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Early life adversity (ELA)- including childhood physical, emotional, and sexual abuse, as well as childhood neglect- is an important predictive factor for negative psychopathology, including Major Depressive Disorder (MDD). ELA can epigenetically regulate key emotional and behavioral systems in ways that can stably persist into adulthood and contribute to the development of MDD and other psychopathology. DNA methylation has been one of the most investigated forms of epigenetic regulation in ELA to MDD pathway. From these studies, genes and sites associated with ELA/MDD have been identified and should be further investigated in order to identify potential avenues for intervention.

Early life adversity (ELA)- including childhood physical, emotional, and sexual abuse, as well as childhood neglect- is an important predictive factor for negative psychopathology, including Major Depressive Disorder (MDD). ELA can epigenetically regulate key emotional and behavioral systems in ways that can stably persist into adulthood and contribute to the development of MDD and other psychopathology. DNA methylation has been one of the most investigated forms of epigenetic regulation in ELA to MDD pathway. From these studies, genes and sites associated with ELA/MDD have been identified and should be further investigated in order to identify potential avenues for intervention. [ABSTRACT FROM AUTHOR]

In major depressive disorder (MDD), not only the pathophysiology of this disease is unknown but also the mechanisms of clinical efficacy across its therapeutic strategies are unclear. Although neuroimaging studies adopted activation likelihood estimation (ALE) approach to identify the convergent abnormalities of human brain in the MDD patients, the common alterations after antidepressant therapies were not summarized. Thus, we extracted the coordinates of brain regions in the MDD patients that showed differences in resting-state function, gray matter morphometry, and task-evoked neuronal responses after therapies. The ALE algorithm (GingerALE2.0.3) was employed in all 53 studies (64 experiments with 1406 MDD patients). Consistent results across treatment therapies were reported in the affective control network, including the bilateral thalamus, bilateral amygdala/parahippocampal gyrus, right anterior cingulate cortex/middle frontal gyrus, and right insular cortex/claustrum. Only electroconvulsive therapy partially replicated above findings. Our results indicate the antidepressant therapies efficiently influence core structures of the affective control network, which might be the underlying mechanism of remission in depression and provides potential targets for further treatment strategies. • Conjunctions of brain alterations after antidepressant treatments are unknown. • Affective control network in brain was significantly convergent across treatments. • Only electroconvulsive therapy constantly activated the emotional-related regions. [ABSTRACT FROM AUTHOR]