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32 results on '"Zollman, Paula"'

1. Data from Phase I Trial of Intraperitoneal Administration of an Oncolytic Measles Virus Strain Engineered to Express Carcinoembryonic Antigen for Recurrent Ovarian Cancer

Author

Galanis, Evanthia, primary, Hartmann, Lynn C., primary, Cliby, William A., primary, Long, Harry J., primary, Peethambaram, Prema P., primary, Barrette, Brigitte A., primary, Kaur, Judith S., primary, Haluska, Paul J., primary, Aderca, Ileana, primary, Zollman, Paula J., primary, Sloan, Jeff A., primary, Keeney, Gary, primary, Atherton, Pamela J., primary, Podratz, Karl C., primary, Dowdy, Sean C., primary, Stanhope, C. Robert, primary, Wilson, Timothy O., primary, Federspiel, Mark J., primary, Peng, Kah-Whye, primary, and Russell, Stephen J., primary

Published
2023
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2. Supplementary Figure 2 from Phase I Trial of Intraperitoneal Administration of an Oncolytic Measles Virus Strain Engineered to Express Carcinoembryonic Antigen for Recurrent Ovarian Cancer

Author

Galanis, Evanthia, primary, Hartmann, Lynn C., primary, Cliby, William A., primary, Long, Harry J., primary, Peethambaram, Prema P., primary, Barrette, Brigitte A., primary, Kaur, Judith S., primary, Haluska, Paul J., primary, Aderca, Ileana, primary, Zollman, Paula J., primary, Sloan, Jeff A., primary, Keeney, Gary, primary, Atherton, Pamela J., primary, Podratz, Karl C., primary, Dowdy, Sean C., primary, Stanhope, C. Robert, primary, Wilson, Timothy O., primary, Federspiel, Mark J., primary, Peng, Kah-Whye, primary, and Russell, Stephen J., primary

Published
2023
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3. Supplementary Figure 4 from Phase I Trial of Intraperitoneal Administration of an Oncolytic Measles Virus Strain Engineered to Express Carcinoembryonic Antigen for Recurrent Ovarian Cancer

Author

Galanis, Evanthia, primary, Hartmann, Lynn C., primary, Cliby, William A., primary, Long, Harry J., primary, Peethambaram, Prema P., primary, Barrette, Brigitte A., primary, Kaur, Judith S., primary, Haluska, Paul J., primary, Aderca, Ileana, primary, Zollman, Paula J., primary, Sloan, Jeff A., primary, Keeney, Gary, primary, Atherton, Pamela J., primary, Podratz, Karl C., primary, Dowdy, Sean C., primary, Stanhope, C. Robert, primary, Wilson, Timothy O., primary, Federspiel, Mark J., primary, Peng, Kah-Whye, primary, and Russell, Stephen J., primary

Published
2023
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4. Supplementary Figure 5 from Phase I Trial of Intraperitoneal Administration of an Oncolytic Measles Virus Strain Engineered to Express Carcinoembryonic Antigen for Recurrent Ovarian Cancer

Author

Galanis, Evanthia, primary, Hartmann, Lynn C., primary, Cliby, William A., primary, Long, Harry J., primary, Peethambaram, Prema P., primary, Barrette, Brigitte A., primary, Kaur, Judith S., primary, Haluska, Paul J., primary, Aderca, Ileana, primary, Zollman, Paula J., primary, Sloan, Jeff A., primary, Keeney, Gary, primary, Atherton, Pamela J., primary, Podratz, Karl C., primary, Dowdy, Sean C., primary, Stanhope, C. Robert, primary, Wilson, Timothy O., primary, Federspiel, Mark J., primary, Peng, Kah-Whye, primary, and Russell, Stephen J., primary

Published
2023
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5. Supplementary Figure Legends 1-5 from Phase I Trial of Intraperitoneal Administration of an Oncolytic Measles Virus Strain Engineered to Express Carcinoembryonic Antigen for Recurrent Ovarian Cancer

