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Oxidized mitochondrial DNA induces gasdermin D oligomerization in systemic lupus erythematosus

Authors :
Naijun Miao
Zhuning Wang
Qinlan Wang
Hongyan Xie
Ninghao Yang
Yanzhe Wang
Jin Wang
Haixia Kang
Wenjuan Bai
Yuanyuan Wang
Rui He
Kepeng Yan
Yang Wang
Qiongyi Hu
Zhaoyuan Liu
Fubin Li
Feng Wang
Florent Ginhoux
Xiaoling Zhang
Jianyong Yin
Limin Lu
Jing Wang
Source :
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Publication Year :
2023
Publisher :
Nature Portfolio, 2023.

Abstract

Systemic lupus erythematosus is characterised by the generation of antibodies targeting DNA and nuclear antigens. Here, the authors show that oxidised mitochondrial DNA induces gasdermin D oligomerization and promotes pore formation in neutrophils from patients with SLE.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
14
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.8a7bdcb11f134a0a95c8aa53d94c12a7
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-023-36522-z