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This study describes the protective effects of piperazine derived compounds against aspirin induced gastric injuries and evaluated the role of nitric oxide, inflammatory cytokines and serum level of aspartate aminotransaminases (AST), alanine aminotransaminases (ALT), high density lipoprotein (HDL) and malondialdehyde (MDA). The oral administration of the compounds at doses 30 and 60 mg/kg protected the gastric against the nectrotizing effects of aspirin. The level of nitric oxide (NO) was elevated in the group pretreated with the compounds. The results also showed that pre-treatment with piperazine compounds has led to the decrease in the amount of MDA and increased the activity of AST, ALT and HDL. In conclusion, pre-treatment with piperazine derived compounds; (E)-2-(1-(2-(piperazin-1-yl)ethylimino)ethyl)phenol (2HP), (E)-4-(1-(2-(piperazin-1-yl)ethylimino)ethyl) benzene-1,3-diol (DHP) and their zinc complexes has provided a significant protection to the gastric from damaging effects of aspirin.

A theoretical study of the dimerization of amphiphilic Schiff-base bis(salicylaldiminato)Zinc(II) complex (1) in dichloromethane with and without pyridine, is reported in this paper. A comparative investigation between experimental and calculated 1 H NMR and UV–vis spectra was performed to evaluate the percentage contribute of each conformer in non-coordinating solvent. DFT calculations and a detailed analysis of the rotational barrier were carried out to study various dimer aggregate. Gibbs free energy related to the dimerization process, in presence of pyridine, was also estimated. Results highlight that in solution of non-coordinating solvent are mainly present three different conformers ( D1 , D2 and D3 ) which can convert each other at room temperature. Moreover, it was confirmed that dimerization is a favored process in the non-coordinating solvent. Without a doubt, best fit procedure demonstrates that the greater contribute to the dimers distribution in solution, is due to conformer D3 . UV–vis bands were also assigned to the corresponding electronic transitions. Finally the dimerization process is, thermodynamically, not favored in presence of pyridine. In this case the stable complex monomer–pyridine is formed. [ABSTRACT FROM AUTHOR]

This study describes the protective effects of piperazine derived compounds against aspirin induced gastric injuries and evaluated the role of nitric oxide, inflammatory cytokines and serum level of aspartate aminotransaminases (AST), alanine aminotransaminases (ALT), high density lipoprotein (HDL) and malondialdehyde (MDA). The oral administration of the compounds at doses 30 and 60 mg/kg protected the gastric against the nectrotizing effects of aspirin. The level of nitric oxide (NO) was elevated in the group pretreated with the compounds. The results also showed that pre-treatment with piperazine compounds has led to the decrease in the amount of MDA and increased the activity of AST, ALT and HDL. In conclusion, pre-treatment with piperazine derived compounds; (E)-2-(1-(2-(piperazin-1-yl)ethylimino)ethyl)phenol (2HP), (E)-4-(1-(2-(piperazin-1-yl)ethylimino)ethyl) benzene-1,3-diol (DHP) and their zinc complexes has provided a significant protection to the gastric from damaging effects of aspirin. [ABSTRACT FROM AUTHOR]