CIP is studied. It has been shown that CIP oxidizes according to a diffusion-controlled mechanism involving the transfer of one electron and two protons. Furthermore, this study demonstrates that the zwitterionic form of CIP is thermodynamically more reactive to electrochemical oxidation than the cationic and anionic forms. Under optimized conditions, a linear calibration curve was obtained by square wave voltammetry for CIP in the concentration range 5–100 µM with a detection limit of 0.16 µM. The f-MWCNT-coated GCE showed great improvement, as compared to bare GCE, in the anodic oxidation reactivity of CIP with high simplicity of preparation, selectivity, repeatability, and reproducibility. Also, CIP analytical determination was performed successfully, using f-MWCNT-coated GCE, in-hospital effluent, treated domestic wastewater effluent, and natural water source, allowing promising and feasible applications in on-site environmental monitoring. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
3. Evolution of Bacterial Persistence to Antibiotics during a 50,000-Generation Experiment in an Antibiotic-Free Environment.
- Author
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Mathé-Hubert, Hugo, Amia, Rafika, Martin, Mikaël, Gaffé, Joël, and Schneider, Dominique
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BACTERIAL evolution ,ANTIBIOTICS ,DRUG resistance in bacteria ,CELL growth - Abstract
Failure of antibiotic therapies causes > 700,000 deaths yearly and involves both bacterial resistance and persistence. Persistence results in the relapse of infections by producing a tiny fraction of pathogen survivors that stay dormant during antibiotic exposure. From an evolutionary perspective, persistence is either a 'bet-hedging strategy' that helps to cope with stochastically changing environments or an unavoidable minimal rate of 'cellular errors' that lock the cells in a low activity state. Here, we analyzed the evolution of persistence over 50,000 bacterial generations in a stable environment by improving a published method that estimates the number of persister cells based on the growth of the reviving population. Our results challenged our understanding of the factors underlying persistence evolution. In one case, we observed a substantial decrease in persistence proportion, suggesting that the naturally observed persistence level is not an unavoidable minimal rate of 'cellular errors'. However, although there was no obvious environmental stochasticity, in 11 of the 12 investigated populations, the persistence level was maintained during 50,000 bacterial generations. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
4. Tendinopathie achilléenne compliquée d´une rupture du tendon d´Achille consécutives à une automédication par la ciprofloxacine chez une hémodialysée: à propos d´un cas
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Gaël Clovis Gassongo Koumou, Kevin Parfait Bienvenu Bouhelo Pam, Mohamed Arrayhani, Tarik Sqalli Houssaini, and Abdelmajid El Mrini
- Subjects
tendinopathie achilléenne ,rupture du tendon d´achille ,effets secondaires ,ciprofloxacine ,rapport de cas ,Medicine - Abstract
L´objectif de ce travail était de rappeler aux praticiens cette complication des fluoroquinolones, la tendinopathie. Il s´agit d´un effet secondaire rare mais, qui peut être source de handicap fonctionnel. Une femme de 79 ans, hémodialysée depuis 11 années avait présenté une douleur soudaine de la cheville gauche et une impotence fonctionnelle relative du membre homolatéral au 5e jour d´une automédication par la ciprofloxacine. Elle avait comme comorbidités, une gonarthrose chronique, une hyperparathyroïdie secondaire et une cardiopathie ischémique. Le diagnostic de tendinopathie achilléenne bilatérale et d´une rupture achilléenne gauche étaient retenus sur la base des arguments cliniques, confortés par l´échographie achilléenne. La responsabilité de la ciprofloxacine était évaluée à l´aide de la méthode française d´imputabilité des effets inattendus ou toxiques des médicaments. La prise en charge était chirurgicale suivie d´une rééducation fonctionnelle avec une évolution satisfaisante. La fréquence des tendinopathies liées aux fluoroquinolones varie de 15 à 20 accidents pour 100 000 sujets traités dont un tiers de cas sont compliqués de rupture tendineuse. L´incidence est liée à l´âge, avec un âge de prédilection > 60 ans impliquant le vieillissement tissulaire. La péfloxacine et la ciprofloxacine sont les molécules les plus incriminées. Le délai d´apparition des symptômes noté à cinq jours dans cette observation corrobore avec la littérature. Nous avons retrouvé certains facteurs favorisants connus à savoir : insuffisance rénale chronique, dialyse, corticothérapie, hypolipémiant (statine). La présentation clinique est classique, suffisante pour poser le diagnostic. La localisation est majoritairement achilléenne. Elle est bilatérale dans 40 à 66 %. La rupture tendineuse est la principale complication. La prise en charge est chirurgicale. Elle permet de rétablir l´anatomie et de prévenir le handicap fonctionnel préjudiciable. Nous rapportons un effet secondaire rare mais, potentiellement grave, lié aux fluoroquinolones et, qui expose à un handicap fonctionnel. L´âge avancé, l´insuffisance rénale chronique, l´hémodialyse chronique, la prise concomitante de statine et de corticoïde sont des facteurs traditionnels favorisants retrouvés ici. Les hémodialysés constituent une population à risque pour qui une surveillance même à distance d´un traitement à base de ces molécules revêt un intérêt non négligeable.
- Published
- 2021
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5. Tendinopathie achilléenne compliquée d´une rupture du tendon d´Achille consécutives à une automédication par la ciprofloxacine chez une hémodialysée: à propos d´un cas.
- Author
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Gassongo Koumou, Gaël Clovis, Bienvenu Bouhelo Pam, Kevin Parfait, Arrayhani, Mohamed, Houssaini, Tarik Sqalli, and Mrini, Abdelmajid El
- Subjects
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MEDICAL personnel , *ACHILLES tendon rupture , *TENDON rupture , *MYOCARDIAL ischemia , *DIAGNOSIS , *TENDON injuries , *ACHILLES tendinitis - Abstract
This study aims to remind clinicians of fluoroquinolone-related tendinopathies. They are rare side effects, but which can result in functional disability. We report the case of a 79-year-old woman with a 11-year history of haemodialysis who had sudden left ankle pain and functional impairment in the ipsilateral member on day 5th after self-medication with ciprofloxacin. Comorbidities included chronic gonarthrosis, secondary hyperparathyroidism and ischemic heart disease. The diagnosis of bilateral Achilles tendinopathy and rupture of the left Achilles tendon was retained due to clinical features and confirmed by ultrasound of ankles. Ciprofloxacinassociated tendon rupture was evaluated using the French method of accountability for drug unexpected side effects or toxicity. Tendon rupture management was based on surgery followed by functional rehabilitation program with satisfactory outcome. The frequency of fluoroquinolone-related tendinopathies ranges from 15 to 20 accidents per 100,000 subjects treated, a third of whom are complicated by tendon rupture. Incidence is related to age, affecting mainly people > 60 years and involving tissular aging. Pefloxacin and ciprofloxacin are the most offending molecules. In our study, the delay in the onset of symptoms on day 5 after self-medication was consistent with literature. We detected some common contributing factors including chronic renal failure, hemodialysis and the assumption of statins and corticosteroids. Fluoroquinolone-related tendinopathies are characterized by common clinical features which allow diagnosis. They mostly affect Achilles tendon. They are bilateral in 40-66% of cases. Tendon rupture is the main complication. Management is based on surgery. It allows to restore anatomy and to prevent detrimental functional disability. We here report a rare but potentially serious fluoroquinolonesrelated side effect, exposing the patient to the risk of functional disability. Advanced age, chronic renal failure, chronic haemodialysis, concomitant use of statins and corticosteroids are common contributing factors confirmed in this study. Hemodialysis patients constitute a population at risk; hence the importance of remote monitoring after treatment with these molecules. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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6. Fatal case of toxic epidermal necrolysis induced by ciprofloxacin in a child.
- Author
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Schiestel, Thomas
- Subjects
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TOXIC epidermal necrolysis , *CIPROFLOXACIN , *DRUG eruptions , *TREATMENT delay (Medicine) , *STEVENS-Johnson Syndrome , *CHILD patients - Abstract
Bullous drug eruptions such as Toxic Epidermal Necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are rare but known adverse reactions of fluoroquinolones. Although uncommon, TEN can be life-threatening for the patient, especially in the context of delayed treatment and in fragile patients such as the pediatric population. In the present case, TEN occurred in a 13-year-old girl with no medical history following initiation of ciprofloxacin treatment for an inguinal cyst. We hope that the case report will make interrogate the practices concerning the use of antibiotics, in particular fluoroquinolones in the context of an use not prescribed by the Marketing Authorization of the drug in children. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
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7. Study the antibacterial effect of N_butanol extract of Urticadioica.
- Author
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Ahmed, Ahmed Abdulaziz, Kamal, Yaser Mustafa, and Abdula, Baydaa Hameed
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BUTANOL ,STINGING nettle ,URINARY tract infections ,KLEBSIELLA pneumoniae ,GRAM-positive bacteria - Abstract
Copyright of Al-Mustansiriyah Journal for Pharmaceutical Sciences is the property of Republic of Iraq Ministry of Higher Education & Scientific Research (MOHESR) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2021
8. ACTIVE FRACTIONS FROM E. COLI ATCC 35218 WITH ANTIMICROBIAL AND ANTIOXIDANT PROPERTIES.
- Author
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Maqsood, M, Mushtaq, Z., Jilani, Kashif, and Khan, U.
- Subjects
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FUSARIUM solani , *SOLVENT extraction , *BACILLUS subtilis , *ESCHERICHIA coli , *FREE radicals , *HEXANE , *ETHYL acetate - Abstract
Discovery of new therapeutic agents has become crucial because mankind is experiencing issues regarding health and environment. In the current study Escherichia coli (ATCC 35218) extracts were evaluated for their antimicrobial and antioxidant potentials against different bacterial and fungal species. Different extracts were prepared following different methods including soxhlet extraction with ethanol using cell mass of E. coli. Some other extracts like crude proteins, crude isoprenoid quinine and polar lipids were extracted from the E. coli cell mass with different extraction solvents. Another extraction was done using solvents in order of increasing polarity by using methanol as well as n-hexane. chloroform, ethyl acetate and water. The antimicrobial potential was evaluated by well diffusion as well as disc diffusion method. The antioxidant effect of E. coli extracts were investigated in terms of DPPH free radical scavenging activity. Polar lipids showed maximum antibacterial activity in a range of 5-9 mm against Bacillus subtilis, Staphylococcus aureus and Pasturella multocida. Extract of Crude proteins exhibited maximum antioxidant activity (83.45%). A significant antifungal activity of about 13 mm against Fusarium solani was also shown by crude polar lipids. Finally, results were analyzed statistically by the paired t-test (Tucky's test) using software Statistix, version 8.1. [ABSTRACT FROM AUTHOR]
- Published
- 2019
9. Dépôts cornéens de ciprofloxacine en post chirurgie de cataracte
- Author
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Ghita Bouayad and Abdelbarre Oubaaz
- Subjects
dépôts ,cornée ,ciprofloxacine ,Medicine - Abstract
Nous rapportons le cas d’un patient âgé de 62 ans, opéré de cataracte de l’œil gauche par phacoémulsification avec suites simples; il a reçu en post opératoire un traitement comprenant la ciprofloxacine en collyres. Le patient a été perdu de vue pendant 2 mois sans arrêter le traitement; il se présente avec une opacité para-centrale, blanche, d’allure cristalline, correspondant à un dépôt cornéen de ciprofloxacine. Le collyre antibiotique a été immédiatement suspendu et le patient a bénéficié d’un débridement chirurgical très superficiel, et a été mis sous agents mouillants à fortes doses, avec cicatrisation complète de l’ulcération en regard du dépôt cornéen, mais il a gardé une opacité épithéliale para-pupillaire inférieure ne gênant toutefois pas la vision.
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- 2018
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10. EVALUASI KLINIS DARI TERAPI LESI STERILISASI DAN PERBAIKAN JARINGAN (LSTR) 3MIX-MP
- Author
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Reni A. Reni, Tri L. Tri, Etty W. Etty, Harry B. S. Harry, Cheryl A. Cheryl, Sri P. Sri, Floriana S. Floriana, and Hoshino E. Hoshino
- Subjects
3 antibacterial drugs (3Mic) ,ciprofloxacine ,metronidazole ,minocycline ,Dentistry ,RK1-715 - Abstract
A combination of 3 antibacterial drugs (3Mic), ciprofloxacine, metronidazole, and minocycline has been proved to be effective on all kinds of bacteria in oral lesions, and carious lesions after elimination of causative bacteria, can be repaired by host's healing abilities. A total of 285 cases of 110 caries and 175 endodontic cases, consisted of 269 permanent and 16 primary teeth were treated by 3Mix, further mixed with propylene glycol (P) and Macrogol (M), pains on bite (61 cases), abscess (13 cases) and fistulae (11 cases) were eliminated by one-time application of 3Mix-MP therapy in all cases except for 8 cases which need more than 2 times visits easily and quickly in all cases. The results demonstrate that 3Mix-MP therapy would be of great use in dental treatment in Indonesia. Long-term evaluation is in progress.
