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Quercetin (1) was converted into quercetin 7-O-succinyl glucoside (2) by used Bacillus amyloliquefaciens FJ18 as a solvent-resistant whole-cell biocatalyst. The structure of the new compound was confirmed by LC-MS analysis and NMR spectroscopy. The water-solubility of this novel quercetin 7-O-succinyl glucoside (2) was approximately 1000 times higher than that of native quercetin (2). Quercetin (1) and quercetin 7-O-succinyl glucoside (2) exhibited significant DPPH scavenging capacity with IC50 values of 23.55 and 36.05 µM, respectively. Both compounds showed moderate cytotoxic effects against the two human cancer cell lines (MCF-7 and HepG2) with IC50 values ranging from 39.45-63.38 µM.

To investigate the prevalence and etiology of people with hearing disability in China and to provide evidence for development of related prevention and treatment strategies.Using the statistics and inference from data of the Second China National Sample Survey on Disability.27.80 million people were diagnosed with hearing disability, including 20.04 million with pure disability. The overall prevalence was 2.11% including 'single disability' as 1.52% (accounting for 72.08%) and the rate was 11.04% among the elderly(accounting for 73.57%). The prevalence of hearing disability was higher in males than in females as well as higher in the rural than in the urban. Sufferers were mainly engaging in agriculture with poor education background. Among all the people with hearing disability, Grade III and IV was accounted for 73.42% but among the elderly, they were accounted for 79.13%. Grade I and II was accounted for 67.36% among children aged four to six and 83.90% in children aged below three. Speech disabilities were more than 70% in aged below six. The whole etiology contains presbycusis, unknown causation and tympanitis with primary causes as heredity, pregnant virus infection, neonatal asphyxiation, drug-induced deafness, premature delivery and low birth avoirdupois, other than unknown deaf among the 0-6 year olds. However, the primary causation would include presbycusis, tympanitis, sickness, noise/detonation and drug-induced deafness for the elderly.Active prevention on presbycusis with emphasis on prevention and cure to rural population was important in reducing the venture of hearing disability. Related consultation on genetic factors was another measure to be taken to prevent hearing disability developed in the newborns.

To explore the status of rehabilitation demands and services of persons with disability in Beijing and to provide evidence for rehabilitation establishment programmed by government and civil society.Using both qualitative and descriptive methodologies to analyze the data of 4852 disabled persons who had been confirmed of requiring rehabilitation services in Beijing. Data was from the Second China National Sample Survey on Disability in conferring the demands for rehabilitation services.The consciousness and demand for rehabilitation was higher among urban disabled residents than those living in the rural areas. Demand on rehabilitation training from children was accounted for 75.23%. Rates of demand on assistant device and medical service among the elderly were 57.05%, 66.86% respectively. Primary rehabilitation format of grade I and II appeared to be community-based and family service while grade III and IV were institutional rehabilitation programs. Rates on needs regarding vision and limb accounted for 85.23% and 59.91% respectively. 76.95% of the disability persons among intelligentsia needed community and family service. The rates on demand of medical treatment of mental, vision, limbs services were 92.80%, 86.77% and 68.24% respectively while the demand for assistant device of hearing disability was 83.09%. Rates of demand on rehabilitative training from mental, dication and mind disabled were 84.36%, 77.42%, 62.82%. Other kinds of demand and services seemed relatively low other than medical treatment.The gap between demand and salvation on rehabilitation was relatively great, suggesting the enhancement of disabled rehabilitation programs be strengthened to promote the build-up of a correct concept on rehabilitation among the disabled. Demands from the disabled persons should be extensively met.