Author

Galanis, Evanthia, primary, Hartmann, Lynn C., primary, Cliby, William A., primary, Long, Harry J., primary, Peethambaram, Prema P., primary, Barrette, Brigitte A., primary, Kaur, Judith S., primary, Haluska, Paul J., primary, Aderca, Ileana, primary, Zollman, Paula J., primary, Sloan, Jeff A., primary, Keeney, Gary, primary, Atherton, Pamela J., primary, Podratz, Karl C., primary, Dowdy, Sean C., primary, Stanhope, C. Robert, primary, Wilson, Timothy O., primary, Federspiel, Mark J., primary, Peng, Kah-Whye, primary, and Russell, Stephen J., primary

Published
2023
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6. Supplementary Figure 1 from Phase I Trial of Intraperitoneal Administration of an Oncolytic Measles Virus Strain Engineered to Express Carcinoembryonic Antigen for Recurrent Ovarian Cancer

Author

Galanis, Evanthia, primary, Hartmann, Lynn C., primary, Cliby, William A., primary, Long, Harry J., primary, Peethambaram, Prema P., primary, Barrette, Brigitte A., primary, Kaur, Judith S., primary, Haluska, Paul J., primary, Aderca, Ileana, primary, Zollman, Paula J., primary, Sloan, Jeff A., primary, Keeney, Gary, primary, Atherton, Pamela J., primary, Podratz, Karl C., primary, Dowdy, Sean C., primary, Stanhope, C. Robert, primary, Wilson, Timothy O., primary, Federspiel, Mark J., primary, Peng, Kah-Whye, primary, and Russell, Stephen J., primary

Published
2023
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7. Supplementary Figure 3 from Phase I Trial of Intraperitoneal Administration of an Oncolytic Measles Virus Strain Engineered to Express Carcinoembryonic Antigen for Recurrent Ovarian Cancer

Author

Galanis, Evanthia, primary, Hartmann, Lynn C., primary, Cliby, William A., primary, Long, Harry J., primary, Peethambaram, Prema P., primary, Barrette, Brigitte A., primary, Kaur, Judith S., primary, Haluska, Paul J., primary, Aderca, Ileana, primary, Zollman, Paula J., primary, Sloan, Jeff A., primary, Keeney, Gary, primary, Atherton, Pamela J., primary, Podratz, Karl C., primary, Dowdy, Sean C., primary, Stanhope, C. Robert, primary, Wilson, Timothy O., primary, Federspiel, Mark J., primary, Peng, Kah-Whye, primary, and Russell, Stephen J., primary

Published
2023
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8. Supplementary Table 1 from Phase I Trial of Intraperitoneal Administration of an Oncolytic Measles Virus Strain Engineered to Express Carcinoembryonic Antigen for Recurrent Ovarian Cancer

Author

Galanis, Evanthia, primary, Hartmann, Lynn C., primary, Cliby, William A., primary, Long, Harry J., primary, Peethambaram, Prema P., primary, Barrette, Brigitte A., primary, Kaur, Judith S., primary, Haluska, Paul J., primary, Aderca, Ileana, primary, Zollman, Paula J., primary, Sloan, Jeff A., primary, Keeney, Gary, primary, Atherton, Pamela J., primary, Podratz, Karl C., primary, Dowdy, Sean C., primary, Stanhope, C. Robert, primary, Wilson, Timothy O., primary, Federspiel, Mark J., primary, Peng, Kah-Whye, primary, and Russell, Stephen J., primary

Published
2023
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13. Hypoxic effect of exogenous insulin on normal and diabetic peripheral nerve

Author

Kihara, Mikihiro, Zollman, Paula J., Smithson, Inge L., Lagerlund, Terrence D., and Low, Phillip A.

Subjects
Insulin -- Physiological aspects, Nerves, Peripheral -- Physiological aspects, Biological sciences
Abstract

Insulin treatment induces temporal hypoxia in normal, nondiabetic nerves. Its prolongation has a dual effect of normalizing energy substrates and making the diabetic nerves susceptible to endoneural hypoxia. Insulin exerts a vasoconstrictor effect on the conjunctival vessels in humans and causes orthostatic hypotension, apart from inducing vasodilation.