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- 2015
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11. SİPROFLOKSASİN TAYİNİ İÇİN NANOPARTİKÜL TEMELLİ DUYARLI SPEKTROFOTOMETRİK YÖNTEM GELİŞTİRİLMESİ
- Author
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BALCI, Hakan, ERDOĞAN, Zehra Özden, and ÖZDEMİR, Alperen
- Subjects
Farmakoloji ve Eczacılık ,AgNPs ,ciprofloxacine ,spectrophotometry ,AgNP ,siprofloksasin ,spektrofotometri ,Pharmacology and Pharmacy - Abstract
Objective: Ciprofloxacin is a fluoroquinolone antibiotic used in the fight against many bacterial infections. The aim of this study is to develop a rapid and sensitive method for the spectrophotometric determination of metal nanoparticle-based ciprofloxacin.Material and Method: AgNP was used as metal nanoparticle to develop the method. The localized surface plasmon resonance (LSPR) absorption band of AgNP at 395.5 nm was used for the spectrophotometric determination of ciprofloxacin. In order to determine the optimum pH value of the phosphate buffer solution used in the experimental studies, the changes in the absorbance value of ciprofloxacin-AgNP at different pH values were examined. Changes in AgNP size were detected by DLS measurements.Result and Discussion: In our study, a new spectrophotometric method based on AgNP was developed for the determination of ciprofloxacin in pharmaceutical preparations. The linear working range for the developed method was determined as 0.003-3.313 mg/L in pH 6.0 phosphate buffer and 0.025-2.50 mg/L in pH 8.0 phosphate buffer. In the recovery study performed to determine the amount of ciprofloxacin in the ophthalmic solution, the recovery value was found to be 87±3.3%. In the light of these data, it is thought that the AgNP-based method developed for the determination of ciprofloxacin can be used as an effective analysis method in clinical analysis., Amaç: Siprofloksasin, pek çok bakteriyel enfeksiyon ile savaşta kullanılan bir florokinolon grubu antibiyotiktir. Bu çalışmanın amacı, siprofloksasinin spektrofotometrik tayini için nanopartikül temelli hızlı ve duyarlı bir yöntem geliştirmektir.Gereç ve Yöntem: Yöntem geliştirilmesinde metal nanopartikül olarak AgNP kullanıldı. Siprofloksasinin spektrofotometrik tayininde, AgNP’nin 395.5 nm’deki lokalize yüzey plazmon rezonans (LSPR) absorbsiyon bantı kullanıldı. Deneysel çalışmalarda kullanılan fosfat tampon çözeltisinin optimum pH değerini belirlemek için, farklı pH değerlerindeki siprofloksasin-AgNP’nin absorbans değerindeki değişiklikler incelendi. Dinamik Işın Spektrometresi (DLS) ölçümleri ile AgNP boyutundaki değişiklikler tespit edildi.Sonuç ve Tartışma: Çalışmamızda siprofloksasinin farmasötik preparatlarda tayini için AgNP’ye dayalı yeni bir spektrofotometrik yöntem geliştirildi. Geliştirilen yöntem için doğrusal çalışma aralığı, pH 6.0 fosfat tamponunda 0.003-3.313 mg/L ve pH 8.0 fosfat tamponunda 0.025-2.50 mg/L olarak belirlendi. Oftalmik solüsyondaki siprofloksasin miktarının belirlenmesi için yapılan geri kazanım çalışmasında geri kazanım değeri %87±3.3 olarak bulundu. Bu veriler ışığında, siprofloksasin tayini için geliştirilen AgNP bazlı yöntemin klinik analizlerde etkili bir analiz yöntemi olarak kullanılabileceği düşünülmektedir.
- Published
- 2022
12. FepR as a Central Genetic Target in the Adaptation to Quaternary Ammonium Compounds and Cross-Resistance to Ciprofloxacin in Listeria monocytogenes
- Author
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Pierre-Emmanuel Douarre, Yann Sévellec, Patricia Le Grandois, Christophe Soumet, Arnaud Bridier, Sophie Roussel, Laboratoire de sécurité des aliments de Maisons-Alfort (LSAl), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Laboratoire de Fougères - ANSES, and European Project: 773830, H2020-SFS-2017-1 ,One Health EJP(2018)
- Subjects
Microbiology (medical) ,désinfectant ,Listeria monocytogènes ,gène fepR ,test microbiologique ,benzalkonium chloride ,résistance aux médicaments ,Microbiology ,bactéries ,ciprofloxacine ,ciprofloxacin ,quaternary ammonium compounds ,bacteria ,disinfection ,didecyldimethylammonium chloride ,fepR gene ,drug resistance ,désinfection ,[SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE] ,biocide ,biocide adaptation ,Listeria monocytogenes ,[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology ,chloride de benzalkonium ,microbiologic test ,composés d'ammonium quaternaire ,cross-resistance ,disinfectant - Abstract
The foodborne pathogen, Listeria monocytogenes, (Lm), frequently undergoes selection pressure associated with the extensive use of disinfectants, such as quaternary ammonium compounds, which are widely used in food processing plants. The repeated exposure to sub-inhibitory biocide concentrations can induce increased tolerance to these compounds, but can also trigger the development of antibiotic resistance, and both increase the risk of food contamination and persistence in food production environments. Although the acquisition of genes can explain biocide tolerance, the genetic mechanisms underlying the adaptive cross-resistance to antibiotics remain unclear. We previously showed that repeated exposure to benzalkonium chloride (BC) and didecyldimethyl ammonium chloride (DDAC) led to reduced susceptibility to ciprofloxacin in Lm strains from diverse sources. Here, we compared the genomes of 16 biocide-adapted and 10 parental strains to identify the molecular mechanisms of fluoroquinolone cross-resistance. A core genome SNP analysis identified various mutations in the transcriptional regulator fepR (lmo2088) for 94% of the adapted strains and mutations in other effectors at a lower frequency. FepR is a local repressor of the MATE fluoroquinolone efflux pump FepA. The impact of the mutations on the structure and function of the protein was assessed by performing in silico prediction and protein homology modeling. Our results show that 75% of the missense mutations observed in fepR are located in the HTH domain of the protein, within the DNA interaction site. These mutations are predicted to reduce the activity of the regulator, leading to the overexpression of the efflux pump responsible for the ciprofloxacin-enhanced resistance.
- Published
- 2022
13. Evolution of Bacterial Persistence to Antibiotics during a 50,000-Generation Experiment in an Antibiotic-Free Environment
- Author
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Hugo Mathe-Hubert, Rafika Amia, Mikael Martin, Joel Gaffe, and Dominique Schneider
- Subjects
Microbiology (medical) ,antibiotic persistence ,evolution ,Escherichia coli ,beta-lactam ,ampicillin ,fluoroquinolones ,ciprofloxacine ,Start Growth Time ,bacterial quantification ,Infectious Diseases ,Pharmacology (medical) ,General Pharmacology, Toxicology and Pharmaceutics ,Biochemistry ,Microbiology - Abstract
Failure of antibiotic therapies causes > 700,000 deaths yearly and involves both bacterial resistance and persistence. Persistence results in the relapse of infections by producing a tiny fraction of pathogen survivors that stay dormant during antibiotic exposure. From an evolutionary perspective, persistence is either a ‘bet-hedging strategy’ that helps to cope with stochastically changing environments or an unavoidable minimal rate of ‘cellular errors’ that lock the cells in a low activity state. Here, we analyzed the evolution of persistence over 50,000 bacterial generations in a stable environment by improving a published method that estimates the number of persister cells based on the growth of the reviving population. Our results challenged our understanding of the factors underlying persistence evolution. In one case, we observed a substantial decrease in persistence proportion, suggesting that the naturally observed persistence level is not an unavoidable minimal rate of ‘cellular errors’. However, although there was no obvious environmental stochasticity, in 11 of the 12 investigated populations, the persistence level was maintained during 50,000 bacterial generations.
- Published
- 2022
- Full Text
- View/download PDF
14. Influence de la source lumineuse et de la nature de l'eau sur l'élimination de la ciprofloxacine.
- Author
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Kouadio, Léonce David, Diarra, Moussa, Akessé, Djamatché Paul-Valérie, Aboua, Narcisse Kouassi, Soro, Baba Donafologo, Méité, Ladji, Dembélé, Ardjouma, Mamadou, Koné, and Traoré, Sory Karim
- Abstract
The aim of this work was to study the effect of the light source and the nature of water on the degradation of ciprofloxacin. Thus, the absorption spectrum and the photolysis of this molecule were respectively studied with a double beam spectrophotometer SAFAS 190 DES and a Waters 2695 high pressure liquid chromatograph. Ciprofloxacin has an absorption band of between 200 nm and 400 nm with maximum absorption peaks at 275 nm and 322 nm. The direct photolysis of ciprofloxacin carried out under the exposure of monochromatic (λ = 253.7 nm) and polychromatic (λ> 285 nm) lamps in distilled water, tap and lagoon showed the degradation of this molecule. Ciprofloxacin degrades faster under the monochromatic lamp (Kapp between 0.542.10-3 and 1.667.10-3) than under the polychromatic lamp (Kapp between 0.313.10-3 and 0.576.10-3) which simulates solar radiation. Depending on the nature of the light source, degradation of ciprofloxacin is greater in tap water (Kapp = 1.667.10-3 under LM and 0.576.10-3 under LP) than in distilled water (Kapp = 0.715.10- 3 under LM and 0.313.10-3 under LP) and in lagoon water (Kapp = 0.542.10-3 under LM and 0.319.10-3 under LP). [ABSTRACT FROM AUTHOR]
- Published
- 2017
15. ENHANCEMENT OF SOLAR DRIVEN DEGRADATION OF CIPROFLOXACIN BY PHOTODEPOSITED Ag ONTO ISO-TYPE HOMOJUNCTION BiVO4 SURFACE
- Author
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Popović, Marin, Coha, Rafaela, Ištef, Lukas, Tomičić, Samanta, Sharifi, Tayebeh, Peternel, Igor, Kovačić, Marin, Kraljić Roković, Marijana, Kušić, Hrvoje, Lavrenčič Štangar, Urška, Lončarić Bozić, Ana, Đaković, Marijana, Korać, Petra, Lukić, Aleksandar, Marušić-Paloka, Eduard, Novak, Predrag, Pezelj, Đurđica, Pikelj, Kristina, Smolčić, Vernesa, and Schneider, Petra
- Subjects
BiVO4 ,photodeposition ,solar photocatalysis ,ciprofloxacine ,silver nanoparicles - Abstract
BiVO4 has attracted attention of researchers as one of the promising candidates for visible-light photocatalysis due to its suitable bandgap (≈2.4 eV) and appropriate band structure for the water oxidation. However, the high recombination rate of photo-generated electron-hole pairs as well as short diffusion of charge carries may lead to low photocatalytic efficiency of BiVO4. These limitations may be overcome employing various strategies, including a design of iso-type homojunction, i.e. a junction between two different crystal phases of the same semiconducting material. Such structure can effectively suppress the charge recombination process improving the photocatalytic activity. In this study an iso-type homojunction (monoclinic- tetragonal) BiVO4 material was synthesized and then modified employing photodeposition technique using different amounts of Ag nanoparticles. The as-prepared Ag-BiVO4 has been characterized using SEM, XRD, FTIR, BET, and UV-vis spectra. The impact of Ag nanoparticles on the photoelectrochemical activity of BiVO4 has been systematically evaluated. In addition, electrochemical impedance spectroscopy (EIS) has conducted for the semiconductor/electrolyte interface. The results revealed that the charge transfer resistance decreased under illumination for all as-prepared materials, and Ag-BiVO4 exhibited smaller charge transfer resistance compared to pristine iso-type homojunction BiVO4 material. The photocatalytic activity of as- prepared materials was examined by monitoring the degradation of ciprofloxacin (CIP) as a model organic contaminant under solar irradiation within different pH range (4 to 8) employing Ag-BiVO4 with different Ag content photo-deposited (1 to 15%) and concentration of H2O2 (5 to 30 times the concentration of CIP) and compared to that of pristine iso-type homojunction BiVO4.
- Published
- 2022
16. ENHANCEMENT OF SOLAR DRIVEN DEGRADATION OF CIPROFLOXACIN BY PHOTODEPOSITED AG AND FE ONTO ISO-TYPE HOMOJUNCTION BIVO4 SURFACE
- Author
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Popović, Marin, Sharifi, Tayebeh, Kovačić Marin, Kraljić Roković, Marijana, Kušić Hrvoje, Lavrenčič Štangar, Urška, Lončarić Božić, Ana, Žižek, Krunoslav, Katančić, Zvonimir, and Kovačić, Marin
- Subjects
BiVO4 ,photodeposition ,solar photocatalysis ,ciprofloxacine - Abstract
After synthesis of iso-type homojunction (monoclinic-tetragonal) BiVO4 material, this material was enhanced by photodeposition of silver and iron separately. The newly synthesized materials shown to enhance photocatalytic degradation of ciprofloxacin (CIP), antibiotic from the European commission's Watch list. These enhancements happened due to different effects. Photodepsotion of silver enhanced the degradation of CIP, due to the effects of silver lowering the recombination in the material. Iron compound served as a photo-Fenton reagent which activated the production of hydroxyl radicals from hydrogen peroxide in photocatalytic reaction with H2O2. The goal of this study was to get both enhancements (recombination decrease and photo- Fenton activation of H2O2) in one material for an increase in CIP degradation. For that purpose, we combined the synthesis methods for the best photocatalyst from our previous research to see whether we will get the above mentioned combination of effects. The new materials were categorized by XRD, DRS, and SEM. All the new materials showed better solar light photocatalytic performance in CIP degradation then pristine BiVO4.
- Published
- 2022
17. Étude de l’effet de différents antibiotiques sur l’expression de gènes de virulence sur une collection de souches d’Escherichia coli adhérentes invasives
- Author
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Seddiki, Bouziane, Faculté de Pharmacie - Clermont-Auvergne (FP - UCA), Université Clermont Auvergne (UCA), and Frédéric Robin
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Ciprofloxacine ,Gènes de Virulence ,Rifaximine ,Résistance ,[SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences ,Maladie de Crohn ,Escherichia coli adhérent invasif - Abstract
La maladie de Crohn (MC) est une pathologie inflammatoire de l’intestin qui évolue de manière chronique (MICI) d’étiologie mal connue et dont les conséquences sur la qualité́ de vie des patients sont considérables. La maladie de Crohn (MC) est enjeu majeur de santé publique du fait de l’absence de thérapeutique curative. La muqueuse intestinale de certains patients atteints de la MC est anormalement colonisée par des Escherichia coli adhérents invasifs (AIEC) qui semblent jouer un rôle dans l’évolution de cette pathologie. Au vu de leur implication dans la maladie de Crohn, les AIEC semble être une cible thérapeutique intéressante. Des études préliminaires sur des modèles cellulaires ont mis en évidence un effet de certains antibiotiques sur les capacités d’adhésion, d’invasion et de survie en macrophage des AIEC. Au cours de cette étude, nous avons étudié l’effet de trois antibiotiques, la rifaximine, la ciprofloxacine et la clarithromycine ainsi que deux associations, rifaximine plus ciprofloxacine et rifaximine plus clarithromycine à des doses sub inhibitrices sur le niveau d’expression de différents gènes impliqués potentiellement dans la virulence des AIEC. Nous avons pu confirmer l’activité de ces antibiotiques sur l’expression de ces gènes, mais ce travail doit être poursuivi sur une collection plus importante et à l’aide d’autres stratégies notamment protéomiques. Les résultats obtenus permettront de mieux préciser le rôle des antibiotiques dans la prise en charge des patients colonisés par des souches d’AIEC.
