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Utilization of Acidic α-Amino Acids as Acyl Donors: An Effective Stereo-Controllable Synthesis of Aryl-Keto α-Amino Acids and Their Derivatives
- Source :
- Molecules, Molecules, Vol 19, Iss 5, Pp 6349-6367 (2014)
- Publication Year :
- 2014
- Publisher :
- MDPI, 2014.
-
Abstract
- Aryl-keto-containing α-amino acids are of great importance in organic chemistry and biochemistry. They are valuable intermediates for the construction of hydroxyl α-amino acids, nonproteinogenic α-amino acids, as well as other biofunctional components. Friedel-Crafts acylation is an effective method to prepare aryl-keto derivatives. In this review, we summarize the preparation of aryl-keto containing α-amino acids by Friedel-Crafts acylation using acidic α-amino acids as acyl-donors and Lewis acids or Brönsted acids as catalysts.
- Subjects :
- Acylation
Amino Acids, Acidic
Pharmaceutical Science
Review
Catalysis
Friedel-Crafts acylation
Analytical Chemistry
lcsh:QD241-441
chemistry.chemical_compound
lcsh:Organic chemistry
Drug Discovery
Organic chemistry
Lewis acids and bases
Physical and Theoretical Chemistry
Friedel–Crafts reaction
aryl-keto α-amino acid
Lewis Acids
chemistry.chemical_classification
Mesylates
triflic acid
Aryl
Organic Chemistry
Lewis acid
Amino acid
chemistry
Chemistry (miscellaneous)
Molecular Medicine
lipids (amino acids, peptides, and proteins)
Brønsted–Lowry acid–base theory
Triflic acid
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 19
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....7da7e35d231f1bf39e0b4ee7f2a86b15