Published
1994

17. -Lipoic Acid: Effect on Glucose Uptake, Sorbitol Pathway, and Energy Metabolism in Experimental Diabetic Neuropathy

Author

Kishi, Yutaka, Schmelzer, James D., Yao, Jeffrey K., Zollman, Paula J., Nickander, Kim K., Tritschler, Hans J., and Low, Phillip A.

Subjects
Complications and side effects, Physiological aspects, Development and progression, Energy metabolism -- Physiological aspects, Diabetes mellitus -- Complications and side effects -- Development and progression, Diabetic neuropathies -- Development and progression -- Complications and side effects, Bioenergetics -- Physiological aspects, Diabetes -- Complications and side effects -- Development and progression
Abstract

The peripheral nerve of experimental diabetic neuropathy (EDN) is reported to be ischemic and hypoxic, with an increased dependence on anaerobic metabolism, requiring increased energy substrate stores. When glucose stores [...]

Published
1999

18. Phase I Trial of Intraperitoneal Administration of an Oncolytic Measles Virus Strain Engineered to Express Carcinoembryonic Antigen for Recurrent Ovarian Cancer

Author

Galanis, Evanthia, primary, Hartmann, Lynn C., additional, Cliby, William A., additional, Long, Harry J., additional, Peethambaram, Prema P., additional, Barrette, Brigitte A., additional, Kaur, Judith S., additional, Haluska, Paul J., additional, Aderca, Ileana, additional, Zollman, Paula J., additional, Sloan, Jeff A., additional, Keeney, Gary, additional, Atherton, Pamela J., additional, Podratz, Karl C., additional, Dowdy, Sean C., additional, Stanhope, C. Robert, additional, Wilson, Timothy O., additional, Federspiel, Mark J., additional, Peng, Kah-Whye, additional, and Russell, Stephen J., additional

Published
2010
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19. Toxicology Study of Repeat Intracerebral Administration of a Measles Virus Derivative Producing Carcinoembryonic Antigen in Rhesus Macaques in Support of a Phase I/II Clinical Trial for Patients with Recurrent Gliomas

Author

Myers, Rae, primary, Harvey, Mary, additional, Kaufmann, Timothy J., additional, Greiner, Suzanne M., additional, Krempski, James W., additional, Raffel, Corey, additional, Shelton, Steven E., additional, Soeffker, Diane, additional, Zollman, Paula, additional, Federspiel, Mark J., additional, Blanco, Michael, additional, and Galanis, Evanthia, additional

Published
2008
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20. Oncolytic measles virus strains in the treatment of gliomas

Author

Allen, Cory, primary, Paraskevakou, Georgia, additional, Liu, Chunsheng, additional, Iankov, Ianko D, additional, Msaouel, Pavlos, additional, Zollman, Paula, additional, Myers, Rae, additional, Peng, Kah Whye, additional, Russell, Stephen J, additional, and Galanis, Evanthia, additional

Published
2008
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21. Combination of Measles Virus Virotherapy and Radiation Therapy Has Synergistic Activity in the Treatment of Glioblastoma Multiforme

Author

Liu, Chunsheng, primary, Sarkaria, Jann N., additional, Petell, Cory A., additional, Paraskevakou, Georgia, additional, Zollman, Paula J., additional, Schroeder, Mark, additional, Carlson, Brett, additional, Decker, Paul A., additional, Wu, Wenting, additional, James, C. David, additional, Russell, Stephen J., additional, and Galanis, Evanthia, additional

Published
2007
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22. 729. Phase I Trial of Intraperitoneal (IP) Administration of a Measles Virus (MV) Strain Expressing the Human Carcinoembryonic Antigen (CEA) in Ovarian Cancer Patients