- Published
- 2021
18. Six cases during 2012-2015 and literature review of Chryseobacterium indologenes infections in pediatric patients.
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Aykac, Kubra, Ozsurekci, Yasemin, Tuncer, Ozlem, Sancak, Banu, Cengiz, Ali Bulent, Kara, Ates, and Ceyhan, Mehmet
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- *
BACTERIAL diseases in children , *MULTIDRUG resistance in bacteria , *ANTIBIOTICS , *ARTIFICIAL respiration , *CIPROFLOXACIN , *BACTERIAL disease treatment - Abstract
Chryseobacterium indologenes is a widespread bacteria in the environment, especially hospitals, and a rarely reported human pathogen. The lowest frequency has been reported in children under 5 years of age. Clinical manifestations of C. indologenes include nosocomial pneumoniae, biliary tract infection, peritonitis, surgical wound infection, intravascular catheter-related bacteremia, cellulitis, and primary bacteremia. There is a knowledge gap in the management of C. indologenes infections, especially pertaining children, because of multiple antibiotic resistance and limited data in the literature concerning effective empirical treatment. In the published literature, a total of 16 cases of C. indologenes infections were reported in the pediatric age group. Herein, we present our experience in 6 children with C. indologenes infections. Early and prompt management of C. indologenes infections, particularly in children with mechanic ventilation, with polymicrobial infections, and under the age of 2 years, is of major importance because these factors seem to have a negative effect on the prognosis of infections caused by C. indologenes. Ciprofloxacin and TPM-SMX may be the best therapeutic choices for a combined initial empirical treatment of the patients. [ABSTRACT FROM AUTHOR]
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- 2016
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19. Fabrication of a highly sensitive and selective electrochemical sensor based on chitosan-coated Fe3O4 magnetic nanoparticle for determination of antibiotic ciprofloxacin and its application in biological samples.
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Dehdashtian, Sara, Gholivand, Mohammad Bagher, Shamsipur, Mojtaba, Azadbakht, Azadeh, and Karimi, Ziba
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- *
CIPROFLOXACIN , *ELECTROCHEMICAL sensors , *CHITOSAN , *LINEAR differential equations , *MAGNETIC nanoparticles - Abstract
A simple and sensitive sensor has been developed for the electrochemical determination of ciprofloxacin (CF). The proposed sensor was designed by chitosan-coated Fe3O4 magnetic nanoparticle incorporated in the carbon paste electrode (CPE), which provides remarkably improved sensitivity for the electrochemical determination of CF. The proposed sensor was characterized with scanning electron microscopy and electrochemical impedance spectroscopy. Under optimum conditions, the sensor provides two linear differential pulse voltammetry responses in the range of 0.05-6 μmol/L and 6-75 μmol/L for CF with a detection limit of 0.01 μmol/L. The proposed sensor exhibited high sensitivity and good selectivity and was successfully applied for CF determination in serum and urine samples. [ABSTRACT FROM AUTHOR]
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- 2016
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20. Exposure to Quaternary Ammonium Compounds Selects Resistance to Ciprofloxacin in Listeria monocytogenes
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Alizée, Guérin, Arnaud, Bridier, Patricia, Le Grandois, Yann, Sévellec, Federica, Palma, Benjamin, Félix, Listadapt Study Group, Sophie, Roussel, Christophe, Soumet, Laboratoire de Fougères - ANSES, Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Laboratoire de santé animale, sites de Maisons-Alfort et de Dozulé, European Project: 773830,ListAdapt, European Project: 773830, Laboratoire de santé animale, sites de Maisons-Alfort et de Normandie, European Project: 773830,H2020,H2020-SFS-2017-1 ,ListAdapt (a component of European Joint Programme One Health)(2018), and European Project: 773830, H2020-SFS-2017-1 ,One Health EJP(2018)
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Listéria monocytogènes ,désinfectant ,bacterial adaptation ,fluoroquinolone ,MESH: Listeria monocytogenes ,biocides ,benzalkonium chloride ,Article ,Exposure ,ciprofloxacine ,antibiotique ,résistance aux antimicrobiens ,ciprofloxacin ,antibiotic ,ammonium quaternaire ,antimicrobial resistance ,MIC ,microbiologie ,bactérie ,désinfection ,MESH: Disinfectants ,didecyl dimethylammonium chloride ,biocide ,Listeria monocytogenes ,[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology ,décontamination ,quaternary Ammonium - Abstract
One Health European Joint Programme is acknowledged for the funding of the ListAdapt project and the support of A.G.’s postdoctoral fellowship. Laurent Guillier is acknowledged for his participation in the supervision of the ListAdapt project.; International audience; In this contribution, the antimicrobial susceptibility toward 11 antibiotics and four biocides of a panel of 205 Listeria monocytogenes (Lm) strains isolated from different ecological niches (i.e., food, animals and natural environment) was evaluated. The impact of exposure to biocides on the antibiotic susceptibilities of Lm was also investigated. Lm strains isolated from food exhibited overall a lower susceptibility (higher minimal inhibitory concentrations, MIC) for ammonium quaternary compounds (QACs) and peracetic acid (PAC) than strains isolated from animals and natural environments. Conversely, the ecological origins of Lm strains did not significantly affect their susceptibilities towards antibiotics. Interestingly, repeated exposure to QACs recurrently led to a decrease in susceptibility toward ciprofloxacin (CIP), a fluoroquinolone antibiotic, largely used in human medicine. Moreover, these lower levels of susceptibility to CIP remained stable in most Lm strains even after subcultures without biocide selection pressure, suggesting an adaptation involving modifications at the genetic level. Results underlined the ability of Lm to adapt to biocides, especially QACs, and the potential link between this adaptation and the selection of resistance toward critical antibiotics such as ciprofloxacin. These data support a potential role of the extensive use of QACs from “farm to fork” in the selection of biocide and antibiotic resistance in pathogenic bacteria such as Lm.
- Published
- 2021
21. [Should fluoroquinolones be feared during pregnancy and breastfeeding?]
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Vauzelle C
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- Child, Pregnancy, Humans, Female, Microbial Sensitivity Tests, Levofloxacin therapeutic use, Anti-Bacterial Agents adverse effects, Fear, Fluoroquinolones adverse effects, Breast Feeding
- Abstract
Fluoroquinolones (ciprofloxacin, ofloxacin, levofloxacin and moxifloxacin) are antibiotics which pharmacological and therapeutic advantages resulted in a large use, now restricted because of resistances emergence and adverse effect risk. For pregnant or breastfeeding women they still are a cause of concern, based on the joint toxicity described in children directly treated, thus limiting their use in these populations. However, the data about exposed pregnancies published over time have not so far confirm these fears and allow, when a fluoroquinolone is clearly indicated, not to deprive pregnant patients of the therapeutic benefit of these important antibiotics and to envisage their use whatever the term of the pregnancy, within the current scope of their prescription. During breastfeeding the use of some of them can be considered., (Copyright © 2022 Elsevier Masson SAS. All rights reserved.)
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- 2022
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22. Tendinopathie achilléenne compliquée d´une rupture du tendon d´Achille consécutives à une automédication par la ciprofloxacine chez une hémodialysée: à propos d'un cas
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Kevin Parfait Bienvenu Bouhelo Pam, Gaël Clovis Gassongo Koumou, Tarik Sqalli Houssaini, Abdelmajid El Mrini, and Mohamed Arrayhani
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medicine.medical_specialty ,Side effect ,medicine.medical_treatment ,Population ,Case Report ,rupture of the Achilles tendon ,ciprofloxacine ,ciprofloxacin ,medicine ,rapport de cas ,education ,Tendinopathie achilléenne ,rupture du tendon d´Achille ,about a case ,Achilles tendon ,education.field_of_study ,Achilles tendinopathy ,business.industry ,General Medicine ,effets secondaires ,medicine.disease ,Surgery ,side effects ,medicine.anatomical_structure ,Concomitant ,Secondary hyperparathyroidism ,Hemodialysis ,Tendinopathy ,Complication ,business - Abstract
L´objectif de ce travail était de rappeler aux praticiens cette complication des fluoroquinolones, la tendinopathie. Il s´agit d´un effet secondaire rare mais, qui peut être source de handicap fonctionnel. Une femme de 79 ans, hémodialysée depuis 11 années avait présenté une douleur soudaine de la cheville gauche et une impotence fonctionnelle relative du membre homolatéral au 5ejour d´une automédication par la ciprofloxacine. Elle avait comme comorbidités, une gonarthrose chronique, une hyperparathyroïdie secondaire et une cardiopathie ischémique. Le diagnostic de tendinopathie achilléenne bilatérale et d´une rupture achilléenne gauche étaient retenus sur la base des arguments cliniques, confortés par l´échographie achilléenne. La responsabilité de la ciprofloxacine était évaluée à l´aide de la méthode française d´imputabilité des effets inattendus ou toxiques des médicaments. La prise en charge était chirurgicale suivie d´une rééducation fonctionnelle avec une évolution satisfaisante. La fréquence des tendinopathies liées aux fluoroquinolones varie de 15 à 20 accidents pour 100 000 sujets traités dont un tiers de cas sont compliqués de rupture tendineuse. L´incidence est liée à l´âge, avec un âge de prédilection > 60 ans impliquant le vieillissement tissulaire. La péfloxacine et la ciprofloxacine sont les molécules les plus incriminées. Le délai d´apparition des symptômes noté à cinq jours dans cette observation corrobore avec la littérature. Nous avons retrouvé certains facteurs favorisants connus à savoir: insuffisance rénale chronique, dialyse, corticothérapie, hypolipémiant (statine). La présentation clinique est classique, suffisante pour poser le diagnostic. La localisation est majoritairement achilléenne. Elle est bilatérale dans 40 à 66%. La rupture tendineuse est la principale complication. La prise en charge est chirurgicale. Elle permet de rétablir l´anatomie et de prévenir le handicap fonctionnel préjudiciable. Nous rapportons un effet secondaire rare mais, potentiellement grave, lié aux fluoroquinolones et, qui expose à un handicap fonctionnel. L´âge avancé, l´insuffisance rénale chronique, l´hémodialyse chronique, la prise concomitante de statine et de corticoïde sont des facteurs traditionnels favorisants retrouvés ici. Les hémodialysés constituent une population à risque pour qui une surveillance même à distance d´un traitement à base de ces molécules revêt un intérêt non négligeable.
- Published
- 2021
23. DETERMINING THE QUALITY OF CIPROFLOXACINE IN PHARMACEUTICAL FORMULATIONS (TABLETS, EYE DROPS AND INFUSION SOLUTIONS) USING HPLC METHOD WITH FLUORESCENCE DETECTION.
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Akbari, A. and Heydari, A.
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CIPROFLOXACIN ,DOSAGE forms of drugs ,GENETIC techniques - Published
- 2014
24. Synthesis and Development New 8-Hydroxyquinoline Derivatives for the Treatment of Chlamydia trachomatis Infection
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Vu, Thi Huyen, Interfaces, Traitements, Organisation et Dynamique des Systèmes (ITODYS (UMR_7086)), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Université de Paris, Nawal Serradji, and STAR, ABES
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Spectrophotometry ,Folic acid ,Nanoparticules ,Chlamydia trachomatis ,Spectrophotométrie ,8-hydroxyquinoline ,[CHIM.OTHE] Chemical Sciences/Other ,Ciprofloxacin ,Ciprofloxacine ,8-hydroxyquinoléine ,Iron chelation ,Carbon dots ,Chélateurs de fer ,Acide folique ,[CHIM.OTHE]Chemical Sciences/Other - Abstract
Chlamydia trachomatis, a Gram-negative bacterium, is responsible for both the most common sexually transmitted bacterial infection in the world and trachoma, an important cause of blindness worldwide. No vaccine is available but antibiotics (azithromycine, doxycycline) are recommended by the World Health Organization. However, treatment failure is reported 10-20% of patients and probably results from a lack of sensitivity of persistent forms of bacteria and modest intracellular concentrations of the conventionally prescribed drugs. For this reasons, the aim of my thesis was to propose new tools to fight C. trachomatis infection such as novel 8-hydroxyquinoline derivatives active against this bacterium.In the first part, I synthesised new compounds and evaluated their anti-chlamydia activity as well as their iron-chelating properties. Compound 1 results from the coupling of 8-hydroxyquinoline-2-carboxylic acid and Ciprofloxacin (Cip), a commercially available antibiotic. We wanted to obtain more active derivatives than the parent antibiotic through its metal-chelating properties and its antibiotic effect. Compound 1 presents a higher antichlamydia activity than Cip but this antibacterial effect seems not be linked to its iron-chelating properties. Modifying physicochemical parameters such as lipophilicity, we synthesized several derivatives. We also prepared a folic acid conjugate to enable its delivery to the infected cells through folic acid receptor. All compounds are more potent than Ciprofloxacin, one of them reaching nanomolar potency against C. trachomatis.In the second part, I studied the influence of the carbonyl position on the iron-chelating properties of the 8-hydroxyquinoline heterocycle. For this purpose, we performed a mixed experimental (organic synthesis, spectrophotometry and isothermal titration calorimetry) and theoretical (density-functional theory) study. Two 8-hydroxyquinoline ester-derivatives, at 2-position and 7-position, were synthesized and the corresponding iron-complexes were investigated. We demonstrated that according to the position of the withdrawing group on the heterocyclic skeleton, the steric hindrance can destabilize the iron(III) complex by forcing it to adopt a distorted structure far from the ideal octahedral environment.In the last part, I synthesized and characterized Carbon dots (CDs) from folic acid and Ciprofloxacin as new nano-tools to target the infected cells and inhibit the bacterial growth. Both populations of CDs have a 4-5 nm size, emit in blue light and present an excitation-independent fluorescent behaviour. These nanoparticles are actually under biological investigation., Chlamydia trachomatis, une bactérie à Gram négatif, est responsable, à la fois, de l'infection bactérienne sexuellement transmissible la plus diagnostiquée dans le monde et du trachome, une cause importante de cécité. Aucun vaccin n'est disponible mais deux antibiotiques (Azithromycine, Doxycycline) sont recommandés par l'Organisation Mondiale de la Santé. Toutefois, un échec du traitement est signalé chez 10 à 20% des patients et résulte probablement d'un manque de sensibilité des formes persistantes de la bactérie et des modestes concentrations intracellulaires des médicaments conventionnellement prescrits. Pour ces raisons, l'objectif de ma thèse était de proposer de nouveaux outils de lutte l'infection à C. trachomatis tels que de nouveaux dérivés de la 8-hydroxyquinoléine actifs contre cette bactérie. J'ai, tout d’abord, synthétisé de nouvelles molécules et évalué leur activité anti-chlamydiale ainsi que leurs propriétés chélatantes du fer. Le composé 1 résulte du couplage de l'acide 8-hydroxyquinoléine-2-carboxylique et de la Ciprofloxacine (Cip), un antibiotique actif contre C. trachomatis. Nous voulions obtenir des dérivés plus actifs que l'antibiotique-parent par ses propriétés chélatantes de métaux et son effet antibiotique. Le composé 1 présente effectivement une activité anti-chlamydiale plus élevée que la Cip mais cet effet ne semble pas lié à ses propriétés chélatantes du métal. En modifiant certains paramètres physicochimiques tels que la lipophilie, nous avons synthétisé plusieurs dérivés du composé 1. Nous avons également préparé un conjugué d'acide folique pour permettre sa délivrance aux cellules infectées via le récepteur de ce dernier. Tous les composés obtenus sont plus actifs que la Ciprofloxacine, l'un d'entre eux atteignant une activité au nanomolaire contre la bactérie.Dans la deuxième partie, nous avons étudié l'influence de la position du carbonyle sur les propriétés chélatantes du fer de la 8-hydroxyquinoléine. Pour cela, nous avons effectué une étude mixte expérimentale (synthèse organique, spectrophotométrie et calorimétrie de titrage isotherme) et théorique (théorie de la densité fonctionnelle). Deux dérivés esters de 8-hydroxyquinoléine, en position 2 et position 7, ont été synthétisés et les complexes de fer correspondants ont été étudiés. Nous avons démontré que selon la position du groupe attracteur d’électrons sur le squelette hétérocyclique, l'encombrement stérique peut déstabiliser le complexe de fer (III) en le forçant à adopter une structure déformée, éloignée de l'environnement octaédrique idéal.Dans la dernière partie, j'ai synthétisé et caractérisé des Carbone dots (CDs) d’acide folique et de Ciprofloxacine, comme nouveaux nano-objets pour cibler les cellules infectées et inhiber la croissance bactérienne. Les deux populations de CDs ont une taille de 4 à 5 nm, émettent en lumière bleue et présentent un comportement fluorescent indépendant de l'excitation. L’efficacité antibactérienne de ces nanoparticules est actuellement en cours d’étude.
