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Synthesis and gastroprotective activities of some zinc (II) complexes derived from (E)-2-(1-(2-(piperazin-1-yl)ethylimino)ethyl)phenol and (E)-4-(1-(2-(piperazin-1-yl)ethylimino)ethyl)benzene-1,3-diol Schiff bases against aspirin induced ulceration
- Source :
- Arabian Journal of Chemistry, Vol 10, Iss S2, Pp S1578-S1589 (2017)
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- This study describes the protective effects of piperazine derived compounds against aspirin induced gastric injuries and evaluated the role of nitric oxide, inflammatory cytokines and serum level of aspartate aminotransaminases (AST), alanine aminotransaminases (ALT), high density lipoprotein (HDL) and malondialdehyde (MDA). The oral administration of the compounds at doses 30 and 60 mg/kg protected the gastric against the nectrotizing effects of aspirin. The level of nitric oxide (NO) was elevated in the group pretreated with the compounds. The results also showed that pre-treatment with piperazine compounds has led to the decrease in the amount of MDA and increased the activity of AST, ALT and HDL. In conclusion, pre-treatment with piperazine derived compounds; (E)-2-(1-(2-(piperazin-1-yl)ethylimino)ethyl)phenol (2HP), (E)-4-(1-(2-(piperazin-1-yl)ethylimino)ethyl) benzene-1,3-diol (DHP) and their zinc complexes has provided a significant protection to the gastric from damaging effects of aspirin.
- Subjects :
- 0301 basic medicine
Chemistry(all)
Stereochemistry
General Chemical Engineering
Diol
chemistry.chemical_element
Zinc
Medicinal chemistry
Nitric oxide
lcsh:Chemistry
Lipid peroxidation
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Oral administration
Phenol
GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
ComputingMilieux_MISCELLANEOUS
Ulcerations
Aspirin
General Chemistry
Malondialdehyde
Lipid-peroxidation
digestive system diseases
Piperazine
030104 developmental biology
lcsh:QD1-999
chemistry
030220 oncology & carcinogenesis
Chemical Engineering(all)
Cytokines
Zn-complexes
Subjects
Details
- ISSN :
- 18785352
- Database :
- OpenAIRE
- Journal :
- Arabian Journal of Chemistry
- Accession number :
- edsair.doi.dedup.....99dad442a701fd4ba19de4956b25df3e
- Full Text :
- https://doi.org/10.1016/j.arabjc.2013.05.028