Author

Galanis, Evanthia, primary, Hartmann, Lynn C., additional, Cliby, William A., additional, Zollman, Paula, additional, Peethambaram, Prema P., additional, Long, Harry J., additional, Kaur, Judith S., additional, Sloan, Jeff A., additional, Poland, Gregory A., additional, Peng, Kah-Whye, additional, and Russell, Stephen J., additional

Published
2006
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23. 297. Safety of Repeat Intracerebral Administration of MV-CEA in Rhesus Macaques in Support of a Phase I/II Clinical Trial for Patients with Recurrent Gliomas

Author

Myers, Rae M., primary, Harvey, Mary E., additional, Greiner, Suzanne M., additional, Soeffker, Diane C., additional, Krempski, James W., additional, Zollman, Paula J., additional, Shelton, Steven E., additional, Corey, Raffel, additional, Stephan, Goerss J., additional, Timothy, Kaufmann J., additional, Mark, Federspiel J., additional, Kah-Whye, Peng, additional, Stephen, Russell J., additional, and Evanthia, Galanis, additional

Published
2006
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32. Alpha-lipoic acid: effect on glucose uptake, sorbitol pathway, and energy metabolism in experimental diabetic neuropathy.

Author

Kishi, Yutaka, Schmelzer, James D., Yao, Jeffrey K., Zollman, Paula J., Nickander, Kim K., Tritschler, Hans J., Low, Phillip A., Kishi, Y, Schmelzer, J D, Yao, J K, Zollman, P J, Nickander, K K, Tritschler, H J, and Low, P A

Subjects
DIABETIC neuropathies, GLUCOSE, ENERGY metabolism, PROTEIN kinase C, STREPTOZOTOCIN, GLUCOSE metabolism, ANIMAL experimentation, BLOOD sugar, CARBOXYLIC acids, COMPARATIVE studies, DIABETES, DOSE-effect relationship in pharmacology, FRUCTOSE, SENSORY ganglia, INOSITOL, RESEARCH methodology, MEDICAL cooperation, RATS, RESEARCH, SCIATIC nerve, SORBITOL, TRANSFERASES, EVALUATION research
Abstract

The peripheral nerve of experimental diabetic neuropathy (EDN) is reported to be ischemic and hypoxic, with an increased dependence on anaerobic metabolism, requiring increased energy substrate stores. When glucose stores become reduced, fiber degeneration has been reported. We evaluated glucose uptake, nerve energy metabolism, the polyol pathway, and protein kinase C (PKC) activity in EDN induced by streptozotocin. Control and diabetic rats received lipoic acid (0, 10, 25, 50, 100 mg/kg). Duration of diabetes was 1 month, and alpha-lipoic acid was administered intraperitoneally 5 times per week for the final week of the experiment. Nerve glucose uptake was reduced to 60, s 37, and 30% of control values in the sciatic nerve, L5 dorsal root ganglion, and superior cervical ganglion (SCG), respectively, in rats with EDN. Alpha-lipoic acid supplementation had no effect on glucose uptake in normal nerves at any dose, but reversed the deficit in EDN, with a threshold between 10 and 25 mg/kg. Endoneurial glucose, fructose, sorbitol, and myo-inositol were measured in sciatic nerve. Alpha-lipoic acid had no significant effect on either energy metabolism or polyol pathway of normal nerves. In EDN, endoneurial glucose, fructose, and sorbitol were significantly increased, while myo-inositol was significantly reduced. Alpha-lipoic acid had a biphasic effect: it dose-dependently increased fructose, glucose, and sorbitol, peaking at 25 mg/kg, and then fell beyond that dose, and it dose-dependently increased myo-inositol. Sciatic nerve cytosolic PKC was increased in EDN. ATP, creatine phosphate, and lactate were measured in sciatic nerve and SCG. Alpha-lipoic acid prevented the reduction in SCG creatine phosphate. We conclude that glucose uptake is reduced in EDN and that this deficit is dose-dependently reversed by alpha-lipoic acid, a change associated with an improvement in peripheral nerve function. [ABSTRACT FROM AUTHOR]

Published
1999
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