- Published
- 2020
25. Determinación de residuos de fármacos y sus metabolitos en plantas silvestres. Ensayos de exposición y evaluación de la bioactividad
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Barreales Suárez, Sofía, Institut de Chimie de Nice (ICN), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), COMUE Université Côte d'Azur (2015 - 2019), Universidad de Sevilla (Espagne), Stéphane Azoulay, Miguel Ángel Bello López, Rut María Fernández Torres, and STAR, ABES
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Médicaments ,Diclofénac ,Parc National de Doñana ,Enzimas ,Lipoxygenase ,Collagenase ,Ibuprofen ,Antioxidantes ,Salicornia europaea ,Juncus sp ,Ibuprofeno ,Antioxidants ,Fluméquine ,Ciprofloxacin ,Elastase ,Essais d'exposition ,Metabolites ,Enrofloxacin ,Inhibición enzimática ,Drugs ,Elastasa ,Inhibition enzymatique ,Enzymes ,Lavandula dentata ,Carbamazepine ,Tyrosinase ,Carbamazepina ,Doñana National Park ,[CHIM.ANAL] Chemical Sciences/Analytical chemistry ,Diclofenac ,Ciprofloxacina ,Colagenasa ,Uptake assay ,Enrofloxacina ,Tirosinasa ,Ibuprofène ,Flumequina ,Élastase ,Parque Nacional de Doñana ,Ciprofloxacine ,[CHIM.ANAL]Chemical Sciences/Analytical chemistry ,Enzymatic inhibition ,Principios activos farmacológicos ,Metabolitos ,Lipoxigenasa ,Lipoxygénase ,Collagénase ,Ensayos de exposición ,Antioxydants ,Carbamazépine ,Enrofloxacine ,Diclofenaco ,Métabolites - Abstract
The presence of pharmaceuticals in environmental waters or plant matrices suppose a challenge for environment preservation, which makes necessary to evaluate, monitor and carry out an environmental diagnosis of the areas affected by pollution in order to know the ecosystems damaged by the presence of pollutants and thus evaluate the consequences of these on living beings. For this reason, this Thesis focuses its study on the effects of pollution on the native flora of the Doñana National Park (Spain), providing qualitative and quantitative data on the effect of pharmacologically active substances (such as emerging contaminants) in three plant species in this area, in addition similar studies are virtually nonexistent. This work aims to increase knowledge about the consequences of anthropogenic pressure in the ecosystem of Doñana National Park, simulating at laboratory scale the presence of pharmaceuticals, their degradation compounds and metabolites, in plant matrices from this natural environment. The antioxidant and enzymatic capacity as well as the identification of inhibitory molecules to the enzymes used in this study were evaluated in a collection of 150 selected plants from Doñana. An analytical procedure using high resolution liquid chromatography with detection of mass spectrometry - flight time has been optimized and validated for the identification and quantification of six active pharmacological principles, carbamazepine, flumequine, ciprofloxacin, enrofloxacin, ibuprofen and diclofenac, in extracts from three plant species: Lavandula dentata, Juncus sp. and Salicornia europaea. An uptake study has been carried out, irrigating the selected plants with aqueous solutions containing variable concentrations of the pharmaceuticals. The samples have been analyzed at 7, 15, 21 and 30 days (end of the assay) and the accumulation of the selected substances have been determined. Additionally, non-targeted analytical techniques using appropriate software (MetabolynxTM) have been applied to data from the samples subjected to the uptake study to identify possible metabolites and degradation products and possible metabolic routes involved. Additionally, some methods were optimized to evaluate antioxidant and inhibitory activities, using different enzymes (tyrosinase, elastase, collagenase and lipoxygenase), in the extracts of a selection of 150 plants from the Doñana National Park. For this purpose, the specimens were extracting using solvents of different polarity and extracting capacity: hexane, ethanol, water: ethanol (1:1, v/v) and ethyl acetate. These methods were applied to evaluate the enzymatic inhibition capacity as well as antioxidant capacity of the extracts., Actualmente, la presencia de sustancias farmacológicas en el agua utilizada para el riego o en las matrices de las plantas es un problema para el medioambiente, siendo cada vez, más necesario evaluar, monitorizar y realizar un diagnostico medioambiental de las zonas afectadas por la contaminación para conocer los ecosistemas dañados por la presencia de los contaminantes y así evaluar la consecuencia de estos en los seres vivos. Por lo tanto, esta tesis centra su estudio en los efectos de la contaminación para aumentar el conocimiento de sus consecuencias sobre la flora autóctona del Parque Nacional de Doñana (España), aportanto datos cualitativos y cuantitativos sobre el efecto de las sustancias farmacológicamente activas (consideradas como contaminantes emergentes) sobre tres especies vegetales típicas de esta región. Prácticamente son inexistentes los estudios que simulan a nivel de laboratorio la presencia de principios activos farmacológicos, sus compuestos de degradación y metabolitos en las matrices de las plantas en este medio natural, evaluando también la capacidad antioxidante y enzimática, así como la identificación de las moléculas inhibidoras de las enzimas utilizadas en este estudio en un conjunto de 150 plantas del mencionado entorno protegido. Se ha optimizado y validado un procedimiento analítico mediante cromatografía líquida de alta resolución con detección por espectrometría de masas en tiempo de vuelo para la identificación y cuantificación de seis principios activos farmacológicos, carbamazepina, flumequina, ciprofloxacina, enrofloxacina, ibuprofeno y diclofenaco, en extractos de tres especies de plantas, Lavandula dentata y Juncus sp. y Salicornia europaea, especies presentes en diferentes hábitats del Parque Nacional de Doñana. Se ha dieseñado y llevado a cabo una prueba de exposición, regando las plantas seleccionadas con soluciones acuosas que contenían concentraciones variables de productos farmacéuticos. Las muestras se analizaron a los 7, 15, 21 y 30 días (final de la prueba) y se determinó la acumulación de las sustancias seleccionadas. Asimismo, se aplicaron técnicas analíticas no específicas utilizando programas informáticos adecuados (MetabolynxTM) a los datos de las muestras del estudio de absorción para identificar posibles metabolitos y productos de degradación y las vías metabólicas implicadas. Además, se han optimizado algunos métodos para evaluar las actividades antioxidantes e inhibidoras, utilizando diferentes enzimas (tirosinasa, elastasa, colagenasa y lipoxigenasa), en extractos de una selección de 150 especies de plantas recolectadas y presentes en el Parque Nacional de Doñana, y/o su entorno, las muestras se extrajeron utilizando disolventes de diferente polaridad y capacidad de extracción: hexano, etanol, agua: etanol (1:1, v/v) y acetato de etilo. Estos métodos se aplicaron para evaluar la capacidad de inhibición de las enzimas, así como la capacidad antioxidante de los extractos y en muestras seleccionadas a partir de ensayos de exposición, lo que indica, como era de esperar, el aumento de la capacidad inhibitoria de las enzimas en muestras sometidas a altas concentraciones de soluciones de dopantes. Se ha establecido una relación metabólica entre las posibles moléculas bioactivas de extractos de plantas que no están documentadas en la literatura por su actividad inhibidora de enzimas y los inhibidores conocidos de estas enzimas, lo que explica la existencia de actividad inhibidora., Actuellement, la présence de substances pharmacologiques dans l'eau utilisée pour l'irrigation ou dans les matrices végétales est un problème pour l'environnement. En effet, il est de plus en plus nécessaire d’évaluer, surveiller et faire un diagnostic environnemental des zones affectées par la pollution afin de connaître les écosystèmes endommagés par la présence de polluants et ainsi évaluer les conséquences de ceux-ci sur les êtres vivants. Par conséquent, cette thèse se concentre sur les effets de la pollution afin d'accroître la connaissance de ses conséquences sur la flore indigène du Parc National de Doñana (Espagne), en fournissant des données qualitatives et quantitatives sur l'effet des substances pharmacologiquement actives (considérées comme polluants émergents) chez trois espèces de plantes typiques de cette région. De plus, les études, simulant à l'échelle du laboratoire la présence de principes actifs pharmacologiques, de leurs composés de dégradation et de leurs métabolites dans les matrices végétales de cet environnement naturel, évaluant également la capacité antioxydante et enzymatique ainsi que l'identification des molécules inhibitrices des enzymes utilisées dans cette étude dans une collection de 150 plantes du milieu protégé mentionné précédemment sont pratiquement inexistantes. Une procédure analytique a été optimisée et validée par chromatographie liquide à haute performance avec détection par spectrométrie de masse au temps de vol pour l'identification et la quantification de six principes pharmacologiques actifs, carbamazépine, fluméquine, ciprofloxacine, enrofloxacine, ibuprofène et diclofénac, en extraits de trois espèces végétales, Lavandula dentata et Juncus sp. et Salicornia europaea, espèces présentes dans différents habitats du Parc National de Doñana. Un essai d'exposition a été conçu et réalisé, irriguant les plantes sélectionnées avec des solutions aqueuses contenant des concentrations variables de produits pharmaceutiques. Les échantillons ont été analysés à 7, 15, 21 et 30 jours (fin du test) et l'accumulation des substances sélectionnées a été déterminée. De plus, des techniques d'analyse non ciblées à l'aide d'un logiciel approprié (MetaboLynxTM) ont été appliquées aux données des échantillons soumis à l'étude d'absorption afin d'identifier les métabolites et les produits de dégradation possibles et les voies métaboliques en cause. En outre, certaines méthodes ont été optimisées pour évaluer les activités antioxydantes et inhibitrices, en utilisant différentes enzymes (tyrosinase, élastase, collagénase et lipoxygénase), dans les extraits d'une sélection de 150 espèces végétales collectées et présentes dans le Parc National de Doñana, et/ou leur environnement, les échantillons ont été extraits à l'aide de solvants de polarité et de capacité d'extraction différentes : hexane, éthanol, eau : éthanol (1:1, v/v) et acétate d'éthyle. Ces méthodes ont été appliquées pour évaluer la capacité d'inhibition enzymatique ainsi que la capacité antioxydante des extraits et dans des échantillons choisis parmi les tests d'exposition indiquant comme prévu l'augmentation de la capacité inhibitrice des enzymes dans les échantillons soumis à de fortes concentrations de solutions dopantes. Une relation métabolique a été établie entre les molécules bioactives possibles d'extraits végétaux qui ne sont pas documentées dans la littérature pour leur activité d'inhibition enzymatique et les inhibiteurs connus de ces enzymes, expliquant ainsi l'existence d'une activité inhibitrice.
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- 2019
26. Le devenir et l’élimination de la ciprofloxacine et de ses complexes métalliques dans les stations d’épuration.
- Author
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Cuprys, Agnieszka and Cuprys, Agnieszka
- Abstract
La ciprofloxacine (CIP) est un antibiotique à large spectre appartenant à la famille des fluoroquinolones. Son utilisation fréquente a contribué à sa détection répandue dans l'environnement à de très faibles concentrations. Les processus de traitement actuels de l'usine de traitement des eaux usées (STEP) ne permettent pas d'éliminer efficacement les contaminants à l'état de traces. Les objectifs principaux de cette thèse étaient d’étudier le devenir de la CIP dans l’environnement et au cours du traitement des eaux usées, ainsi que de tester de nouvelles techniques d’enlèvement. Premièrement, la stabilité de cinq complexes de CIP-métal (CIP-Me) a été étudiée. Les ions métalliques visés étaient Al3+, Co2+, Cu2+, Fe3+ et Mg2+ en raison de leur prévalence dans les eaux usées et les boues d’épuration. Les complexes de CIP-Al sont les plus stables, suivis de CIP-Cu et CIP-Co. Les complexes entre CIP et Fe3 + et Mg2 + présentaient les plus grandes variations de la stabilité des complexes. La présence de substances humiques (HS) a diminué la stabilité de tous les complexes. La toxicité des complexes CIP-Me a également été évaluée. Dans l’eau ultrapure, les complexes CIP-Me présentent une toxicité plus élevée vis-à-vis d’Enterobacter aeruginosa à Gram négatif, la toxicité vis-à-vis de Bacillus subtilis à Gram positif étant constante pour les complexes (avec l’exception CIP-Mg) et le CIP seul. La présence de HS réduit l'activité antimicrobienne des complexes CIP-Me d'au moins 2 fois vis-à-vis de E. aeruginosa. Cependant, la toxicité vis-à-vis de B. subtilis est restée pratiquement inchangée. La complexation des antibiotiques avec des ions métalliques peut affecter leur distribution dans la station d’épuration, ce qui n’est généralement pas pris en compte. L'étude analytique a été menée pour évaluer la concentration de CIP, de chlorotétracycline (CTC) et d'autres ions choisis dans la station d'épuration. Plus de 70% des CTC ont été récupérés lors du traitement des eaux usées
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- 2019
27. Optimization of the use of ciprofloxacin
- Author
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Aubert, G., Carricajo, A., Fonsale, N., and Vautrin, A.-C.
