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Abstract Shared‐energy storage (SES) can break the energy interaction barrier between the demand side and the supply side, which is becoming an option for improving the flexibility of energy systems. This study designed a novel structure for the shared‐energy aggregator (SEA), incorporating a microgrid (MG), prosumer and SES. Then, a two‐level market transaction optimization model for SEA, considering the robust stochastic optimization method, is proposed; namely, at the day‐ahead stage, a robust stochastic operation optimization model is constructed to achieve the dispatching plan from the demand side under the objective of achieving the minimum energy consumption cost for the prosumer, and at the real‐time market stage, a robust stochastic operation optimization model from the supply side is constructed to arrange the optimal dispatching strategy under the objective of the maximum aggregator benefits of MG and SES. Finally, an industrial park micro‐grid in Qinghai Province, China, is selected as an example for analysis.

Summary: The art of passive thermal management lies in effectively mitigating heat stress by manipulating the optical spectra of target objects. However, a significant obstacle remains in finding a structure that can seamlessly adapt to diverse thermal environments. In response to this challenge, we posit that Janus fabrics have unique advantages for multi-scene applications when carefully engineered. A Janus fabric with an upper side exhibiting a 92% solar reflectivity and a 94% emissivity, along with a lower side possessing an infrared emissivity below 30% could enable energy savings at a large scale. It outperforms commercial products in terms of energy-saving efficiency under different climate conditions. Furthermore, the scalable manufacturing compatibility and outstanding performance make the Janus structure a promising avenue for diverse passive thermal management scenarios.

Systemic lupus erythematosus is characterised by the generation of antibodies targeting DNA and nuclear antigens. Here, the authors show that oxidised mitochondrial DNA induces gasdermin D oligomerization and promotes pore formation in neutrophils from patients with SLE.

Objective. Cuproptosis is a newly discovered copper-independent cell death modality, and limited evidence suggests the critical implications in human cancers. Nonetheless, the clinical impacts of cuproptosis-relevant lncRNAs in lung adenocarcinoma (LUAD) remain largely ill-defined. The present study was aimed at defining a cuproptosis-relevant lncRNA signature for LUAD and discuss the clinical utility. Methods. We collected transcriptome expression profiling, clinical information, somatic mutation, and copy number variations from TCGA-LUAD cohort retrospectively. The genetic alterations of cuproptosis genes were systematically assessed across LUAD, and cuproptosis-relevant lncRNAs were screened for defining a LASSO prognostic model. Genomic alterations, immunological and stemness features, and therapeutic sensitivity were studied with a series of computational approaches. Results. Cuproptosis genes displayed aberrant expression and widespread genomic alterations across LUAD, potentially modulated by m6A/m5C/m1A RNA modification mechanisms. We defined a cuproptosis-relevant lncRNA signature, with a reliable efficacy in predicting clinical outcomes. High-risk subset displayed higher somatic mutations, CNVs, TMB, SNV neoantigens, aneuploidy score, CTA score, homologous recombination defects, and intratumor heterogeneity, cytolytic activity, CD8+ T effector, and antigen processing machinery, proving that this subset might benefit from immunotherapy. Increased stemness indexes and activity of oncogenic pathways might contribute to undesirable prognostic outcomes for high-risk subset. Additionally, high-risk patients generally exhibited higher response to chemotherapeutic agents (cisplatin, etc.). We also predicted several small molecule compounds (GSK461364, KX2-391, etc.) for treating this subset. Conclusion. Accordingly, this cuproptosis-relevant lncRNA signature offers an efficient approach to identify and characterize diverse prognosis, genomic alterations, and treatment outcomes in LUAD, thus potentially assisting personalized therapy.

China has developed a preliminary policy system for the development of new energy vehicles regarding the law, electricity price, grid-connected standards, project management, and financial support, however, defects remain in the policy and market environment, market mechanism, control technology, infrastructure, etc. We analyze new energy vehicles based on the analysis of basic data such as the number of electric vehicles and charging facilities, focusing on industrial development strategies, related subsidies, and tax policies. First, this paper summarizes the development status of China’s new energy vehicles in different scenarios. In 2021, China’s new energy vehicle production was 3545 thousand, and sales amounted to 3521 thousand. According to preliminary estimates, the number of new energy vehicles will exceed 15 million in 2030. The research route for the development of new energy vehicle bottlenecks is proposed. Secondly, we analyze foreign and Chinese policies on different stages and construct the implementation path for the healthy and stable development of China’s new energy vehicles. By comparing the basic indicators, related policies, and related innovation activities of new energy vehicles in China, we conclude that the development of the national electric vehicle industry needs to be increased in terms of government policies, business model innovation, and public awareness.