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Bridging Basic and Clinical Research in Early Life Adversity, DNA Methylation, and Major Depressive Disorder
- Source :
- Frontiers in Genetics, Vol 10 (2019), Frontiers in Genetics
- Publication Year :
- 2019
- Publisher :
- Frontiers Media S.A., 2019.
-
Abstract
- Early life adversity (ELA)- including childhood physical, emotional, and sexual abuse, as well as childhood neglect- is an important predictive factor for negative psychopathology, including Major Depressive Disorder (MDD). ELA can epigenetically regulate key emotional and behavioral systems in ways that can stably persist into adulthood and contribute to the development of MDD and other psychopathology. DNA methylation has been one of the most investigated forms of epigenetic regulation in ELA to MDD pathway. From these studies, genes and sites associated with ELA/MDD have been identified and should be further investigated in order to identify potential avenues for intervention.
- Subjects :
- 0301 basic medicine
antidepressant therapies
lcsh:QH426-470
Review
behavioral disciplines and activities
03 medical and health sciences
0302 clinical medicine
Intervention (counseling)
mental disorders
medicine
Genetics
Epigenetics
Genetics (clinical)
early life adversity
DNA methylation
epigenetics
major depressive disorder
business.industry
biomarkers
medicine.disease
Early life
lcsh:Genetics
030104 developmental biology
Clinical research
Sexual abuse
030220 oncology & carcinogenesis
Molecular Medicine
Major depressive disorder
business
Psychopathology
Clinical psychology
Subjects
Details
- Language :
- English
- ISSN :
- 16648021
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Frontiers in Genetics
- Accession number :
- edsair.doi.dedup.....2510fbb25539c23df8e037630ee7579f