- Subjects
- *
CIPROFLOXACIN , *ANTIBIOTICS , *ESCHERICHIA coli , *GENETIC mutation - Abstract
Abstract: Aims: To compare mutant prevention concentration (MPC) of ciprofloxacin and time-killing curve with regards to 11 genotyped Escherichia coli. Method: MICs were determined using the E-test method. Time-killing studies were performed in accordance with the NCCLS guidelines. The genes gyrA, gyrB, parC, parE and marR were amplified by PCR and sequenced. The MPC was defined as the lowest antibiotic concentration preventing the growth of resistant colonies when 1010 CFU/mL were spread on a solid medium. Results: Strains with no genes gyrA, gyrB, parC, parE and marR mutation presented MIC less or equal to 0.023mg/L and MPC less or equal to 0.25mg/L. Strains with two mutations (gyrA and parC) presented MIC equal to 1.5mg/L and MPC equal to 4mg/L. Strains with one mutation (gyrA) presented MIC less or equal to 0.75mg/L, but MPC ranged from 0.5 to 6mg/L depending of the MIC of ciprofloxacin. The time-killing curves for ciprofloxacin showed a bactericidal activity of 0.25mg/L in 1h for strains without mutation, compared with a bactericidal activity of 2 and 4mg/L in 4h for strains with one and two mutations, respectively. Conclusion: For strains of E. coli resistant to nalidixic acid, it was necessary to evaluate the MIC of ciprofloxacin in order to asses the optimal dosage of ciprofloxacin. [Copyright &y& Elsevier]
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- 2009
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28. Achillessehnenruptur unter Fluorochinolonen.
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Bravo, A. Rätz, Stoll, R., Bürr, P., and Haschke, M.
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- *
ACHILLES tendon , *EXERCISE , *QUINOLONE antibacterial agents , *CIPROFLOXACIN , *CHLAMYDIA infections , *ANTIBIOTICS - Abstract
We report the case of a 38-year-old patient with a rupture of the right Achilles tendon after physical exercise. A few days before he had been treated with ciprofloxacine 500 mg bid for chlamydial urethritis. We discuss known risk factors for Achilles tendon ruptures and the possible contribution of ciprofloxacin and fluorquinolones in this case. [ABSTRACT FROM AUTHOR]
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- 2008
- Full Text
- View/download PDF
29. In vitro activity of three different antimicrobial agents against ESBL producing Escherichia coli and Klebsiella pneumoniae blood isolates
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Kizirgil, Ahmet, Demirdag, Kutbettin, Ozden, Mehmet, Bulut, Yasemin, Yakupogullari, Yusuf, and Asci Toraman, Zulal
- Subjects
- *
ANTIBIOTICS , *ESCHERICHIA coli , *DRUG resistance , *ANTI-infective agents - Abstract
Summary: Extended spectrum -lactamases (ESBLs) usually associated with multiple drug resistance, including -lactam and non--lactam antibiotics. This resistance can cause limitation in the choice of drugs appropriate for using in clinical practice, especially in life-threatening infections. In this study we aimed to investigate in vitro activity of meropenem, ciprofloxacine and amikacin against ESBL-producing and non-producing blood isolates of Escherichia coli and Klebsiella pneumoniae strains. Fifty-eight E. coli (21 ESBL-producing, 37 non-ESBL producing) and 99 K. pneumoniae (54 ESBL-producing, 45 non-ESBL producing) strains were included in the study. The presence of ESBL was investigated by double disk synergy test and E-test methods. Antibiotic susceptibility test was done by microdilution method according to NCCLS guideline. In vitro susceptibilities of ESBL producing E. coli and K. pneumoniae strains were found as 100% for meropenem, 33.3% and 25.9% for ciprofloxacine, 94.5% and 83.3% for amikacin. It was observed that; meropenem was equally active agent in both ESBL-producing and non-producing strains, and its activity was not affected by ESBL production. Whereas amikacin activity was minimally affected and ciprofloxacine activity was markedly decreased by ESBL production. In conclusion, meropenem seems to be better choice of antibiotic should be used for ESBL positive life-threatening infections, because of remaining highest activity. [Copyright &y& Elsevier]
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- 2005
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30. Neurological feature of Mediterranean spotted fever: a study of four cases
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Alioua, Z., Bourazza, A., Lamsyah, H., Erragragui, Y., Boudi, O., Karouach, K., Ghfir, M., Mossedaq, R., and Sedrati, O.
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- *
FEVER , *RICKETTSIA , *RICKETTSIAL diseases , *CENTRAL nervous system diseases , *MENINGOENCEPHALITIS , *DISEASES in older people - Abstract
Background. – Rickettsia conorii is the etiologic agent of Mediterranean spotted fever that is endemic in Mediterranean.Exegesis. – We report four cases of serious form of Mediterranean spotted fever with neurological feature. Two of them 56 and 62 years old had meningoencephalitis. Two others had cerebellitis, they are aged 43 and 56. The course has been favourable with ciprofloxacin.Conclusion. – It is a benign well-known illness in spite of apparition of severe visceral complications, which can drag the death in 2.5% of cases. Neurological feature is more frequent and present in 28% of cases. Precocious treatment prevents this unfavourable evolution. [Copyright &y& Elsevier]
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- 2003
- Full Text
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31. Ciprofloxacin Stress Proteome of the Extended-Spectrum β-lactamase Producing Escherichia coli from Slaughtered Pigs
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Gilberto Igrejas, Michel Hébraud, Ingrid Chafsey, Patrícia Poeta, Sónia Ramos, Margarida Sousa, Functional Genomics and Proteomics Unit, Universidade de Trás-os-Montes e Alto Douro, Microbiologie Environnement Digestif Santé (MEDIS), INRA Clermont-Ferrand-Theix-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Department of Veterinary Science, Nippon Veterinary and Life Science University, and Fundacao para a Ciencia e Tecnologia (FCT), POPH QREN Type 4.1-Advanced Training, National Funds of the Ministry of Science and Technology for High Education (MCTES) SFRH/BD/47706/2008 SFRH/BD/87302/2012,FCT/MEC UID/Multi/04378/2013, ERDF POCI-01-0145-FEDER-007728, European Social Fund
- Subjects
0301 basic medicine ,antibiotic resistance ,résistance aux antibiotiques ,Biology ,medicine.disease_cause ,Biochemistry ,ciprofloxacine ,Microbiology ,03 medical and health sciences ,proteomics ,ciprofloxacin ,medicine ,protéomique ,Molecular Biology ,Escherichia coli ,proteomic ,Microbiology and Parasitology ,swine ,biochemical phenomena, metabolism, and nutrition ,abattage ,Microbiologie et Parasitologie ,3. Good health ,Ciprofloxacin ,[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology ,030104 developmental biology ,ESBL ,resistance to antibiotics ,Proteome ,escherichia coli ,porc ,medicine.drug - Abstract
The increasing prevalence of bacteria resistant to even the most current arsenal of antibiot- ics is a serious concern for public health globally. The resistant bacteria which cause human infection are thought to emerge in food and animals. Our goal was to study the proteome of an extended- spectrum -lactamase (ESBL)-producing Escherichia coli , SU03, strain recovered from faecal sam- ples of pigs slaughtered for human consumption. This strain exhibited ciprofloxacin resistance asso- ciated with mutations in type II topoisomerase structural gene GyrA (Ser83Leu + Asp87Asn) and ParC (Ser80Ile). We studied how the proteome of this strain responded to stress by applying double the minimum inhibitory concentration of ciprofloxacin. The hydrolase L-asparaginase was overex- pressed when SU03 was cultured with double the minimum inhibitory concentration of ciproflox- acin. Further research should determine how this enzyme contributes to ciprofloxacin resistance.
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- 2016
32. Exploration de l'adaptation de Pseudomonas aeruginosa en biofilm : rôle dans l'échec des traitements antibiotiques
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Soares, Anaïs, Groupe de Recherche sur l'Adaptation Microbienne (GRAM 2.0), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Université de Caen Normandie (UNICAEN), Normandie Université (NU), Normandie Université, Manuel Étienne, François Caron, and STAR, ABES
- Subjects
Small Colony Variants ,[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology ,Biofilm ,Ciproflaxin ,biochemical phenomena, metabolism, and nutrition ,[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology ,Stringent response ,Persistence ,Réponse stringente ,Ciprofloxacine ,Pseudomonas aeruginosa ,[SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology ,Persistance ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
Biofilm device-related infections can lead to antibiotic failure requiring frequent removal of medical device. Pseudomonas aeruginosa has emerged as the typical pathogen for biofilm infections. To explore the determinants of antibiotic failure in biofilm, an in vitro P. aeruginosa biofilm model exposed to suprainhibitory antibiotic concentrations was developed. In planktonic culture, the ciprofloxacin and amikacin combination prevented the selection of resistant mutants in ciprofloxacin and amikacinlow-level resistant P. aeruginosa strains overexpressing efflux. In biofilm, the ciprofloxacin and amikacin combination, used simultaneously or sequentially, didn’t show superior effects compared to monotherapies. Despite an initial bacterial reduction, biofilm eradication was not obtained. Regardless of wild-type or efflux strains and antibiotic regimen used, antibiotic failure was related to the selection of antibiotic-tolerant cells named “persisters”. Ciprofloxacin induced significant alterations in the biofilm structure, notably a considerable reduction in the exopolysaccharides of the matrix. The transcriptomic analysis of genes, potentially involved in persistence, suggested that early activation of the stringent response might be one of the main pathways for ciprofloxacin tolerance in biofilm. Finally, the emergence of "small colony variants" within the biofilm, characterized by enhanced ability to form biofilm, attested to biofilm heterogeneity. This work therefore contributes to a better understanding of how P. aeruginosa biofilms escape antibiotic., Les infections en biofilm, notamment de dispositifs médicaux, mettent fréquemment en échec les traitements antibiotiques, imposant le retrait du matériel. Pseudomonas aeruginosa s’est imposé comme le pathogène-type des infections en biofilm. Pour explorer les déterminants de l’échec du traitement antibiotique en biofilm, un modèle de biofilm in vitro à P. aeruginosa exposé à des doses supra-inhibitrices d’antibiotiques a été développé. En culture planctonique, une bithérapie deciprofloxacine et d’amikacine permettait de prévenir la sélection de mutants résistants pour des souches de P. aeruginosa de sensibilité diminuée à la ciprofloxacine ou à l’amikacine par surexpression d’efflux. En biofilm, l’association de la ciprofloxacine et de l’amikacine, administrées simultanément ou séquentiellement, n’était pas supérieure aux monothérapies, permettant une réduction bactérienne, mais pas d’éradication complète du biofilm. Quelles que soient les souches (sauvages ou exprimant un efflux) et l’antibiotique, l’échec microbiologique en biofilm était lié à la sélection de cellules persistantes, tolérantes aux antibiotiques. La ciprofloxacine induisait des modifications importantes de la structure du biofilm avec une réduction considérable des exopolysaccharides, composants majeurs de la matrice. L’étude transcriptomique de gènes potentiellement impliqués dans la persistance suggérait que l’activation précoce de la réponse stringente pourrait être une des voies principales de la tolérance en biofilm sous ciprofloxacine. Enfin, la présence de « small colony variants » au sein du biofilm, dotés d’une capacité accrue de formation de biofilm, témoignait de la diversité des populations en biofilm. Ces travaux participent ainsi à une meilleure compréhension des mécanismes d’échappement aux antibiotiques de P. aeruginosa en biofilm.
- Published
- 2019
33. Dégradation du paracétamol et de la ciprofloxacine par des procédés d'oxydation avancés dans des eaux usées
- Author
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González-Labrada, Katia, Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE), and Institut National Polytechnique de Toulouse - INPT (FRANCE)
- Subjects
Ultraviolet radiation ,Paracetamol ,Ultrasons-rayonnement gamma – Rayonnement ultraviolet ,Ciprofloxacine ,Ozonation ,Polluants pharmaceutiques- paracétamol ,Advanced oxidation processes ,Génie chimique ,Pharmaceuticals ,Ciprofloxacin – Wastewaters Procédé d’oxydation avancée-ozonation ,Génie des procédés ,Eaux résiduaires ,Ultrasound-gamma radiation - Abstract
In this work, the feasibility of paracetamol and ciprofloxacin degradation by different advanced oxidation processes (AOPs) was investigated. These molecules are representative of pharmaceutical pollutants found in wastewater. The used processes were the ozonation, the high frequency ultrasound, the gamma radiation and the ultraviolet radiation, alone or in combination with oxidizers and/or catalysts (hydrogen peroxide, Fenton’s reagent and zeolite Fe/MFI). The influence of different operations parameters (pH, oxidant concentration, catalyst concentration, gamma radiation dose and ultrasonic power and frequency) for each processes were studied, in order to determine the optimal operating ranges for the degradation and mineralization of the pharmaceuticals pollutants. Results showed marked synergistic effects by combining individual processes with hydrogen peroxide or Fenton’s reagent, being the most important synergy factors those corresponding to the heterogeneous catalytic ozonation and photo-Fenton processes. Taking into account the energy consumption, the mineralization and the synergy factor, the most effective treatments were radio-Fenton oxidation and photo-Fenton oxidation. Optimal conditions for photo-Fenton oxidation were studied in an open channel reactor at bench scale in tap water and in a real matrix from a municipal wastewater treatment plant. Samples were spiked with a mixture of the pharmaceuticals. In both cases 95% degradation within the first 15 minutes was achieved and its mineralization exceeded 55% in three hours. Ce travail étudie la faisabilité de différents procédés d’oxydation avancée (POAs) pour le traitement d’eaux usées industrielles. Le secteur visé est l’industrie pharmaceutique, les essais ont été menés sur des eaux synthétiques contenant deux molécules modèles: le paracétamol et la ciprofloxacine. Les procédés étudiés dans ce travail sont l’ozonation, la sonochimie, le traitement par radiation gamma et la dégradation par radiation ultraviolet. Ces techniques sont envisagées en mono-traitement ou en combinaison avec des oxydants et/ou des catalyseurs (peroxyde d’hydrogène, réactif de Fenton et zéolite Fe/MFI). Pour chaque procédé, l'influence de différents paramètres opératoires est analysée et interprétée dans l'objectif de déterminer les meilleures conditions pour la conversion et la minéralisation du chaque polluant. Parmi les paramètres étudiés se trouvent le pH, la concentration en oxydant, la concentration du catalyseur, la dose de la radiation gamma, la fréquence et la puissance ultrasonore. Des effets synergiques importants sont trouvés pour l’ozonation catalytique et pour le photo-Fenton par rapport aux procédés seuls. D’un point de vue purement énergétique, les traitements les plus efficaces sont l’oxydation radio- Fenton et l’oxydation photo-Fenton. Sur la base de ces résultats, un photo-réacteur solaire à recirculation est mis en oeuvre pour traiter par oxydation photo-Fenton des solutions synthétiques préparées avec un mélange de paracétamol et de ciprofloxacine dans l’eau du robinet mais aussi avec des eaux usées réelles dopées avec les deux composés. Dans les deux cas, la dégradation des molécules dépasse 95% dans les 15 premières minutes et la minéralisation dépasse 55% en 180 minutes.
