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2 results on '"aryl-keto α-amino acid"'

1. Utilization of Acidic α-Amino Acids as Acyl Donors: An Effective Stereo-Controllable Synthesis of Aryl-Keto α-Amino Acids and Their Derivatives

Author

Lei Wang, Yuta Murai, Takuma Yoshida, Masashi Okamoto, Zetryana Puteri Tachrim, Yasuyuki Hashidoko, and Makoto Hashimoto

Subjects
aryl-keto α-amino acid, Friedel-Crafts acylation, Lewis acid, triflic acid, Organic chemistry, QD241-441
Abstract

Aryl-keto-containing α-amino acids are of great importance in organic chemistry and biochemistry. They are valuable intermediates for the construction of hydroxyl α-amino acids, nonproteinogenic α-amino acids, as well as other biofunctional components. Friedel-Crafts acylation is an effective method to prepare aryl-keto derivatives. In this review, we summarize the preparation of aryl-keto containing α-amino acids by Friedel-Crafts acylation using acidic α-amino acids as acyl-donors and Lewis acids or Brönsted acids as catalysts.

Published
2014
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2. Utilization of Acidic α-Amino Acids as Acyl Donors: An Effective Stereo-Controllable Synthesis of Aryl-Keto α-Amino Acids and Their Derivatives

Author

Takuma Yoshida, Lei Wang, Zetryana Puteri Tachrim, Yuta Murai, Masashi Okamoto, Makoto Hashimoto, and Yasuyuki Hashidoko

Subjects
Acylation, Amino Acids, Acidic, Pharmaceutical Science, Review, Catalysis, Friedel-Crafts acylation, Analytical Chemistry, lcsh:QD241-441, chemistry.chemical_compound, lcsh:Organic chemistry, Drug Discovery, Organic chemistry, Lewis acids and bases, Physical and Theoretical Chemistry, Friedel–Crafts reaction, aryl-keto α-amino acid, Lewis Acids, chemistry.chemical_classification, Mesylates, triflic acid, Aryl, Organic Chemistry, Lewis acid, Amino acid, chemistry, Chemistry (miscellaneous), Molecular Medicine, lipids (amino acids, peptides, and proteins), Brønsted–Lowry acid–base theory, Triflic acid
Abstract

Aryl-keto-containing α-amino acids are of great importance in organic chemistry and biochemistry. They are valuable intermediates for the construction of hydroxyl α-amino acids, nonproteinogenic α-amino acids, as well as other biofunctional components. Friedel-Crafts acylation is an effective method to prepare aryl-keto derivatives. In this review, we summarize the preparation of aryl-keto containing α-amino acids by Friedel-Crafts acylation using acidic α-amino acids as acyl-donors and Lewis acids or Brönsted acids as catalysts.

Published
2014

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