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Oxidized mitochondrial DNA induces gasdermin D oligomerization in systemic lupus erythematosus
- Source :
- Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
- Publication Year :
- 2023
- Publisher :
- Nature Portfolio, 2023.
-
Abstract
- Systemic lupus erythematosus is characterised by the generation of antibodies targeting DNA and nuclear antigens. Here, the authors show that oxidised mitochondrial DNA induces gasdermin D oligomerization and promotes pore formation in neutrophils from patients with SLE.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 14
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.8a7bdcb11f134a0a95c8aa53d94c12a7
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-023-36522-z