- Published
- 2018
34. DRESS syndrome à la ciprofloxacine.
- Author
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Sahnoun, Rym, El Aïdli, Sihem, Zaïem, Ahmed, Lakhoua, Ghozlane, Kastalli, Sarrah, and Daghfous, Riadh
- Abstract
Résumé Le syndrome d’hypersensibilité ou DRESS syndrome ( Drug rash with hypereosinophilia and systemic symptoms ) est un syndrome d’hypersensibilité médicamenteuse grave. Il a été exceptionnellement décrit avec la ciprofloxacine. Nous rapportons une observation médicale d’une patiente âgée de 34 ans ayant développé un DRESS syndrome, 2 jours après la prise de ciprofloxacine pour une infection urinaire. Le tableau clinique a associé une éruption cutanée maculopapuleuse généralisée, une rhabdomyolyse sévère, une cytolyse hépatique, une insuffisance rénale et une hyperéosinophilie. La symptomatologie clinique a complètement régressé après l’arrêt de la ciprofloxacine. L’insuffisance rénale a régressé après un traitement corticoïde. The Drug rash with hypereosinophilia and systemic symptoms (DRESS) syndrome, or hypersensitivity syndrome, is a severe drug-induced hypersensitivity syndrome. It has been exceptionally described with ciprofloxacin. We report a 47-year-old-woman who developed DRESS syndrome, 2 days after taking ciprofloxacin for a urinary infection. She had a generalized maculopapular rash, severe rhabdomyolysis, liver involvement, renal failure and hypereosinophilia. Clinical symptoms had completely resolved after ciprofloxacin withdrawal. Renal failure has decrease after short corticosteroid treatment. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
35. Dépôts cornéens de ciprofloxacine en post chirurgie de cataracte
- Author
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Abdelbarre Oubaaz and Ghita Bouayad
- Subjects
Gynecology ,medicine.medical_specialty ,business.industry ,Pan african ,After cataract ,General Medicine ,Images in Medicine ,ciprofloxacine ,ciprofloxacin ,cornée ,cornea ,Medicine ,Deposits ,Dépôts ,business - Abstract
Nous rapportons le cas d’un patient âge de 62 ans, opere de cataracte de l’œil gauche par phacoemulsification avec suites simples; il a recu en post operatoire un traitement comprenant la ciprofloxacine en collyres. Le patient a ete perdu de vue pendant 2 mois sans arreter le traitement; il se presente avec une opacite para-centrale, blanche, d’allure cristalline, correspondant a un depot corneen de ciprofloxacine. Le collyre antibiotique a ete immediatement suspendu et le patient a beneficie d’un debridement chirurgical tres superficiel, et a ete mis sous agents mouillants a fortes doses, avec cicatrisation complete de l’ulceration en regard du depot corneen, mais il a garde une opacite epitheliale para-pupillaire inferieure ne genant toutefois pas la vision.
- Published
- 2018
36. Comparación entre ciprofloxacina y antibióticos de otros grupos farmacológicos para el tratamiento de infecciones del tracto urinario
- Author
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Arias Porras, José and Arias Porras, José
- Abstract
Introduction. Urinary tract infections are a common reason of consultation in medical practical in ambulatory and emergency rooms in centers of health. The inadequate and irrational use of antibiotics can favor the appearance of resistant bacterial strain and limit the capacity of response of these medicines. This article seeks to review the use of quinolones (specifically ciprofloxacine) with antibiotics of other pharmacological groups and to compare efficiency and bacterial resistance.Method. From the methodology that indicates the clinical practice based on the evidence for the rapid reviews, there was established a clinical question to which response was tried to give by means of the search of primary investigations in electronic databases like MEDLINE, PubMed, Cochrane Library Plus and the Journal of Infection.Result. According to the type of bacterium and analyzed bacterial strain there is presence of resistance to diverse antibiotics. The infections of community origin have been treated by beta-lactamics, nitrofurantoine, trimetoprim-sulfametoxasol and fluoroquinolones (specially ciprofloxacine).Conclusion. It was not possible to determine if the quinolonas are more effective than the antibiotics that belong to other pharmacological groups., Introdução. As infecções do trato urinário são um tema comum nos serviços de consulta externa e emergências dos centros de saúde. O uso inadequado e irracional de antibióticos pode favorecer o aparecimento de cepas resistentes e limitar a capacidade de resposta destes medicamentos. Este artigo busca revisar o uso de quinolonas (especificamente ciprofloxacina) com antibióticos de outros grupos farmacológicos e comparar efetividade e resistência bacteriana.Método. A partir da metodologia que aponta a prática clínica baseada na evidência para as revisões rápidas, se estabeleceu uma pergunta clínica que se procurou responder mediante pesquisas primárias em bases de dados eletrônicas como MEDLINE, PubMed, Cochrane Library Plus e o Journal of Infection.Resultado. Segundo o tipo de bactéria e cepa analisada, há presença de resistência a diversos antibióticos. As infecções de origem comunitária tem sido tratadas com betalactâmicos, nitrofurantoína, trimetoprim-sulfametoxasol e fluoroquinolonas (especialmente ciprofloxacina).Conclusão. Não se determinou se as quinolonas são mais eficazes que os antibióticos que pertencem a outros grupos farmacológicos, Introducción. Las infecciones de tracto urinario son un tema común en los servicios de consulta externa y emergencias de los centros de salud. El uso inadecuado e irracional de antibióticos puede favorecer la aparición de cepas resistentes y limitar la capacidad de respuesta de estos fármacos. Este artículo busca revisar el uso de quinolonas (específicamente ciprofloxacina) con antibióticos de otros grupos farmacológicos y comparar efectividad y resistencia bacteriana.Método. A partir de la metodología que señala la práctica clínica basada en la evidencia para las revisiones rápidas, se estableció una pregunta clínica a la que se le procuró responder mediante la búsqueda de investigaciones primarias en bases de datos electrónicas como MEDLINE, PubMed, Cochrane Library Plus y el Journal of Infection.Resultado. Según el tipo de bacteria y cepa analizada, hay presencia de resistencia a diversos antibióticos. Las infecciones de origen comunitario han sido tratadas con betalactámicos, nitrofurantoína, trimetoprim-sulfametoxasol y fluoroquinolonas (especialmente ciprofloxacina).Conclusión. No se determinó si las quinolonas son más efectivas que los antibióticos que pertenecen a otros grupos farmacológicos
- Published
- 2017
37. TAMiDOpex : Randomized, multi-center, controlled, phase IV clinical trial of single-dose antibiotic for treatment of soldiers' diarrhea during operations overseas
- Author
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Le Dault, Erwan, Aix-Marseille Université - Faculté de médecine (AMU MED), Aix Marseille Université (AMU), and Thierry Coton
- Subjects
Diarrhée ,Ciprofloxacine ,[SDV]Life Sciences [q-bio] ,Opération extérieure ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology ,Militaire - Abstract
Objectif : Evaluer l’efficacité du traitement monodose par ciprofloxacine un gramme au cours de la diarrhée aiguë du militaire français en opération extérieure.Matériel et Méthode : Notre essai thérapeutique de phase IV multicentrique, randomisé, contrôlé se déroulait de mai 2015 à juin 2016 sur les théâtres d'opération extérieure de Bangui, N'Djamena et Gao. Les militaires français présentant au moins une selle liquide depuis moins de 24 heures étaient randomisés en deux bras de traitement : bras symptomatique (racécadotril et des solutés de réhydratation orale); bras antibiotique (traitement symptomatique et ciprofloxacine un gramme monodose). La guérison était évaluée en aveugle à 72 heures.Résultats : 242 patients étaient inclus dans l'analyse per protocole : 124 dans le bras antibiotique, 118 dans le bras symptomatique. La proportion de guérison à 72 heures était respectivement de 94,4% contre 74,6% (OR=5,7; IC95% [2,4-13,6], p
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- 2017
38. TAMiDOpex : Essai phase IV multicentrique contrôlé randomisé du Traitement par Antibiothérapie Minute de la Diarrhée du militaire déployé en Opération extérieure
- Author
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Le Dault, Erwan, Aix-Marseille Université - Faculté de médecine (AMU MED), Aix Marseille Université (AMU), and Thierry Coton
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Diarrhée ,Ciprofloxacine ,[SDV]Life Sciences [q-bio] ,Opération extérieure ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology ,Militaire - Abstract
Objectif : Evaluer l’efficacité du traitement monodose par ciprofloxacine un gramme au cours de la diarrhée aiguë du militaire français en opération extérieure.Matériel et Méthode : Notre essai thérapeutique de phase IV multicentrique, randomisé, contrôlé se déroulait de mai 2015 à juin 2016 sur les théâtres d'opération extérieure de Bangui, N'Djamena et Gao. Les militaires français présentant au moins une selle liquide depuis moins de 24 heures étaient randomisés en deux bras de traitement : bras symptomatique (racécadotril et des solutés de réhydratation orale); bras antibiotique (traitement symptomatique et ciprofloxacine un gramme monodose). La guérison était évaluée en aveugle à 72 heures.Résultats : 242 patients étaient inclus dans l'analyse per protocole : 124 dans le bras antibiotique, 118 dans le bras symptomatique. La proportion de guérison à 72 heures était respectivement de 94,4% contre 74,6% (OR=5,7; IC95% [2,4-13,6], p
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- 2017
39. Subproteomic signature comparison of in vitro selected fluoroquinolone resistance and ciprofloxacin stress in Salmonella Typhimurium DT104B
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Patrícia Poeta, Gilberto Igrejas, Carmen Torres, Manuela Caniça, Ingrid Chafsey, José Luis Capelo, Susana Correia, Christophe Chambon, Didier Viala, Michel Hébraud, department of neurology, clinical dementia center and DZNE, University Medical Centre Goettingen, Microbiologie Environnement Digestif Santé - Clermont Auvergne ( MEDIS ), INRA Clermont-Ferrand-Theix-Université Clermont Auvergne ( UCA ), Qualité des Produits Animaux ( QUAPA ), Institut National de la Recherche Agronomique ( INRA ), Unité Mixte de Recherches sur les Herbivores ( UMR 1213 Herbivores ), VetAgro Sup ( VAS ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Recherche Agronomique ( INRA ), Universidad de La Rioja ( UR ), National Reference Laboratory of Antibiotic Resistances and Healthcare Associated Infections (NRL-AMR-HAI), Department of Infectious Diseases, National Institute of Health Doutor Ricardo Jorge, I.P, UCIBIO-REQUIMTE, Faculty of Science and Technology, Universidade Nova de Lisboa, Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro, Department of Genetics and Biotechnology, Department of Genetics and Biotechnology, Functional Genomics and Proteomics Unit, University of Trás-os-Montes and Alto Douro (Portugal), Veterinary Science Department, Unidade de Ciencias Biomoleculares Aplicadas (UCIBIO), Requimte, Universidade do Porto [Porto]-Departamento de Química (DQ), Faculdade de Ciências e Tecnologia (FCT NOVA), Universidade Nova de Lisboa (NOVA)-Universidade Nova de Lisboa (NOVA)-Faculdade de Ciências e Tecnologia (FCT NOVA), Universidade Nova de Lisboa (NOVA)-Universidade Nova de Lisboa (NOVA)-Universidade do Porto [Porto]-Departamento de Química (DQ), Universidade Nova de Lisboa (NOVA)-Universidade Nova de Lisboa (NOVA), Microbiologie Environnement Digestif Santé - Clermont Auvergne (MEDIS), Université Clermont Auvergne (UCA)-INRA Clermont-Ferrand-Theix, Qualité des Produits Animaux (QuaPA), Institut National de la Recherche Agronomique (INRA), Unité Mixte de Recherches sur les Herbivores - UMR 1213 (UMRH), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Recherche Agronomique (INRA), Área de Bioquímica y Biología Molecular, Universidad de La Rioja (UR), Faculty of Sciences and Technology (FCT NOVA), Universidade Nova de Lisboa (NOVA), Departamento de Química (DQ), Universidade Nova de Lisboa (NOVA)-Universidade Nova de Lisboa (NOVA)-Universidade do Porto [Porto], Faculty of Sciences and Technology, ProteoMass Scientific Society, Universidade do Porto = University of Porto-Departamento de Química (DQ), Faculdade de Ciências e Tecnologia = School of Science & Technology (FCT NOVA), Universidade Nova de Lisboa = NOVA University Lisbon (NOVA)-Universidade Nova de Lisboa = NOVA University Lisbon (NOVA)-Faculdade de Ciências e Tecnologia = School of Science & Technology (FCT NOVA), Universidade Nova de Lisboa = NOVA University Lisbon (NOVA)-Universidade Nova de Lisboa = NOVA University Lisbon (NOVA)-Universidade do Porto = University of Porto-Departamento de Química (DQ), Universidade Nova de Lisboa = NOVA University Lisbon (NOVA)-Universidade Nova de Lisboa = NOVA University Lisbon (NOVA), Microbiologie Environnement Digestif Santé (MEDIS), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Unité Mixte de Recherche sur les Herbivores - UMR 1213 (UMRH), Institut National de la Recherche Agronomique (INRA)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS), Instituto Nacional de Saùde Dr Ricardo Jorge [Portugal] (INSA), Universidade Nova de Lisboa = NOVA University Lisbon (NOVA), Portuguese Foundation for Science and Technology (FCT) SFRH/BD/75160/2010, European Social Fund Ministry of Education and Science (MEC), national funds from FCT/MEC UID/Multi/04378/2013, ERDF under the PT Partnership Agreement POCI-01-0145-FEDER-007728, Universidade Nova de Lisboa = NOVA University Lisbon (NOVA)-Universidade Nova de Lisboa = NOVA University Lisbon (NOVA)-Universidade do Porto-Departamento de Química (DQ), Universidade Nova de Lisboa = NOVA University Lisbon (NOVA)-Universidade Nova de Lisboa = NOVA University Lisbon (NOVA)-Universidade do Porto, INRA Clermont-Ferrand-Theix-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut National de la Recherche Agronomique (INRA)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Universidade do Porto-Departamento de Química (DQ), and Institut National de la Recherche Agronomique (INRA)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement
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0301 basic medicine ,Salmonella ,Proteome ,[SDV]Life Sciences [q-bio] ,[ SDV.AEN ] Life Sciences [q-bio]/Food and Nutrition ,education ,Shotgun Proteomics ,Salmonella Typhimurium DT104B ,Biology ,[ SDV.MP.BAC ] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology ,medicine.disease_cause ,fluoroquinolone ,Biochemistry ,Microbiology ,ciprofloxacine ,03 medical and health sciences ,stress ,Antibiotic resistance ,Stress, Physiological ,ciprofloxacin ,Lc ms ms ,Drug Resistance, Bacterial ,medicine ,antimicrobial resistance ,Selection, Genetic ,LC-MS/MS ,Shotgun proteomics ,Molecular Biology ,ComputingMilieux_MISCELLANEOUS ,Comparative Subproteomics ,[ SDV ] Life Sciences [q-bio] ,Resistência aos Antimicrobianos ,comparative subproteomics ,in vitro ,2-DE ,salmonella Typhimurium DT104B ,In vitro ,Fluoroquinolone resistance ,3. Good health ,Anti-Bacterial Agents ,Ciprofloxacin ,030104 developmental biology ,shotgun proteomics ,Antimicrobial Resistance ,salmonella typhimurium ,medicine.drug ,Fluoroquinolones - Abstract
Background: Fluoroquinolone resistance in nontyphoidal Salmonella is a situation of serious and international concern, particularly in S. Typhimurium DT104B multiresistant strains. Although known to be multifactorial, fluoroquinolone resistance is still far from a complete understanding. Methods: Subproteome changes between an experimentally selected fluoroquinolone-resistant strain (Se6-M) and its parent strain (Se6), and also in Se6-M under ciprofloxacin (CIP) stress, were evaluated in order to give new insights into the mechanisms involved. Proteomes were compared at the intracellular and membrane levels by a 2-DE~LC-MS/MS and a shotgun LC-MS/MS approach, respectively. Results: In total, 35 differentially abundant proteins were identified when comparing Se6 with Se6-M (25 more abundant in Se6 and 10 more abundant in Se6-M) and 82 were identified between Se6-M and Se6-M+CIP (51 more abundant in Se6-M and 31 more abundant under ciprofloxacin stress). Conclusion: Several proteins with known and possible roles in quinolone resistance were identified which provide important information about mechanism-related differential protein expression, supporting the current knowledge and also leading to new testable hypotheses on the mechanism of action of fluoroquinolone drugs. info:eu-repo/semantics/publishedVersion
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- 2017
40. Comparación entre ciprofloxacina y antibióticos de otros grupos farmacológicos para el tratamiento de infecciones del tracto urinario
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José Arias Porras
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medicine.medical_specialty ,Emergency rooms ,resistencia-bacteriana-afármacos ,antibióticoprofilaxia ,medicine.drug_class ,Antibiotics ,quinolonas ,MEDLINE ,Cochrane Library ,infección-urinaria ,antibiotics ,ciprofloxacine ,ciprofloxacina ,Internal medicine ,Medicine ,business.industry ,bacterial-resistance ,urinary-infection ,resistência-bacteriana-amedicamentos ,Bacterial strain ,Surgery ,Clinical Practice ,infecção-urinária ,Clinical question ,quinolones ,business - Abstract
ResumenIntroducción. Las infecciones de tracto urinario son un tema común en los servicios de consulta externa y emergencias de los centros de salud. El uso inadecuado e irracional de antibióticos puede favorecer la aparición de cepas resistentes y limitar la capacidad de respuesta de estos fármacos. Este artículo busca revisar el uso de quinolonas (específicamente ciprofloxacina) con antibióticos de otros grupos farmacológicos y comparar efectividad y resistencia bacteriana.Método. A partir de la metodología que señala la práctica clínica basada en la evidencia para las revisiones rápidas, se estableció una pregunta clínica a la que se le procuró responder mediante la búsqueda de investigaciones primarias en bases de datos electrónicas como MEDLINE, PubMed, Cochrane Library Plus y el Journal of Infection.Resultado. Según el tipo de bacteria y cepa analizada, hay presencia de resistencia a diversos antibióticos. Las infecciones de origen comunitario han sido tratadas con betalactámicos, nitrofurantoína, trimetoprimsulfametoxasol y fluoroquinolonas (especialmente ciprofloxacina).Conclusión. No se determinó si las quinolonas son más efectivas que los antibióticos que pertenecen a otros grupos farmacológicos AbstractIntroduction. Urinary tract infections are a common reason of consultation in medical practical in ambulatory and emergency rooms in centers of health. The inadequate and irrational use of antibiotics can favor the appearance of resistant bacterial strain and limit the capacity of response of these medicines. This article seeks to review the use of quinolones (specifically ciprofloxacine) with antibiotics of other pharmacological groups and to compare efficiency and bacterial resistance.Method.From the methodology that indicates the clinical practice based on the evidence for the rapid reviews, there was established a clinical question to which response was tried to give by means of the search of primary investigations in electronic databases like MEDLINE, PubMed, Cochrane Library Plus and the Journal of Infection.Result. According to the type of bacterium and analyzed bacterial strain there is presence of resistance to diverse antibiotics. The infections of community origin have been treated by beta-lactamics, nitrofurantoine, trimetoprimsulfametoxasol and fluoroquinolones (specially ciprofloxacine).Conclusion. It was not possible to determine if the quinolonas are more effective than the antibiotics that belong to other pharmacological groups. ResumoIntrodução. As infecções do trato urinário são um tema comum nos serviços de consulta externa e emergências dos centros de saúde. O uso inadequado e irracional de antibióticos pode favorecer o aparecimento de cepas resistentes e limitar a capacidade de resposta destes medicamentos. Este artigo busca revisar o uso de quinolonas (especificamente ciprofloxacina) com antibióticos de outros grupos farmacológicos e comparar efetividade e resistência bacteriana.Método. A partir da metodologia que aponta a prática clínica baseada na evidência para as revisões rápidas, se estabeleceu uma pergunta clínica que se procurou responder mediante pesquisas primárias em bases de dados eletrônicas como MEDLINE, PubMed, Cochrane Library Plus e o Journal of Infection.Resultado. Segundo o tipo de bactéria e cepa analisada, há presença de resistência a diversos antibióticos. As infecções de origem comunitária tem sido tratadas com betalactâmicos, nitrofurantoína, trimetoprimsulfametoxasol e fluoroquinolonas (especialmente ciprofloxacina).Conclusão. Não se determinou se as quinolonas são mais eficazes que os antibióticos que pertencem a outros grupos farmacológicos
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- 2017
41. Resistentie-ontwikkeling bij Pseudomonas aeruginosa tegen quinolonen in vitro
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norfloxacine ,vgz ,nalidixinezuur ,ciprofloxacine - Abstract
Een klinisch isolaat van Ps.aeruginosa werd in vitro geselecteerd op concentratiereeksen van twee nieuwe nalidixinezuur-analogen, nl. norfloxacine en ciprofloxacine in agar. De minimaal remmende concentraties (MRC) van de twee quinolonen bedroegen resp. 0,5 en 0,12 ug/ml. Voor beide verbindingen werden na eenmaal selecteren mutanten gevonden met een MRC die 8x zo hoog was als de oorspronkelijke MRC, in een frequentie van ca. 10-8. Deze frequentie komt overeen met vroeger gevonden mutantenfrequenties van nalidixinezuur en cinoxacine. Na tweemaal selecteren werden mutanten gevonden met een MRC van 16 ug/ml norfloxacine resp. 4 ug/ml ciprofloxacine. De conclusie is dat ook bij de nieuwe quinolonen in vitro trapsgewijze resistentie-ontwikkeling kan optreden.
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- 2017
42. Cyclodextrin modified PLLA parietal reinforcement implant with prolonged antibacterial activity
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Bernard Martel, G Vermet, Feng Chai, Pierre-Edouard Danjou, Nicolas Blanchemain, Christel Neut, Claudia Flores, Mickaël Maton, Stephanie Degoutin, Unité Matériaux et Transformations - UMR 8207 (UMET), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Supérieure de Chimie de Lille (ENSCL)-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS), Institut National de la Recherche Agronomique (INRA), Cousin Biotech, Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 (MBLC - ADDS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille, Université de Lille, Centre Hospitalier Universitaire de Lille (CHU de Lille), Lille Inflammation Research International Center - U 995 (LIRIC), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Institut National de la Santé et de la Recherche Médicale (INSERM), Unité de Chimie Environnementale et Interactions sur le Vivant (UCEIV), Université du Littoral Côte d'Opale (ULCO), Centre National de la Recherche Scientifique (CNRS)-Université de Lille-Ecole Nationale Supérieure de Chimie de Lille (ENSCL)-Institut National de la Recherche Agronomique (INRA), Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation, Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Institut National de la Santé et de la Recherche Médicale (INSERM), Lille Inflammation Research International Center (LIRIC), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), UCEIV Unité de Chimie Environnementale et Interactions sur le Vivant, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), and Université du Littoral Côte d’Opale (ULCO)
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[SDV]Life Sciences [q-bio] ,Biocompatible Materials ,Mechanical properties ,02 engineering and technology ,030230 surgery ,Biochemistry ,Visceral mesh ,ciprofloxacine ,Mice ,chemistry.chemical_compound ,Drug Delivery Systems ,0302 clinical medicine ,Polylactic acid ,Materials Testing ,chemistry.chemical_classification ,Cyclodextrin ,Textiles ,General Medicine ,021001 nanoscience & nanotechnology ,Anti-Bacterial Agents ,3. Good health ,Lactic acid ,Polyester ,0210 nano-technology ,Antibacterial activity ,Biotechnology ,Degradation study ,Staphylococcus aureus ,Materials science ,Cell Survival ,Polyesters ,Drug delivery system ,Biomedical Engineering ,Biomaterials ,cyclodextrine ,03 medical and health sciences ,Differential scanning calorimetry ,ciprofloxacin ,Escherichia coli ,Animals ,Humans ,Surgical Wound Infection ,Cellulose ,Molecular Biology ,Herniorrhaphy ,Polypropylene ,Cyclodextrins ,Surgical Mesh ,Cytocompatibility ,chemistry ,cyclodextrin ,Microscopy, Electron, Scanning ,NIH 3T3 Cells ,Surface modification ,Biomedical engineering - Abstract
The use of textile meshes in hernia repair is widespread in visceral surgery. Though, mesh infection is a complication that may prolong the patient recovery period and consequently presents an impact on public health economy. Such concern can be avoided thanks to a local and extended antibiotic release on the operative site. In recent developments, poly- l -lactic acid (PLLA) has been used in complement of polyethyleneterephthalate (Dacron®) (PET) or polypropylene (PP) yarns in the manufacture of semi-resorbable parietal implants. The goal of the present study consisted in assigning drug reservoir properties and prolonged antibacterial effect to a 100% PLLA knit through its functionalization with a cyclodextrin polymer (polyCD) and activation with ciprofloxacin. The study focused i) on the control of degree of polyCD functionalization of the PLLA support and on its physical and biological characterization by Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC) and cell viability, ii) on the understanding of drug/meshes interaction using mathematic model and iii) on the correlation between drug release studies in phosphate buffer saline (PBS) and microbiological evaluation of meshes and release medium against E. coli and S. aureus . All above mentioned tests highlighted the contribution of polyCD on the improved performances of the resulting antibacterial implantable material. Statement of Significance 1. We managed for the first time, with well-defined parameters in terms of temperature and time of treatment, to functionalize a bio-absorbable synthetic material to improve drug sorption and drug release properties without affecting its mechanical properties. 2. We analyzed for the first time the degradation of our coating products by mass spectroscopy to show that only citrate and cyclodextrin residues (and glucose units) without any cytotoxicity are formed. 3. We managed to improve the mechanical properties of the PLA with the cyclodextrin polymer to form a composite. The assembly (cyclodextrin polymer and PLLA) remains biodegradable.
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- 2017
43. Comparative subproteomic analysis of clinically acquired fluoroquinolone resistance and ciprofloxacin stress in Salmonella Typhimurium DT104B
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José Luis Capelo, Susana Correia, Christophe Chambon, Michel Hébraud, Yolanda Sáenz, Gilberto Igrejas, Didier Viala, Ingrid Chafsey, Patrícia Poeta, Functional Genomics and Proteomics Unit, Universidade de Trás-os-Montes e Alto Douro, Department of Genetics and Biotechnology, University of Tras-os-Montes and Alto Douro, Veterinary Science Department, University of Trás-os-Montes and Alto Douro (Portugal), Unidade de Ciencias Biomoleculares Aplicadas (UCIBIO), Requimte, Departamento de Química (DQ), Faculdade de Ciências e Tecnologia (FCT NOVA), Universidade Nova de Lisboa (NOVA)-Universidade Nova de Lisboa (NOVA)-Faculdade de Ciências e Tecnologia (FCT NOVA), Universidade Nova de Lisboa (NOVA)-Universidade Nova de Lisboa (NOVA)-Universidade do Porto [Porto]-Departamento de Química (DQ), Universidade Nova de Lisboa (NOVA)-Universidade Nova de Lisboa (NOVA)-Universidade do Porto [Porto], Microbiologie Environnement Digestif Santé - Clermont Auvergne (MEDIS), Université Clermont Auvergne (UCA)-INRA Clermont-Ferrand-Theix, Qualité des Produits Animaux (QuaPA), Institut National de la Recherche Agronomique (INRA), Unité Mixte de Recherches sur les Herbivores - UMR 1213 (UMRH), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Recherche Agronomique (INRA), Área de Microbiología Molecular, Centro de Investigación Biomédica de La Rioja (CIBIR), Faculty of Sciences and Technology (FCT NOVA), Universidade Nova de Lisboa (NOVA), Portuguese Foundation for Science and Technology (FCT) SFRH/BD/75160/2010, European Social Fund, Ministry of Education and Science (MEC), FCT/MEC UID/Multi/04378/2013, ERDF POCI-01-0145-FEDER-007728, Universidade do Porto = University of Porto-Departamento de Química (DQ), Faculdade de Ciências e Tecnologia = School of Science & Technology (FCT NOVA), Universidade Nova de Lisboa = NOVA University Lisbon (NOVA)-Universidade Nova de Lisboa = NOVA University Lisbon (NOVA)-Faculdade de Ciências e Tecnologia = School of Science & Technology (FCT NOVA), Universidade Nova de Lisboa = NOVA University Lisbon (NOVA)-Universidade Nova de Lisboa = NOVA University Lisbon (NOVA)-Universidade do Porto = University of Porto-Departamento de Química (DQ), Universidade Nova de Lisboa = NOVA University Lisbon (NOVA)-Universidade Nova de Lisboa = NOVA University Lisbon (NOVA), Microbiologie Environnement Digestif Santé (MEDIS), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Unité Mixte de Recherche sur les Herbivores - UMR 1213 (UMRH), Institut National de la Recherche Agronomique (INRA)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS), Universidade Nova de Lisboa = NOVA University Lisbon (NOVA), department of neurology, clinical dementia center and DZNE, University Medical Centre Goettingen, Microbiologie Environnement Digestif Santé - Clermont Auvergne ( MEDIS ), Université Clermont Auvergne ( UCA ) -INRA Clermont-Ferrand-Theix, Qualité des Produits Animaux ( QUAPA ), Institut National de la Recherche Agronomique ( INRA ), Unité Mixte de Recherches sur les Herbivores ( UMR 1213 Herbivores ), VetAgro Sup ( VAS ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Recherche Agronomique ( INRA ), Centro de Investigación Biomédica de La Rioja, UCIBIO-REQUIMTE, Faculty of Science and Technology, Universidade Nova de Lisboa, Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro, Universidade do Porto [Porto]-Departamento de Química (DQ), Universidade Nova de Lisboa (NOVA)-Universidade Nova de Lisboa (NOVA), INRA Clermont-Ferrand-Theix-Université Clermont Auvergne ( UCA ), Faculty of Sciences and Technology, Universidade Nova de Lisboa ( UNINOVA ), Universidade do Porto-Departamento de Química (DQ), Universidade Nova de Lisboa = NOVA University Lisbon (NOVA)-Universidade Nova de Lisboa = NOVA University Lisbon (NOVA)-Universidade do Porto-Departamento de Química (DQ), INRA Clermont-Ferrand-Theix-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Institut National de la Recherche Agronomique (INRA)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Universidade Nova de Lisboa = NOVA University Lisbon (NOVA)-Universidade Nova de Lisboa = NOVA University Lisbon (NOVA)-Universidade do Porto, and VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut National de la Recherche Agronomique (INRA)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement
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0301 basic medicine ,Serotype ,Salmonella ,fluoroquinolone resistance ,salmonella typhimurium DT104B ,[ SDV.AEN ] Life Sciences [q-bio]/Food and Nutrition ,[SDV]Life Sciences [q-bio] ,Clinical Biochemistry ,[ SDV.MP.BAC ] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology ,medicine.disease_cause ,fluoroquinolone ,Microbiology ,ciprofloxacine ,03 medical and health sciences ,Antibiotic resistance ,Stress, Physiological ,ciprofloxacin ,Drug Resistance, Bacterial ,medicine ,Humans ,antimicrobial resistance ,ciprofloxacin stress ,ComputingMilieux_MISCELLANEOUS ,résistance antimicrobienne ,biology ,Strain (chemistry) ,[ SDV ] Life Sciences [q-bio] ,comparative subproteomics ,biology.organism_classification ,3. Good health ,Ciprofloxacin ,030104 developmental biology ,Mechanism of action ,Salmonella enterica ,Proteome ,medicine.symptom ,salmonella typhimurium ,medicine.drug - Abstract
PURPOSE Antimicrobial resistance is a worldwide public health threat and Salmonella enterica subsp. enterica serotype Typhimurium phage type DT104B multiresistant strains with additional quinolone resistance have been responsible for global outbreaks and high mortality. Quinolone resistance is known to be multifactorial but is still far from a complete understanding. To give new insights about the resistance mechanisms involved, this work aimed to evaluate subproteome changes between an S. Typhimurium DT104B clinical strain that acquired fluoroquinolone resistance after treatment (Se20) and its pretreatment parental strain (Se6), and also subproteome variations in Se20 under ciprofloxacin (CIP) stress (Se20+CIP). EXPERIMENTAL DESIGN The proteomes were compared at the intracellular and membrane levels by a 2-DE∼LC-MS/MS and a shotgun LC-MS/MS approach, respectively. RESULTS In total, 14 differentially abundant proteins were identified when comparing Se6 with Se20 and 91 were identified between Se20 and Se20+CIP. Several proteins with known and possible roles in quinolone resistance (AAC(6')-Ib-cr4, OmpD, OmpX, GlmS, GlmU, H-NS, etc.) were identified and discussed. CONCLUSIONS AND CLINICAL RELEVANCE The great number of proteins identified in this study provides important information about mechanism-related differential protein expression which supports the current knowledge and might lead to new testable hypotheses on the mechanism of action of fluoroquinolone drugs.
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- 2017
44. Comparative subproteomic analysis of experimentally induced fluoroquinolone resistance and ciprofloxacin stress in Salmonella Typhimurium DT104B
- Author
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Correia, Susana, Hébraud, Michel, Chafsey, Ingrid, Chambon, Christophe, Viala, Didier, Torres, Carmen, Caniça, Manuela, Capelo, José-Luis, Poeta, Patricia, Igrejas, Gilberto, Functional Genomics and Proteomics Unit, Universidade de Trás-os-Montes e Alto Douro, UCIBIO-REQUIMTE, Faculty of Science and Technology, Universidade de Lisboa = University of Lisbon (ULISBOA), Microbiologie Environnement Digestif Santé (MEDIS), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Qualité des Produits Animaux (QuaPA), Institut National de la Recherche Agronomique (INRA), Unité Mixte de Recherche sur les Herbivores - UMR 1213 (UMRH), Institut National de la Recherche Agronomique (INRA)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS), Universidad de La Rioja (UR), Instituto Nacional de Saùde Dr Ricardo Jorge [Portugal] (INSA), Universidade Nova de Lisboa = NOVA University Lisbon (NOVA), Veterinary Science Department, University of Trás-os-Montes and Alto Douro (Portugal), Department of Genetics and Biotechnology, Universidade de Lisboa (ULISBOA), INRA Clermont-Ferrand-Theix-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut National de la Recherche Agronomique (INRA)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, and Institut National de la Recherche Agronomique (INRA)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement
- Subjects
résistance antimicrobienne ,stress ,[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology ,Microbiology and Parasitology ,salmonella typhimurium ,fluoroquinolone ,ComputingMilieux_MISCELLANEOUS ,Microbiologie et Parasitologie ,ciprofloxacine - Abstract
International audience
- Published
- 2017
45. Francisella tularensis meningitis
- Author
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Contentin, L., Soret, J., Zamfir, O., Gontier, O., Lherm, T., Hamrouni, M., Ouchenir, A., Monchamps, G., and Kalfon, P.
- Published
- 2011
- Full Text
- View/download PDF
46. Comparación entre ciprofloxacina y antibióticos de otros grupos farmacológicos para el tratamiento de infecciones del tracto urinario
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Arias Porras, José
- Subjects
infecção-urinária ,antibióticoprofilaxia ,ciprofloxacina ,bacterial-resistance ,resistência-bacteriana-a-medicamentos ,urinary-infection ,quinolonas ,quinolones ,resistencia-bacteriana-a-fármacos ,antibiotics ,infección-urinaria ,ciprofloxacine - Abstract
Introduction. Urinary tract infections are a common reason of consultation in medical practical in ambulatory and emergency rooms in centers of health. The inadequate and irrational use of antibiotics can favor the appearance of resistant bacterial strain and limit the capacity of response of these medicines. This article seeks to review the use of quinolones (specifically ciprofloxacine) with antibiotics of other pharmacological groups and to compare efficiency and bacterial resistance.Method. From the methodology that indicates the clinical practice based on the evidence for the rapid reviews, there was established a clinical question to which response was tried to give by means of the search of primary investigations in electronic databases like MEDLINE, PubMed, Cochrane Library Plus and the Journal of Infection.Result. According to the type of bacterium and analyzed bacterial strain there is presence of resistance to diverse antibiotics. The infections of community origin have been treated by beta-lactamics, nitrofurantoine, trimetoprim-sulfametoxasol and fluoroquinolones (specially ciprofloxacine).Conclusion. It was not possible to determine if the quinolonas are more effective than the antibiotics that belong to other pharmacological groups. Introducción. Las infecciones de tracto urinario son un tema común en los servicios de consulta externa y emergencias de los centros de salud. El uso inadecuado e irracional de antibióticos puede favorecer la aparición de cepas resistentes y limitar la capacidad de respuesta de estos fármacos. Este artículo busca revisar el uso de quinolonas (específicamente ciprofloxacina) con antibióticos de otros grupos farmacológicos y comparar efectividad y resistencia bacteriana.Método. A partir de la metodología que señala la práctica clínica basada en la evidencia para las revisiones rápidas, se estableció una pregunta clínica a la que se le procuró responder mediante la búsqueda de investigaciones primarias en bases de datos electrónicas como MEDLINE, PubMed, Cochrane Library Plus y el Journal of Infection.Resultado. Según el tipo de bacteria y cepa analizada, hay presencia de resistencia a diversos antibióticos. Las infecciones de origen comunitario han sido tratadas con betalactámicos, nitrofurantoína, trimetoprim-sulfametoxasol y fluoroquinolonas (especialmente ciprofloxacina).Conclusión. No se determinó si las quinolonas son más efectivas que los antibióticos que pertenecen a otros grupos farmacológicos Introdução. As infecções do trato urinário são um tema comum nos serviços de consulta externa e emergências dos centros de saúde. O uso inadequado e irracional de antibióticos pode favorecer o aparecimento de cepas resistentes e limitar a capacidade de resposta destes medicamentos. Este artigo busca revisar o uso de quinolonas (especificamente ciprofloxacina) com antibióticos de outros grupos farmacológicos e comparar efetividade e resistência bacteriana.Método. A partir da metodologia que aponta a prática clínica baseada na evidência para as revisões rápidas, se estabeleceu uma pergunta clínica que se procurou responder mediante pesquisas primárias em bases de dados eletrônicas como MEDLINE, PubMed, Cochrane Library Plus e o Journal of Infection.Resultado. Segundo o tipo de bactéria e cepa analisada, há presença de resistência a diversos antibióticos. As infecções de origem comunitária tem sido tratadas com betalactâmicos, nitrofurantoína, trimetoprim-sulfametoxasol e fluoroquinolonas (especialmente ciprofloxacina).Conclusão. Não se determinou se as quinolonas são mais eficazes que os antibióticos que pertencem a outros grupos farmacológicos
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- 2016
47. Dépôts cornéens de ciprofloxacine en post chirurgie de cataracte.
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Bouayad, Ghita and Oubaaz, Abdelbarre
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EYE drops , *CATARACT surgery , *WETTING agents , *POSTOPERATIVE period , *PHACOEMULSIFICATION , *DEBRIDEMENT , *VISION disorders - Abstract
We here report the case of a 62-year old patient who had undergone left eye phacoemulsification cataract surgery with good outcome. In the postoperative period he had received treatment with ciprofloxacin ophthalmic (eye drops). The patient had been lost to follow-up for 2 months. He hadn't stopped therapy during these months. He presented with paracentral white crystalline opacity, corresponding to corneal deposit of ciprofloxacin. The therapy with antibiotic eye drops was immediately suspended. The patient underwent very superficial surgical debridement and received wetting agents at high doses with complete ulcer healing at the level of the corneal deposit. However he continued to have epithelial inferior parapupillary opacity without visual impairment. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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48. Infectieuze complicaties en antibiotische profylaxe bij transrectale echogeleide prostaatbiopsie
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Vlek, A.L.M., Ruiter, A.E.C., Vijverberg, P.L.M., and Kaan, J.A.
- Published
- 2014
- Full Text
- View/download PDF
49. Persistence of fluoroquinolones and ciprofloxacin resistant Enterobacteriacae in soil after poultry manure application
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Dabert, P., Pourcher, A.M., Jadas Hécart, A., Cotinet, P., Ziebal, C., Le Roux, S., Moraru, R., Kempf, Isabelle, Optimisation des procédés en Agriculture, Agroalimentaire et Environnement (UR OPAALE), Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Littoral, Environnement, Télédétection, Géomatique UMR 6554 (LETG), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Université d'Angers (UA)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Brest (UBO)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Géographie et d'Aménagement Régional de l'Université de Nantes (IGARUN), Université de Nantes (UN)-Université de Nantes (UN), Chambre Régionale d'Agriculture de Bretagne, UNIVERSITATEA DE STIINTE AGRICOLES IASI ROM, Partenaires IRSTEA, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), and Irstea Publications, Migration
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[SDE] Environmental Sciences ,CIPROFLOXACINE ,FLUOROQUINOLONE ,[SDE]Environmental Sciences - Abstract
International audience; This study aimed to evaluate the persistence (i) of two fluoroquinolones, enrofloxacin (ENR) and ciprofloxacin (CIP), and (ii) of CIP-resistant Enterobacteriaceae in soil after poultry manure application. The amounts of ENR and CIP in soil did not significantly change over the 48 day- experimental period. CIP (≤ 30 μg kg-1) was detected in weaker concentrations than ENR (20 to 250 μg kg-1 of soil). The concentration of Enterobacteriaceae (102-103 CFU g-1) did not significantly decrease until Day 36. A total of 145 isolates were identified as belonging to E. coli and to 6 genera. The ciprofloxacin MIC of E. coli reached 32 mg L-1 whereas the other strains of Enterobacteriaceae had a MIC ≤ 0.25 mg L-1. The 71 strains of E. coli were classified in 12 ERIC-PCR genotypes. One genotype, corresponding to a resistant strain, was detected until Day 89. This study showed that enrofloxacin and CIP-resistant E. coli persisted at least 48 and 89 days, respectively, in soil. However, their presence did not increase the MIC of Enterobacteriaceae originating from soil.
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- 2015
50. Prévalence de la résistance aux antibiotiques dans la flore digestive de chiens en consultation à l’Ecole nationale vétérinaire de Toulouse
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Feuillastre, Caroline and Ecole Nationale Vétérinaire de Toulouse - ENVT (FRANCE)
- Subjects
Médecine vétérinaire et santé animal ,Fluoroquinolone ,Ciprofloxacine ,Flore digestive ,Céfotaxime ,Céphalosporines ,Chien ,Antibiorésistance ,Entérobactéries - Abstract
La sélection de bactéries résistantes aux antibiotiques dans la flore digestive des animaux domestiques peut contribuer à l’émergence de résistances chez l’Homme notamment par l’intermédiaire des contacts entre les animaux de compagnie et leurs propriétaires. L’objectif de cette thèse était d’évaluer la prévalence de la résistance aux antibiotiques dans la flore digestive de chiens venant en consultation à l’Ecole nationale vétérinaire de Toulouse. Des prélèvements de matières fécales ont été réalisés par écouvillonnage et déposés sur milieu de culture. La sensibilité des colonies d’enterobactéries ainsi obtenues a été testée vis-à-vis de quatre antibiotiques : deux quinolones, acide nalidixique et ciprofloxacine, et deux bêta-lactamines, amoxicilline et céfotaxime. Les résultats obtenus ont montré des pourcentages élevés de résistance aux quatre antibiotiques mais n’ont pas mis en évidence d’effet du sexe, du poids, du régime alimentaire ou de l’âge.
- Published
- 2015
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